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1. 发明申请

US20170219603A1 Application of TRPM8 protein, related peptide fragment and their antibodies 审中-公开
公开(公告)号：US20170219603A1
公开(公告)日：2017-08-03
申请号：US15352607
申请日：2016-11-16
申请人： Lei Han , Xiaohui Zhou , Yuyan Zhou , Li Zhou , Guohua Li , Yongzhen Li
发明人： Lei Han , Xiaohui Zhou , Yuyan Zhou , Li Zhou , Guohua Li , Yongzhen Li
IPC分类号： G01N33/68 , C07K16/28 , C07K14/47
CPC分类号： C07K16/28 , A61K2039/505 , C07K14/705 , G01N33/6872 , G01N2800/342
摘要： A TRPM8 related peptide fragment, comprising amino acid sequence as shown in SEQ ID No: 1-18 is provided. Furthermore, application of TRPM8 protein, TRPM8 related peptide fragment and their antibodies in preparing diagnostic reagent for chronic prostatitis/chronic pelvic pain syndromes (CP/CPPS) is provided. By detecting level of TRPM8 protein molecule, TRPM8 related peptide fragment and their antibodies, the chronic prostatitis/chronic pelvic pain syndromes (CP/CPPS) is effectively diagnosed, and the present invention is capable of effectively making a distinction between CP/CPPS and other diseases of prostate. In addition, by intravenously or subcutaneously injecting 1˜30000 IU TRPM8 protein or TRPM8 related polypeptide fragments with or without combining nanoparticles for desensitization therapy, or monoclonal or polyclonal antibodies of the TRPM8 protein or polypeptide fragments, the present invention is capable of curing or significantly relieve clinical symptoms of the chronic prostatitis/chronic pelvic pain syndromes (CP/CPPS) and having an therapeutic effect.

2. 发明授权

US11175289B2 Application of TRPM8 protein, related peptide fragment and their antibodies 有权
公开(公告)号：US11175289B2
公开(公告)日：2021-11-16
申请号：US15352607
申请日：2016-11-16
申请人： Lei Han , Xiaohui Zhou , Yuyan Zhou , Li Zhou , Guohua Li , Yongzhen Li
发明人： Lei Han , Xiaohui Zhou , Yuyan Zhou , Li Zhou , Guohua Li , Yongzhen Li
IPC分类号： C07K14/705 , G01N33/564 , C07K16/28
摘要： A TRPM8 related peptide fragment, comprising amino acid sequence as shown in SEQ ID No: 1-18 is provided. Furthermore, application of TRPM8 protein, TRPM8 related peptide fragment and their antibodies in preparing diagnostic reagent for chronic prostatitis/chronic pelvic pain syndromes (CP/CPPS) is provided. By detecting level of TRPM8 protein molecule, TRPM8 related peptide fragment and their antibodies, the chronic prostatitis/chronic pelvic pain syndromes (CP/CPPS) is effectively diagnosed, and the present invention is capable of effectively making a distinction between CP/CPPS and other diseases of prostate. In addition, by intravenously or subcutaneously injecting 1˜30000 IU TRPM8 protein or TRPM8 related polypeptide fragments with or without combining nanoparticles for desensitization therapy, or monoclonal or polyclonal antibodies of the TRPM8 protein or polypeptide fragments, the present invention is capable of curing or significantly relieve clinical symptoms of the chronic prostatitis/chronic pelvic pain syndromes (CP/CPPS) and having an therapeutic effect.

3. 发明授权

US08112516B2 Selective user notification based on IP flow information 有权
标题翻译：基于IP流量信息的选择性用户通知
公开(公告)号：US08112516B2
公开(公告)日：2012-02-07
申请号：US11844317
申请日：2007-08-23
申请人： Alex Wang , David Bainbridge , Xiaohui Zhou , Beecher Adams
发明人： Alex Wang , David Bainbridge , Xiaohui Zhou , Beecher Adams
IPC分类号： G06F15/173
CPC分类号： H04L41/507 , H04L41/0213 , H04L67/24 , H04L69/40
摘要： An example embodiment of the present invention provides a process that uses IP flow information to selectively notify users of an application server of the server's unavailability. In the example embodiment, the process, which might run on a system comprising a router, monitors IP flow records as to dropped packets and learns that an application server has become unavailable. The process then uses the IP flow records to identify active users of the application server, for example, by passing a source IP address to a presence service. Once the process has identified an active user, the process determines a means of notification for the user, which might be through the presence service, and transmits a notification to the user as to the unavailability of the application server. In the example embodiment, the process transmits a later notification as to the availability of the application server, using reverse camp-on functionality.
摘要翻译：本发明的示例性实施例提供了一种使用IP流信息选择性地通知应用服务器的用户服务器不可用性的过程。在示例实施例中，可能在包括路由器的系统上运行的进程监视关于丢弃分组的IP流记录，并且学习应用服务器变得不可用。然后，该过程使用IP流记录来识别应用服务器的活动用户，例如，通过将源IP地址传递到在场服务。一旦该过程已经识别出活动用户，则该过程确定可能通过在场服务的用户的通知手段，并且向用户发送关于应用服务器的不可用性的通知。在示例实施例中，该过程使用反向驻留功能来发送关于应用服务器的可用性的稍后通知。

4. 发明申请

US20120136995A1 Selective User Notification Based on IP Flow Information 有权
标题翻译：基于IP流量信息的选择性用户通知
公开(公告)号：US20120136995A1
公开(公告)日：2012-05-31
申请号：US13367021
申请日：2012-02-06
申请人： Alex Wang , David Bainbridge , Xiaohui Zhou , Beecher Adams
发明人： Alex Wang , David Bainbridge , Xiaohui Zhou , Beecher Adams
IPC分类号： G06F15/173
CPC分类号： H04L41/507 , H04L41/0213 , H04L67/24 , H04L69/40
摘要： An example embodiment of the present invention provides a process that uses IP flow information to selectively notify users of an application server of the server's unavailability. In the example embodiment, the process, which might run on a system comprising a router, monitors IP flow records as to dropped packets and learns that an application server has become unavailable. The process then uses the IP flow records to identify active users of the application server, for example, by passing a source IP address to a presence service. Once the process has identified an active user, the process determines a means of notification for the user, which might be through the presence service, and transmits a notification to the user as to the unavailability of the application server. In the example embodiment, the process transmits a later notification as to the availability of the application server, using reverse camp-on functionality.
摘要翻译：本发明的示例性实施例提供了一种使用IP流信息选择性地通知应用服务器的用户服务器不可用性的过程。在示例实施例中，可能在包括路由器的系统上运行的进程监视关于丢弃分组的IP流记录，并且学习应用服务器变得不可用。然后，该过程使用IP流记录来识别应用服务器的活动用户，例如，通过将源IP地址传递到在场服务。一旦该过程已经识别出活动用户，则该过程确定可能通过在场服务的用户的通知手段，并且向用户发送关于应用服务器的不可用性的通知。在示例实施例中，该过程使用反向驻留功能来发送关于应用服务器的可用性的稍后通知。

5. 发明申请

US20120059214A1 Active hydraulic ventricular attaching support system 有权
标题翻译：主动液压心室附着支撑系统
公开(公告)号：US20120059214A1
公开(公告)日：2012-03-08
申请号：US13319520
申请日：2010-04-30
申请人： Xiaohui Zhou
发明人： Xiaohui Zhou
IPC分类号： A61M1/12
CPC分类号： A61F2/2481 , A61M1/1008 , A61M1/106 , A61M1/1068 , A61M1/12
摘要： An active hydraulic ventricular attachable support system includes a net cover for surrounding a ventricle and is formed by hollow tubes. All the hollow tubes can completely communicate with each other or form a plurality of independent areas, and the interior of each independent area is intercommunicating, while the independent areas are not communicating with each other. The system as a whole is positioned on the surface of the heart. The hollow tubular structure can be filled with various kinds of liquid of different physical characteristics, and then the corresponding reaction pressure generated can be applied to the ventricle and the surfaces of the heart. The system also can be incorporated with local administration.
摘要翻译：活动的液压心室可附接支撑系统包括用于围绕心室并由中空管形成的网罩。所有中空管可以彼此完全通信或形成多个独立区域，并且每个独立区域的内部是相互通信的，而独立区域彼此不相通。整个系统位于心脏表面。中空管状结构可以填充不同物理特性的各种液体，然后产生的相应反应压力可应用于心室和心脏表面。该系统也可以与当地管理相结合。

6. 发明申请

US20090055501A1 Selective User Notification Based on IP Flow Information 有权
标题翻译：基于IP流量信息的选择性用户通知
公开(公告)号：US20090055501A1
公开(公告)日：2009-02-26
申请号：US11844317
申请日：2007-08-23
申请人： Alex Wang , David Bainbridge , Xiaohui Zhou , Beecher Adams
发明人： Alex Wang , David Bainbridge , Xiaohui Zhou , Beecher Adams
IPC分类号： G06F15/16
CPC分类号： H04L41/507 , H04L41/0213 , H04L67/24 , H04L69/40
摘要： An example embodiment of the present invention provides a process that uses IP flow information to selectively notify users of an application server of the server's unavailability. In the example embodiment, the process, which might run on a system comprising a router, monitors IP flow records as to dropped packets and learns that an application server has become unavailable. The process then uses the IP flow records to identify active users of the application server, for example, by passing a source IP address to a presence service. Once the process has identified an active user, the process determines a means of notification for the user, which might be through the presence service, and transmits a notification to the user as to the unavailability of the application server. In the example embodiment, the process transmits a later notification as to the availability of the application server, using reverse camp-on functionality.
摘要翻译：本发明的示例性实施例提供了一种使用IP流信息选择性地通知应用服务器的用户服务器不可用性的过程。在示例实施例中，可能在包括路由器的系统上运行的进程监视关于丢弃分组的IP流记录，并且学习应用服务器已经变得不可用。然后，该过程使用IP流记录来识别应用服务器的活动用户，例如，通过将源IP地址传递到在场服务。一旦该过程已经识别出活动用户，则该过程确定可能通过在场服务的用户的通知手段，并且向用户发送关于应用服务器的不可用性的通知。在示例实施例中，该过程使用反向驻留功能来发送关于应用服务器的可用性的稍后通知。

7. 发明申请

US20170105675A1 Cardiac function monitor and/or intervention system attached outside or inside of heart 审中-公开
公开(公告)号：US20170105675A1
公开(公告)日：2017-04-20
申请号：US15394852
申请日：2016-12-30
申请人： Xiaohui Zhou
发明人： Xiaohui Zhou , Lei Han , Yuyan Zhou , Li Zhou , Guohua Li , Yongzhen Li
IPC分类号： A61B5/00 , A61B5/0402 , A61B5/0205 , A61B5/01 , A61N1/362 , A61B5/02 , A61N2/00 , A61H9/00 , A61M5/31 , A61M39/10 , A61N2/02 , A61B5/145
CPC分类号： A61B5/4836 , A61B5/01 , A61B5/02055 , A61B5/0215 , A61B5/026 , A61B5/0432 , A61B5/14503 , A61B5/14539 , A61H9/00 , A61M1/106 , A61M1/1068 , A61M1/122 , A61M5/31 , A61M39/10 , A61N1/0597 , A61N1/362 , A61N2/002
摘要： A surface attached cardiac function monitor and/or intervention system comprises of a cardiac support device, a cardiac function monitor device and/or intervention device. Cardiac support device is attached on an external or internal surface of a cardiac chamber and supports it. The cardiac function monitor device is connected with a biochemical and physiological sensor. The physiological and biochemical sensor transmits variations of biochemical and physiological parameters that are received by the cardiac function monitor device. The intervention device has at least one member selected from pressure intervention device, an electrical/magnetic stimulation intervention device and a medicine intervention device. This medical system of the present invention could help in diagnosis as well as treatment of the heart failure and other myocardial diseases to improve the condition of patient. It could also be helpful for the monitoring, diagnosis and treatment of diseases of lungs, kidney, liver, spleen, stomach and bladder, etc.

8. 发明授权

US09089425B2 Active hydraulic ventricular attaching support system 有权
标题翻译：主动液压心室附着支撑系统
公开(公告)号：US09089425B2
公开(公告)日：2015-07-28
申请号：US13319520
申请日：2010-04-30
申请人： Xiaohui Zhou
发明人： Xiaohui Zhou
IPC分类号： A61F2/24 , A61M1/10
CPC分类号： A61F2/2481 , A61M1/1008 , A61M1/106 , A61M1/1068 , A61M1/12
摘要： An active hydraulic ventricular attachable support system includes a net cover for surrounding a ventricle and is formed by hollow tubes. All the hollow tubes can completely communicate with each other or form a plurality of independent areas, and the interior of each independent area is intercommunicating, while the independent areas are not communicating with each other. The system as a whole is positioned on the surface of the heart. The hollow tubular structure can be filled with various kinds of liquid of different physical characteristics, and then the corresponding reaction pressure generated can be applied to the ventricle and the surfaces of the heart. The system also can be incorporated with local administration.
摘要翻译：活动的液压心室可附接支撑系统包括用于围绕心室并由中空管形成的网罩。所有中空管可以彼此完全通信或形成多个独立区域，并且每个独立区域的内部是相互通信的，而独立区域彼此不相通。整个系统位于心脏表面。中空管状结构可以填充不同物理特性的各种液体，然后产生的相应反应压力可应用于心室和心脏表面。该系统也可以并入本地管理。

9. 发明授权

US08433795B2 Selective user notification based on IP flow information 有权
标题翻译：基于IP流量信息的选择性用户通知
公开(公告)号：US08433795B2
公开(公告)日：2013-04-30
申请号：US13367021
申请日：2012-02-06
申请人： Alex Wang , David Bainbridge , Xiaohui Zhou , Beecher Adams
发明人： Alex Wang , David Bainbridge , Xiaohui Zhou , Beecher Adams
IPC分类号： G06F15/173 , G06F15/16
CPC分类号： H04L41/507 , H04L41/0213 , H04L67/24 , H04L69/40
摘要： An example embodiment of the present invention provides a process that uses IP flow information to selectively notify users of an application server of the server's unavailability. In the example embodiment, the process, which might run on a system comprising a router, monitors IP flow records as to dropped packets and learns that an application server has become unavailable. The process then uses the IP flow records to identify active users of the application server, for example, by passing a source IP address to a presence service. Once the process has identified an active user, the process determines a means of notification for the user, which might be through the presence service, and transmits a notification to the user as to the unavailability of the application server. In the example embodiment, the process transmits a later notification as to the availability of the application server, using reverse camp-on functionality.
摘要翻译：本发明的示例性实施例提供了一种使用IP流信息选择性地通知应用服务器的用户服务器不可用性的过程。在示例实施例中，可能在包括路由器的系统上运行的进程监视关于丢弃分组的IP流记录，并且学习应用服务器变得不可用。然后，该过程使用IP流记录来识别应用服务器的活动用户，例如，通过将源IP地址传递到在场服务。一旦该过程已经识别出活动用户，则该过程确定可能通过在场服务的用户的通知手段，并且向用户发送关于应用服务器的不可用性的通知。在示例实施例中，该过程使用反向驻留功能来发送关于应用服务器的可用性的稍后通知。

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