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1. 发明授权

US5704362A Method for oscillometric blood pressure determination employing curve fitting 失效
标题翻译：使用曲线拟合的示波血压测定方法
公开(公告)号：US5704362A
公开(公告)日：1998-01-06
申请号：US106280
申请日：1993-08-13
申请人： Lawrence T. Hersh , Bruce Friedman , Richard Medero
发明人： Lawrence T. Hersh , Bruce Friedman , Richard Medero
IPC分类号： G06F19/00 , G06K9/00 , A61B5/00
CPC分类号： G06K9/00536
摘要： A method of measuring blood pressure where a plurality of oscillometric data values are measured from a subject at a plurality pressure levels, a function curve having the shape of an oscillometric envelope is selected and computational model fit to the data, using the Gauss-Marquardt method of model fitting. Once the curve is model fit, blood pressure is measured using the oscillometric method. Included in the step of model fitting is the step of computing the parameter of the function curve that minimizes the error between the function curve and the data values at the respective pressure levels thereby approximating the oscillometric envelope based upon data values.
摘要翻译：一种测量血压的方法，其中从多个压力水平上的对象测量多个示波数据值，选择具有示波包络形状的函数曲线，并使用高斯 - 马夸特方法对计算模型拟合数据的模型拟合。曲线拟合后，使用示波法测量血压。包括在模型拟合步骤中的步骤是计算函数曲线的参数的步骤，其使功能曲线和各压力水平下的数据值之间的误差最小化，从而基于数据值近似示波包络。

2. 发明申请

US20080243009A1 METHOD OF CONTROLLING INFLATION OF A CUFF IN BLOOD PRESSURE DETERMINATION 审中-公开
标题翻译：控制血压在血压测定中的运动方法
公开(公告)号：US20080243009A1
公开(公告)日：2008-10-02
申请号：US11694178
申请日：2007-03-30
申请人： Lawrence T. Hersh , Sai Kolluri , Bruce Friedman , Richard Medero
发明人： Lawrence T. Hersh , Sai Kolluri , Bruce Friedman , Richard Medero
IPC分类号： A61B5/02
CPC分类号： A61B5/02255 , A61B5/02225
摘要： The present application discloses a method of calculating an initial inflation pressure during a blood pressure determination using an NIB system. The cuff provided with the system is inflated towards a default initial inflation pressure and a plurality of oscillometric pulses are obtained during inflation. A quick systolic pressure is estimated from a pre-defined function having a physiologically- expected shape of an oscillometric envelope fitted to oscillometric data obtained during the inflation. In an embodiment, the parameters within the function are specifically found by fitting a plurality of oscillometric pulse amplitudes along with their corresponding cuff pressures obtained during inflation to the pre-defined function. The cuff is inflated up to a calculated initial inflation pressure, which is found from the estimated quick systolic pressure. After the cuff is brought to the initial inflation pressure, deflation is begun for determining the actual systolic and diastolic pressures for output to a user.
摘要翻译：本申请公开了一种使用NIB系统计算在血压测定期间的初始充气压力的方法。提供有系统的袖带朝向默认的初始充气压力充气，并且在充气期间获得多个示波脉冲。从预先定义的功能估计出快速的收缩压，该功能具有适应于在充气期间获得的示波数据的示波包络的生理预期形状。在一个实施例中，功能中的参数通过将多个示波脉冲幅度及其在充气期间获得的相应袖带压力拟合到预定义功能而具体发现。袖带充气到计算的初始充气压力，这是从估计的快速收缩压中发现的。在袖带被带到初始通货膨胀压力之后，开始通货紧缩来确定输出给用户的实际收缩压和舒张压。

3. 发明授权

US6050951A NIBP trigger in response to detected heart rate variability 失效
标题翻译： NIBP触发响应于检测到的心率变异性
公开(公告)号：US6050951A
公开(公告)日：2000-04-18
申请号：US966719
申请日：1997-11-10
申请人： Bruce Friedman , Lawrence T. Hersh , Richard Medero
发明人： Bruce Friedman , Lawrence T. Hersh , Richard Medero
IPC分类号： A61B5/022 , A61N5/00
CPC分类号： A61B5/02405 , A61B5/022 , A61B5/02225 , A61B5/7285 , Y10S128/90
摘要： An automated sphygmomanometer which triggers a blood pressure determination upon detection of a significant change in the patient's heart rate variability (HRV). The HRV can be measured directly from the NIBP signal or, when a multiparameter monitor is used, the HRV can be measured from the ECG signal or the NIBP signal. HRV is continuously monitored and the baseline HRV is correlated with baseline blood pressure values. Changes in HRV are displayed continuously on a display so that the clinician can determine whether to initiate an NIBP measurement or, on the other hand, the NIBP measurement can be triggered automatically in response to a change in HRV without any intervention by the clinician. Alternatively, the patient monitor can "learn" the correlation between HRV and blood pressure changes and only alert the clinician when a significant change in HRV has taken place. The technique of the invention allows the clinician to monitor NIBP at less frequent intervals without the concern of missing physiologically significant changes in blood pressure and without the requirement of "check inflates" in a guard mode.
摘要翻译：一种自动血压计，其在检测到患者心率变异性（HRV）的显着变化时触发血压测定。可以直接从NIBP信号测量HRV，或者当使用多参数监视器时，可以从ECG信号或NIBP信号测量HRV。持续监测HRV，基线HRV与基线血压值相关。在显示器上连续显示HRV的变化，以便临床医生可以确定是否启动NIBP测量，或者另一方面可以响应于HRV的变化而自动地触发NIBP测量，而无需临床医师的任何干预。或者，患者监护仪可以“学习”HRV与血压变化之间的相关性，并且只有在发生HRV的显着变化时才向临床医生发出警报。本发明的技术允许临床医生以不太频繁的间隔监测NIBP，而不考虑血压的生理学显着变化，并且不需要在保护模式下“检查膨胀”。

4. 发明授权

US07288070B2 Method and apparatus for determining extreme blood pressure values 失效
标题翻译：用于确定极端血压值的方法和装置
公开(公告)号：US07288070B2
公开(公告)日：2007-10-30
申请号：US10847934
申请日：2004-05-18
申请人： Sai Kolluri , Lawrence T. Hersh , Bruce Friedman , Richard Medero
发明人： Sai Kolluri , Lawrence T. Hersh , Bruce Friedman , Richard Medero
IPC分类号： A61B5/02 , A61B5/04
CPC分类号： A61B5/02225 , A61B5/0225 , A61B5/0456
摘要： In a method and apparatus for measuring extreme blood pressure values during a single non-invasive blood measurement, the time intervals between sequential heartbeats are measured for a series of heartbeats in an oscillometric blood pressure measurement time period. Oscillometric blood pressure measurement data for the heartbeats of the series is obtained and associated with the heartbeat time intervals. An average time interval between heartbeats is also determined. A first data bin may be defined for blood pressure data associated with time intervals that are longer as compared to the average time interval. A second data bin is defined for blood pressure data with time intervals that are shorter as compared to the average time interval. The measured oscillometric blood pressure data is sorted into the data bins in accordance with the associated time intervals. The data in the first data bin is used to derive a high systolic blood pressure value and a low diastolic blood pressure value. The data in the second bin is used to derive a low systolic blood pressure value and a high diastolic blood pressure value. A typical blood pressure value may also be determined.
摘要翻译：在用于在单次非侵入性血液测量期间测量极端血压值的方法和装置中，测量在示波血压测量时间段内的一系列心跳的连续心跳之间的时间间隔。获得该系列心跳的示波血压测量数据，并与心跳时间间隔相关联。心跳之间的平均时间间隔也被确定。可以为与与平均时间间隔相比较长的时间间隔相关联的血压数据定义第一数据箱。第二个数据仓被定义为与平均时间间隔相比时间间隔更短的血压数据。测量的示波血压数据根据相关联的时间间隔被分类到数据箱中。第一数据箱中的数据用于导出高收缩压值和低舒张压值。第二个仓中的数据用于导出低收缩压值和高舒张压值。也可以确定典型的血压值。

5. 发明授权

US06358213B1 Calculation of quality and its use in determination of indirect noninvasive blood pressure 有权
标题翻译：质量计算及其在间接无创血压测定中的应用
公开(公告)号：US06358213B1
公开(公告)日：2002-03-19
申请号：US09376854
申请日：1999-08-18
申请人： Bruce Friedman , Lawrence T. Hersh , Richard Medero
发明人： Bruce Friedman , Lawrence T. Hersh , Richard Medero
IPC分类号： A61B500
CPC分类号： A61B5/02225 , A61B5/022
摘要： An automated sphygmomanometer which utilizes quality algorithms to stop any further analysis at various points during a blood pressure determination because of corrupted data. If the data is so corrupted that giving blood pressure numbers is inappropriate, this is recognized and the determination stopped. The quality algorithms make a decision to get more data with the hope of improving the blood pressure estimation. The request for data occurs both before and/or after a curve fitting process, if such a process is utilized. Some information is also provided to the cuff pressure control function about which pressure levels would be best for gathering the additional data. The quality algorithms are also used to make a decision as to whether it is appropriate to publish the blood pressure values obtained. Control parameters (weights) may be set within the blood pressure algorithm to help with other aspects of the NIBP algorithm and improve the quality of the final published numbers. The quality algorithms may also help the system to decide whether to publish any warnings when significant artifact is present.
摘要翻译：一种自动血压计，其利用质量算法在由于损坏的数据在血压测定期间在各个点处停止任何进一步的分析。如果数据如此破坏，使得血压数字不适当，则会被识别并确定停止。质量算法决定获得更多的数据，希望改善血压估计。如果使用这种过程，则在曲线拟合过程之前和/或之后发生数据请求。袖带压力控制功能还提供了一些信息，其中压力水平对于收集附加数据将是最佳的。质量算法也用于作出是否适当发布获得的血压值的决定。可以在血压算法内设置控制参数（权重），以帮助NIBP算法的其他方面，并提高最终公布的数字的质量。质量算法还可以帮助系统决定是否在出现重大假象时发布任何警告。

6. 发明授权

US06423010B1 Oscillometric blood pressure monitor with improved performance in the presence of arrhythmias 有权
标题翻译：示波器血压监测仪在心律失常的情况下具有改善的表现
公开(公告)号：US06423010B1
公开(公告)日：2002-07-23
申请号：US09678650
申请日：2000-10-04
申请人： Bruce Friedman , Lawrence T. Hersh , Christopher J. Dedyo
发明人： Bruce Friedman , Lawrence T. Hersh , Christopher J. Dedyo
IPC分类号： A61B502
CPC分类号： A61B5/02225 , A61B5/021 , A61B5/02416 , A61B5/0402
摘要： The present invention relates to an improved apparatus and method for measuring blood pressure. Both include a first sensor for detecting an instantaneous pulse rate, an inflatable cuff, and a second sensor to monitoring the pressure within the cuff. The cuff sensor adapted to detect oscillometric complexes associated with a patient's pulse. Both the apparatus and the method provide for detecting arrhythmia from the patient's instantaneous pulse rate. A characteristic of the oscillometric complexes is measured, and match determination means provided for determining whether at least two adjacent oscillometric complexes are equivalent. A first set matching criteria are used under normal conditions. A second set of matching criteria are used when arrhythmia are detected. A controller is provided for controlling the pressure within the cuff. At the outset of a blood pressure measurement the cuff is inflated to a pressure greater than the patient's systolic pressure. In response to a determination that two adjacent oscillometric complexes are equivalent the control means reduces the cuff pressure by a fixed increment and the match determination means continues to determine whether adjacent complexes are equivalent. A blood pressure determination means is provided responsive to the control means and the measuring means. The blood pressure determination means compares the measured characteristic of the oscillometric complexes from various cuff pressures and determines the cuff pressure at which the measured characteristic reaches a limit. This cuff pressure corresponds to the patient's mean arterial pressure.
摘要翻译：本发明涉及一种用于测量血压的改进的装置和方法。两者都包括用于检测瞬时脉率的第一传感器，可充气袖带和用于监测袖带内的压力的第二传感器。袖带传感器适于检测与患者脉搏相关联的示波复合物。该装置和方法都提供从患者的瞬时脉搏率中检测心律失常。测量示波复合物的特性，并且提供用于确定至少两个相邻示波复合物是否相当的匹配确定装置。在正常条件下使用第一组匹配标准。当检测到心律失常时，使用第二组匹配标准。提供控制器来控制袖带内的压力。在血压测量开始时，将袖带充气至大于患者收缩压的压力。响应于确定两个相邻示波复合体是等效的，控制装置将袖带压力减小固定的增量，并且匹配确定装置继续确定相邻复合体是否相等。响应于控制装置和测量装置提供血压确定装置。血压测定装置比较来自各种袖带压力的示波复合物的测量特性，并确定测量特征达到极限的袖带压力。该袖带压力对应于患者的平均动脉压。

7. 发明申请

US20070129638A1 METHOD AND SYSTEM FOR CUFF PRESSURE REVERSIONS 有权
标题翻译：压力反应的方法和系统
公开(公告)号：US20070129638A1
公开(公告)日：2007-06-07
申请号：US11626170
申请日：2007-01-23
申请人： Lawrence Hersh , Richard Medero , Bruce Friedman , Sai Kolluri
发明人： Lawrence Hersh , Richard Medero , Bruce Friedman , Sai Kolluri
IPC分类号： A61B5/02
CPC分类号： A61B5/02225 , A61B5/0225 , A61B5/7207 , G06F19/00
摘要： A method and system for determining when to make a reversion to smaller cuff pressure steps during an oscillometric blood pressure measurement is disclosed. The method and system comprise comparing conformance of oscillometric envelope blood pressure data with previous blood pressure data, including measuring a shift between the oscillometric envelope blood pressure data and an oscillometric envelope derived from the previous blood pressure data. In addition, the method and system include making a reversion decision based on whether the shift exceeds an allowable threshold. Once a reversion decision is made a subsequent decision may be made as to the need for increasing the cuff pressure level.
摘要翻译：公开了一种用于在示波器血压测量期间确定何时进行更小的袖带压力步骤的方法和系统。所述方法和系统包括比较示波包络血压数据与先前血压数据的一致性，包括测量示波包络血压数据与从先前血压数据得出的示波包络之间的偏移。此外，所述方法和系统包括基于所述偏移是否超过允许阈值来进行回归决定。一旦进行回归决定，可以随后作出关于增加袖带压力水平的需要的决定。

8. 发明申请

US20050261597A1 Method and apparatus for determining extreme blood pressure values 失效
标题翻译：用于确定极端血压值的方法和装置
公开(公告)号：US20050261597A1
公开(公告)日：2005-11-24
申请号：US10847934
申请日：2004-05-18
申请人： Sai Kolluri , Lawrence Hersh , Bruce Friedman , Richard Medero
发明人： Sai Kolluri , Lawrence Hersh , Bruce Friedman , Richard Medero
IPC分类号： A61B5/02 , A61B5/0225 , A61B5/04 , A61B5/0456
CPC分类号： A61B5/02225 , A61B5/0225 , A61B5/0456
摘要： In a method and apparatus for measuring extreme blood pressure values during a single non-invasive blood measurement, the time intervals between sequential heartbeats are measured for a series of heartbeats in an oscillometric blood pressure measurement time period. Oscillometric blood pressure measurement data for the heartbeats of the series is obtained and associated with the heartbeat time intervals. An average time interval between heartbeats is also determined. A first data bin may be defined for blood pressure data associated with time intervals that are longer as compared to the average time interval. A second data bin is defined for blood pressure data with time intervals that are shorter as compared to the average time interval. The measured oscillometric blood pressure data is sorted into the data bins in accordance with the associated time intervals. The data in the first data bin is used to derive a high systolic blood pressure value and a low diastolic blood pressure value. The data in the second bin is used to derive a low systolic blood pressure value and a high diastolic blood pressure value. A typical blood pressure value may also be determined.
摘要翻译：在用于在单次非侵入性血液测量期间测量极端血压值的方法和装置中，测量在示波血压测量时间段内的一系列心跳的连续心跳之间的时间间隔。获得该系列心跳的示波血压测量数据，并与心跳时间间隔相关联。心跳之间的平均时间间隔也被确定。可以为与与平均时间间隔相比较长的时间间隔相关联的血压数据定义第一数据箱。第二个数据仓被定义为与平均时间间隔相比时间间隔更短的血压数据。测量的示波血压数据根据相关联的时间间隔被分类到数据箱中。第一数据箱中的数据用于导出高收缩压值和低舒张压值。第二个仓中的数据用于导出低收缩压值和高舒张压值。也可以确定典型的血压值。

9. 发明申请

US20070129636A1 Vital sign monitor utilizing historic patient data 审中-公开
标题翻译：利用历史病人数据进行生命体征监测
公开(公告)号：US20070129636A1
公开(公告)日：2007-06-07
申请号：US11292037
申请日：2005-12-01
申请人： Bruce Friedman , John Booth , Richard Medero
发明人： Bruce Friedman , John Booth , Richard Medero
IPC分类号： A61B5/02 , A61B5/00
CPC分类号： A61B5/0205 , A61B5/02225 , A61B5/0225 , A61B5/7495
摘要： A vital sign monitoring system that can be used with multiple patients and utilizes historic patient data information for the patient to optimize the process of obtaining current vital sign measurements. Each patient is identified with a unique patient identification device that is automatically detected by the vital sign monitor. The vital sign monitor communicates with a medical records database and obtains historic patient data information for the patient identified by the patient identification device. The historic patient data information can be utilized by the vital sign monitor to set alarm limits for the vital sign measurements and automatically control the operation of an NIBP monitor for the specific patient.
摘要翻译：一个生命体征监测系统，可与多个患者一起使用，并利用患者的历史患者数据信息来优化获取当前生命体征测量的过程。每个患者都有一个唯一的患者识别装置，由生命体征监测器自动检测。生命体征监测器与医疗记录数据库进行通信，并获得由患者识别装置识别的患者的历史病人数据信息。生命体征监测器可利用历史患者数据信息来设置生命体征测量的报警限值，并自动控制特定患者的NIBP监测器的运行。

10. 发明申请

US20070123784A1 METHOD OF CONTROLLING BLOOD PRESSURE CUFF DEFLATION 有权
标题翻译：控制血压压力缺陷的方法
公开(公告)号：US20070123784A1
公开(公告)日：2007-05-31
申请号：US11290272
申请日：2005-11-30
申请人： Lawrence Hersh , Sai Kolluri , Bruce Friedman , Richard Medero
发明人： Lawrence Hersh , Sai Kolluri , Bruce Friedman , Richard Medero
IPC分类号： A61B5/02
CPC分类号： A61B5/0225 , A61B5/02141 , A61B5/02225
摘要： A method of operating a non-invasive blood pressure (NIBP) monitor that includes a blood pressure cuff and a pressure transducer. The method initially inflates the blood pressure cuff to a level above systolic pressure and begins to deflate the pressure cuff using a continuous or linear deflation technique. During the linear deflation of the pressure cuff, the oscillation pulses from the pressure transducer are obtained and compared to predicted pulse estimates. If the obtained oscillation pulses vary from the predicted pulse estimates, the linear deflation technique is interrupted and the pressure cuff is then deflated in a sequence of distinct pressure steps. During each pressure step, the oscillation pulses are obtained and the pressure cuff is not deflated to the next pressure step until the oscillation pulses correspond to each other.
摘要翻译：一种操作包括血压袖带和压力换能器的非侵入性血压（NIBP）监测器的方法。该方法首先将血压袖带膨胀至高于收缩压的水平，并使用连续或线性放气技术开始压缩压力袖带。在压力袖带的线性放气期间，获得来自压力传感器的振荡脉冲并与预测的脉冲估计值进行比较。如果获得的振荡脉冲从预测的脉冲估计变化，则线性放气技术被中断，并且压力袖带然后以不同压力步骤的顺序放气。在每个压力步骤期间，获得振荡脉冲，并且压力袖带不会放气到下一个压力步骤，直到振荡脉冲彼此对应。

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