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1. 发明授权

US06994676B2 Method and apparatus for assessing ventricular contractile status 失效
标题翻译：评估心室收缩状态的方法和装置
公开(公告)号：US06994676B2
公开(公告)日：2006-02-07
申请号：US10426425
申请日：2003-04-30
申请人： Lawrence J. Mulligan , Ursula Gebhardt
发明人： Lawrence J. Mulligan , Ursula Gebhardt
IPC分类号： A61B5/04
CPC分类号： A61N1/3627
摘要： Methods and devices for improving ventricular contractile status of a patient suitably exploit changes in ventricular pressure and/or dP/dtmax to provide and/or optimize a response to a patient. The ventricular pressure may be appropriately correlated to intracellular calcium regulation, which is indicative of contractile status. To assess ventricular contractile status, the device suitably observes a cardiac perturbation of the patient and measures force interval potentiation following the perturbation. The contractile potentiation can then be stored and/or quantified in the implantable medical device to determine the ventricular contractile status of the patient, and an appropriate response may be provided to the patient as a function of the ventricular contractile status. Examples of responses may include administration of drug or neuro therapies, modification of a pacing rate, or the like. Force interval potentiation may also be used to optimize or improve a parameter for a response provided by the implantable medical device.
摘要翻译：用于改善患者的心室收缩状态的方法和装置适当地利用心室压力和/或dP / dt最大值的变化来提供和/或优化对患者的反应。心室压力可以适当地与细胞内钙调节相关，细胞内钙调节指示收缩状态。为了评估心室收缩状态，该装置适当地观察患者的心脏摄动，并测量扰动后的力间隔增强作用。收缩增强能随后在可植入的医疗装置中被储存和/或定量，以确定患者的心室收缩状态，并且作为心室收缩状态的函数可以向患者提供适当的响应。反应的实例可包括药物或神经疗法的施用，起搏速率的改变等。力间隔增强也可用于优化或改善由可植入医疗装置提供的响应的参数。

2. 发明授权

US07519424B2 Intravascular medical device 失效
公开(公告)号：US07519424B2
公开(公告)日：2009-04-14
申请号：US11342734
申请日：2006-01-30
申请人： Charles L. Dennis , George J. Klein , Ursula Gebhardt , Kenneth M Anderson , Glenn C. Zillmer
发明人： Charles L. Dennis , George J. Klein , Ursula Gebhardt , Kenneth M Anderson , Glenn C. Zillmer
IPC分类号： A61N1/372 , A61N1/38 , A61N1/39
CPC分类号： A61N1/372 , A61N1/37205
摘要： An implantable medical device is configured so that all of the major components including a housing and attached leads are disposed within the vasculature of a patient. A tether extends from the housing of the device to an implant location where the tether is secured to tissue outside of the vasculature. In this manner, an intravascular medical device may be implanted at a location remote from final placement, delivered via the vasculature and anchored at the initial entry point.

3. 发明申请

US20090198295A1 Intravascular Medical Device 审中-公开
标题翻译：血管内医疗器械
公开(公告)号：US20090198295A1
公开(公告)日：2009-08-06
申请号：US12423605
申请日：2009-04-14
申请人： Charles L. Dennis , George J. Klein , Ursula Gebhardt , Kenneth M. Anderson , Glenn C. Zillmer
发明人： Charles L. Dennis , George J. Klein , Ursula Gebhardt , Kenneth M. Anderson , Glenn C. Zillmer
IPC分类号： A61N1/39 , A61N1/375 , A61B17/00
CPC分类号： A61N1/372 , A61N1/37205
摘要： An implantable medical device is configured so that all of the major components including a housing and attached leads are disposed within the vasculature of a patient. A tether extends from the housing of the device to an implant location where the tether is secured to tissue outside of the vasculature. In this manner, an intravascular medical device may be implanted at a location remote from final placement, delivered via the vasculature and anchored at the initial entry point.
摘要翻译：可植入医疗装置被构造成使得包括壳体和附接的引线的所有主要部件被布置在患者的脉管系统内。系绳从装置的壳体延伸到植入位置，其中系绳固定到脉管系统外部的组织。以这种方式，血管内医疗装置可以植入远离最终放置的位置，通过脉管系统递送并锚定在初始入口处。

4. 发明申请

US20100137936A1 INTRAVASCULAR MEDICAL DEVICE 失效
标题翻译：血管内科医疗器械
公开(公告)号：US20100137936A1
公开(公告)日：2010-06-03
申请号：US12622221
申请日：2009-11-19
申请人： Charles L. Dennis , George J. Klein , Ursula Gebhardt , Kenneth M. Anderson , Glenn C. Zillmer
发明人： Charles L. Dennis , George J. Klein , Ursula Gebhardt , Kenneth M. Anderson , Glenn C. Zillmer
IPC分类号： A61N1/378
CPC分类号： A61N1/056 , A61N1/057 , A61N1/37205 , A61N1/375 , A61N1/3785 , A61N1/3787
摘要： An implantable medical device is configured so that all of the major components including a housing and attached leads are disposed within the vasculature of a patient. A tether extends from the housing of the device to an implant location where the tether is secured to tissue outside of the vasculature. In this manner, an intravascular medical device may be implanted at a location remote from final placement, delivered via the vasculature and anchored at the initial entry point.
摘要翻译：可植入医疗装置被构造成使得包括壳体和附接的引线的所有主要部件被布置在患者的脉管系统内。系绳从装置的壳体延伸到植入位置，其中系绳固定到脉管系统外部的组织。以这种方式，血管内医疗装置可以植入远离最终放置的位置，通过脉管系统递送并锚定在初始入口处。

5. 发明授权

US07616992B2 Intravascular medical device 失效
公开(公告)号：US07616992B2
公开(公告)日：2009-11-10
申请号：US11342948
申请日：2006-01-30
申请人： Charles L. Dennis , George J. Klein , Ursula Gebhardt , Kenneth M. Anderson , Glenn C. Zillmer
发明人： Charles L. Dennis , George J. Klein , Ursula Gebhardt , Kenneth M. Anderson , Glenn C. Zillmer
IPC分类号： A61N1/36
CPC分类号： A61N1/372 , A61N1/025 , A61N1/362 , A61N1/37205 , A61N1/37229 , A61N1/375 , A61N1/3968
摘要： An implantable medical device is configured so that all of the major components including a housing and attached leads are disposed within the vasculature of a patient. A tether extends from the housing of the device to an implant location where the tether is secured to tissue outside of the vasculature. In this manner, an intravascular medical device may be implanted at a location remote from final placement, delivered via the vasculature and anchored at the initial entry point.

6. 发明授权

US07130681B2 Use of accelerometer signal to augment ventricular arrhythmia detection 有权
标题翻译：使用加速度计信号来增加室性心律失常检测
公开(公告)号：US07130681B2
公开(公告)日：2006-10-31
申请号：US10435174
申请日：2003-05-09
申请人： Ursula Gebhardt , Michael F. Hess
发明人： Ursula Gebhardt , Michael F. Hess
IPC分类号： A61B5/04 , A61B5/103
CPC分类号： A61N1/3622 , A61N1/36542
摘要： A system and method for detecting and discriminating atrial arrhythmias based on mechanical signals of cardiac wall motion and electrical signals of cardiac depolarizations. A mechanical event rate determined from sensed mechanical events is used to corroborate an electrical event rate determined from sensed EGM or ECG signals to classify the heart rhythm. If the event rates are not correlated, other parameterized data from the mechanical signal and electrical signal are evaluated to detect evidence of an arrhythmia. If electrical and mechanical event data do not corroborate a common arrhythmia condition, electrical and mechanical sensing parameters may be adjusted.
摘要翻译：一种基于心脏壁运动和心脏去极化电信号的机械信号检测和鉴别心房心律失常的系统和方法。使用从感测的机械事件确定的机械事件速率来确认从感测的EGM或ECG信号确定的电事件速率以分类心律。如果事件发生率不相关，则评估来自机械信号和电信号的其他参数化数据，以检测心律失常的证据。如果电气和机械事件数据不能证实常见的心律失常状况，则可以调整电气和机械传感参数。

7. 发明授权

US06748653B2 Method of making a temporary medical lead having biodegradable electrode mounting pad loaded with therapeutic drug 失效
标题翻译：制造具有装有治疗药物的可生物降解电极安装垫的临时医用引线的方法
公开(公告)号：US06748653B2
公开(公告)日：2004-06-15
申请号：US09947433
申请日：2001-09-07
申请人： Fredric W. Lindemans , Ursula Gebhardt , Marc Hendriks
发明人： Fredric W. Lindemans , Ursula Gebhardt , Marc Hendriks
IPC分类号： H05K1300
CPC分类号： A61N1/0587 , Y10T29/49147 , Y10T29/49169 , Y10T29/49174 , Y10T29/49208
摘要： A method of making a temporary medical electrical lead for pacing or defibrillating a heart of a patient. The method comprises providing at least one electrical conductor having proximal and distal ends; providing an insulating sheath formed of biocompatible material extending over and covering at least portions of the at least one electrical conductor, attaching an electrical connector assembly to the proximal end of the at least one electrical conductor for attachment to a device capable of providing pacing or defibrillation pulses; providing an electrode mounting pad in the form of a cast matrix structure made of a biodegradable, biocompatible material soluble in human body fluids and having an outer heart non-contacting surface and an inner heart contacting surface, the outer surface being less permeable to passage of body fluids than the inner surface and wherein the inner surface of the pad has larger interstices and is less dense than the outer surface; providing a drug for treating for treating a medical condition of the patient's heart; loading the drug into the matrix of the pad; and attaching at least portions of the distal end of the at least one electrical conductor or of the electrode member to the electrode mounting pad.
摘要翻译：制造用于起搏或除颤患者心脏的临时医用电线的方法。该方法包括提供至少一个具有近端和远端的电导体; 提供由生物相容性材料形成的绝缘护套，所述绝缘护套由所述至少一个电导体的至少一部分延伸并覆盖所述至少一个电导体的至少一部分，将电连接器组件附接到所述至少一个电导体的近端以附接到能够提供起搏或除颤的装置脉冲提供由可溶于人体液体的可生物降解的生物相容性材料制成的铸造基质结构形式的电极安装垫，并且具有外部心脏非接触表面和内部心脏接触表面，所述外部表面对于通过体液比内表面多，并且其中垫的内表面具有较大的间隙并且密度小于外表面; 提供用于治疗患者心脏的医疗状况的药物; 将药物加载到垫的基质中; 以及将所述至少一个电导体或所述电极构件的远端的至少一部分附接到所述电极安装垫。

8. 发明授权

US08078279B2 Intravascular medical device 失效
标题翻译：血管内医疗器械
公开(公告)号：US08078279B2
公开(公告)日：2011-12-13
申请号：US12622221
申请日：2009-11-19
申请人： Charles L. Dennis , George J. Klein , Ursula Gebhardt , Kenneth M. Anderson , Glenn C. Zillmer
发明人： Charles L. Dennis , George J. Klein , Ursula Gebhardt , Kenneth M. Anderson , Glenn C. Zillmer
IPC分类号： A61N1/372 , A61N1/38 , A61N1/39
CPC分类号： A61N1/056 , A61N1/057 , A61N1/37205 , A61N1/375 , A61N1/3785 , A61N1/3787
摘要： An implantable medical device is configured so that all of the major components including a housing and attached leads are disposed within the vasculature of a patient. A tether extends from the housing of the device to an implant location where the tether is secured to tissue outside of the vasculature. In this manner, an intravascular medical device may be implanted at a location remote from final placement, delivered via the vasculature and anchored at the initial entry point.
摘要翻译：可植入医疗装置被构造成使得包括壳体和附接的引线的所有主要部件被布置在患者的脉管系统内。系绳从装置的壳体延伸到植入位置，其中系绳固定到脉管系统外部的组织。以这种方式，血管内医疗装置可以植入远离最终放置的位置，通过脉管系统递送并锚定在初始入口处。

9. 发明授权

US07627376B2 Intravascular medical device 失效
标题翻译：血管内医疗器械
公开(公告)号：US07627376B2
公开(公告)日：2009-12-01
申请号：US11342735
申请日：2006-01-30
申请人： Charles L. Dennis , George J. Klein , Ursula Gebhardt , Kenneth M. Anderson , Glenn C. Zillmer
发明人： Charles L. Dennis , George J. Klein , Ursula Gebhardt , Kenneth M. Anderson , Glenn C. Zillmer
IPC分类号： A61N1/372 , A61N1/38 , A61N1/39
CPC分类号： A61N1/056 , A61N1/057 , A61N1/37205 , A61N1/375 , A61N1/3785 , A61N1/3787
摘要： An implantable medical device is configured so that all of the major components including a housing and attached leads are disposed within the vasculature of a patient. A tether extends from the housing of the device to an implant location where the tether is secured to tissue outside of the vasculature. In this manner, an intravascular medical device may be implanted at a location remote from final placement, delivered via the vasculature and anchored at the initial entry point.
摘要翻译：可植入医疗装置被构造成使得包括壳体和附接的引线的所有主要部件被布置在患者的脉管系统内。系绳从装置的壳体延伸到植入位置，其中系绳固定到脉管系统外部的组织。以这种方式，血管内医疗装置可以植入远离最终放置的位置，通过脉管系统递送并锚定在初始入口处。

10. 发明申请

US20070179581A1 Intravascular medical device 失效
标题翻译：血管内医疗器械
公开(公告)号：US20070179581A1
公开(公告)日：2007-08-02
申请号：US11342734
申请日：2006-01-30
申请人： Charles Dennis , George Klein , Ursula Gebhardt , Kenneth Anderson , Glenn Zillmer
发明人： Charles Dennis , George Klein , Ursula Gebhardt , Kenneth Anderson , Glenn Zillmer
IPC分类号： A61N1/36
CPC分类号： A61N1/372 , A61N1/37205
摘要： An implantable medical device is configured so that all of the major components including a housing and attached leads are disposed within the vasculature of a patient. A tether extends from the housing of the device to an implant location where the tether is secured to tissue outside of the vasculature. In this manner, an intravascular medical device may be implanted at a location remote from final placement, delivered via the vasculature and anchored at the initial entry point.
摘要翻译：可植入医疗装置被构造成使得包括壳体和附接的引线的所有主要部件被布置在患者的脉管系统内。系绳从装置的壳体延伸到植入位置，其中系绳固定到脉管系统外部的组织。以这种方式，血管内医疗装置可以植入远离最终放置的位置，通过脉管系统递送并锚定在初始入口处。

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