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1. 发明授权

US5688517A Method for assessing sensitivity of tumor cells to cephalomannine and 10-deacetyltaxol 失效
标题翻译：评估肿瘤细胞对头孢麻黄碱和10-脱乙酰紫杉醇敏感性的方法
公开(公告)号：US5688517A
公开(公告)日：1997-11-18
申请号：US10821
申请日：1993-01-29
申请人： Lawrence Helson , Sterling K. Ainsworth
发明人： Lawrence Helson , Sterling K. Ainsworth
IPC分类号： G01N33/50 , A61F13/00
CPC分类号： G01N33/5011 , Y10S436/815
摘要： A method for assessing the sensitivity of a patient's tumor cells to cephalomannine and 10-deacetyltaxol in order to treat those tumor cells involves the removal of a sample of the tumor cells and establishing a cell line therefrom. Cells from the cell line are cultured and then contacted with varying concentrations of cephalomannine or 10-deacetyltaxol to form treated cells. The treated cells are assessed to determine the cytotoxic effect of the cephalomannine and/or the 10-deacetyltaxol and, where cytotoxic response is exhibited, a therapeutic dosage is formulated using the selected concentration of cephalomannine or 10-deacetyltaxol and a carrier material. The method is particularly useful for neural and glial tumor cells.
摘要翻译：用于评估患者肿瘤细胞对头孢霉宁和10-脱乙酰紫杉醇以治疗这些肿瘤细胞的敏感性的方法包括去除肿瘤细胞的样品并从其中建立细胞系。培养来自细胞系的细胞，然后与不同浓度的头孢麻黄碱或10-脱乙酰紫杉醇接触以形成处理的细胞。评估处理的细胞以确定头孢麻黄碱和/或10-脱乙酰紫杉醇的细胞毒性作用，并且在显示细胞毒性反应的情况下，使用所选浓度的头孢麻黄碱或10-脱乙酰紫杉醇和载体材料配制治疗剂量。该方法对于神经和神经胶质瘤细胞特别有用。

2. 发明授权

US5696153A Therapeutic regimen for treating patients 失效
标题翻译：治疗方案治疗患者
公开(公告)号：US5696153A
公开(公告)日：1997-12-09
申请号：US685155
申请日：1996-07-23
申请人： Sterling K. Ainsworth , Lawrence Helson
发明人： Sterling K. Ainsworth , Lawrence Helson
IPC分类号： A61K31/337 , A61K31/335
CPC分类号： A61K31/337
摘要： A method for administration of taxol by infusing taxol over a duration of 60 to 180 minutes for a pluratily of times during a 21 day period, each of said times being separated by an interval of between 4 to 5 days.
摘要翻译：一种通过在二十一天的时间内多次输注紫杉醇在60至180分钟内进行紫杉醇的方法，每个时间间隔4至5天。

3. 发明申请

US20120308643A1 LIPOSOMAL MITIGATION OF DRUG-INDUCED LONG QT SYNDROME AND POTASSIUM DELAYED-RECTIFIER CURRENT 有权
标题翻译：药物诱导的长QT综合征和钾延迟整流剂电流的药物缓解
公开(公告)号：US20120308643A1
公开(公告)日：2012-12-06
申请号：US13487233
申请日：2012-06-03
申请人： Lawrence Helson
发明人： Lawrence Helson
IPC分类号： A61K9/127 , A61K31/122 , A61P9/00 , A61K31/445 , B82Y5/00
CPC分类号： A61K9/127 , A61K31/12 , A61K31/445 , A61K31/4545
摘要： Compositions and methods for the treatment of drug-induced long QT syndrome and other cardiac channelopathies are disclosed herein. The compositions and methods of the present invention comprise binding one or more QT prolonging drugs with a liposome prior to parenteral (intravenous or subcutaneous) administration, or administration of an empty liposome prior to or concomitantly with therapeutic agents known to have a high risk of QT prolongation, or immediately following an envenomation. The results presented show an abrogation of the adverse effects of QT prolonging drugs in a dose-dependent manner by the compositions of the present invention.
摘要翻译：本文公开了用于治疗药物诱导的长QT综合征和其它心脏通道病变的组合物和方法。本发明的组合物和方法包括在口服（静脉内或皮下）给药之前将一种或多种QT延长药物与脂质体结合，或在已知具有高QT风险的治疗剂之前或伴随地使用空脂质体延长，或紧随其后。所呈现的结果表明，本发明组合物以剂量依赖的方式消除了QT延长药物的副作用。

4. 发明申请

US20110229555A1 INTRAVENOUS CURCUMIN AND DERIVATIVES FOR TREATMENT OF NEURODEGENERATIVE AND STRESS DISORDERS 有权
标题翻译：用于治疗神经损伤和应激障碍的静脉曲张和衍生物
公开(公告)号：US20110229555A1
公开(公告)日：2011-09-22
申请号：US13052822
申请日：2011-03-21
申请人： Lawrence Helson , Simon Chiu
发明人： Lawrence Helson , Simon Chiu
IPC分类号： A61K9/127 , A61K31/12 , A61P25/28 , A61P25/16 , A61P25/00 , A61K47/48
CPC分类号： A61K9/127 , A61K31/12 , A61K47/593
摘要： Liposomal formulations and polymer conjugates of curcumin, curcumin analogues and derivatives thereof for parenteral administration are disclosed herein. The formulations are effective in the treatment of progressive supranuclear palsy, Alzheimer's disease (AD), Parkinson's disease (PD), Tauopathies or stress disorders including Post Traumatic Stress Disorder (PTSD). Curcumin crosses the blood brain barrier, localizes in the hippocampus and striata, prevents stress-induced neuronal cell damage, and stimulates neurogenesis and remediation of damaged neural circuits.
摘要翻译：本文公开了用于肠胃外给药的姜黄素，姜黄素类似物及其衍生物的脂质体制剂和聚合物缀合物。该制剂在治疗进行性核上性麻痹，阿尔茨海默病（AD），帕金森病（PD），Tauopathies或包括创伤后应激障碍（PTSD）的应激障碍）中是有效的。姜黄素穿过血脑屏障，局限于海马和纹状体，预防应激诱导的神经元细胞损伤，并刺激神经发生和修复损伤的神经回路。

5. 发明授权

US07981928B2 Chemotherapy method using x-rays 有权
标题翻译：使用X射线的化疗方法
公开(公告)号：US07981928B2
公开(公告)日：2011-07-19
申请号：US10651307
申请日：2003-08-28
申请人： Chia-Gee Wang , Lawrence Helson
发明人： Chia-Gee Wang , Lawrence Helson
IPC分类号： A61K31/35
CPC分类号： A61K41/00
摘要： A method of treating cancer in a human uses x-rays to disrupt a linkage in a complex of a chemotherapeutic agent and a carrier compound comprising a pre-selected element. The complex is administered to the human and then a localized region of cells which contains the cancerous cells is irradiated with line emission x-rays of an energy selected to cause emission of Auger electrons from the pre-selected element of the carrier compound to disrupt the linkage and release the chemotherapeutic agent near the cancer cells. A kit useful for the treatment comprises an x-ray tube capable of emitting monochromatic line emission x-rays and the complex compound. A transfer compound useful in the method comprises a chemotherapeutic agent linked to a carrier compound.
摘要翻译：一种治疗人类癌症的方法使用X射线来破坏化学治疗剂和包含预先选择的元件的载体化合物的复合物中的连接。将复合物施用于人，然后将包含癌细胞的细胞的局部区域用能量的线发射x射线照射，所述能量被选择以引起来自载体化合物的预先选择的元素的俄歇电子的发射以破坏连接并释放癌细胞附近的化疗剂。可用于治疗的试剂盒包括能够发射单色线发射x射线的X射线管和复合化合物。用于该方法的转移化合物包括与载体化合物连接的化学治疗剂。

6. 发明申请

US20110117186A1 INTRAVENOUS INFUSION OF CURCUMIN AND A CALCIUM CHANNEL BLOCKER 有权
标题翻译：胰岛素和钙通道阻断剂的静脉输注
公开(公告)号：US20110117186A1
公开(公告)日：2011-05-19
申请号：US12949897
申请日：2010-11-19
申请人： Lawrence Helson
发明人： Lawrence Helson
IPC分类号： A61K9/127 , A61P35/00 , A61P25/28 , A61P33/00 , A61P27/02 , A61P27/12 , A61P25/16 , A61K31/12
CPC分类号： A61K31/12 , A61K9/0019 , A61K9/127 , A61K9/1271 , A61K9/5031 , A61K45/06
摘要： Compositions and methods for treating systemic diseases by intravenous administration of formulations of synthesized curcumin (diferuloylmethane) and concomitantly a calcium channel blocker to human subjects with neoplastic and neurodegenerative diseases are disclosed herein. The diseases are treated by prolonged administration of sub-optimal doses of liposomal curcumin or polymeric nanocurcumin or the sustained release curcumin from PLGA nanocurcumin at dosages below systemic hemolytic thresholds concomitantly with or without calcium channel blockers.
摘要翻译：本文公开了通过静脉内施用合成的姜黄素（二月桂基甲烷）的制剂以及伴随的具有肿瘤和神经变性疾病的人受体的钙通道阻断剂来治疗全身性疾病的组合物和方法。通过在低于系统性溶血阈值的同时伴有或不含钙通道阻滞剂的剂量下长期施用次最佳剂量的脂质体姜黄素或聚合纳米胱氨酸或来自PLGA纳米胱红质的持续释放姜黄素来治疗这些疾病。

7. 发明授权

US08753674B2 Liposomal mitigation of drug-induced long QT syndrome and potassium delayed-rectifier current 有权
标题翻译：药物诱导的长QT综合征和钾延迟整流电流的脂质体减轻
公开(公告)号：US08753674B2
公开(公告)日：2014-06-17
申请号：US13487233
申请日：2012-06-03
申请人： Lawrence Helson
发明人： Lawrence Helson
IPC分类号： A61K9/127 , A61P9/00 , A61K31/445 , A61K31/122 , B82Y5/00
CPC分类号： A61K9/127 , A61K31/12 , A61K31/445 , A61K31/4545
摘要： Compositions and methods for the treatment of drug-induced long QT syndrome and other cardiac channelopathies are disclosed herein. The compositions and methods of the present invention comprise binding one or more QT prolonging drugs with a liposome prior to parenteral (intravenous or subcutaneous) administration, or administration of an empty liposome prior to or concomitantly with therapeutic agents known to have a high risk of QT prolongation, or immediately following an envenomation. The results presented show an abrogation of the adverse effects of QT prolonging drugs in a dose-dependent manner by the compositions of the present invention.
摘要翻译：本文公开了用于治疗药物诱导的长QT综合征和其它心脏通道病变的组合物和方法。本发明的组合物和方法包括在口服（静脉内或皮下）给药之前将一种或多种QT延长药物与脂质体结合，或在已知具有高QT风险的治疗剂之前或伴随地使用空脂质体延长，或紧随其后。所呈现的结果表明，本发明组合物以剂量依赖的方式消除了QT延长药物的副作用。

8. 发明授权

US06667346B2 Method for protecting cells and tissues from ionizing radiation toxicity with &agr;, &bgr; unsaturated aryl sulfones 有权
标题翻译：用α，β不饱和芳基砜保护细胞和组织免受电离辐射毒性的方法
公开(公告)号：US06667346B2
公开(公告)日：2003-12-23
申请号：US10085745
申请日：2002-02-28
申请人： E. Premkumar Reddy , M. V. Ramana Reddy , Stephen C. Cosenza , Lawrence Helson
发明人： E. Premkumar Reddy , M. V. Ramana Reddy , Stephen C. Cosenza , Lawrence Helson
IPC分类号： A61K3110
CPC分类号： A61K31/435 , A61K31/10 , A61K31/275 , A61K31/35 , A61K31/40 , A61K31/425 , A61K41/00 , A61K2300/00
摘要： Pre-treatment with &agr;,&bgr; unsaturated aryl sulfones protects normal cells from the toxic side effects of ionizing radiation. Administration of a radioprotective &agr;,&bgr; unsaturated aryl sulfone compound to a patient prior to anticancer radiotherapy reduces the cytotoxic side effects of the radiation on normal cells. The radioprotective effect of the &agr;,&bgr; unsaturated aryl sulfone allows the clinician to safely increase the dosage of anticancer radiation. In some instances, amelioration of toxicity following inadvertent radiation exposure may be mitigated with administration of &agr;,&bgr; unsaturated arylsulfone.
摘要翻译：用α，β不饱和芳基砜进行预处理可保护正常细胞免受电离辐射的毒副作用。在抗癌放射治疗之前向患者施用放射性保护性α，β不饱和芳基砜化合物减少了辐射对正常细胞的细胞毒性副作用。 α，β不饱和芳基砜的放射防护作用使临床医生能够安全地增加抗癌辐射剂量。在某些情况下，通过施用α，β不饱和芳基砜可以减轻无意的辐射暴露后的毒性的改善。

9. 发明授权

US08784881B2 Liposomal curcumin for treatment of diseases 有权
标题翻译：脂质体姜黄素治疗疾病
公开(公告)号：US08784881B2
公开(公告)日：2014-07-22
申请号：US11949027
申请日：2007-12-01
申请人： Razelle Kurzrock , Lan Li , Kapil Mehta , Bharat Bhushan Aggarawal , Lawrence Helson
发明人： Razelle Kurzrock , Lan Li , Kapil Mehta , Bharat Bhushan Aggarawal , Lawrence Helson
IPC分类号： A61K9/127
CPC分类号： A61K9/1271 , A61K9/1272 , A61K31/12 , A61K45/06 , A61P35/00
摘要： The present invention provides compositions and methods for the treatment of a human patient. The methods and compositions of the present invention include composition for the efficient loading of curcumin, comprising: an amount of a curcuminoid:liposome complex effective to load curcumin into the liposome, wherein the curcuminoids has between 2 to 9 weight percent of the total composition and the curcuminoids are natural or synthetic.
摘要翻译：本发明提供了用于治疗人类患者的组合物和方法。本发明的方法和组合物包括用于有效负载姜黄素的组合物，其包含：一定量的姜黄素：有效将姜黄素加载到脂质体中的脂质体复合物，其中姜黄素占总组合物的2至9重量％姜黄素是天然的或合成的。

10. 发明授权

US08747890B2 Intravenous infusion of curcumin and a calcium channel blocker 有权
标题翻译：静脉输注姜黄素和钙通道阻滞剂
公开(公告)号：US08747890B2
公开(公告)日：2014-06-10
申请号：US12949897
申请日：2010-11-19
申请人： Lawrence Helson
发明人： Lawrence Helson
IPC分类号： A61K9/127
CPC分类号： A61K31/12 , A61K9/0019 , A61K9/127 , A61K9/1271 , A61K9/5031 , A61K45/06
摘要： Compositions and methods for treating systemic diseases by intravenous administration of formulations of synthesized curcumin (diferuloylmethane) and concomitantly a calcium channel blocker to human subjects with neoplastic and neurodegenerative diseases are disclosed herein. The diseases are treated by prolonged administration of sub-optimal doses of liposomal curcumin or polymeric nanocurcumin or the sustained release curcumin from PLGA nanocurcumin at dosages below systemic hemolytic thresholds concomitantly with or without calcium channel blockers.
摘要翻译：本文公开了通过静脉内施用合成的姜黄素（二月桂基甲烷）的制剂以及伴随的具有肿瘤和神经变性疾病的人受体的钙通道阻断剂来治疗全身性疾病的组合物和方法。通过在低于系统性溶血阈值的同时伴有或不含钙通道阻滞剂的剂量下长期施用次最佳剂量的脂质体姜黄素或聚合纳米胱氨酸或来自PLGA纳米半胱氨酸的持续释放姜黄素来治疗这些疾病。

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