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    • 10. 发明申请
    • Blood Pressure Reduction in Salt-Sensitive Hypertension
    • 盐敏感性高血压血压降低
    • US20090042951A1
    • 2009-02-12
    • US10588673
    • 2005-02-22
    • Robert Danziger
    • Robert Danziger
    • A61K31/4015A61P9/12A61K31/44
    • A61K31/40
    • This invention provides methods and compositions, most preferably pharmaceutical compositions, for treating salt-sensitive hypertension through the inhibition of certain enzymes in the beta-adrenergic pathway that are involved in the regulation of the secretion of water and sodium. These enzymes are cyclic nucleotide phosphodiesterases (PDE) that selectively hydrolyze the second messenger cAMP and, therefore, down-regulate beta-adrenergic signaling. Specifically provided are methods and pharmaceutical compositions for treating salt-sensitive hypertension by inhibiting certain members of the PDE4 family of cyclic nucleotide phosphodiesterases, particularly members of the PDE4B and PDE4D sub-families and, more particularly, the PDE4B1 and PDE4D5 isotypes thereof.
    • 本发明提供了通过抑制参与调节水和钠分泌的β-肾上腺素能途径中的某些酶来治疗盐敏感性高血压的方法和组合物,最优选药物组合物。 这些酶是选择性水解第二信使cAMP并因此下调β-肾上腺素能信号的环核苷酸磷酸二酯酶(PDE)。 具体提供的是通过抑制环核苷酸磷酸二酯酶的PDE4家族的特定成员,特别是PDE4B和PDE4D亚族的成员,更具体地,其PDE4B1和PDE4D5同种型来治疗盐敏感性高血压的方法和药物组合物。