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1. 发明申请

US20110268782A1 POLYURETHANES FOR OSTEOIMPLANTS 有权
标题翻译：聚氨酯泡沫塑料
公开(公告)号：US20110268782A1
公开(公告)日：2011-11-03
申请号：US13181715
申请日：2011-07-13
申请人： David Knaack , John Winterbottom , David Kaes , Todd Boyce , Lawrence A. Shimp
发明人： David Knaack , John Winterbottom , David Kaes , Todd Boyce , Lawrence A. Shimp
IPC分类号： A61F2/28 , A61P19/08 , A61K33/06 , A61K33/42 , A61K35/32 , A61K33/10
CPC分类号： A61L27/3608 , A61L27/18 , A61L27/46 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/426 , A61L2430/02 , C08G18/10 , C08G18/36 , C08G18/3878 , C08G18/3882 , C08G18/6484 , C08G18/73 , C08G18/771 , C08G18/798 , C08G2230/00 , C08L75/04
摘要： Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.
摘要翻译：生物基聚氨酯及其制备方法。聚氨酯通过可生物降解的多异氰酸酯（例如赖氨酸二异氰酸酯）与任选羟基化的生物分子反应形成聚氨酯而形成。形成的聚合物可以与陶瓷和/或骨颗粒结合以形成可用作骨样植入物的复合物。

2. 发明授权

US08002843B2 Polyurethanes for osteoimplants 有权
标题翻译：用于骨样植入物的聚氨酯
公开(公告)号：US08002843B2
公开(公告)日：2011-08-23
申请号：US10771736
申请日：2004-02-04
申请人： David Knaack , John Winterbottom , David Kaes , Todd Boyce , Lawrence A. Shimp
发明人： David Knaack , John Winterbottom , David Kaes , Todd Boyce , Lawrence A. Shimp
IPC分类号： A61F2/28 , A61F2/02 , A61F2/30 , A61K6/08
CPC分类号： A61L27/3608 , A61L27/18 , A61L27/46 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/426 , A61L2430/02 , C08G18/10 , C08G18/36 , C08G18/3878 , C08G18/3882 , C08G18/6484 , C08G18/73 , C08G18/771 , C08G18/798 , C08G2230/00 , C08L75/04
摘要： Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.
摘要翻译：生物基聚氨酯及其制备方法。聚氨酯通过可生物降解的多异氰酸酯（例如赖氨酸二异氰酸酯）与任选羟基化的生物分子反应形成聚氨酯而形成。形成的聚合物可以与陶瓷和/或骨颗粒结合以形成可用作骨样植入物的复合物。

3. 发明授权

US08771719B2 Synthesis of a bone-polymer composite material 有权
标题翻译：骨 - 聚合物复合材料的合成
公开(公告)号：US08771719B2
公开(公告)日：2014-07-08
申请号：US10639912
申请日：2003-08-12
申请人： Lawrence A. Shimp , John M. Winterbottom , Todd M. Boyce , David Knaack
发明人： Lawrence A. Shimp , John M. Winterbottom , Todd M. Boyce , David Knaack
IPC分类号： A61F2/00 , A61K35/32 , A01N63/00 , A61L27/46 , A61L27/36 , A61L27/48
CPC分类号： A61L27/48 , A61L27/3608 , A61L27/46 , A61L2430/02 , C08L89/00
摘要： A method of producing a bone-polymer composite. The method comprises the steps of providing a plurality of bone particles, combining the bone particles with a polymer precursor, and polymerizing the polymer precursor.
摘要翻译：骨聚合物复合材料的制造方法。该方法包括以下步骤：提供多个骨颗粒，将骨颗粒与聚合物前体组合，并聚合聚合物前体。

4. 发明授权

US08686064B2 Coupling agents for orthopedic biomaterials 有权
标题翻译：骨科生物材料偶联剂
公开(公告)号：US08686064B2
公开(公告)日：2014-04-01
申请号：US11856977
申请日：2007-09-18
申请人： Lawrence A. Shimp , David Knaack
发明人： Lawrence A. Shimp , David Knaack
IPC分类号： A61F2/28 , A61K35/32 , A61F2/02
CPC分类号： A61L27/3821 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3687 , A61L27/3847 , A61L27/44 , A61L27/46 , A61L2430/02
摘要： The invention provides a method for the preparation of bone-polymer composites wherein the mineral portion of the bone is treated with a coupling agent before being incorporated into a biocompatible polymeric matrix. The resulting composites may be used as such or be further processed to form an osteoimplant.
摘要翻译：本发明提供了一种用于制备骨 - 聚合物复合材料的方法，其中骨的矿物部分在被并入生物相容的聚合物基质之前用偶联剂处理。所得到的复合物可以原样使用或进一步加工以形成骨样植入物。

5. 发明授权

US07270813B2 Coupling agents for orthopedic biomaterials 有权
标题翻译：骨科生物材料偶联剂
公开(公告)号：US07270813B2
公开(公告)日：2007-09-18
申请号：US10681651
申请日：2003-10-08
申请人： Lawrence A. Shimp , David Knaack
发明人： Lawrence A. Shimp , David Knaack
IPC分类号： A61K45/00 , A61F13/00
CPC分类号： A61L27/3821 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3687 , A61L27/3847 , A61L27/44 , A61L27/46 , A61L2430/02
摘要： The invention provides a method for the preparation of bone-polymer composites wherein the mineral portion of the bone is treated with a coupling agent before being incorporated into a biocompatible polymeric matrix. The resulting composites may be used as such or be further processed to form an osteoimplant.
摘要翻译：本发明提供了一种用于制备骨 - 聚合物复合材料的方法，其中骨的矿物部分在被并入生物相容的聚合物基质之前用偶联剂处理。所得到的复合物可以原样使用或进一步加工以形成骨样植入物。

6. 发明授权

US08333985B2 Non-glycerol stabilized bone graft 有权
标题翻译：非甘油稳定的骨移植物
公开(公告)号：US08333985B2
公开(公告)日：2012-12-18
申请号：US10589226
申请日：2005-01-27
申请人： David Knaack , Michele Diegmann , Albert Manrique , Keyvan Benham
发明人： David Knaack , Michele Diegmann , Albert Manrique , Keyvan Benham
IPC分类号： A61F2/28
CPC分类号： A61L27/3608 , A61F2002/2817 , A61F2002/2835 , A61K31/728 , A61K35/32 , A61K38/55 , A61L27/365 , A61L27/3695 , A61L2430/02 , B33Y80/00 , A61K2300/00
摘要： A demineralized bone matrix (DBM) or other matrix composition is provided that has been stabilized by lowering the pH of the composition, reducing the water content, adding water substitutes, and/or increasing the amount of deuterated water present in the composition in order to reduce the activity of endogenous degrading enzymes such as proteases. A hydrated form of a stabilized DBM composition may be stable up to a year at room temperature at acidic pH. The acidified DBM compositions may be further stabilized by the addition of a stabilizing agent such as deuterated water, water substitutes, polymers, protease inhibitors, glycerol or hydrogels.
摘要翻译：提供了一种软化骨基质（DBM）或其他基质组合物，其已经通过降低组合物的pH，降低水含量，加入水代用品和/或增加组合物中存在的氘代水来稳定，以便降低内源性降解酶如蛋白酶的活性。稳定的DBM组合物的水合形式在酸性pH下在室温下可稳定至一年。酸化的DBM组合物可以通过加入稳定剂如氘化水，水代用品，聚合物，蛋白酶抑制剂，甘油或水凝胶进一步稳定。

7. 发明授权

US07985414B2 Polyurethanes for osteoimplants 有权
公开(公告)号：US07985414B2
公开(公告)日：2011-07-26
申请号：US11336127
申请日：2006-01-19
申请人： David Knaack , John Winterbottom , David Kaes , Todd Boyce , Larry Shimp
发明人： David Knaack , John Winterbottom , David Kaes , Todd Boyce , Larry Shimp
IPC分类号： A61F13/00 , A61K31/74
CPC分类号： A61L27/18 , A61F2/28 , A61F2002/2817 , A61F2310/00359 , A61K31/785 , A61L27/46 , A61L27/48 , C08G18/10 , C08G18/3882 , C08G18/6484 , C08G18/73 , C08G18/771 , C08G18/798 , C08G2230/00 , C08L75/04 , C08G18/36
摘要： Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.

8. 发明授权

US06599516B1 Malleable implant containing solid element that resorbs or fractures to provide access channels 有权
$Malleable implant containing solid element that resorbs or fractures to provide access channels$
标题翻译：含有固体元素的可塑性植入物可以吸收或断裂以提供通道
公开(公告)号：US06599516B1
公开(公告)日：2003-07-29
申请号：US09661828
申请日：2000-09-14
申请人： David Knaack
发明人： David Knaack
IPC分类号： A61F200
CPC分类号： A61L31/148 , A61L27/12 , A61L27/16 , A61L27/18 , A61L27/225 , A61L27/24 , A61L27/56 , A61L27/58 , A61L31/02 , A61L31/044 , A61L31/046 , A61L31/048 , A61L31/06 , A61L31/146 , C08L33/12 , C08L67/04
摘要： A malleable implant for implantation into living tissue is prepared having access means for cells into the interior of the implant. The implant is capable of being deformed under pressure required to insert the implant into an implant site. The access means can be hollow or solid. The solid comprises a material that more rapidly resorbs in vivo than the malleable implant to provide channels, or comprises a mechanically weak material that fractures under force at an implant site to produce channels or cracks. The access means may be inserted in the malleable implant at an implant site. A multilaminar structure may be formed having layers of malleable implant and layers of access means, or the access means may be heterogeneously distributed throughout the malleable implant. A kit can contain a powder such as calcium phosphate for making a paste implant material, and an access means insertable into the paste.
摘要翻译：制备用于植入生物组织的可延展植入物，其具有用于将细胞进入植入物内部的进入装置。植入物能够在将植入物插入植入部位所需的压力下变形。进入装置可以是中空的或固体的。固体包括在体内比可延展的植入物更快地吸收以提供通道的材料，或包括在植入部位处在力作用下产生通道或裂缝的机械弱材料。进入装置可以在植入部位插入可延展的植入物中。可以形成多层结构，其具有可延展的植入物层和存取装置层，或者访问装置可以非均匀地分布在整个可延展的植入物中。试剂盒可以含有用于制造糊料植入材料的粉末如磷酸钙，以及可插入糊料中的通道装置。

9. 发明申请

US20060216323A1 Polyurethanes for osteoimplants 有权
公开(公告)号：US20060216323A1
公开(公告)日：2006-09-28
申请号：US11336127
申请日：2006-01-19
申请人： David Knaack , John Winterbottom , David Kaes , Todd Boyce , Larry Shimp
发明人： David Knaack , John Winterbottom , David Kaes , Todd Boyce , Larry Shimp
IPC分类号： A61K31/785 , C08G63/91 , C08G63/48
CPC分类号： A61L27/18 , A61F2/28 , A61F2002/2817 , A61F2310/00359 , A61K31/785 , A61L27/46 , A61L27/48 , C08G18/10 , C08G18/3882 , C08G18/6484 , C08G18/73 , C08G18/771 , C08G18/798 , C08G2230/00 , C08L75/04 , C08G18/36
摘要： Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.

10. 发明申请

US20050283255A1 Tissue-derived mesh for orthopedic regeneration 有权
标题翻译：用于矫形再生的组织衍生网
公开(公告)号：US20050283255A1
公开(公告)日：2005-12-22
申请号：US11018853
申请日：2004-12-20
申请人： Perry Geremakis , Jennifer Grasso , David Knaack , Jo-Wen Lin , Lawrence Shimp , Robert Waterman , John Winterbottom
发明人： Perry Geremakis , Jennifer Grasso , David Knaack , Jo-Wen Lin , Lawrence Shimp , Robert Waterman , John Winterbottom
IPC分类号： A61B17/00 , A61B17/06 , A61F2/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61F2/44 , A61F2/46 , A61L27/36 , B29C67/02
CPC分类号： A61L27/3641 , A61B17/06166 , A61B2017/00004 , A61F2/0063 , A61F2/28 , A61F2/3094 , A61F2/4455 , A61F2/4601 , A61F2/4644 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2240/001 , A61F2250/0067 , A61F2310/00011 , A61F2310/00179 , A61F2310/00359 , A61L27/3608 , A61L27/3633 , A61L27/3645 , A61L27/3804 , A61L27/3843 , B29C67/02
摘要： An implant including a substantially cohesive aggregate comprising bone-derived particles. Cohesiveness is maintained by a member of mechanical interlocking, engagement of adjacent bone-derived particles with one another through engagement with a binding agent, thermal bonding, chemical bonding, or a matrix material in which the bone-derived particles are retained. The aggregate is shaped as a one-dimensional or two-dimensional body.
摘要翻译：一种植入体，其包括基本上凝聚的聚集体，其包含骨衍生的颗粒。粘合性通过机械互锁的成员维持，相邻的骨衍生的颗粒通过与粘合剂的接合，热粘合，化学粘合或其中保留骨衍生的颗粒的基质材料相互粘合。聚集体成形为一维或二维体。

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