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1. 发明授权

US08765390B2 Identification and isolation of squamous carcinoma stem cells 有权
标题翻译：鉴定和分离鳞状细胞癌干细胞
公开(公告)号：US08765390B2
公开(公告)日：2014-07-01
申请号：US12001336
申请日：2007-12-10
申请人： Laurie Ailles , Irving L. Weissman , Michael Clarke
发明人： Laurie Ailles , Irving L. Weissman , Michael Clarke
IPC分类号： G01N33/574 , G01N33/483
CPC分类号： C12N5/0695 , G01N33/5073 , G01N33/57407 , G01N33/57492
摘要： Squamous carcinoma stem cells (SCSC) are identified. The cells can be prospectively isolated or identified from primary tumor samples, and are shown to possess the unique properties of cancer stem cells in functional assays for cancer stem cell self-renewal and differentiation, and to form unique histological microdomains useful in cancer diagnosis.
摘要翻译：鉴定鳞状细胞癌干细胞（SCSC）。这些细胞可以从原发性肿瘤样品前瞻性分离或鉴定，并且在癌症干细胞自我更新和分化的功能测定中显示具有癌干细胞的独特性质，并形成用于癌症诊断的独特组织学微结构域。

2. 发明申请

US20080220453A1 Identification and isolation of squamous carcinoma stem cells 有权
标题翻译：鉴定和分离鳞状细胞癌干细胞
公开(公告)号：US20080220453A1
公开(公告)日：2008-09-11
申请号：US12001336
申请日：2007-12-10
申请人： Laurie Ailles , Irving L. Weissman , Michael Clarke
发明人： Laurie Ailles , Irving L. Weissman , Michael Clarke
IPC分类号： G01N33/53 , C12N5/06
CPC分类号： C12N5/0695 , G01N33/5073 , G01N33/57407 , G01N33/57492
摘要： Squamous carcinoma stem cells (SCSC) are identified. The cells can be prospectively isolated or identified from primary tumor samples, and are shown to possess the unique properties of cancer stem cells in functional assays for cancer stem cell self-renewal and differentiation, and to form unique histological microdomains useful in cancer diagnosis.
摘要翻译：鉴定鳞状细胞癌干细胞（SCSC）。这些细胞可以从原发性肿瘤样品前瞻性分离或鉴定，并且在癌症干细胞自我更新和分化的功能测定中显示具有癌干细胞的独特性质，并形成用于癌症诊断的独特组织学微结构域。

3. 发明申请

US20110124032A1 Methods and Compositions for Treating Carcinoma Stem Cells 审中-公开
标题翻译：治疗癌细胞干细胞的方法和组合
公开(公告)号：US20110124032A1
公开(公告)日：2011-05-26
申请号：US12865092
申请日：2009-01-30
申请人： Maximilian Diehn , Michael Clarke , Irving L. Weissman
发明人： Maximilian Diehn , Michael Clarke , Irving L. Weissman
IPC分类号： C12Q1/02
CPC分类号： G01N33/57496 , G01N33/5011 , G01N33/57407 , G01N33/57415 , G01N33/57419 , G01N2800/52
摘要： Cancer stem cells (CSCs) have been prospectively isolated or identified from primary tumor samples, and shown to possess the unique properties of self-renewal and differentiation, and can form unique histological microdomains useful in cancer diagnosis. Such cancer stem cells are shown herein to have the phenotype of containing decreased levels of reactive oxygen species (ROS) relative to non-tumorigenic (non-stem cell) cancer cells, as well as expression of other protective pathways. The CSCs are further shown to be more resistant to ionizing radiation (IR) and certain chemotherapies and to express high levels of ROS genes.
摘要翻译：已经从原发性肿瘤样品前瞻性分离或鉴定了癌干细胞（CSCs），并显示其具有自我更新和分化的独特性质，并且可以形成用于癌症诊断的独特的组织学微区域。这种癌干细胞在本文中显示为具有相对于非致瘤性（非干细胞）癌细胞降低的活性氧（ROS）水平以及其它保护途径的表达的表型。进一步证明CSCs对电离辐射（IR）和某些化学疗法更具抗性，并表达高水平的ROS基因。

4. 发明申请

US20110081314A1 ANTIVIRAL PHOSPHINATE COMPOUNDS 有权
标题翻译：抗磷酸化合物
公开(公告)号：US20110081314A1
公开(公告)日：2011-04-07
申请号：US12913692
申请日：2010-10-27
申请人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyungjung Pyun , Xiaoning C. Sheng , Jianying Wang
发明人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyungjung Pyun , Xiaoning C. Sheng , Jianying Wang
IPC分类号： A61K38/21 , C07D245/04 , A61K31/675 , A61K31/70 , A61K31/7056 , A61K31/7068 , A61P31/14
CPC分类号： C07F9/65583
摘要： The invention is related to anti-viral phosphinate compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译：本发明涉及抗病毒次膦酸盐化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法，以及可用于制备这些化合物的方法和中间体。

5. 发明申请

US20110021607A1 Methods and Compositions Relating to Carcinoma Stem Cells 审中-公开
标题翻译：与癌干细胞相关的方法和组成
公开(公告)号：US20110021607A1
公开(公告)日：2011-01-27
申请号：US12865090
申请日：2009-01-30
申请人： Michael Clarke , Yohei Shimono
发明人： Michael Clarke , Yohei Shimono
IPC分类号： A61K31/7088 , C12N5/09 , C12N5/071 , A61P35/00
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/16 , C12Q2600/178
摘要： MicroRNA markers of breast cancer stem cells (BCSC) are provided herein. The markers are polynucleotides that are differentially expressed in BCSC as compared to normal counterpart cells. Uses of the markers include use as targets for therapeutic intervention; as targets for drug development, and for diagnostic or prognostic methods relating to breast cancer and BCSC cell populations. BCSCs have the phenotype of having lower expression of certain miRNAs compared to normal breast epithelial cells, or to cancer cells that are not cancer stem cells.
摘要翻译：本文提供了乳腺癌干细胞（BCSC）的微小RNA标记。标记是与正常对照细胞相比在BCSC中差异表达的多核苷酸。标记物的使用包括用作治疗干预的靶标; 作为药物开发的目标，以及与乳腺癌和BCSC细胞群有关的诊断或预后方法。 BCSCs具有与正常乳腺上皮细胞相比具有较低表达某些miRNA的表型，或与不是癌症干细胞的癌细胞相比。

6. 发明申请

US20080185044A1 SYSTEM AND METHOD OF CHEMICAL DILUTION AND DISPENSE 审中-公开
标题翻译：化学沉淀和溶解的系统与方法
公开(公告)号：US20080185044A1
公开(公告)日：2008-08-07
申请号：US12024689
申请日：2008-02-01
申请人： Michael Clarke , Marc Laverdiere , Robert F. McLoughlin , J. Karl Niermeyer , Joseph E. Smith , Rosario Mollica
发明人： Michael Clarke , Marc Laverdiere , Robert F. McLoughlin , J. Karl Niermeyer , Joseph E. Smith , Rosario Mollica
IPC分类号： B67D5/56 , G05D11/13 , B01F15/04
CPC分类号： B01F5/0685 , B01F3/088 , G05D11/132 , Y10T137/0329
摘要： Embodiments disclosed herein provide a pump or a multiple-pump system that can mix chemicals without dilution tanks and can dispense the mixture of chemicals in a precise and highly controllable manner, particularly useful in semiconductor manufacturing processes. In some embodiments, one or more piston pumps of similar displacement are used to mix and dispense the chemical directly. A first valve is opened to a first chemical source. A piston is moved in a first direction to a selected position in a chamber to draw the first chemical into the chamber. The first valve is closed and a second valve is opened to a second chemical source. The piston is moved in the first direction to a second position in the chamber to draw in the second chemical and mix the chemicals. The second valve is closed and the piston is moved to dispense the fluids through a dispense port.
摘要翻译：本文公开的实施例提供了一种泵或多泵系统，其可以混合没有稀释罐的化学品，并且可以精确和高度可控的方式分配化学品的混合物，特别适用于半导体制造过程。在一些实施例中，使用类似位移的一个或多个活塞泵来直接混合和分配化学品。第一阀打开到第一化学源。活塞在第一方向上移动到室中的选定位置以将第一化学品吸入室中。第一阀关闭，第二阀打开到第二化学源。活塞沿第一方向移动到腔室中的第二位置以吸入第二化学品并混合化学品。关闭第二个阀门并移动活塞以通过分配口分配流体。

7. 发明申请

US20080067163A1 HEATED CLOTHING FOR PETS 审中-公开
标题翻译： PETS加热衣服
公开(公告)号：US20080067163A1
公开(公告)日：2008-03-20
申请号：US11781060
申请日：2007-07-20
申请人： Grigore Axinte , Richard Fine , Russell Borgmann , Amy Martin , Michael Clarke
发明人： Grigore Axinte , Richard Fine , Russell Borgmann , Amy Martin , Michael Clarke
IPC分类号： A01K13/00
CPC分类号： A01K13/006 , A01K13/008
摘要： A heated clothing item for a pet is provided that includes at least one heating element for heating the surface of the clothing contacting the pet wearing the clothing. The clothing can be heated evenly throughout the portions contacting the animal so that the animal is uniformly warmed. Alternatively, the heater element can be divided into multiple sections that can be selectively energized. Multiple sections can be useful to provide heat to only a selected area of an animal as when it has an arthritic hip or some other localized ailment.
摘要翻译：提供了一种用于宠物的加热衣物，其包括至少一个加热元件，用于加热与穿着衣服的宠物接触的衣服的表面。服装可以在与动物接触的部分中均匀地加热，使得动物均匀地加热。或者，加热器元件可以被分成可以选择性地通电的多个部分。多个部分可用于仅向动物的选定区域提供热量，因为它具有关节炎髋部或某些其它局部的疾病。

8. 发明授权

US07279450B2 Packaged fibrous toilette article and process 失效
标题翻译：包装纤维香水制品和工艺
公开(公告)号：US07279450B2
公开(公告)日：2007-10-09
申请号：US11000633
申请日：2004-12-01
申请人： Filomena Augusta Macedo , Gregory Aaron Grissett , Diane Marie Keenan , David Robert Williams , Michael Clarke
发明人： Filomena Augusta Macedo , Gregory Aaron Grissett , Diane Marie Keenan , David Robert Williams , Michael Clarke
IPC分类号： C11D17/04 , C11D11/00
CPC分类号： C11D17/041 , C11D17/0047 , C11D17/006 , C11D17/048
摘要： A cleansing article and process for manufacture is provided, the article being a solid or semi-solid foamable composition joinably penetrating a fibrous web, the combination being molded and held for sale to consumers in a single use disposable sealed plastic receptacle. The receptacle includes indicia printed onto or associated with the plastic receptacle.
摘要翻译：提供了一种清洁用品和制造方法，该制品是固体或半固体可发泡组合物，其可连续地穿透纤维幅材，该组合被模制并保持在一次性一次性密封塑料容器中销售给消费者。容器包括印刷在塑料容器上或与塑料容器相关联的标记。

9. 发明申请

US20070231325A1 Prospective identification and characterization of breast cancer stem cells 有权
标题翻译：乳腺癌干细胞的前瞻性鉴定和表征
公开(公告)号：US20070231325A1
公开(公告)日：2007-10-04
申请号：US11607780
申请日：2006-12-01
申请人： Michael Clarke , Max Wicha , Muhammad Al-Hajj
发明人： Michael Clarke , Max Wicha , Muhammad Al-Hajj
IPC分类号： A61K39/395
CPC分类号： C12N5/0695 , A01K67/0271 , A61K39/39558 , A61K2039/505 , A61K2039/5152 , A61K2039/5158 , C07K14/705 , C07K14/70585 , C07K14/71 , C07K16/28 , C07K16/2863 , C07K16/30 , C12N2501/42 , C12N2503/00 , C12N2503/02 , C12Q1/6886 , G01N33/5011 , G01N33/57492
摘要： A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. Thus, solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell. We have developed a xenograft model in which we have been able to establish tumors from primary tumors via injection of tumors in the mammary gland of severely immunodeficient mice. These xenograft assay have allowed us to do biological and molecular assays to characterize clonogenic solid tumor stem cells. We have also developed evidence that strongly implicates the Notch pathway, especially Notch 4, as playing a central pathway in carcinogenesis. This discovery is the basis for solid tumor stem cell compositions, methods for distinguishing functionally different populations of tumor cells, methods for using these tumor cell populations for studying the effects of therapeutic agents on tumor growth, and methods for identifying and testing novel anti-cancer therapies directed to solid tumor stem cells.
摘要翻译：建立的实体瘤内的一小部分细胞具有干细胞的特性。这些实体肿瘤干细胞产生更多的肿瘤干细胞和肿瘤中大部分已经失去广泛增殖能力的细胞和产生新肿瘤的能力。因此，实体肿瘤异质性反映了由固体肿瘤干细胞产生的肿瘤细胞后代的存在。我们已经开发了异种移植模型，其中我们已经能够通过在严重免疫缺陷小鼠的乳腺中注射肿瘤来从原发肿瘤中建立肿瘤。这些异种移植物测定使我们能够进行生物学和分子测定来表征克隆型实体瘤干细胞。我们还发现证据强烈地暗示Notch途径，特别是Notch 4，作为致癌过程的中心途径。该发现是实体肿瘤干细胞组合物的基础，区分功能不同的肿瘤细胞群体的方法，使用这些肿瘤细胞群体研究治疗剂对肿瘤生长的影响的方法，以及用于鉴定和测试新型抗癌剂的方法针对固体肿瘤干细胞的疗法。

10. 发明申请

US20060144235A1 Apparatus and process for carbon dioxide absorption 有权
公开(公告)号：US20060144235A1
公开(公告)日：2006-07-06
申请号：US10536659
申请日：2003-12-01
申请人： Michael Clarke , Ian Hallas
发明人： Michael Clarke , Ian Hallas
IPC分类号： B01D53/22
CPC分类号： B01D53/229 , A61M16/22 , B01D61/38 , Y02C10/10
摘要： Carbon dioxide is separated from a gas stream using a supported carrier liquid membrane having a selected concentration of carrier species, the method being especially suitable for use in anaesthesia under conditions of periodic flow.

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