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1. 发明授权

US09745602B2 Modified microorganisms and use thereof for terpene production 有权
公开(公告)号：US09745602B2
公开(公告)日：2017-08-29
申请号：US14128074
申请日：2012-06-01
申请人： Laurent Daviet , Michel Schalk , Jens Nielsen , Verena Siewers , Christoph Knuf , Gionata Scalcinati
发明人： Laurent Daviet , Michel Schalk , Jens Nielsen , Verena Siewers , Christoph Knuf , Gionata Scalcinati
IPC分类号： C12P5/00 , C12N15/00 , C12N1/20 , C12N9/10 , C12N1/14 , C12Q1/68 , C07H21/04 , C12P5/02 , C12N9/88 , C12N15/81 , C12N15/63
CPC分类号： C12P5/026 , C12N9/1085 , C12N9/88 , C12N15/635 , C12N15/81 , C12P5/002 , C12P5/007 , C12P5/02
摘要： The present invention relates to the control of gene expression by a heterologous glucose-regulated promoter, to microorganisms in which gene expression is controlled by a heterologous glucose-regulated promoter and to methods using said microorganisms for the production of terpenes during glucose-limited fed-batch fermentation.

2. 发明申请

US20140113343A1 MODIFIED MICROORGANISMS AND USE THEREOF FOR TERPENE PRODUCTION 有权
标题翻译：改良微生物及其用于生产TERPENE生产
公开(公告)号：US20140113343A1
公开(公告)日：2014-04-24
申请号：US14128074
申请日：2012-06-01
申请人： Lauren Daviet , Michel Schalk , Jens Nielsen , Verena Siewers , Christoph Knuf , Gionata Scalcinati
发明人： Lauren Daviet , Michel Schalk , Jens Nielsen , Verena Siewers , Christoph Knuf , Gionata Scalcinati
IPC分类号： C12P5/02 , C12P5/00
CPC分类号： C12P5/026 , C12N9/1085 , C12N9/88 , C12N15/635 , C12N15/81 , C12P5/002 , C12P5/007 , C12P5/02
摘要： The present invention relates to the control of gene expression by a heterologous glucose-regulated promoter, to microorganisms in which gene expression is controlled by a heterologous glucose-regulated promoter and to methods using said microorganisms for the production of terpenes during glucose-limited fed-batch fermentation.
摘要翻译：本发明涉及通过异源葡萄糖调节启动子对基因表达由异源葡萄糖调节的启动子控制的基因表达的控制以及使用所述微生物用于在葡萄糖限制性加料期间产生萜烯的方法，分批发酵。

3. 发明申请

US20150079646A1 GENETICALLY ENGINEERED YEAST CELLS 有权
标题翻译：遗传工程YEAST细胞
公开(公告)号：US20150079646A1
公开(公告)日：2015-03-19
申请号：US14370959
申请日：2012-12-17
申请人： Jens Nielsen , Verena Siewers , Yun Chen , Laurent Daviet , Michel Schalk
发明人： Jens Nielsen , Verena Siewers , Yun Chen , Laurent Daviet , Michel Schalk
IPC分类号： C12N15/81 , C12P7/16 , C12N9/10 , C12N9/04 , C12N9/02 , C12N9/00 , C12P5/00 , C12P7/62
CPC分类号： C12N15/81 , C12N9/0006 , C12N9/0008 , C12N9/1025 , C12N9/1029 , C12N9/93 , C12P5/007 , C12P7/16 , C12P7/625 , C12Y101/01002 , C12Y102/01004 , C12Y203/01009 , C12Y602/01001 , Y02E50/10
摘要： The present invention relates to yeast cells producing high levels of acetoacetyl-CoA. It also relates to a method for making such yeast cells and to the use of such yeast cells in a method for producing acetyl-CoA derived products.
摘要翻译：本发明涉及产生高含量乙酰乙酰辅酶A的酵母细胞。本发明还涉及制备这种酵母细胞的方法以及在制备乙酰辅酶A衍生产物的方法中使用这种酵母细胞。

4. 发明授权

US09670494B2 Genetically engineered yeast cells 有权
公开(公告)号：US09670494B2
公开(公告)日：2017-06-06
申请号：US14370959
申请日：2012-12-17
申请人： Jens Nielsen , Verena Siewers , Yun Chen , Laurent Daviet , Michel Schalk
发明人： Jens Nielsen , Verena Siewers , Yun Chen , Laurent Daviet , Michel Schalk
IPC分类号： C12P7/16 , C12N9/90 , C12N15/81 , C12N9/04 , C12N9/10 , C12N9/00 , C12P5/00 , C12P7/62 , C12N9/02
CPC分类号： C12N15/81 , C12N9/0006 , C12N9/0008 , C12N9/1025 , C12N9/1029 , C12N9/93 , C12P5/007 , C12P7/16 , C12P7/625 , C12Y101/01002 , C12Y102/01004 , C12Y203/01009 , C12Y602/01001 , Y02E50/10
摘要： The present invention relates to yeast cells producing high levels of acetoacetyl-CoA. It also relates to a method for making such yeast cells and to the use of such yeast cells in a method for producing acetyl-CoA derived products.

5. 发明授权

US08048658B2 Method for producing terpenes and MEP-transformed microorganisms therefore 有权
标题翻译：因此生产萜烯和MEP转化的微生物的方法
公开(公告)号：US08048658B2
公开(公告)日：2011-11-01
申请号：US12279300
申请日：2007-02-13
申请人： Anthony Clark , Jérôme Maury , Mohammad Ali Asadollahi , Kasper Møller , Jens Nielsen , Michel Schalk
发明人： Anthony Clark , Jérôme Maury , Mohammad Ali Asadollahi , Kasper Møller , Jens Nielsen , Michel Schalk
IPC分类号： C12P5/00 , C12N1/19 , C12N1/63 , C07C403/00
CPC分类号： C12N15/52 , C12P23/00
摘要： The present invention relates to a microorganism capable of producing a terpene of choice. The microorganism expresses a heterologous pathway for the formation of isoprene units and, preferably, a heterologous terpene synthase. In this way, high amounts of terpene can be isolated from the medium of the microorganism.
摘要翻译：本发明涉及能够产生选择的萜烯的微生物。微生物表达用于形成异戊二烯单元的异源途径，优选异源萜烯合酶。以这种方式，可以从微生物的培养基中分离出大量的萜烯。

6. 发明申请

US20090155874A1 METHOD FOR PRODUCING TERPENES AND MEP-TRANSFORMED MICROORGANISMS THEREFORE 有权
标题翻译：用于生产天然产物和改性微生物的方法
公开(公告)号：US20090155874A1
公开(公告)日：2009-06-18
申请号：US12279300
申请日：2007-02-13
申请人： Anthony Clark , Jêrome Maury , Mohammad Ali Asadollahi , Kasper Møller , Jens Nielsen , Michel Schalk
发明人： Anthony Clark , Jêrome Maury , Mohammad Ali Asadollahi , Kasper Møller , Jens Nielsen , Michel Schalk
IPC分类号： C12P5/02 , C12N1/19 , C12N15/87
CPC分类号： C12N15/52 , C12P23/00
摘要： The present invention relates to a microorganism capable of producing a terpene of choice. The microorganism expresses a heterologous pathway for the formation of isoprene units and, preferably, a heterologous terpene synthase. In this way, high amounts of terpene can be isolated from the medium of the microorganism.
摘要翻译：本发明涉及能够产生选择的萜烯的微生物。微生物表达用于形成异戊二烯单元的异源途径，优选异源萜烯合酶。以这种方式，可以从微生物的培养基中分离出大量的萜烯。

7. 发明授权

US09297004B2 Method for producing α-santalene 有权
标题翻译： α-檀香草的制备方法
公开(公告)号：US09297004B2
公开(公告)日：2016-03-29
申请号：US12918140
申请日：2009-03-04
申请人： Michel Schalk
发明人： Michel Schalk
IPC分类号： C12N15/29 , C12N15/60 , C12N15/82 , C12P15/00 , C12N9/88 , C12P5/00
CPC分类号： C12N9/88 , C12P5/007 , C12P15/00 , C12Y402/03082
摘要： The present invention provides a method of producing α-santalene by contacting at least one polypeptide with farnesyl phyrophosphate (fpp). In particular, the method may be carried out in vitro or in vivo to produce α-santalene, a very useful compound in the fields of perfumery and flavoring. The present invention also provides the amino acid sequence of a polypeptide useful in the method of the invention. A nucleic acid encoding the polypeptide of the invention and an expression vector containing the nucleic acid represent part of the present invention. A non-human host organism and a cell transformed to be used in the method of producing α-santalene are also part of the present invention.
摘要翻译：本发明提供了通过使至少一种多肽与法呢基磷酸（fpp）接触来生产α-檀香草的方法。特别地，该方法可以在体外或体内进行以产生α-香豆素，在香料和香料领域中非常有用的化合物。本发明还提供了可用于本发明方法的多肽的氨基酸序列。编码本发明多肽的核酸和含有核酸的表达载体代表本发明的一部分。非人宿主生物体和转化用于生产α-檀香烃的方法的细胞也是本发明的一部分。

8. 发明申请

US20110041218A1 METHOD FOR PRODUCING SCLAREOL 有权
标题翻译：生产SCLAREOL的方法
公开(公告)号：US20110041218A1
公开(公告)日：2011-02-17
申请号：US12867861
申请日：2009-02-12
申请人： Michel Schalk
发明人： Michel Schalk
IPC分类号： C12P7/02 , C12N9/16 , C07H21/00 , C12N15/63 , C12N5/10 , C12N1/21 , C12N1/19 , A01H5/00
CPC分类号： C12P7/18 , C07D307/92 , C07D311/92 , C07K2319/00 , C12N9/88
摘要： The present invention provides a method of producing sclareol, said method comprising contacting a particular polypeptide having a sclareol synthase activity with labdenediol diphosphate (LPP). In particular, said method may be carried out in vitro or in vivo to produce sclareol, a very useful compound in the fields of perfumery and flavoring. The present invention also provides the amino acid sequence of the polypeptide used in the method. A nucleic acid derived from Salvia sclarea and encoding the polypeptide of the invention, an expression vector containing said nucleic acid, as well as a non-human host organism or a cell transformed to harbor the same nucleic acid, are also part of the present invention.
摘要翻译：本发明提供了生产香紫苏醇的方法，所述方法包括将具有香紫苏醇合成酶活性的特定多肽与二硫代二磷酸酯（LPP）接触。特别地，所述方法可以在体外或体内进行以产生香紫苏醇，香料和香料领域中非常有用的化合物。本发明还提供了该方法中使用的多肽的氨基酸序列。衍生自丹参的核酸并编码本发明的多肽，含有所述核酸的表达载体以及非人宿主生物或转化成携带相同核酸的细胞也是本发明的一部分。

9. 发明申请

US20080201796A1 Transformed plants accumulating mono-and/or sesquiterpenes 审中-公开
标题翻译：积累单和/或倍半萜的转化植物
公开(公告)号：US20080201796A1
公开(公告)日：2008-08-21
申请号：US11916272
申请日：2006-06-26
申请人： Joe Chappell , Shuiqin Wu , Michel Schalk , Athony Clark
发明人： Joe Chappell , Shuiqin Wu , Michel Schalk , Athony Clark
IPC分类号： A01H1/00 , A01H5/00 , C12N15/82 , C12N15/00
CPC分类号： C12N15/8243 , C12N9/0006 , C12N9/1085
摘要： The present invention relates to plant expressing transgenes and to plants transformed to comprise additional copies of genes, said genes encoding at least a HMGR-CoA reductase and a terpene synthase. The invention further claims methods for preparing the plants, and a method for producing terpenes. The present thus provides a reliable and cost effective platform for generating any terpene, in particular any mono- and/or sesquiterpene of interest. For example, the skilled person may use any gene encoding a sesquiterpene synthase for accumulating the respective sesquiterpene in the plant of the present invention.
摘要翻译：本发明涉及表达转基因的植物和转化成包含编码另外的基因拷贝的植物，所述基因编码至少HMGR-CoA还原酶和萜烯合酶。本发明进一步要求制备植物的方法以及萜烯的制备方法。因此，本发明提供了用于产生任何萜烯，特别是感兴趣的任何单 - 和/或倍半萜的可靠和具有成本效益的平台。例如，技术人员可以使用编码倍半萜合酶的任何基因来在本发明的植物中积累相应的倍半萜烯。

10. 发明授权

US06787337B1 Recording of DNA sequences to enable them to be expressed in yeasts, and the transformed yeasts obtained 失效
标题翻译：记录DNA序列以使其能够在酵母中表达，并获得转化的酵母
公开(公告)号：US06787337B1
公开(公告)日：2004-09-07
申请号：US09713794
申请日：2000-11-15
申请人： Yannick Batard , Francis Durst , Michel Schalk , Daniele Werck-Reichhart
发明人： Yannick Batard , Francis Durst , Michel Schalk , Daniele Werck-Reichhart
IPC分类号： C12P2100
CPC分类号： C12N9/0042 , C12N15/67 , C12N15/81
摘要： The present invention relates to a recombinant non-yeast DNA, which encodes a protein of interest, wherein an unmodified DNA corresponding to the recombinant non-yeast DNA contains a region having a high content of codons that are poorly suited to yeasts, wherein a number of the codons that are poorly suited to yeasts are replaced in said region of the recombinant non-yeast DNA with synonymous codons coding for the same amino acid that are well-suited to yeasts, and wherein the number of replaced codons is sufficient to permit expression in yeasts. The present invention also relates to DNA sequences which originate from dicotyledonous or monocotyledonous plants, and in particular plants of the graminae family which are selected from among wheat, barley, oats, rice, maize, sorghum and cane sugar, as well as to vectors and transformed yeasts which contain the DNA sequences of the invention.
摘要翻译：本发明涉及编码感兴趣的蛋白质的重组非酵母DNA，其中对应于重组非酵母DNA的未修饰的DNA含有具有高度不适于酵母的密码子的高含量区域，其中数目的不适于酵母的密码子在所述重组非酵母DNA的所述区域中被替换，其具有编码相当于酵母的相同氨基酸的同义密码子，并且其中替换的密码子的数目足以允许表达在酵母中本发明还涉及源自双子叶植物或单子叶植物的DNA序列，特别是选自小麦，大麦，燕麦，稻，玉米，高粱和蔗糖的格氏族的植物，以及载体和转化酵母含有本发明的DNA序列。

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