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1. 发明申请

US20090123928A1 Genomic Landscapes of Human Breast and Colorectal Cancers 审中-公开
标题翻译：人类乳腺癌和结肠直肠癌的基因组学风景
公开(公告)号：US20090123928A1
公开(公告)日：2009-05-14
申请号：US12247464
申请日：2008-10-08
申请人： Laura D. Wood , Williams D. Parsons , Sian Jones , Jimmy Lin , Tobias Sjoblom , Thomas Barber , Giovanni Parmigiani , Victor Velculescu , Kenneth W. Kinzler , Bert Vogelstein
发明人： Laura D. Wood , Williams D. Parsons , Sian Jones , Jimmy Lin , Tobias Sjoblom , Thomas Barber , Giovanni Parmigiani , Victor Velculescu , Kenneth W. Kinzler , Bert Vogelstein
IPC分类号： C12Q1/68 , C12Q1/02
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/156
摘要： Human cancer is caused by the accumulation of mutations in oncogenes and tumor suppressor genes. To catalogue the genetic changes that occur during tumorigenesis, we isolated DNA from 11 breast and 11 colorectal tumors and determined the sequences of the genes in the Reference Sequence database in these samples. Based on analysis of exons representing 20,857 transcripts from 18,191 genes, we conclude that the genomic landscapes of breast and colorectal cancers are composed of a handful of commonly mutated gene “mountains” and a much larger number of gene “hills” that are mutated at low frequency. We describe statistical and bioinformatic tools that may help identify mutations with a role in tumorigenesis. These results have implications for understanding the nature and heterogeneity of human cancers and for using personal genomics for tumor diagnosis and therapy.
摘要翻译：人类癌症是由致癌基因和肿瘤抑制基因突变的积累引起的。为了列出肿瘤发生过程中发生的遗传变化，我们从11个乳腺和11个结肠直肠肿瘤中分离出DNA，并在这些样品中确定了参考序列数据库中的基因序列。根据对18,191个基因的20,857个转录本的外显子的分析，我们得出结论，乳腺癌和结肠直肠癌的基因组景观由少数常见的突变基因“山”组成，更多的基因“山”在低位突变频率。我们描述了统计和生物信息学工具，可以帮助识别在肿瘤发生中发挥作用的突变。这些结果有助于了解人类癌症的性质和异质性以及使用个人基因组学进行肿瘤诊断和治疗。

2. 发明授权

US08741573B2 Consensus coding sequences of human breast and colorectal cancers 有权
标题翻译：人乳腺癌和结肠直肠癌的共识编码序列
公开(公告)号：US08741573B2
公开(公告)日：2014-06-03
申请号：US12377073
申请日：2007-08-13
申请人： Tobias Sjoblom , Sian Jones , D. Williams Parsons , Laura D. Wood , Jimmy Lin , Thomas Barber , Diana Mandelker , Bert Vogelstein , Kenneth W. Kinzler , Victor E. Velculesu
发明人： Tobias Sjoblom , Sian Jones , D. Williams Parsons , Laura D. Wood , Jimmy Lin , Thomas Barber , Diana Mandelker , Bert Vogelstein , Kenneth W. Kinzler , Victor E. Velculesu
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/156
摘要： Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ˜90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. The vast majority of these genes were not known to be genetically altered in tumors and are predicted to affect a wide range of cellular functions, including transcription, adhesion, and invasion. These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention and monitoring.
摘要翻译：分析11个乳房和11个结直肠癌中的13,023个基因显示，个体肿瘤平均累积〜90个突变基因，但只有其中一个子集对肿瘤过程有贡献。使用严格的标准来描绘这一亚型，我们确定了189个基因（平均每个肿瘤11个），以显着的频率突变。这些基因绝大多数不知道在肿瘤中被遗传改变，并被预测会影响广泛的细胞功能，包括转录，粘附和侵袭。这些数据定义了两种人类癌症类型的遗传景观，为诊断和治疗干预和监测提供了新的目标。

3. 发明申请

US20100316995A1 CONSENSUS CODING SEQUENCES OF HUMAN BREAST AND COLORECTAL CANCERS 有权
标题翻译：人类乳腺癌和彩色癌症的共识编码序列
公开(公告)号：US20100316995A1
公开(公告)日：2010-12-16
申请号：US12377073
申请日：2007-08-13
申请人： Tobias Sjoblom , Sian Jones , D. Williams Parsons , Laura D. Wood , Jimmy Lin , Thomas Barber , Diana Mandelker , Bert Vogelstein , Kenneth W. Kinzler , Victor E. Velculesu
发明人： Tobias Sjoblom , Sian Jones , D. Williams Parsons , Laura D. Wood , Jimmy Lin , Thomas Barber , Diana Mandelker , Bert Vogelstein , Kenneth W. Kinzler , Victor E. Velculesu
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/156
摘要： Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ˜90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. The vast majority of these genes were not known to be genetically altered in tumors and are predicted to affect a wide range of cellular functions, including transcription, adhesion, and invasion. These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention and monitoring.
摘要翻译：分析11个乳房和11个结直肠癌中的13,023个基因显示，个体肿瘤平均累积〜90个突变基因，但只有其中一个子集对肿瘤过程有贡献。使用严格的标准来描绘这一亚型，我们确定了189个基因（平均每个肿瘤11个），以显着的频率突变。这些基因绝大多数不知道在肿瘤中被遗传改变，并被预测会影响广泛的细胞功能，包括转录，粘附和侵袭。这些数据定义了两种人类癌症类型的遗传景观，为诊断和治疗干预和监测提供了新的目标。

4. 发明申请

US20100301388A1 SEMICONDUCTOR DEVICE AND LATERAL DIFFUSED METAL-OXIDE-SEMICONDUCTOR TRANSISTOR 有权
标题翻译：半导体器件和侧向扩散金属氧化物半导体晶体管
公开(公告)号：US20100301388A1
公开(公告)日：2010-12-02
申请号：US12477054
申请日：2009-06-02
申请人： Jimmy Lin , Shang-Hui Tu , Ming-Horng Hsiao
发明人： Jimmy Lin , Shang-Hui Tu , Ming-Horng Hsiao
IPC分类号： H01L29/73 , H01L27/06
CPC分类号： H01L29/7393 , H01L27/0262 , H01L29/0696 , H01L29/7436 , H01L29/87
摘要： The invention provides a semiconductor device and a lateral diffused metal-oxide-semiconductor transistor. The semiconductor device includes a substrate having a first conductive type. A gate is disposed on the substrate. A source doped region is formed in the substrate, neighboring with a first side of the gate, wherein the source doped region has a second conductive type different from the first conductive type. A drain doped region is formed in the substrate, neighboring with a second side opposite to the first side of the gate. The drain doped region is constructed by a plurality of first doped regions with the first conductive type and a plurality of second doped regions with the second conductive type, wherein the first doped regions and the second doped regions are alternatively arranged.
摘要翻译：本发明提供一种半导体器件和横向漫射金属氧化物半导体晶体管。半导体器件包括具有第一导电类型的衬底。栅极设置在基板上。源极掺杂区域形成在与栅极的第一侧相邻的衬底中，其中源极掺杂区域具有不同于第一导电类型的第二导电类型。漏极掺杂区域形成在衬底中，与栅极的第一侧相对的第二侧相邻。漏极掺杂区域由具有第一导电类型的多个第一掺杂区域和具有第二导电类型的多个第二掺杂区域构成，其中交替布置第一掺杂区域和第二掺杂区域。

5. 发明申请

US20110162486A1 Open end ratchet wrench 审中-公开
标题翻译：开口棘轮扳手
公开(公告)号：US20110162486A1
公开(公告)日：2011-07-07
申请号：US12655737
申请日：2010-01-07
申请人： Jack Lee , Jimmy Lin
发明人： Jack Lee , Jimmy Lin
IPC分类号： B25B13/08 , B25B13/46
CPC分类号： B25B13/463 , B25B13/08
摘要： An open end ratchet wrench includes a socket member received in an opened head member and having an open notch for selectively aligning with an open slot of the head member, a pawl engaged in the head member for determining the rotating direction of the socket member by the head member, and a spring biasing member engaged with the pawl and having two end portions extended out of the pawl and engaged with the head member for anchoring the spring biasing member to the head member and for evenly biasing the pawl to engage with the teeth of the socket member, the wrench head member includes rounded upper and lower peripheral portions for allowing the socket member and the ring member to be reached and to be easily operated by the user.
摘要翻译：开口棘轮扳手包括容纳在打开的头部构件中的插座构件，并且具有用于选择性地与头部构件的开口槽对准的开口;用于通过头部构件确定插座构件的旋转方向的棘爪头部构件和弹簧偏压构件，其与棘爪接合并且具有从棘爪延伸出的两个端部并与头部构件接合，用于将弹簧偏压构件锚固到头部构件，并且用于均匀地偏压棘爪以与牙齿啮合插座构件，扳手头构件包括圆形的上下周边部分，用于允许插座构件和环构件到达并且易于由使用者操作。

6. 发明授权

US08093630B2 Semiconductor device and lateral diffused metal-oxide-semiconductor transistor 有权
标题翻译：半导体器件和横向扩散金属氧化物半导体晶体管
公开(公告)号：US08093630B2
公开(公告)日：2012-01-10
申请号：US12477054
申请日：2009-06-02
申请人： Jimmy Lin , Shang-Hui Tu , Ming-Horng Hsiao
发明人： Jimmy Lin , Shang-Hui Tu , Ming-Horng Hsiao
IPC分类号： H01L27/088
CPC分类号： H01L29/7393 , H01L27/0262 , H01L29/0696 , H01L29/7436 , H01L29/87
摘要： The invention provides a semiconductor device and a lateral diffused metal-oxide-semiconductor transistor. The semiconductor device includes a substrate having a first conductive type. A gate is disposed on the substrate. A source doped region is formed in the substrate, neighboring with a first side of the gate, wherein the source doped region has a second conductive type different from the first conductive type. A drain doped region is formed in the substrate, neighboring with a second side opposite to the first side of the gate. The drain doped region is constructed by a plurality of first doped regions with the first conductive type and a plurality of second doped regions with the second conductive type, wherein the first doped regions and the second doped regions are alternatively arranged.
摘要翻译：本发明提供一种半导体器件和横向漫射金属氧化物半导体晶体管。半导体器件包括具有第一导电类型的衬底。栅极设置在基板上。源极掺杂区域形成在与栅极的第一侧相邻的衬底中，其中源极掺杂区域具有不同于第一导电类型的第二导电类型。漏极掺杂区域形成在衬底中，与栅极的第一侧相对的第二侧相邻。漏极掺杂区域由具有第一导电类型的多个第一掺杂区域和具有第二导电类型的多个第二掺杂区域构成，其中交替布置第一掺杂区域和第二掺杂区域。

7. 发明申请

US20060059416A1 Architecture and methodology of redirection for dynamic new URL links 有权
标题翻译：动态新URL链接的重定向的架构和方法
公开(公告)号：US20060059416A1
公开(公告)日：2006-03-16
申请号：US11225074
申请日：2005-09-14
申请人： Jimmy Lin
发明人： Jimmy Lin
IPC分类号： G06F17/24 , G06F17/21
CPC分类号： G06F17/289 , G06F17/30887
摘要： An architecture and methodology of redirection for dynamic new URL Links uses a first server device to get information flow content from a second server device. By inserting an application into the information flow content retrieved from the second server device, the first server device replaces the web objects, which may generate dynamic new URL links, with the redirect functions in the code and sends the content to the browser. The browser will execute the code automatically. Whenever the browser generates new dynamic new URL links, it would call the provided redirect functions, and thus redirect them and retrace back to the first server device.
摘要翻译：动态新URL链接的重定向的架构和方法使用第一个服务器设备从第二个服务器设备获取信息流内容。通过将应用插入到从第二服务器设备检索的信息流内容中，第一服务器设备将可能生成动态新URL链接的web对象与代码中的重定向功能取代，并将内容发送到浏览器。浏览器将自动执行代码。每当浏览器生成新的动态新URL链接时，它将调用提供的重定向功能，从而重定向它们并回溯到第一个服务器设备。

8. 发明申请

US20110094348A1 Open end ratchet wrench 审中-公开
标题翻译：开口棘轮扳手
公开(公告)号：US20110094348A1
公开(公告)日：2011-04-28
申请号：US12589709
申请日：2009-10-27
申请人： Jack Lee , Jimmy Lin
发明人： Jack Lee , Jimmy Lin
IPC分类号： B25B13/46 , B25B13/48
CPC分类号： B25B13/463 , B25B13/48
摘要： An open end ratchet wrench includes a socket member rotatably received in an opened head member and having a number of teeth and having an open notch for selectively aligning with an open slot of the head member, a pawl engaged in the head member and having a toothed end for selectively engaging with the teeth of the socket member and for allowing the socket member to be rotated in one direction by the head member, and a spring biasing member engaged with the pawl and having two end portions extended out of the pawl and engaged with the head member for anchoring the spring biasing member to the head member and for evenly biasing the pawl to engage with the teeth of the socket member.
摘要翻译：开口棘轮扳手包括可旋转地容纳在打开的头部构件中并具有多个齿并且具有用于选择性地与头部构件的开口槽对准的开口的凹口的插座构件，与头部构件接合并具有齿形的棘爪端部，用于选择性地与插座构件的齿接合并且允许插座构件通过头部构件沿一个方向旋转;以及弹簧偏压构件，其与棘爪接合并且具有从棘爪延伸出的两个端部，并与头部构件用于将弹簧偏置构件锚固到头部构件，并且用于均匀地偏置棘爪以与插座构件的齿接合。

9. 外观设计

USD602546S1 Golf club grip 有权
公开(公告)号：USD602546S1
公开(公告)日：2009-10-20
申请号：US29312575
申请日：2008-10-29
申请人： Jimmy Lin
设计人： Jimmy Lin

10. 发明申请

US20080269754A1 Preparation Tools and Methods of Using the Same 审中-公开
标题翻译：准备工具及其使用方法
公开(公告)号：US20080269754A1
公开(公告)日：2008-10-30
申请号：US12042979
申请日：2008-03-05
申请人： Gregory E. Lutz , Hans Hull , Jimmy Lin
发明人： Gregory E. Lutz , Hans Hull , Jimmy Lin
IPC分类号： A61B17/00 , A61B17/32
CPC分类号： A61B17/320016 , A61B17/1624 , A61B17/1626 , A61B17/1659 , A61B17/1671 , A61B17/32002 , A61B17/3472 , A61B2017/00867 , A61B2017/1602 , A61B2017/32004 , A61B2090/034
摘要： Various devices and methods for accessing and preparing treatment sites within the intervertebral disc space for subsequent negligible-incision surgical (NIS) or percutaneous procedures to treat disc degeneration and disc related back pain are disclosed. Also disclosed is a method for performing a percutaneous spine procedure including preparing a treatment site within the intervertebral disc space for subsequent delivery of a biomaterial to treat disc degeneration and disc related back pain.
摘要翻译：公开了用于访问和制备椎间盘空间内用于随后的可忽略切口手术（NIS）或经皮手术以治疗椎间盘退变和椎间盘相关背痛的治疗部位的各种装置和方法。还公开了一种用于执行经皮脊柱手术的方法，包括在椎间盘空间内制备治疗部位，用于随后递送生物材料以治疗椎间盘退变和椎间盘相关的背部疼痛。

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