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1. 发明授权

US06756402B2 Cyclipostins, process for their preparation and use thereof 有权
标题翻译： Cyclipostins，其制备和使用的方法
公开(公告)号：US06756402B2
公开(公告)日：2004-06-29
申请号：US09886044
申请日：2001-06-22
申请人： Laszlo Vertesy , Klaus Ehrlich , Michael Kurz , Joachim Wink
发明人： Laszlo Vertesy , Klaus Ehrlich , Michael Kurz , Joachim Wink
IPC分类号： A61K31335
CPC分类号： C12R1/465 , C07F9/65744 , C12P9/00
摘要： The invention relates to compounds of formula I in which R1, R2, E, X1, X2, and X3 have the meaning as described in the specification and claims, obtained by culturing Streptomyces species HAG 004107 (DSM 13381), and their physiologically tolerable salts and chemical equivalents. The invention furthermore relates to a process for the preparation of the cyclipostins, the microorganism HAG 004107 (DSM 13381), the use of the cyclipostins and their physiologically tolerable salts and chemical equivalents as pharmaceuticals, in particular as inhibitors of lipases, and pharmaceutical preparations which contain cyclipostin or a physiologically tolerable salt or equivalent thereof.
摘要翻译：本发明涉及式Iin化合物，其中R 1，R 2，E，X 1，X 2和X 3具有如说明书和权利要求书中所述的含义，通过培养链霉菌种类HAG 004107（DSM 13381），及其生理上可耐受的盐和化学当量。本发明还涉及一种制备环肽酶，微生物HAG 004107（DSM 13381），环肽素及其生理上可耐受的盐和化学等价物作为药物，特别是作为脂肪酶抑制剂的药物制剂的方法，以及药物制剂含有Cycipostin或生理上可耐受的盐或其等同物。

2. 发明授权

US5939399A Polyene antibiotics, 3874 H1 to H6, processes for their preparation and use 失效
标题翻译：多烯抗生素，3874 H1至H6，其制备和使用过程
公开(公告)号：US5939399A
公开(公告)日：1999-08-17
申请号：US914652
申请日：1997-08-19
申请人： Laszlo Vertesy , Michael Kurz , Joachim Wink , Astrid Markus , Wilhelm Stahl
发明人： Laszlo Vertesy , Michael Kurz , Joachim Wink , Astrid Markus , Wilhelm Stahl
IPC分类号： C12P17/18 , A61K31/365 , A61P31/04 , A61P31/10 , A61P33/02 , C07D493/04 , C07H17/08 , C12N1/20 , C12P19/62 , C12R1/465 , A61K31/70 , C07G11/00 , C07H17/04 , C12P19/46
CPC分类号： C07H17/08 , C12P19/62 , Y10S435/886 , Y10S435/892
摘要： Novel polyene antibiotics, 3874 H1 to H6, processes for their preparation and use which are suitable for treating fungal diseases, trichomonad diseases, and for treating diseases associated with an increased steroid concentration.
摘要翻译：新型多烯抗生素，3874 H1至H6，其制备和使用方法适用于治疗真菌性疾病，毛滴虫病和用于治疗与增加的类固醇浓度相关的疾病。

3. 发明授权

US06927236B2 Coniosulfides and their derivatives, processes for preparing them, and their use as pharmaceuticals 失效
标题翻译：连环硫化物及其衍生物，制备方法及其作为药物的用途
公开(公告)号：US06927236B2
公开(公告)日：2005-08-09
申请号：US10247102
申请日：2002-09-19
申请人： Laszlo Vertesy , Klaus Ehrlich , Michael Kurz , Marian Paul Segeth , Luigi Toti
发明人： Laszlo Vertesy , Klaus Ehrlich , Michael Kurz , Marian Paul Segeth , Luigi Toti
IPC分类号： A61K31/4015 , A61K38/00 , C07K5/06 , C07K5/083 , C12P11/00 , C12P13/00 , C12P13/02 , A01N37/00 , A01N37/12 , A01N37/44 , A61K31/195 , A61K31/20
CPC分类号： C12P13/001 , A61K31/4015 , A61K38/00 , C07K5/06026 , C07K5/0806 , C12P11/00 , C12P13/02
摘要： The present invention relates to compounds of the formula which are formed during fermentation by the microorganism Coniochaeta ellipsoidea Udagawa, DSM 13856, or by one of its mutations and/or variants, and chemically derivatized if appropriate. The invention furthermore relates to a process for preparing compounds of the formula (I), and to their use as pharmaceuticals. In addition, the invention relates to the use of a compound of the formula (VI) for producing a pharmaceutical for the treatment and prophylaxis of degenerative neuropathics or of Alzheimer's disease.
摘要翻译：本发明涉及在发酵过程中通过微生物虹节藻（Rhodobsoidea Udagawa），DSM 13856或其突变和/或变体之一形成的下式的化合物，并且如果合适的话化学衍生化。本发明还涉及制备式（I）化合物的方法及其作为药物的用途。此外，本发明涉及式（VI）化合物在制备用于治疗和预防退行性神经病学或阿尔茨海默病的药物中的用途。

4. 发明授权

US07148254B2 2-Phenylbenzofuran derivatives, a process for preparing them, and their use 有权
标题翻译： 2-苯基苯并呋喃衍生物，其制备方法及其应用
公开(公告)号：US07148254B2
公开(公告)日：2006-12-12
申请号：US10972546
申请日：2004-10-25
申请人： Laszlo Vertesy , Michael Kurz , Astrid Markus-Erb , Luigi Toti
发明人： Laszlo Vertesy , Michael Kurz , Astrid Markus-Erb , Luigi Toti
IPC分类号： A61K31/34 , C07D307/86 , C12P17/04 , C12N1/18
CPC分类号： C12R1/66 , C07D307/86 , C12P17/04
摘要： The present invention relates to 2-phenylbenzofurans of formula (I) which are formed, during fermentation, by the microorganism Aspergillus flavipes ST003878 (DSM 15290), to a process for preparing them and to their use as pharmaceuticals for the treatment and/or prophylaxis of bacterial infectious diseases or mycoses.
摘要翻译：本发明涉及式（I）的2-苯基苯并呋喃，其在发酵过程中由微生物黄曲霉ST003878（DSM15290）制成，涉及其制备方法及其作为药物用于治疗和/或预防的用途的细菌感染性疾病或真菌病。

5. 发明授权

US07067112B2 Cephaibols: novel antiparasitics from Acremonium tubakii, process for their production, and use thereof 有权
标题翻译：头孢唑醇：来自Acremonium tubakii的新型抗寄生虫药，其生产方法及其用途
公开(公告)号：US07067112B2
公开(公告)日：2006-06-27
申请号：US10411144
申请日：2003-04-11
申请人： Laszlo Vertesy , Michael Kurz , Matthias Schiell , Joachim Hofmann
发明人： Laszlo Vertesy , Michael Kurz , Matthias Schiell , Joachim Hofmann
IPC分类号： A61K49/00 , A61K38/10 , C07K7/08
CPC分类号： C07K7/08 , A61K38/00
摘要： The invention relates to compounds of the formula I AcPhe-Aib-Aib-Aib-x-w-Leu-y-Aib-Hyp-Gln-z-Hyp-Aib-Pro-R (I) in which R is Phe-ol or Phe-al and w, x, y, and z have the following meanings: a) w is Gly or Ala; x is Aib and y and z are Iva; b) w is Gly; x, y and z are Iva; c) w is Gly; x and z are Aib and y is Iva; d) w is Gly; x, y and z are Aib; or e) w is Gly; x and y are Aib and z is Iva; or of the formula II AcPhe-Iva-Gln-Aib-lle-Thr-Aib-Leu-Aib-x-Gln-Aib-Hyp-Aib-Pro-Phe-Ser, (II) wherein x is Hyp or Pro, which are synthesized by Acremonium tubakii FH 1685 DSM 12774 during fermentation and released into the culture medium, a process for the isolation of the cephaibols from the culture medium, and their purification, and the use of the cephaibols as pharmacologically active compounds, in particular for the control of parasites.
摘要翻译：本发明涉及式I化合物<？in-line-formula description =“In-line Formulas”end =“lead”→AcPhe-Aib-Aib-Aib-xw-Leu-y-Aib-Hyp-Gln -z-Hyp-Aib-Pro-R（I）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中R是Phe-ol或Phe-al，w，x ，y和z具有以下含义：a）w是Gly或Ala; x是Aib，y和z是Iva; b）w是Gly; x，y和z是Iva; c）w是Gly; x和z是Aib，y是Iva; d）w是Gly; x，y和z是Aib; 或e）w是Gly; x和y是Aib，z是Iva; AcPhe-Iva-Gln-Aib-Lle-Thr-Aib-Leu-Aib-x-Gln-Aib，或者式II <？in-line-formula description =“In-line Formulas”end =“lead” -Hyp-Aib-Pro-Phe-Ser，（II）<？在线公式描述=“在线公式”end =“tail”？>其中x是Hyp或Pro，它们是由Acremonium tubakii FH 1685 DSM 12774在发酵过程中释放到培养基中，从培养基中分离头孢胆素的方法及其纯化，以及将头孢唑醇用作药物活性化合物，特别是用于控制寄生虫的方法。

6. 发明授权

US07253206B2 Phenalenone derivatives, processes for preparation and use thereof 失效
标题翻译：萘烯酮衍生物，其制备方法和用途
公开(公告)号：US07253206B2
公开(公告)日：2007-08-07
申请号：US10367545
申请日：2003-02-14
申请人： Laszlo Vertesy , Michael Kurz , Ziyu Li , Luigi Toti
发明人： Laszlo Vertesy , Michael Kurz , Ziyu Li , Luigi Toti
IPC分类号： A01N31/35 , C12P17/00 , C12P7/00 , C12P7/22 , C12P1/04
CPC分类号： C07D307/92 , C12P7/22 , C12P17/04 , C12R1/80
摘要： The present invention provides novel phenalenone derivatives of formula (I) which are formed by the microorganism Penicillium herquei Bainer & Sartory, DSM 14142, during fermentation. A process for their preparation, their use as pharmaceutical compositions, and their use for the treatment or prophylaxis of bacterial infections, mycoses, oncoses and rheumatic diseases are also disclosed and claimed
摘要翻译：本发明提供在发酵过程中由微生物青霉菌Bainer＆Sartory DSM 14142形成的新颖的式（I）的phenalenone衍生物。其制备方法，它们作为药物组合物的用途及其用于治疗或预防细菌感染，真菌病，肿瘤和风湿性疾病的用途也被公开和要求保护

7. 发明申请

US20050137254A1 2-Phenylbenzofuran derivatives, a process for preparing them, and their use 有权
标题翻译： 2-苯基苯并呋喃衍生物，其制备方法及其应用
公开(公告)号：US20050137254A1
公开(公告)日：2005-06-23
申请号：US10972546
申请日：2004-10-25
申请人： Laszlo Vertesy , Michael Kurz , Astrid Markus-Erb , Luigi Toti
发明人： Laszlo Vertesy , Michael Kurz , Astrid Markus-Erb , Luigi Toti
IPC分类号： C07D307/86 , C12P17/04 , A61K31/343 , C12N1/16
CPC分类号： C12R1/66 , C07D307/86 , C12P17/04
摘要： The present invention relates to 2-phenylbenzofurans of formula (I) which are formed, during fermentation, by the microorganism Aspergillus flavipes ST003878 (DSM 15290), to a process for preparing them and to their use as pharmaceuticals for the treatment and/or prophylaxis of bacterial infectious diseases or mycoses.
摘要翻译：本发明涉及式（I）的2-苯基苯并呋喃，其在发酵过程中由微生物黄曲霉ST003878（DSM15290）制成，涉及其制备方法及其作为药物用于治疗和/或预防的用途的细菌感染性疾病或真菌病。

8. 发明授权

US06673834B2 Hydroperylene derivatives 有权
标题翻译：氢化衍生物
公开(公告)号：US06673834B2
公开(公告)日：2004-01-06
申请号：US10300963
申请日：2002-11-21
申请人： Michael Kurz , Matthias Herrmann , Luigi Toti , Laszlo Vertesy
发明人： Michael Kurz , Matthias Herrmann , Luigi Toti , Laszlo Vertesy
IPC分类号： A61K31336
CPC分类号： C12R1/645 , C07D303/34 , C12P17/02
摘要： Compounds of the formula I are suitable for producing pharmaceuticals for the prophylaxis and therapy of diseases in which high blood platelet aggregations occur.
摘要翻译：式I化合物适用于生产用于预防和治疗出现高血小板聚集的疾病的药物。

9. 发明授权

US06077830A Bismuth salts of antibiotics of the moenomycin group, processes for their preparation, their use and pharmaceuticals comprising such salts 失效
标题翻译：新霉素组抗生素铋盐，其制备方法及其用途和包含这些盐的药物
公开(公告)号：US06077830A
公开(公告)日：2000-06-20
申请号：US36683
申请日：1998-03-09
申请人： Laszlo Vertesy , Michael Kurz , Astrid Markus , Gerhard Seibert
发明人： Laszlo Vertesy , Michael Kurz , Astrid Markus , Gerhard Seibert
IPC分类号： C07H13/12 , A61K31/70 , A61K31/702 , A61K31/7024 , A61K31/7135 , A61P1/00 , A61P1/04 , A61P31/04 , C07F9/94 , C07H21/00
CPC分类号： A61K31/70
摘要： The present invention relates to bismuth salts of antibiotics of the moenomycin group, processes for their preparation, their use and pharmaceuticals comprising such salts. The salts according to the invention contain antibiotics of the moenomycin group which are so-called phosphoglycolipid antibiotics and which are present individually or as a mixture, or derivatives thereof, and bismuth in defined stoichiometric ratios. They are outstandingly suitable, in particular, for controlling Helicobacter pylori and, thus, for example, for the therapy and prophylaxis of gastric disorders.
摘要翻译：本发明涉及霉霉素组的抗生素铋盐，其制备方法及其用途和包含这些盐的药物。根据本发明的盐含有呼伦霉素基团的抗生素，它是所谓的磷脂糖抗生素，它们单独存在或作为其混合物或其衍生物，以及定义化学计量比的铋。它们特别适用于控制幽门螺杆菌，因此例如用于治疗和预防胃疾病。

10. 发明授权

US08765799B2 Streptospirole derivatives 有权
标题翻译：链球菌衍生物
公开(公告)号：US08765799B2
公开(公告)日：2014-07-01
申请号：US13056751
申请日：2009-07-16
申请人： Cosima Dufour-Schroif , Joachim Wink , Martin Gerlitz , Hélène Olivan , Michael Kurz
发明人： Cosima Dufour-Schroif , Joachim Wink , Martin Gerlitz , Hélène Olivan , Michael Kurz
IPC分类号： A61K31/407 , C07D491/107 , C07D498/10
CPC分类号： C07D498/10 , C07D491/107
摘要： The invention relates to streptospirole derivatives of the general formula (I), wherein R1, R2, R3, X1, X2, Y1 and Y2 are as defined herein, a process for the preparation of said compounds by fermenting the microorganism Streptomyces sp. ST 108140 (DSM 19369) and optionally derivatizing the compounds produced by said microorganism, a pharmaceutical composition comprising at least one compound of the formula (I), and the use of a compound of the formula (I) for the preparation of a medicament for the treatment and/or prophylaxis of bacterial infections.
摘要翻译：本发明涉及通式（I）的链霉菌素衍生物，其中R1，R2，R3，X1，X2，Y1和Y2如本文所定义，通过发酵微生物Streptomyces sp。 ST108404（DSM19369），并任选地衍生由所述微生物产生的化合物，包含至少一种式（I）化合物的药物组合物和式（I）化合物在制备药物中的应用治疗和/或预防细菌感染。

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