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1. 发明授权

US07067112B2 Cephaibols: novel antiparasitics from Acremonium tubakii, process for their production, and use thereof 有权
标题翻译：头孢唑醇：来自Acremonium tubakii的新型抗寄生虫药，其生产方法及其用途
公开(公告)号：US07067112B2
公开(公告)日：2006-06-27
申请号：US10411144
申请日：2003-04-11
申请人： Laszlo Vertesy , Michael Kurz , Matthias Schiell , Joachim Hofmann
发明人： Laszlo Vertesy , Michael Kurz , Matthias Schiell , Joachim Hofmann
IPC分类号： A61K49/00 , A61K38/10 , C07K7/08
CPC分类号： C07K7/08 , A61K38/00
摘要： The invention relates to compounds of the formula I AcPhe-Aib-Aib-Aib-x-w-Leu-y-Aib-Hyp-Gln-z-Hyp-Aib-Pro-R (I) in which R is Phe-ol or Phe-al and w, x, y, and z have the following meanings: a) w is Gly or Ala; x is Aib and y and z are Iva; b) w is Gly; x, y and z are Iva; c) w is Gly; x and z are Aib and y is Iva; d) w is Gly; x, y and z are Aib; or e) w is Gly; x and y are Aib and z is Iva; or of the formula II AcPhe-Iva-Gln-Aib-lle-Thr-Aib-Leu-Aib-x-Gln-Aib-Hyp-Aib-Pro-Phe-Ser, (II) wherein x is Hyp or Pro, which are synthesized by Acremonium tubakii FH 1685 DSM 12774 during fermentation and released into the culture medium, a process for the isolation of the cephaibols from the culture medium, and their purification, and the use of the cephaibols as pharmacologically active compounds, in particular for the control of parasites.
摘要翻译：本发明涉及式I化合物<？in-line-formula description =“In-line Formulas”end =“lead”→AcPhe-Aib-Aib-Aib-xw-Leu-y-Aib-Hyp-Gln -z-Hyp-Aib-Pro-R（I）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中R是Phe-ol或Phe-al，w，x ，y和z具有以下含义：a）w是Gly或Ala; x是Aib，y和z是Iva; b）w是Gly; x，y和z是Iva; c）w是Gly; x和z是Aib，y是Iva; d）w是Gly; x，y和z是Aib; 或e）w是Gly; x和y是Aib，z是Iva; AcPhe-Iva-Gln-Aib-Lle-Thr-Aib-Leu-Aib-x-Gln-Aib，或者式II <？in-line-formula description =“In-line Formulas”end =“lead” -Hyp-Aib-Pro-Phe-Ser，（II）<？在线公式描述=“在线公式”end =“tail”？>其中x是Hyp或Pro，它们是由Acremonium tubakii FH 1685 DSM 12774在发酵过程中释放到培养基中，从培养基中分离头孢胆素的方法及其纯化，以及将头孢唑醇用作药物活性化合物，特别是用于控制寄生虫的方法。

2. 发明授权

US06582949B1 Cephaibols: novel antiparasitics from Acremonium tubakii process for their production, and use thereof 有权
标题翻译： Cephaibols：来自Acremonium tubakii方法的新型抗寄生虫药物的生产及其用途
公开(公告)号：US06582949B1
公开(公告)日：2003-06-24
申请号：US09563505
申请日：2000-05-03
申请人： László Vértesy , Michael Kurz , Matthias Schiell , Joachim Hofmann
发明人： László Vértesy , Michael Kurz , Matthias Schiell , Joachim Hofmann
IPC分类号： C07K708
CPC分类号： C07K7/08 , A61K38/00
摘要： The invention relates to compounds of the formula I AcPhe-Aib-Aib-Aib-x-w-Leu-y-Aib-Hyp-Gln-z-Hyp-Aib-Pro-R (I) in which R is Phe-ol or Phe-al and w, x, y, and z have the following meanings: a) w is Gly or Ala; x is Aib and y and z are Iva; b) w is Gly; x, y and z are va; c) w is Gly; x and z are Aib and y is Iva; d) w is Gly; x, y and z are Aib; or e) w is Gly; x and y are Aib and z is Iva; or of the formula II AcPhe-Iva-Gln-Aib-Ile-Thr-Aib-Leu-Aib-x-Gln-Aib-Hyp-Aib-Pro-Phe-Ser (II), wherein x is Hyp or Pro, which are synthesized by Acremonium tubakii FH 1685 DSM 12774 during fermentation and released into the culture medium, a process for the isolation of the cephaibols from the culture medium, and their purification, and the use of the cephaibols as pharmacologically active compounds, in particular for the control of parasites.
摘要翻译：本发明涉及式Iin化合物，其中R为Phe-ol或Phe-al，w，x，y和z具有以下含义：a）w为Gly或Ala; x是Aib，y和z是Iva; b）w是Gly; x，y和z是va; c）w是Gly; x和z是Aib，y是Iva; d）w是Gly; x，y和z是Aib; 矿石）w是Gly; x和y是Aib，z是Iva;或者其中X是Hyp或Pro的式II，其在发酵过程中被Acremonium tubakii FH 1685 DSM 12774合成并释放到培养基中，从头孢曲松培养基和它们的纯化，以及将头孢吡肟作为药理学活性化合物的用途，特别是用于控制寄生虫。

3. 发明授权

US06335363B1 Use of inhibitors of the KQTI channel and methods of controlling and treating diseases caused by helminths and ectoparasites 有权
标题翻译：使用KQTI通道抑制剂和控制和治疗由蠕虫和外寄生物引起的疾病的方法
公开(公告)号：US06335363B1
公开(公告)日：2002-01-01
申请号：US09461806
申请日：1999-12-16
申请人： Uwe Gerlach , Joachim Hofmann , Hans Jochen Lang , Aguan Wei
发明人： Uwe Gerlach , Joachim Hofmann , Hans Jochen Lang , Aguan Wei
IPC分类号： A61K3135
CPC分类号： A61K31/4433 , A61K31/00 , A61K31/18 , A61K31/352 , A61K31/353
摘要： Use of inhibitors of the KQT1 channel for preparing a medicament for treating diseases caused by helminths and ectoparasites Inhibitors of the KQT1 channel are a novel way of destroying helminths and ectoparasites. For this reason, blockers of the cellular KQT1 channel, which is present in helminths and ectoparasites, are used for preparing a medicament for the treatment of vertebrates and humans infested by helminths or ectoparasites. These KQT1 blockers are used as medicaments on their own or in combination with other medicaments and therapeutic measures. Inhibitors of the KQT1 channel are likewise a novel mechanism of action for phytoparasites such as insects, arachnids, molluscs and nematodes, and consequently, they are used for preparing a crop protection composition.
摘要翻译：使用KQT1通道的抑制剂制备用于治疗由蠕虫和外寄生物引起的疾病的药物KQT1通道的抑制剂是破坏蠕虫和外寄生物的新方法。由于这个原因，存在于蠕虫和外寄生物中的细胞KQT1通道的阻断剂用于制备用于治疗被蠕虫或外寄生虫感染的脊椎动物和人的药物。这些KQT1阻断剂本身或与其他药物和治疗措施结合使用作为药物.KQT1通道的抑制剂同样是植物寄生虫如昆虫，蜘蛛，软体动物和线虫的新作用机制，因此，它们被使用准备作物保护组合物。

4. 发明申请

US20070038337A1 Method for operating a network 审中-公开
标题翻译：操作网络的方法
公开(公告)号：US20070038337A1
公开(公告)日：2007-02-15
申请号：US11502454
申请日：2006-08-11
申请人： Joachim Hofmann , Anja Kuhn
发明人： Joachim Hofmann , Anja Kuhn
IPC分类号： G06F17/00
CPC分类号： G05B19/042
摘要： In a method for operation of a network comprising a plurality of networked controllers in a vehicle, controller groups are each formed from a plurality of controllers, and are designed to carry out various vehicle functions. One of the controllers in each controller group is configured as a function master controller which stores all data relevant for the vehicle function associated with this controller group. A central controller communicates with all of the function master controllers, and stores the data from all of the function master controllers using a global variant coding (GVC). In addition, the central controller transmits a global status message (GSM) in the network, which message comprises a status signal (GSS) that signals whether a change has occurred in the GVC, and at least some of the GVC. All of the active controllers carry out an update, if necessary, by access to the GVC, of all the data which is relevant for the respective controller when the GSM signals a desired GVC.
摘要翻译：在一种包括车辆中的多个联网控制器的网络的操作方法中，控制器组各自由多个控制器形成，并被设计为执行各种车辆功能。每个控制器组中的一个控制器被配置为功能主控制器，其存储与该控制器组相关联的与车辆功能相关的所有数据。中央控制器与所有功能主控制器通信，并使用全局变体编码（GVC）存储来自所有功能主控制器的数据。此外，中央控制器在网络中发送全局状态消息（GSM），该消息包括用于指示GVC中是否发生变化的状态信号（GSS）以及GVC中的至少一些。如果需要，所有主动控制器通过访问GVC，在GSM发出所需的GVC信号时，执行与相应控制器相关的所有数据的更新。

5. 发明授权

US06193971B1 Dictyocaulus viviparus antigen for diagnosing lungworm infestation and for vaccination 失效
标题翻译： Dictyocaulus viviparus抗原用于诊断肺虫感染和接种疫苗
公开(公告)号：US06193971B1
公开(公告)日：2001-02-27
申请号：US08786455
申请日：1997-01-21
申请人： Joachim Hofmann , Karlheinrich Schmid
发明人： Joachim Hofmann , Karlheinrich Schmid
IPC分类号： G01N3353
CPC分类号： C07K14/4354 , A61K38/00
摘要： An immunogenic protein (DV 18) isolated from lungworm Dictyocaulus viviparus including variants and fragments thereof, are described. DNA encoding such protein, methods of isolating and preparing such protein, antibodies against such protein, immunoassays using such protein, a vaccine containg such protein, and methods of immunizing a mammal with such vaccine are also described.
摘要翻译：描述了从肺虫Dictyocaulus viviparus分离的包括其变体和片段的免疫原性蛋白（DV18）。还描述了编码这种蛋白质的DNA，分离和制备这种蛋白质的方法，针对这种蛋白质的抗体，使用这种蛋白质的免疫测定法，包含这种蛋白质的疫苗，以及用这种疫苗免疫哺乳动物的方法。

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