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1. 发明申请

US20050186659A1 Methods for protein purification 审中-公开
标题翻译：蛋白质纯化方法
公开(公告)号：US20050186659A1
公开(公告)日：2005-08-25
申请号：US11040244
申请日：2005-01-20
申请人： Lars Abrahmsen , Joakim Nilsson , Udo Oppermann , Stefan Svensson
发明人： Lars Abrahmsen , Joakim Nilsson , Udo Oppermann , Stefan Svensson
IPC分类号： C07H21/04 , C12N1/21 , C12N9/04 , C12N9/48 , C12N15/53 , C12N15/74 , C12P21/02
CPC分类号： C12N9/0006 , C12P21/02 , C12Y101/01146
摘要： The present invention relates to process for the production of a soluble polypeptide having at least one ligand binding site, the process comprising (i) providing a host cell comprising a nucleic acid sequence encoding the soluble polypeptide; (ii) culturing the host cell under conditions whereby the polypeptide is produced, wherein the cell culture medium comprises a non-proteinaceous ligand capable of binding to a ligand binding site of the polypeptide; and (iii) recovering said polypeptide.
摘要翻译：本发明涉及产生具有至少一个配体结合位点的可溶性多肽的方法，所述方法包括（i）提供包含编码可溶性多肽的核酸序列的宿主细胞; （ii）在产生多肽的条件下培养宿主细胞，其中所述细胞培养基包含能够结合所述多肽的配体结合位点的非蛋白质配体; 和（iii）回收所述多肽。

2. 发明授权

US5763256A Serine protease variants having peptide ligase activity 失效
标题翻译：具有肽连接酶活性的丝氨酸蛋白酶变体
公开(公告)号：US5763256A
公开(公告)日：1998-06-09
申请号：US257467
申请日：1994-06-08
申请人： Lars Abrahmsen , John Burnier , James A. Wells
发明人： Lars Abrahmsen , John Burnier , James A. Wells
IPC分类号： C12N1/21 , C07K14/61 , C12N9/22 , C12N9/54 , C12N15/09 , C12N15/57 , C12P21/02 , C12R1/07 , C12R1/125 , C12N9/52 , C12N9/56
CPC分类号： C12N9/54 , C07K14/61 , C12N9/22 , C12P21/02
摘要： The invention relates to serine protease variants derived from precursor serine proteases via recombinant and/or chemical methods to form protease variants having improved peptide ligase activity. The invention also includes novel ligation substrates which in combination with the serine protease variants and a second ligation substrate are capable of forming a ligation product. The invention also relates to methods for forming such ligation products and the products formed thereby.
摘要翻译：本发明涉及通过重组和/或化学方法衍生自前体丝氨酸蛋白酶的丝氨酸蛋白酶变体，以形成具有改善的肽连接酶活性的蛋白酶变体。本发明还包括与丝氨酸蛋白酶变体组合的新型连接底物，第二连接底物能够形成连接产物。本发明还涉及形成这种连接产品的方法和由此形成的产品。

3. 发明申请

US20140162956A1 POLYPEPTIDES 有权
公开(公告)号：US20140162956A1
公开(公告)日：2014-06-12
申请号：US13808713
申请日：2011-07-08
申请人： Caroline Ekblad , Lars Abrahmsen
发明人： Caroline Ekblad , Lars Abrahmsen
IPC分类号： A61K47/48 , C07K14/00
CPC分类号： C07K14/315 , A61K38/00 , A61K51/081 , C07K14/001 , C07K2319/21 , C07K2319/31 , C07K2319/50 , C07K2319/70 , Y02A50/473
摘要： The present disclosure relates to a class of engineered polypeptides having a binding affinity for albumin. It also relates to new methods and uses that exploit binding by these and other compounds to albumin in different contexts, some of which have significance for treatment or diagnosis of disease in mammals including humans.
摘要翻译：本公开涉及对白蛋白具有结合亲和力的一类工程改造的多肽。它还涉及利用这些和其它化合物在不同背景下结合白蛋白的新方法和用途，其中一些对于包括人在内的哺乳动物的疾病的治疗或诊断具有重要意义。

4. 发明授权

US5736512A Serine protease variants having peptide ligase activity 失效
公开(公告)号：US5736512A
公开(公告)日：1998-04-07
申请号：US475640
申请日：1995-06-07
申请人： Lars Abrahmsen , John Burnier , James A. Wells , David T. Jackson
发明人： Lars Abrahmsen , John Burnier , James A. Wells , David T. Jackson
IPC分类号： C07K14/61 , C12N9/22 , C12N9/54 , C12P21/02 , A61K38/00 , C12P21/06 , C07K1/17
CPC分类号： C12N9/54 , C07K14/61 , C12N9/22 , C12P21/02
摘要： The invention relates to serine protease variants derived from precursor serine proteases via recombinant and/or chemical methods to form protease variants having improved peptide ligase activity. The invention also includes novel ligation substrates which in combination with the serine protease variants and a second ligation substrate are capable of forming a ligation product. The invention also relates to methods for forming such ligation products and the products formed thereby.

5. 发明授权

US07226601B1 Conjugate between a modified superantigen and a target-seeking compound and the use of the conjugate 失效
标题翻译：修饰的超抗原和寻靶化合物之间的缀合以及缀合物的使用
公开(公告)号：US07226601B1
公开(公告)日：2007-06-05
申请号：US08765695
申请日：1995-06-07
申请人： Lars Abrahmsen , Per Bjork , Mikael Dohlsten , Terje Kalland
发明人： Lars Abrahmsen , Per Bjork , Mikael Dohlsten , Terje Kalland
IPC分类号： C07K16/46 , C07K19/00 , A61K39/395
CPC分类号： C07K16/30 , A61K38/00 , A61K47/6863 , A61K2039/505 , C07K14/31 , C07K16/3046 , C07K19/00 , C07K2317/55 , C07K2319/00 , C07K2319/30 , Y10S514/885
摘要： A method for the treatment of a disease in a mammal by administering a therapeutically effective amount of a conjugate comprising a biospecific affinity counterpart and a peptide, wherein the peptide contains an amino acid sequence that is derived from staphylococcal enterotoxin A, binds to a Vβ of a T cell receptor, and has a D227A mutation so that the peptide has a modified ability to bind to MHC class II antigens.
摘要翻译：一种通过施用治疗有效量的包含生物特异性亲和对应物和肽的缀合物来治疗哺乳动物疾病的方法，其中所述肽含有衍生自葡萄球菌肠毒素A的氨基酸序列，其结合到 T细胞受体，并且具有D227A突变，使得肽具有与MHC II类抗原结合的修饰能力。

6. 发明授权

US07226595B2 Modified Chimeric superantigens and their use 有权
标题翻译：改性嵌合超级抗原及其用途
公开(公告)号：US07226595B2
公开(公告)日：2007-06-05
申请号：US10283838
申请日：2002-10-30
申请人： Per Antonsson , Per Bjork , Mikael Dohlsten , Terje Kalland , Lars Abrahmsen , Johan Hansson , Göran Forsberg
发明人： Per Antonsson , Per Bjork , Mikael Dohlsten , Terje Kalland , Lars Abrahmsen , Johan Hansson , Göran Forsberg
IPC分类号： A61K39/00
CPC分类号： C07K16/3023 , A61K38/00 , A61K47/68 , C07K14/31 , C07K16/3046 , C07K19/00 , C07K2317/732 , C07K2319/00
摘要： A conjugate between a target-seeking moiety and a modified superantigen, characterized in that the superantigen is a wild-type superantigen (SA I) in which an amino acid residue in a superantigen region (region I) determining binding to TCR, preferably TCRVβ, and T cell activation have been replaced by another amino acid residue while retaining the ability to activate a subset of T cells.In preferred embodiment the modified superantigen is a chimer between at least two wild-type superantigens (SA I, SA II etc) characterized in that one or more amino acid residues in a region determining binding to TCR and T cell activation have been interchanged between various wild-type superantigens.A therapeutic method making use of modified/chimeric superantigens as defined in the preceding paragraphs.An antibody preparation in which the cysteine residues that provide for interchain disulfide bonds have been mutated so as to forbid interchain disulfide bridges, preferably to serine residues, for use as pharmaceutical.
摘要翻译：目标寻找部分和修饰的超抗原之间的缀合物，其特征在于超抗原是野生型超抗原（SAI），其中超抗原区（区域I）中的氨基酸残基确定结合TCR，优选TCRVβ，并且T细胞激活已被另一个氨基酸残基替代，同时保留激活T细胞亚群的能力。在优选实施方案中，修饰的超抗原是至少两种野生型超级抗原（SA I，SA II等）之间的嵌合体，其特征在于确定结合TCR和T细胞活化的区域中的一个或多个氨基酸残基已经在各种野生型超抗原。使用前面段落中定义的修饰/嵌合超级抗原的治疗方法。其中提供链间二硫键的半胱氨酸残基已被突变以防止链间二硫键，优选丝氨酸残基用作药物的抗体制剂。

7. 发明申请

US20060062795A1 Conjugate between a modified superantigen and a target-seeking compound and the use of the conjugate 审中-公开
标题翻译：修饰的超抗原和寻靶化合物之间的缀合以及缀合物的使用
公开(公告)号：US20060062795A1
公开(公告)日：2006-03-23
申请号：US11193869
申请日：2005-07-29
申请人： Lars Abrahmsen , Per Bjork , Mikael Dohlsten , Terje Kalland
发明人： Lars Abrahmsen , Per Bjork , Mikael Dohlsten , Terje Kalland
IPC分类号： A61K39/395 , C07K16/46
CPC分类号： C07K16/30 , A61K38/00 , A61K47/6863 , A61K2039/505 , C07K14/31 , C07K16/3046 , C07K19/00 , C07K2317/55 , C07K2319/00 , C07K2319/30 , Y10S514/885
摘要： Conjugates comprising a biospecific affinity counterpart and a peptide that is derived from Staphylococcal enterotoxin A, that has the ability to bind to a Vβ of a T cell receptor and has been modified at amino acid position 47, 128, 187, 225 or 227, in order to have reduced ability to bind to MHC class II antigens. Such conjugates are useful, for example, as therapeutic agents, for example, as anti-cancer agents.
摘要翻译：包含生物特异性亲和对应物和衍生自葡萄球菌肠毒素A的肽的缀合物，其具有结合T细胞受体的Vbeta并在氨基酸位置47,128,187,225或227处被修饰的能力，以降低与MHC II类抗原结合的能力。这样的缀合物可用作例如治疗剂，例如作为抗癌剂。

8. 发明授权

US09211344B2 Polypeptides 有权
标题翻译：多肽
公开(公告)号：US09211344B2
公开(公告)日：2015-12-15
申请号：US13808713
申请日：2011-07-08
申请人： Caroline Ekblad , Lars Abrahmsen
发明人： Caroline Ekblad , Lars Abrahmsen
IPC分类号： A61K47/48 , C07K14/00 , C07K14/315 , A61K51/08 , A61K38/00
CPC分类号： C07K14/315 , A61K38/00 , A61K51/081 , C07K14/001 , C07K2319/21 , C07K2319/31 , C07K2319/50 , C07K2319/70 , Y02A50/473
摘要： The present disclosure relates to a class of engineered polypeptides having a binding affinity for albumin. It also relates to new methods and uses that exploit binding by these and other compounds to albumin in different contexts, some of which have significance for treatment or diagnosis of disease in mammals including humans.
摘要翻译：本公开涉及对白蛋白具有结合亲和力的一类工程改造的多肽。它还涉及利用这些和其它化合物在不同背景下结合白蛋白的新方法和用途，其中一些对于包括人在内的哺乳动物的疾病的治疗或诊断具有重要意义。

9. 发明申请

US20130203962A1 IMMUNOGLOBULIN G FC REGION BINDING POLYPEPTIDE 有权
标题翻译：免疫球蛋白G区域结合多肽
公开(公告)号：US20130203962A1
公开(公告)日：2013-08-08
申请号：US13583686
申请日：2011-03-07
申请人： Lars Abrahmsen
发明人： Lars Abrahmsen
IPC分类号： C07K16/00
CPC分类号： C07K16/00 , B01D15/3804 , B01D15/3809 , B01J20/28033 , B01J20/285 , B01J20/286 , B01J20/3274 , C07K14/31 , C07K16/065
摘要： An immunoglobulin G Fc region binding polypeptide is provided, consisting of an amino acid sequence selected from i) and an amino acid sequence which has at least 95% identity thereto. Also provided are methods for producing the polypeptide, compositions comprising the polypeptide, polynucleoties encoding the polypeptide, multimers of the polypeptide, and methods of using the polypeptide.
摘要翻译：提供免疫球蛋白G Fc区结合多肽，其由选自i）的氨基酸序列和与其具有至少95％同一性的氨基酸序列组成。还提供了产生多肽的方法，包含多肽的组合物，编码多肽的多核苷酸，多肽的多聚体以及使用多肽的方法。

10. 发明申请

US20120165650A1 HER2 BINDERS 审中-公开
公开(公告)号：US20120165650A1
公开(公告)日：2012-06-28
申请号：US12975425
申请日：2010-12-22
申请人： Faisal Ahmed Syud , Brian Duh-Lan Lee , Rong Zhang , Peter Brian Iveson , Paul Schaffer , Tove Eriksson , Elin Gunneriusson , Fredrik Frejd , Lars Abrahmsen , Joachim Feldwisch , Nina Herne , Christofer Lendel
发明人： Faisal Ahmed Syud , Brian Duh-Lan Lee , Rong Zhang , Peter Brian Iveson , Paul Schaffer , Tove Eriksson , Elin Gunneriusson , Fredrik Frejd , Lars Abrahmsen , Joachim Feldwisch , Nina Herne , Christofer Lendel
IPC分类号： A61B5/055 , A61K49/00 , C07K14/00
CPC分类号： A61K51/088 , C07K14/71
摘要： Imaging agents comprising an isolated polypeptide conjugated with a radionuclide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.
摘要翻译：包含与放射性核素和螯合剂缀合的分离的多肽的成像剂; 其中所述分离的多肽特异性结合HER2或其变体; 以及制备和使用这些成像剂的方法。

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