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1. 发明申请

US20060057573A1 Methods and reagents for detecting target binding by nucleic acid ligands 审中-公开
标题翻译：用于检测核酸配体靶结合的方法和试剂
公开(公告)号：US20060057573A1
公开(公告)日：2006-03-16
申请号：US10504696
申请日：2003-02-10
申请人： Larry Gold , Jonathan Smith , Dominic Zichi , Daniel Schneider , Chad Greef
发明人： Larry Gold , Jonathan Smith , Dominic Zichi , Daniel Schneider , Chad Greef
IPC分类号： C12Q1/68 , C12Q1/42
CPC分类号： C12N15/115 , G01N33/58
摘要： The present invention provides novel methods and reagents for detecting the binding of protein targets to nucleic acid ligands. Using Universal Protein Stains (UPS), proteins bound by nucleic acid ligands may be labeled with a detectable moiety. The methods and reagents are particularly useful for the detection of protein targets bound to multiplexed arrays of nucleic acid ligands. The present invention also provides novel methods for the multiplexed evaluation of photocrosslinking nucleic acid ligands. The methods allow one simultaneously to: (1) evaluate the performance (dynamic range) of a plurality of photocrosslinking nucleic acid ligands; and (2) assess the specificity of each photocrosslinking nucleic acid ligand for its cognate target protein. Photocrosslinking nucleic acid ligands with the most desirable properties can then be selected for use in diagnostic and prognostic medical assays. The present invention also provides a photocrosslinking nucleic acid ligand that binds specifically to HIV gp120MN.
摘要翻译：本发明提供用于检测蛋白质靶标与核酸配体的结合的新型方法和试剂。使用通用蛋白污渍（UPS），可以用可检测的部分标记由核酸配体结合的蛋白质。所述方法和试剂对于检测与核酸配体复合阵列结合的蛋白质靶标特别有用。本发明还提供了用于光交联核酸配体的多重评价的新方法。该方法同时允许：（1）评估多个光交联核酸配体的性能（动态范围）; 和（2）评估每个光交联核酸配体对其同源靶蛋白的特异性。然后可以选择具有最理想特性的光交联核酸配体用于诊断和预后医学测定。本发明还提供了与HIV gp120MN特异性结合的光交联核酸配体。

2. 发明申请

US20070166740A1 MULTIPLEXED ANALYSES OF TEST SAMPLES 审中-公开
标题翻译：测试样本的多重分析
公开(公告)号：US20070166740A1
公开(公告)日：2007-07-19
申请号：US11623535
申请日：2007-01-16
申请人： James Heil , Daniel Schneider , Daniel Nieuwlandt , Sheri Wilcox , Dominic Zichi , Todd Gander , Bruce Eaton , Larry Gold
发明人： James Heil , Daniel Schneider , Daniel Nieuwlandt , Sheri Wilcox , Dominic Zichi , Todd Gander , Bruce Eaton , Larry Gold
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N33/5308 , C12N15/115 , C12N2310/16 , C12N2310/3519 , C12Q1/6816 , C12Q1/6832 , C12Q1/6834 , G01N33/58 , C12Q2565/514 , C12Q2525/205 , C12Q2525/161 , C12Q2537/101 , C12Q2523/313
摘要： The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. In one embodiment, a test sample is contacted with an aptamer that includes a tag and has a specific affinity for a target molecule. An aptamer affinity complex that includes an aptamer bound to its target molecule is allowed to form. If the test sample contains the target molecule, an aptamer affinity complex will generally form in the test sample. The aptamer affinity complex is optionally converted to an aptamer covalent complex that includes an aptamer covalently bound to its target molecule. The aptamer affinity complex (or optional aptamer covalent complex) can then be detected and/or quantified using any of a variety of methods known to one skilled in the art, including using a solid support, using mass spectrometry, and using quantitative polymerase chain reaction (Q-PCR).
摘要翻译：本公开描述了用于检测可能存在于测试样品中的一种或多种靶分子的方法，装置，试剂和试剂盒。在一个实施方案中，将测试样品与包含标签的适体接触并对靶分子具有特异性亲和力。允许形成包含与其靶分子结合的适体的适体亲和复合体。如果测试样品含有目标分子，通常将在测试样品中形成适体亲和复合体。适体亲和复合物任选地转化为适体共价复合物，其包括与其靶分子共价结合的适体。然后可以使用本领域技术人员已知的各种方法中的任一种检测和/或定量适体亲和复合物（或任选的适体共价复合物），包括使用固体支持物，使用质谱法和使用定量聚合酶链反应（Q-PCR）。

3. 发明申请

US20070166741A1 MULTIPLEXED ANALYSES OF TEST SAMPLES 审中-公开
公开(公告)号：US20070166741A1
公开(公告)日：2007-07-19
申请号：US11623580
申请日：2007-01-16
申请人： James Heil , Daniel Schneider , Daniel Nieuwlandt , Sheri Wilcox , Dominic Zichi , Todd Gander , Bruce Eaton , Larry Gold
发明人： James Heil , Daniel Schneider , Daniel Nieuwlandt , Sheri Wilcox , Dominic Zichi , Todd Gander , Bruce Eaton , Larry Gold
IPC分类号： C12Q1/68 , G01N33/53
摘要： The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. In one embodiment, a test sample is contacted with an aptamer that includes a tag and has a specific affinity for a target molecule. An aptamer affinity complex that includes an aptamer bound to its target molecule is allowed to form. If the test sample contains the target molecule, an aptamer affinity complex will generally form in the test sample. The aptamer affinity complex is optionally converted to an aptamer covalent complex that includes an aptamer covalently bound to its target molecule. The aptamer affinity complex (or optional aptamer covalent complex) can then be detected and/or quantified using any of a variety of methods known to one skilled in the art, including using a solid support, using mass spectrometry, and using quantitative polymerase chain reaction (Q-PCR).

4. 发明公开

US20230297634A1 System and Method for Design-Based Relationship Matchmaking 审中-公开
公开(公告)号：US20230297634A1
公开(公告)日：2023-09-21
申请号：US17695562
申请日：2022-03-15
申请人： Daniel Schneider
发明人： Daniel Schneider
IPC分类号： G06F16/9535 , G06F16/9538 , G06F16/9536 , G06V10/774 , G06N20/00
CPC分类号： G06F16/9535 , G06F16/9538 , G06F16/9536 , G06V10/774 , G06N20/00 , G06Q50/01
摘要： A system and method for providing non-binary profile mapping of individuals according to the present invention is disclosed. The system includes a memory having instructions stored thereon and a processor configured to execute the instructions on the memory to cause the electronic apparatus to perform the method. The method receives user profile data from an external user, the user profile data comprises captured media having a user image and user characteristic information data, pre-processes a user image into training, testing, and updating learning networks, stores processed user profile data into a database, receive user synthetic profile data to create a synthetic profile representation, adjust the synthetic profile representation in response to user input, generates a first set of matching results from processing the synthetic profile representation against user profile data from the database using the learning networks, and provides the first set of matching results for selection.

5. 发明申请

US20200176808A1 MIXED COMPOSITE SOLID STATE ELECTROLYTE FOR ELECTROCHEMICAL CELLS 审中-公开
公开(公告)号：US20200176808A1
公开(公告)日：2020-06-04
申请号：US16640191
申请日：2018-08-18
申请人： Daniel SCHNEIDER , David NAUGHTON , Robert Bosch GmbH
发明人： Daniel Schneider , David Naughton
IPC分类号： H01M10/056 , H01M4/36 , H01M2/16 , H01M4/02
摘要： An electrochemical cell includes a solid state material that functions as an electrolyte and a separator within the electrode assembly. The solid state material is a mixture of a polymer that is interspersed with an ionically conductive ceramic material.

6. 发明申请

US20160017192A1 STRUCTURAL EPOXY RESIN ADHESIVES CONTAINING CHAIN-EXTENDED ELASTOMERIC TOUGHENERS CAPPED WITH PHENOL, POLYPHENOL OR AMINOPHENOL COMPOUNDS 审中-公开
公开(公告)号：US20160017192A1
公开(公告)日：2016-01-21
申请号：US14869126
申请日：2015-09-29
申请人： Andreas Lutz , Daniel Schneider , Christof Braendli , Irene Maeder
发明人： Andreas Lutz , Daniel Schneider , Christof Braendli , Irene Maeder
IPC分类号： C09J163/00 , C08K3/36
CPC分类号： C09J163/00 , C08G18/10 , C08G18/12 , C08G18/4854 , C08G18/6677 , C08G18/73 , C08K3/36 , C09J5/00 , C09J155/00 , C09J2463/003 , Y10T156/10 , C08G18/3215
摘要： Structural adhesives are prepared from a chain extended elastomeric toughener that contains urethane and/or urea groups, and have terminal isocyanate groups that are capped with a phenol, a polyphenol or an aminophenol compound. The adhesives have very good storage stability and cure to form cured adhesives that have good lap shear and impact peel strengths.

7. 发明授权

US09020049B2 Communications system using beamforming 有权
标题翻译：使用波束成形的通信系统
公开(公告)号：US09020049B2
公开(公告)日：2015-04-28
申请号：US13517477
申请日：2010-12-29
申请人： Andreas Schwager , Lothar Stadelmeier , Daniel Schneider
发明人： Andreas Schwager , Lothar Stadelmeier , Daniel Schneider
IPC分类号： H04B3/00 , H04L25/00 , H04L27/26 , H04B3/50 , H04B3/54 , H04B7/04 , H04J11/00 , H04L5/14 , H04L25/02 , H04L25/03 , H04B7/06 , H04L5/00
CPC分类号： H04L27/2646 , H04B3/00 , H04B3/50 , H04B3/54 , H04B7/0417 , H04B7/0634 , H04B7/065 , H04B2203/5408 , H04J11/003 , H04L5/0023 , H04L5/0048 , H04L5/1461 , H04L25/0204 , H04L25/0226 , H04L25/0248 , H04L25/0272 , H04L25/0284 , H04L25/03343 , H04L27/2647 , H04L27/367 , H04L2025/03426 , H04L2025/03808
摘要： In a MIMO communications system a first communications device applies beamforming to a complete transmission packet including both synchronization data and either payload data or training symbols. A second communications device evaluates the beamformed synchronization data and determines and transmits a feedback information indicating minimum required synchronization data and/or a minimum number of training symbols. The first communications device tailors the synchronization data and/or number of training symbols on the basis of the feedback information. Beamforming the complete transmission packet facilitates signal suppression at defined locations. When the channel properties change, the second communications device may provide further channel state information to adapt beamforming in the first communications device without transmission of not beamformed training symbols. The communications system may be a powerline telecommunications system.
摘要翻译：在MIMO通信系统中，第一通信设备将波束成形应用于包括同步数据和有效载荷数据或训练符号的完整传输分组。第二通信设备评估波束形成的同步数据，并确定并发送指示最小所需同步数据和/或最小数目的训练符号的反馈信息。第一通信设备基于反馈信息来调整同步数据和/或训练符号的数量。波束形成完整的传输分组有助于在定义的位置处的信号抑制。当信道属性改变时，第二通信设备可以提供另外的信道状态信息以适应第一通信设备中的波束成形，而不发送没有波束形成的训练符号。通信系统可以是电力线电信系统。

8. 发明授权

US08877965B2 Process for preparing formic acid by reaction of carbon dioxide with hydrogen 有权
标题翻译：通过二氧化碳与氢气反应制备甲酸的方法
公开(公告)号：US08877965B2
公开(公告)日：2014-11-04
申请号：US13171928
申请日：2011-06-29
申请人： Thomas Schaub , Donata Maria Fries , Rocco Paciello , Klaus-Dieter Mohl , Martin Schäfer , Stefan Rittinger , Daniel Schneider
发明人： Thomas Schaub , Donata Maria Fries , Rocco Paciello , Klaus-Dieter Mohl , Martin Schäfer , Stefan Rittinger , Daniel Schneider
IPC分类号： C07C51/15 , C07F15/00 , C07C53/00 , C07C51/44 , C07C51/48
CPC分类号： C07C51/44 , C07C51/15 , C07C51/48 , C07C53/02
摘要： A process for preparing formic acid by reaction of carbon dioxide (1) with hydrogen (2) in a hydrogenation reactor (I) in the presence of a catalyst comprising an element of group 8, 9 or 10 of the Periodic Table, a tertiary amine comprising at least 12 carbon atoms per molecule and a polar solvent comprising one or more monoalcohols selected from among methanol, ethanol, propanols and butanols, to form formic acid/amine adducts as intermediates which are subsequently thermally dissociated, where the work-up of the output (3) from the hydrogenation reactor (I) is carried out by addition of water so as to increase the distribution coefficient of the catalyst between the upper phase (4) and the lower phase.
摘要翻译：在含有元素周期表第8,9,10族元素的催化剂存在下，在氢化反应器（I）中，通过二氧化碳（1）与氢气（2）的反应制备甲酸的方法，每分子含有至少12个碳原子的极性溶剂和包含一种或多种选自甲醇，乙醇，丙醇和丁醇的一元醇的极性溶剂，以形成甲酸/胺加合物作为随后热解离的中间体，其中后处理通过加入水进行加氢反应器（I）的输出（3），以增加催化剂在上相（4）和下相之间的分配系数。

9. 发明授权

US08791297B2 Process for preparing formic acid by reaction of carbon dioxide with hydrogen 有权
标题翻译：通过二氧化碳与氢气反应制备甲酸的方法
公开(公告)号：US08791297B2
公开(公告)日：2014-07-29
申请号：US13172123
申请日：2011-06-29
申请人： Thomas Schaub , Donata Maria Fries , Rocco Paciello , Klaus-Dieter Mohl , Martin Schäfer , Stefan Rittinger , Daniel Schneider
发明人： Thomas Schaub , Donata Maria Fries , Rocco Paciello , Klaus-Dieter Mohl , Martin Schäfer , Stefan Rittinger , Daniel Schneider
IPC分类号： C07C51/44 , C07C53/02 , C07C51/15 , C07C51/48 , C07C51/487
CPC分类号： C07C53/02 , C07C51/15 , C07C51/48 , C07C51/487
摘要： A process for preparing formic acid by reaction of carbon dioxide (1) with hydrogen (2) in a hydrogenation reactor (I) in the presence of a catalyst comprising an element of group 8, 9 or 10 of the Periodic Table, a tertiary amine comprising at least 12 carbon atoms per molecule and a polar solvent comprising one or more monoalcohols selected from among methanol, ethanol, propanols and butanols and also water, to form formic acid/amine adducts as intermediates which are subsequently thermally dissociated, with work-up of the output (3) from the hydrogenation reactor (I) in a plurality of process steps, where a tertiary amine-comprising stream (13) from the work-up is used as selective solvent for the catalyst, is proposed.
摘要翻译：在含有元素周期表第8,9,10族元素的催化剂存在下，在氢化反应器（I）中，通过二氧化碳（1）与氢气（2）的反应制备甲酸的方法，每分子含有至少12个碳原子，以及包含一种或多种选自甲醇，乙醇，丙醇和丁醇的一元醇和极性溶剂的极性溶剂，以形成甲酸/胺加合物作为随后热解离的中间体，具有后处理提出了在多个工艺步骤中，来自加氢反应器（I）的输出物（3）的来自后处理的含叔胺的物流（13）用作催化剂的选择性溶剂。

10. 发明授权

US08462866B2 Transmitting apparatus and method, and receiving apparatus and method 有权
标题翻译：发送装置和方法，以及接收装置和方法
公开(公告)号：US08462866B2
公开(公告)日：2013-06-11
申请号：US13409574
申请日：2012-03-01
申请人： Lothar Stadelmeier , Dietmar Schill , Daniel Schneider
发明人： Lothar Stadelmeier , Dietmar Schill , Daniel Schneider
IPC分类号： H04K1/10
CPC分类号： H04L1/0668 , H04H20/46 , H04H20/72 , H04L1/0071 , H04L1/0606 , H04L1/0643 , H04L5/0023 , H04L5/0044 , H04L5/0048 , H04L5/006 , H04L2001/0093 , H04N21/2383 , H04N21/4382
摘要： A method of transmitting data symbols via an Orthogonal Frequency Division Multiplexed (OFDM) symbols that includes forming data symbols into pairs and generating a first pair of modulation symbols for each of the pairs of data symbols, where the first pair of modulation symbols form first and second modulation symbols of an Alamouti cell. The method further includes forming a first version of the OFDM symbols by modulating the sub-carriers allocated for carrying the data with the first and second modulation symbols of the Alamouti cells, and modulating the one or more pilot carriers of the first version of the OFDM symbol according to a predetermined pattern.
摘要翻译：一种通过正交频分复用（OFDM）符号发送数据符号的方法，该正交频分复用（OFDM）符号包括将数据符号形成成对，并且为每对数据符号生成第一对调制符号，其中第一对调制符号首先形成， Alamouti单元的第二调制符号。该方法还包括通过利用Alamouti小区的第一和第二调制符号调制分配用于携带数据的子载波来形成第一版本的OFDM符号，以及调制OFDM的第一版本的一个或多个导频载波符号。

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