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1. 发明授权

US08844671B2 Apparatus for damping sound in the optical beam path of a microscope, and microscope having a corresponding apparatus 有权
标题翻译：用于在显微镜的光束路径中阻尼声音的装置，以及具有相应装置的显微镜
公开(公告)号：US08844671B2
公开(公告)日：2014-09-30
申请号：US13894726
申请日：2013-05-15
申请人： Leica Microsystems CMS GmbH
发明人： Holger Birk , Volker Seyfried , Dirk-Oliver Fehrer , Vishnu Varden Krishnamachari
IPC分类号： G10K11/172 , H02K5/24 , G02B26/10 , G02B21/24 , G10K11/00 , H02K5/00 , G02B26/00 , G10K11/175
CPC分类号： G10K11/002 , G02B21/24 , G02B26/105 , G10K11/172 , G10K11/175
摘要： An apparatus for damping sound in the optical beam path of a microscope, having an acoustic insulation housing for encapsulating a sound-emitting component, preferably a rapidly moving or oscillating beam deflection means, in particular a resonantly oscillating mirror, the housing comprising at least one optical entrance/exit opening, is characterized in that the housing, preferably the opening of the housing, is embodied and/or configured in such a way that the sound otherwise emerging from the housing is largely extinguished by destructive interference without thereby influencing the optical beam. A microscope having a corresponding apparatus is furthermore claimed.
摘要翻译：一种用于阻尼显微镜的光束路径中的声音的装置，具有用于封装声发射部件的声学绝缘壳体，优选地是快速移动或振荡的光束偏转装置，特别是共振振动反射镜，所述壳体包括至少一个光学入口/出口的特征在于，壳体，优选地是壳体的开口，被实施和/或构造成使得从壳体出来的声音被破坏性的干涉大大地消除，而不会影响光束。还要求具有相应装置的显微镜。

2. 发明授权

US10132754B2 Device and method for illuminating a sample 有权
公开(公告)号：US10132754B2
公开(公告)日：2018-11-20
申请号：US15037451
申请日：2014-11-19
申请人： LEICA MICROSYSTEMS CMS GMBH
发明人： Vishnu Vardhan Krishnamachari , Volker Seyfried , William C. Hay , Manuel Kremer
IPC分类号： G01N21/00 , G01N21/65 , G02B21/00 , G02B21/16
摘要： A device (10) for illuminating a sample (40) is described, having: at least one pulsed laser light source (12) for repeated emission of a first laser pulse along a first light path (14) and of a second laser pulse along a second light path (16) physically separated from the first light path; a superimposition element (32) for collinear superimposition of the two laser pulses in a shared light path (34); a delay stage (26) arranged in the first or the second light path (14, 16), for delaying one of the two laser pulses relative to the other laser pulse in such a way that the two laser pulses sent along the shared light path (34) onto the sample (40) exhibit a temporal superimposition; a shared chirp unit (36) arranged in the shared light path (34), for frequency-modifying influencing both of the first laser pulse and of the second laser pulse; and at least one separate chirp unit (18) arranged in the first light path (14), for frequency-modifying influencing only of the first laser pulse. The shared chirp unit (36) and the separate chirp unit (18) are coordinated with one another in order to achieve a target state. The separate chirp unit (18) is coupled to a control system (20) by which the separate chirp unit (18) is controllable with a control parameter dependent on the wavelength of the first laser pulse in order to establish the target state.

3. 发明申请

US20140168753A1 APPARATUS AND METHOD FOR OPERATING AN ACOUSTO-OPTICAL COMPONENT 审中-公开
标题翻译：用于操作光学元件的装置和方法
公开(公告)号：US20140168753A1
公开(公告)日：2014-06-19
申请号：US14185719
申请日：2014-02-20
申请人： Leica Microsystems CMS GmbH
发明人： Volker Seyfried
IPC分类号： G02F1/33
CPC分类号： G02F1/33 , G02F2203/60
摘要： An apparatus for controlling an acousto-optical component influencing at least one of illumination light and detection light in a microscope is described. The apparatus comprises a radio-frequency generator for supplying the acousto-optical component with a radio frequency. The radio-frequency generator is configured to compensate deviations in the characteristics of the light due to temperature fluctuations in the acousto-optical component by adapting the radio frequency. The apparatus can be operated by generating a control signal for controlling the radio frequency of the radio-frequency generator; measuring the temperature of the acousto-optical component; adapting the control signal depending on the measured temperature; and sending the adapted control signal into the radio-frequency generator for compensating deviations in the characteristics of the light due to temperature fluctuations and can be used in optical coherence tomography, particularly white light interferometry, optical tweezers in lithography, and distance measurement.
摘要翻译：描述了一种用于控制影响显微镜中的照明光和检测光中的至少一种的声光部件的装置。该装置包括用于向声光部件提供射频的射频发生器。射频发生器被配置为通过调整射频来补偿由于声光分量中的温度波动导致的光的特性偏差。可以通过产生用于控制射频发生器的射频的控制信号来操作该装置; 测量声光部件的温度; 根据测量的温度调整控制信号; 并将适应的控制信号发送到射频发生器中，用于补偿由于温度波动引起的光的特性的偏差，并且可以用于光学相干断层摄影，特别是白光干涉测量，光刻中的光学镊子和距离测量。

4. 发明授权

US10386303B2 Raman microscopic imaging device 有权
公开(公告)号：US10386303B2
公开(公告)日：2019-08-20
申请号：US15037455
申请日：2014-11-19
申请人： LEICA MICROSYSTEMS CMS GMBH
发明人： Vishnu Vardhan Krishnamachari , Volker Seyfried , William C. Hay
IPC分类号： G01N21/65 , G01J3/44 , G01J3/02 , G01J3/10
摘要： A Raman microscopy imaging device (100) is described, having: a first laser light source (12) for emitting a first laser beam (16) having a first wavelength along a first light path (20); a second laser light source (44) for emitting a second laser beam (18) having a second wavelength, different from the first wavelength, along a second light path (22) physically separated from the first light path (20); a beam combining element (32) for collinearly combining the two laser beams (16, 18) in one shared light path (34) directed onto a sample; a detector (38) for sensing a measured signal on the basis of the two laser beams (16, 18) interacting with the sample; and an evaluation unit (40) for evaluating the measured signal sensed by the detector (38). According to the present invention the first laser light source (12) is embodied as a pulsed source, and the second laser light source (44) as a continuous source.

5. 发明授权

US10591356B2 Microscope and acousto-optic beam combiner for a microscope 有权
公开(公告)号：US10591356B2
公开(公告)日：2020-03-17
申请号：US14916502
申请日：2014-09-03
申请人： LEICA MICROSYSTEMS CMS GMBH
发明人： Volker Seyfried , Vishnu Vardhan Krishnamachari
IPC分类号： G01J3/12 , G02B21/00 , G02B27/28
摘要： The invention relates to a beam combiner for a microscope, in particular a scanning microscope, which receives at least a first illuminating light bundle and a second illuminating light bundle and combines them into a collinear output light bundle, the first illuminating light bundle and the second illuminating light bundle having the same illuminating light wavelength but a different polarization, in particular linear polarization. The beam combiner is embodied as an acousto-optic beam combiner and is constructed and operated in such a way that by interaction with at least one mechanical wave, both the first illuminating light bundle and the second illuminating light bundle are diffracted and are thereby directed into a common optical axis.

6. 发明授权

US10132682B2 Microscope with an acousto-optical device 有权
公开(公告)号：US10132682B2
公开(公告)日：2018-11-20
申请号：US14916528
申请日：2014-09-03
申请人： LEICA MICROSYSTEMS CMS GMBH
发明人： Volker Seyfried , Vishnu Vardhan Krishnamachari
IPC分类号： G01J3/12 , G02F1/33 , G02B21/00 , G02B27/10 , G02F1/11
摘要： The invention relates to a microscope having an acousto-optic apparatus (13) that, with a mechanical wave that is characterized by a preferably adjustable frequency, removes from a polychromatic and collinear detected light bundle (18) portions of illuminated light, scattered and/or reflected at a sample, having an illuminating light wavelength associated with the frequency. The microscope is notable for the fact that a crystal (30) of the acousto-optic apparatus in which the mechanical wave propagates, and the propagation direction of the mechanical wave, are oriented relative to the detected light bundle incident into the crystal in such a way that the acousto-optic apparatus deflects, with the mechanical wave, both the portion of the detected light bundle having the illuminating wavelength and a first linear polarization direction, and the portion of the detected light bundle having the illuminating wavelength and a second linear polarization direction perpendicular to the first polarization direction, and thereby removes them from the detected light bundle.

7. 发明授权

US09229294B2 Apparatus and method for operating an acousto-optical component 有权
标题翻译：用于操作声光部件的装置和方法
公开(公告)号：US09229294B2
公开(公告)日：2016-01-05
申请号：US14185719
申请日：2014-02-20
申请人： Leica Microsystems CMS GmbH
发明人： Volker Seyfried
IPC分类号： G02F1/33
CPC分类号： G02F1/33 , G02F2203/60
摘要： An apparatus for controlling an acousto-optical component influencing at least one of illumination light and detection light in a microscope is described. The apparatus comprises a radio-frequency generator for supplying the acousto-optical component with a radio frequency. The radio-frequency generator is configured to compensate deviations in the characteristics of the light due to temperature fluctuations in the acousto-optical component by adapting the radio frequency. The apparatus can be operated by generating a control signal for controlling the radio frequency of the radio-frequency generator; measuring the temperature of the acousto-optical component; adapting the control signal depending on the measured temperature; and sending the adapted control signal into the radio-frequency generator for compensating deviations in the characteristics of the light due to temperature fluctuations and can be used in optical coherence tomography, particularly white light interferometry, optical tweezers in lithography, and distance measurement.
摘要翻译：描述了一种用于控制影响显微镜中的照明光和检测光中的至少一种的声光部件的装置。该装置包括用于向声光部件提供射频的射频发生器。射频发生器被配置为通过调整射频来补偿由于声光分量中的温度波动导致的光的特性偏差。可以通过产生用于控制射频发生器的射频的控制信号来操作该装置; 测量声光部件的温度; 根据测量的温度调整控制信号; 并将适应的控制信号发送到射频发生器中，用于补偿由于温度波动引起的光的特性的偏差，并且可以用于光学相干断层摄影，特别是白光干涉测量，光刻中的光学镊子和距离测量。

8. 发明授权

US10520434B2 Fluorescence lifetime imaging microscopy method having time-correlated single-photon counting, which method permits higher light intensities 有权
公开(公告)号：US10520434B2
公开(公告)日：2019-12-31
申请号：US16304168
申请日：2017-05-24
申请人： LEICA MICROSYSTEMS CMS GMBH
发明人： Volker Seyfried , Bernd Widzgowski , Frank Hecht
IPC分类号： G01N21/64
摘要： A fluorescence lifetime imaging microscopy method with time-correlated single photon counting includes periodically exciting a sample to emit fluorescence photons, with a measurement interval being defined between each two successive excitation light pulses. A value characterizing fluorescence decay behavior is determined based on detection times of detected fluorescence photons, and imaging is performed based one the value. An analog detector signal is sampled within a plurality of sampling intervals within a respective one of the measurement intervals and is converted into a sequence of discrete signal values associated with the sampling intervals. It is determined based thereon whether more than a predefined number of fluorescence photons has been detected within the respective measurement interval. If more than the predefined number of fluorescence photons has been detected, the respective measurement interval is discarded in the step of determining the value characterizing the fluorescence decay behavior.

9. 发明授权

US09400404B2 Acousto-optical tunable filter element 有权
标题翻译：声光可调谐滤光片
公开(公告)号：US09400404B2
公开(公告)日：2016-07-26
申请号：US14249872
申请日：2014-04-10
申请人： LEICA MICROSYSTEMS CMS GmbH
发明人： Hilmar Gugel , Volker Seyfried
IPC分类号： G02F1/01 , G02F1/33 , G02F1/11 , G02B21/16 , G02B27/46 , G02F1/29 , G02B3/00 , G02B21/00 , G02F1/00 , G02B27/09 , G02B27/42 , G02F1/03 , G02F1/35
CPC分类号： G02F1/116 , G02B3/0087 , G02B21/0032 , G02B21/0064 , G02B21/16 , G02B27/0927 , G02B27/42 , G02B27/46 , G02F1/00 , G02F1/01 , G02F1/03 , G02F1/11 , G02F1/29 , G02F1/33 , G02F1/353 , G02F2201/305 , G02F2202/32 , G02F2203/12 , G02F2203/18 , G02F2203/24
摘要： An acousto-optical filter element (114) is provided which has an acousto-optical crystal (118) having an acoustic signal transmitter (120) for generating acoustic signals in the acousto-optical crystal (118). The acousto-optical crystal (118) is designed to selectively spatially deflect light of a target wavelength from an input light beam (116) entering into the acousto-optical crystal (118), as a function of a high frequency applied to the acoustic signal transmitter (120), and to thereby produce a target light beam (126) having the target wavelength. In addition, the acousto-optical filter element (114) includes a spatial filter element (132) which is located in the target light beam (126) and is designed to selectively suppress the intensity of the target light beam (126) in a plane perpendicular to the propagation direction of the target light beam (126).
摘要翻译：提供一种声光滤波器元件（114），其具有声光晶体（118），该声光晶体具有用于在声光晶体（118）中产生声信号的声信号发射器（120）。声光晶体（118）被设计为根据进入声光晶体（118）的输入光束（116）选择性地空间偏转目标波长的光，作为施加到声信号的高频的函数发射器（120），从而产生具有目标波长的目标光束（126）。此外，声光滤波器元件（114）包括位于目标光束（126）中的空间滤光元件（132），并被设计成选择性地抑制平面中的目标光束（126）的强度垂直于目标光束（126）的传播方向。

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