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1. 发明授权

US10132754B2 Device and method for illuminating a sample 有权
公开(公告)号：US10132754B2
公开(公告)日：2018-11-20
申请号：US15037451
申请日：2014-11-19
申请人： LEICA MICROSYSTEMS CMS GMBH
发明人： Vishnu Vardhan Krishnamachari , Volker Seyfried , William C. Hay , Manuel Kremer
IPC分类号： G01N21/00 , G01N21/65 , G02B21/00 , G02B21/16
摘要： A device (10) for illuminating a sample (40) is described, having: at least one pulsed laser light source (12) for repeated emission of a first laser pulse along a first light path (14) and of a second laser pulse along a second light path (16) physically separated from the first light path; a superimposition element (32) for collinear superimposition of the two laser pulses in a shared light path (34); a delay stage (26) arranged in the first or the second light path (14, 16), for delaying one of the two laser pulses relative to the other laser pulse in such a way that the two laser pulses sent along the shared light path (34) onto the sample (40) exhibit a temporal superimposition; a shared chirp unit (36) arranged in the shared light path (34), for frequency-modifying influencing both of the first laser pulse and of the second laser pulse; and at least one separate chirp unit (18) arranged in the first light path (14), for frequency-modifying influencing only of the first laser pulse. The shared chirp unit (36) and the separate chirp unit (18) are coordinated with one another in order to achieve a target state. The separate chirp unit (18) is coupled to a control system (20) by which the separate chirp unit (18) is controllable with a control parameter dependent on the wavelength of the first laser pulse in order to establish the target state.

2. 发明授权

US10739193B2 Dynamic lock-in detection bandwidth for SRS imaging 有权
公开(公告)号：US10739193B2
公开(公告)日：2020-08-11
申请号：US15766838
申请日：2016-10-10
申请人： Leica Microsystems CMS GmbH
发明人： Vishnu Vardhan Krishnamachari
IPC分类号： G01J1/44 , G01J3/44 , G02B21/00 , G01J3/02
摘要： An electric circuit for a microscope includes a lock-in amplifier. The lock-in amplifier has an input for an input signal, an input for a reference signal, an output for an output signal and a bandwidth filter configured such that a low bandwidth frequency value and/or a high bandwidth frequency value is variably settable. A dynamic bandwidth controller is configured to receive at least one parameter of a current setting of the microscope as an input, and to control the low bandwidth frequency value and/or the high bandwidth frequency value of the lock-in amplifier as a function of the at least one parameter of the current setting of the microscope.

3. 发明授权

US10386303B2 Raman microscopic imaging device 有权
公开(公告)号：US10386303B2
公开(公告)日：2019-08-20
申请号：US15037455
申请日：2014-11-19
申请人： LEICA MICROSYSTEMS CMS GMBH
发明人： Vishnu Vardhan Krishnamachari , Volker Seyfried , William C. Hay
IPC分类号： G01N21/65 , G01J3/44 , G01J3/02 , G01J3/10
摘要： A Raman microscopy imaging device (100) is described, having: a first laser light source (12) for emitting a first laser beam (16) having a first wavelength along a first light path (20); a second laser light source (44) for emitting a second laser beam (18) having a second wavelength, different from the first wavelength, along a second light path (22) physically separated from the first light path (20); a beam combining element (32) for collinearly combining the two laser beams (16, 18) in one shared light path (34) directed onto a sample; a detector (38) for sensing a measured signal on the basis of the two laser beams (16, 18) interacting with the sample; and an evaluation unit (40) for evaluating the measured signal sensed by the detector (38). According to the present invention the first laser light source (12) is embodied as a pulsed source, and the second laser light source (44) as a continuous source.

4. 发明授权

US09933686B2 Scanning microscope and acousto-optical main beam splitter for a scanning microscope 有权
公开(公告)号：US09933686B2
公开(公告)日：2018-04-03
申请号：US14916520
申请日：2014-09-03
申请人： LEICA MICROSYSTEMS CMS GMBH
发明人： Vishnu Vardhan Krishnamachari
IPC分类号： G02F1/33 , G01J3/12 , G02B21/00 , G02B27/28 , G02F1/11
CPC分类号： G02F1/33 , G01J3/1256 , G02B21/0032 , G02B21/0064 , G02B21/0068 , G02B27/283 , G02F1/116
摘要： The invention relates to an acousto-optic main beam splitter for a scanning microscope, which is embodied and intended to direct illuminating light having a preselected or preselectable illuminating light wavelength into an illumination beam path for illumination of a sample, and to direct detected light coming from a sample into a detection beam path. The acousto-optic main beam splitter is characterized in that a mechanical wave having an acoustic frequency associated with the illuminating light wavelength propagates, or multiple mechanical waves that have the same acoustic frequency associated with the illuminating light wavelength propagate, in the acousto-optic main beam splitter, both a portion of the detected light bundle having the illuminating light wavelength and a first linear polarization direction, and a portion of the detected light having the illuminating light wavelength and a second linear polarization direction perpendicular to the first linear polarization direction, being deflected out of the detected light bundle coming from a sample by interaction with the one mechanical wave or by interaction with the mechanical waves, and are thereby removed from the detected light bundle; and/or the acousto-optic main beam splitter being embodied to direct, by interaction with the one mechanical wave or by interaction with the mechanical waves, both the portion of illuminating light that has the preselected illuminating light wavelength and a first linear polarization direction, and the portion of illuminating light that has the preselected illuminating light wavelength and a second linear polarization direction that is different from, in particular perpendicular to, the first linear polarization direction, into an illumination beam path for illumination of a sample.

5. 发明授权

US10591356B2 Microscope and acousto-optic beam combiner for a microscope 有权
公开(公告)号：US10591356B2
公开(公告)日：2020-03-17
申请号：US14916502
申请日：2014-09-03
申请人： LEICA MICROSYSTEMS CMS GMBH
发明人： Volker Seyfried , Vishnu Vardhan Krishnamachari
IPC分类号： G01J3/12 , G02B21/00 , G02B27/28
摘要： The invention relates to a beam combiner for a microscope, in particular a scanning microscope, which receives at least a first illuminating light bundle and a second illuminating light bundle and combines them into a collinear output light bundle, the first illuminating light bundle and the second illuminating light bundle having the same illuminating light wavelength but a different polarization, in particular linear polarization. The beam combiner is embodied as an acousto-optic beam combiner and is constructed and operated in such a way that by interaction with at least one mechanical wave, both the first illuminating light bundle and the second illuminating light bundle are diffracted and are thereby directed into a common optical axis.

6. 发明授权

US10132682B2 Microscope with an acousto-optical device 有权
公开(公告)号：US10132682B2
公开(公告)日：2018-11-20
申请号：US14916528
申请日：2014-09-03
申请人： LEICA MICROSYSTEMS CMS GMBH
发明人： Volker Seyfried , Vishnu Vardhan Krishnamachari
IPC分类号： G01J3/12 , G02F1/33 , G02B21/00 , G02B27/10 , G02F1/11
摘要： The invention relates to a microscope having an acousto-optic apparatus (13) that, with a mechanical wave that is characterized by a preferably adjustable frequency, removes from a polychromatic and collinear detected light bundle (18) portions of illuminated light, scattered and/or reflected at a sample, having an illuminating light wavelength associated with the frequency. The microscope is notable for the fact that a crystal (30) of the acousto-optic apparatus in which the mechanical wave propagates, and the propagation direction of the mechanical wave, are oriented relative to the detected light bundle incident into the crystal in such a way that the acousto-optic apparatus deflects, with the mechanical wave, both the portion of the detected light bundle having the illuminating wavelength and a first linear polarization direction, and the portion of the detected light bundle having the illuminating wavelength and a second linear polarization direction perpendicular to the first polarization direction, and thereby removes them from the detected light bundle.

7. 发明申请

US20180283939A1 DYNAMIC LOCK-IN DETECTION BANDWIDTH FOR SRS IMAGING 审中-公开
公开(公告)号：US20180283939A1
公开(公告)日：2018-10-04
申请号：US15766838
申请日：2016-10-10
申请人： Leica Microsystems CMS GmbH
发明人： Vishnu Vardhan Krishnamachari
IPC分类号： G01J1/44 , G01J3/02 , G01J3/44 , G02B21/00
摘要： An electric circuit for a microscope includes a lock-in amplifier. The lock-in amplifier has an input for an input signal, an input for a reference signal, an output for an output signal and a bandwidth filter configured such that a low bandwidth frequency value and/or a high bandwidth frequency value is variably settable. A dynamic bandwidth controller is configured to receive at least one parameter of a current setting of the microscope as an input, and to control the low bandwidth frequency value and/or the high bandwidth frequency value of the lock-in amplifier as a function of the at least one parameter of the current setting of the microscope.

8. 发明授权

US09909976B2 Scanning microscope with polarised sample illumination 有权
公开(公告)号：US09909976B2
公开(公告)日：2018-03-06
申请号：US14916538
申请日：2014-09-03
申请人： LEICA MICROSYSTEMS CMS GMBH
发明人： Vishnu Vardhan Krishnamachari
IPC分类号： G01J3/44 , G01N21/21 , G02B21/00 , G02B27/28 , G01N21/65
CPC分类号： G01N21/21 , G01N21/65 , G01N2201/067 , G01N2201/0683 , G02B21/002 , G02B21/0032 , G02B21/0068 , G02B27/283 , G02B27/286
摘要： The invention relates to a method for investigating a sample, the sample being impinged upon by illuminating light, and detected light emerging from the sample being directed to a detector, and the illuminating light being directed through an acousto-optic component with which the impingement upon the sample by illuminating light can be temporarily interrupted. The method is notable for the fact that the sample is illuminated with a first illuminating light bundle that has a first linear polarization direction, and with a second illuminating light bundle whose linear polarization direction is continuously switched over between the first linear polarization direction and a second linear polarization direction different from the first linear polarization direction, the illuminating light having the first linear polarization direction proceeding along a first light path and illuminating light having the second linear polarization direction proceeding along a second light path, and the acousto-optic component combining the light paths.

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