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1. 发明授权

US4955895A Vasodilating catheter 失效
标题翻译：血管扩张导管
公开(公告)号：US4955895A
公开(公告)日：1990-09-11
申请号：US382781
申请日：1989-06-22
申请人： Yoshiaki Sugiyama , Kyuta Sagae
发明人： Yoshiaki Sugiyama , Kyuta Sagae
IPC分类号： A61M25/00 , A61F2/958 , A61M29/02
CPC分类号： A61M25/104 , A61M2025/0004 , A61M2025/0039 , A61M25/0021 , A61M25/1006
摘要： A vasodilating catheter is disclosed which is characterized by using a triple-flow catheter tube and allowing two of the three flow paths formed by the catheter tube to communicate with a balloon. Owing to this configuration, the air entrapped inside the balloon can be easily removed and, as the result, the otherwise inevitable degradation of the balloon's opacitying property is precluded and the angioplasty is performed with increased safety and ease.

2. 发明授权

US4832688A Catheter for repair of blood vessel 失效
标题翻译：导管修复血管
公开(公告)号：US4832688A
公开(公告)日：1989-05-23
申请号：US35444
申请日：1987-04-07
申请人： Kyuta Sagae , Naoto Takemura , Yoshiaki Sugiyama , Susumu Tanabe
发明人： Kyuta Sagae , Naoto Takemura , Yoshiaki Sugiyama , Susumu Tanabe
IPC分类号： A61M25/00 , A61B17/00 , A61B17/12 , A61F2/958 , A61M29/02
CPC分类号： A61M25/104 , A61B17/0057 , A61B17/12022 , A61B17/12109 , A61B17/12136 , A61B17/12186 , A61M25/1011
摘要： A catheter for the repair of an injured blood vessel, characterized by comprising a multiple-lumen type catheter tube having at least two tubular cavities, at least one dilating member disposed in the distal portion of said catheter tube and adapted to communicate with one of said tubular cavities, a lateral hole for the injection of a blood coagulation accelerant disposed on said catheter tube at the proximal side than said dilating member side and adapted to communicate with the other tubular cavity, and a hub having a plurality of flow conduit communicating severally with said tubular cavities of said catheter tube and adapted to communicate with the proximal portion of said catheter tube.
摘要翻译：一种用于修复受伤血管的导管，其特征在于包括具有至少两个管状空腔的多腔型导管，至少一个扩张构件，其设置在所述导管管的远端部分中，并适于与所述管状空腔，用于注射设置在所述导管上的血液凝固促进剂的侧孔，其位于比所述扩张构件侧更靠近的所述导管上，并适于与另一个管状空腔连通;以及毂，其具有多个与第所述导管管的所述管状腔适于与所述导管的近端部分连通。

3. 发明授权

US5171383A Method of manufacturing a differentially heat treated catheter guide wire 失效
标题翻译：制造差异热处理导管导丝的方法
公开(公告)号：US5171383A
公开(公告)日：1992-12-15
申请号：US760813
申请日：1991-09-16
申请人： Kyuta Sagae , Yoshiaki Sugiyama
发明人： Kyuta Sagae , Yoshiaki Sugiyama
IPC分类号： A61M23/00 , A61M25/09
CPC分类号： A61M25/09 , A61M2025/09083 , A61M2025/09108 , A61M2025/09141 , Y10S148/902
摘要： A catheter guide wire is provided for guiding a catheter into a body cavity such as a blood vessel. The base material constituting the wire is made of an elastic alloy wire and subjected to a heat treatment such that its flexibility is sequentially increased from its proximal to distal end portions. A thermoplastic resin or/and a coil spring can be applied to at least the distal end portion of the wire base material. A method of manufacturing the catheter guide wire is also provided. The method is characterized in that the leading end side of the base material is divided into a plurality of areas and subjected to a heat treatment by changing the heat treatment temperature and the time conditions in units of the areas so that the flexibility of the base material is sequentially increased from the proximal to distal end portions of the leading end side.
摘要翻译：提供导管引导线，用于将导管引导到诸如血管的体腔内。构成线材的基材由弹性合金丝制成，经受热处理使其柔软性从其近端部分依次增加到远端部分。热塑性树脂或/和螺旋弹簧可以施加到丝线基材的至少前端部分。还提供了一种制造导管导丝的方法。该方法的特征在于，将基材的前端侧分割为多个区域，通过以区域为单位改变热处理温度和时间条件进行热处理，使得基材的柔软性从前端侧的近端部分到远端部分依次增加。

4. 再颁专利

USRE36628E Method of manufacturing a differentially heat treated catheter guide wire 失效
公开(公告)号：USRE36628E
公开(公告)日：2000-03-28
申请号：US950602
申请日：1997-10-16
申请人： Kyuta Sagae , Yoshiaki Sugiyama
发明人： Kyuta Sagae , Yoshiaki Sugiyama
IPC分类号： A61M23/00 , C12D8/06
CPC分类号： A61M25/09 , A61M2025/09083 , A61M2025/09141
摘要： A catheter guide wire is provided for guiding a catheter into a body cavity such as a blood vessel. The base material constituting the wire is made of an elastic alloy wire and subjected to a heat treatment such that its flexibility is sequentially increased from its proximal to distal end portions. A thermoplastic resin or/and a coil spring can be applied to at least the distal end portion of the wire base material. A method of manufacturing the catheter guide wire is also provided. The method is characterized in that the leading end side of the base material is divided into a plurality of areas and subjected to a heat treatment by changing the heat treatment temperature and the time conditions in units of the areas so that the flexibility of the base material is sequentially increased from the proximal to distal end portions of the leading end side.

5. 发明授权

US4994032A Balloon catheter 失效
标题翻译：气球导管
公开(公告)号：US4994032A
公开(公告)日：1991-02-19
申请号：US277564
申请日：1988-11-29
申请人： Yoshiaki Sugiyama , Kyuta Sagae , Susumu Tanabe
发明人： Yoshiaki Sugiyama , Kyuta Sagae , Susumu Tanabe
IPC分类号： A61M25/00 , A61M29/02
CPC分类号： A61M25/104 , A61M25/0052 , A61M2025/0004
摘要： There is provided a balloon catheter comprising a tubular body including at least one lumen, and a foldable balloon provided at a predetermined distal portion on the outer surface of said tubular body so that the balloon communicates with at least one lumen in said tubular body, wherein reinforcement is provided at a predetermined portion on the outer surface of said tubular body surrounded by said balloon. The reinforcement is preferably formed on an X-ray opague material and in the form of a coil.

6. 发明授权

US4964853A Catheter equipped with expansible member 失效
标题翻译：导管配有可扩展成员
公开(公告)号：US4964853A
公开(公告)日：1990-10-23
申请号：US415345
申请日：1989-10-26
申请人： Yoshiaki Sugiyama , Kyuta Sagae
发明人： Yoshiaki Sugiyama , Kyuta Sagae
IPC分类号： A61M25/00 , A61M29/02
CPC分类号： A61M25/104
摘要： A catheter equipped with an expansible member comprising an inner tube having a first lumen whose tip is open and a second lumen extending to the tip direction of the first lumen; an outer tube disposed coaxially with the inner tube and having a tip at a position recessed by a predetermined distance from the tip of the inner tube and forming a third lumen between it and the outer surface of the inner tube; a contractible or foldable expansible member having a tip end portion and a base end portion, the base end portion being fitted to the outer tube and the tip end portion being fitted to the inner tube, the expansible member communicating with the second lumen near the tip end portion and with the third lumen near the base end portion; a first opening communicating with the first lumen and a second opening communicating with the second lumen each disposed at the base end portion of the inner tube; and a third opening disposed at the base end portion of the outer tube and communicating with the third lumen.
摘要翻译： PCT No.PCT / JP88 / 00201 Sec。 371日期1989年10月26日第 102（e）日期1989年10月26日PCT提交1988年2月25日PCT公布。出版物WO88 / 06464 日本9月7日，1988年。一种装有可膨胀构件的导管，其包括内管，内管具有顶端开口的第一腔和延伸到第一腔的末端方向的第二腔; 外管与内管同轴设置，并且在从内管的尖端凹入预定距离的位置处具有尖端，并在其与内管的外表面之间形成第三腔; 具有前端部和基端部的可收缩或可折叠的可膨胀构件，所述基端部与所述外管嵌合，所述前端部嵌合于所述内管，所述可膨胀构件与所述第二内腔连通，并且在基端部附近具有第三腔体; 与第一内腔连通的第一开口和与内管的基端部分配置的与第二内腔连通的第二开口; 以及第三开口，其设置在所述外管的基端部并与所述第三管腔连通。

7. 外观设计

USD468277S1 TV receiver with digital video disc recorder and printer 失效
标题翻译：带数字视频光盘录像机和打印机的电视机
公开(公告)号：USD468277S1
公开(公告)日：2003-01-07
申请号：US29138192
申请日：2001-03-09
申请人： Yoshiaki Sugiyama
设计人： Yoshiaki Sugiyama

8. 发明授权

US5151726A Camera or printer capable of automatically changing print size 失效
标题翻译：相机或打印机能够自动更改打印尺寸
公开(公告)号：US5151726A
公开(公告)日：1992-09-29
申请号：US349531
申请日：1989-05-05
申请人： Tomonori Iwashita , Akira Egawa , Yoshiaki Sugiyama
发明人： Tomonori Iwashita , Akira Egawa , Yoshiaki Sugiyama
IPC分类号： G03B17/24 , G03B27/46
CPC分类号： G03B17/24 , G03B27/462 , G03B2206/004 , G03B2217/243
摘要： A photographic print control system includes a camera having the feature of indicating print size data and recording data relating to the print size so that a printer can read out the stored print size data and control a printing process for obtaining a print in the indicated size.
摘要翻译：照相打印控制系统包括具有指示打印尺寸数据和记录与打印尺寸相关的数据的特征的相机，使得打印机可以读出所存储的打印尺寸数据并控制打印处理以获得所指示尺寸的打印。

9. 发明授权

US5105317A Cassette loading and lid mechanisms for a portable video tape recorder 失效
标题翻译：用于便携式视频录像机的CASSETTE加载和引导机制
公开(公告)号：US5105317A
公开(公告)日：1992-04-14
申请号：US509746
申请日：1990-04-17
申请人： Yoshiaki Sugiyama , Toshiaki Kojima
发明人： Yoshiaki Sugiyama , Toshiaki Kojima
IPC分类号： G11B15/675 , G11B25/06 , G11B33/02
CPC分类号： G11B15/67549 , G11B25/063 , G11B33/025 , G11B33/027
摘要： A cassette loading apparatus for a video tape recorder includes a cabinet having a cassette insertion opening therein which is adapted to insertably receive a video tape cassette, and a lid mounted on the cabinet for movement between a first position, wherein the cassette insertion opening is closed, and a second position, wherein the cassette insertion opening is open. A cassette holder is adapted to accept and hold a cassette inserted therein and is movable between a cassette insertion position, which is adjacent to the cassette insertion opening, and a cassette operation position, spaced rearwardly and downwardly from the cassette insertion position. A cassette holder driving mechanism is provided to move the cassette holder between the cassette insertion position and the cassette operation position. When the lid is moved to its second or open position, a switch is automatically closed, for actuating the cassette holder driving mechanism so that the cassette holder is moved from the cassette operation position to the cassette insertion position.

10. 发明授权

US08951795B2 Revascularization cells derived from mononuclear cells, and method of inducing differentiation thereof 有权
标题翻译：来自单核细胞的血运重建细胞及其诱导分化的方法
公开(公告)号：US08951795B2
公开(公告)日：2015-02-10
申请号：US13138835
申请日：2010-03-29
申请人： Yusuke Mizukami , Junpei Sasajima , Yoshiaki Sugiyama , Kazuya Sato , Yutaka Kohgo
发明人： Yusuke Mizukami , Junpei Sasajima , Yoshiaki Sugiyama , Kazuya Sato , Yutaka Kohgo
IPC分类号： C12N5/00 , C12N5/078 , A61K35/12
CPC分类号： C12N5/0634 , A61K2035/124 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/145 , C12N2501/165 , C12N2501/22 , C12N2501/26
摘要： The present invention relates to a method of safely and simply inducing differentiation of mononuclear cells into cells that promote neovascular stabilization and maturation, and lead to recovering from ischemia or tissue repair. The cells according to the present invention are obtained by inducing differentiation of a mononuclear cell by culturing the mononuclear cell in a medium (particularly a serum-free medium) containing one or more selected from vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), thrombopoietin (TPO), granulocyte-colony stimulating factor (G-CSF) and FMS-like tyrosine kinase 3 ligand (FLT3L), and collecting a cell population expressing CD11b.
摘要翻译：本发明涉及将单核细胞分化成促进新生血管稳定和成熟的细胞的方法，并且导致从缺血或组织修复中恢复。根据本发明的细胞是通过在含有选自血管内皮生长因子（VEGF），碱性成纤维细胞生长因子（VEGF）的一种或多种的介质（特别是无血清培养基）中培养单核细胞来诱导单核细胞的分化来获得的。（bFGF），血小板生成素（TPO），粒细胞集落刺激因子（G-CSF）和FMS样酪氨酸激酶3配体（FLT3L），并收集表达CD11b的细胞群。

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