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1. 发明授权

US5746977A Automatic analyzer 失效
标题翻译：自动分析仪
公开(公告)号：US5746977A
公开(公告)日：1998-05-05
申请号：US714883
申请日：1996-09-13
申请人： Kyoko Imai , Kazumichi Imai , Yasushi Nomura
发明人： Kyoko Imai , Kazumichi Imai , Yasushi Nomura
IPC分类号： G01N35/00 , G05B19/042 , G01N37/00
CPC分类号： G01N35/00594 , G05B19/0428 , G01N2035/009 , G01N35/00871 , Y10T436/115831 , Y10T436/12
摘要： An automatic analyzer in which a suitable transmission destination remote from a body of the automatic analyzer is selected in accordance with the contents of to be transmitted and the contents are transmitted to the transmission destination; a suitable operation control instruction is received from a suitable person on duty; and a suitable process is carried out to make it possible to improve analysis efficiency.
摘要翻译：一种自动分析器，其中根据要发送的内容选择远离自动分析仪的主体的适当的发送目的地，并将内容发送到发送目的地; 由合适的人员接收适当的操作控制指令; 并且进行适当的处理以使得可以提高分析效率。

2. 发明授权

US5543292A Process for the measurement of nucleic acids 失效
标题翻译：核酸测量方法
公开(公告)号：US5543292A
公开(公告)日：1996-08-06
申请号：US76165
申请日：1993-06-14
申请人： Kyoko Imai , Kazumichi Imai , Yasushi Nomura
发明人： Kyoko Imai , Kazumichi Imai , Yasushi Nomura
IPC分类号： C12Q1/68 , G01N15/14 , G01N35/00 , G01N35/02
CPC分类号： G01N35/025 , C12Q1/6823 , C12Q1/6834 , G01N2015/1409 , G01N2035/00485
摘要： A process for detecting the existence of at least one sequence of oligonucleotide in a nucleic acid sample includes at least one performance of a step of mixing the sample witha labeled common polynucleotide, anda polynucleotide probe comprising a sequence complementary to at least a part of the sequence of oligonucleotide and a sequence complementary to at least a part of the labeled common polynucleotide. The existence of a sequence of oligonucleotide which is an analyte existing in a nucleic acid sample can be detected by the use of a common reagent and an unattached polynucleotide having a base sequence specific for the analyte to be measured.
摘要翻译：用于检测核酸样品中至少一个寡核苷酸序列的存在的方法包括将样品与标记的共同多核苷酸混合的步骤的至少一个性能，以及包含与至少一部分寡核苷酸序列和与标记的共同多核苷酸的至少一部分互补的序列。存在核酸样品中存在的分析物的寡核苷酸序列的存在可以通过使用具有对待测量的分析物特异的碱基序列的常见试剂和未附着的多核苷酸来检测。

3. 发明授权

US5695718A Automatic analyzer 失效
标题翻译：自动分析仪
公开(公告)号：US5695718A
公开(公告)日：1997-12-09
申请号：US405345
申请日：1995-03-16
申请人： Kyoko Imai , Kazumichi Imai , Yasushi Nomura
发明人： Kyoko Imai , Kazumichi Imai , Yasushi Nomura
IPC分类号： G01N35/00 , G05B19/042 , G01N35/02 , G08B1/08
CPC分类号： G01N35/00594 , G05B19/0428 , G01N2035/009 , G01N35/00871 , Y10T436/115831 , Y10T436/12
摘要： An automatic analyzer in which a suitable transmission destination remote from a body of the automatic analyzer is selected in accordance with the contents of to be transmitted and the contents are transmitted to the transmission destination; a suitable operation control instruction is received from a suitable person on duty; and a suitable process is carried out to make it possible to improve analysis efficiency.
摘要翻译：一种自动分析器，其中根据要发送的内容选择远离自动分析仪的主体的适当的发送目的地，并将内容发送到发送目的地; 由合适的人员接收适当的操作控制指令; 并且进行适当的处理以使得可以提高分析效率。

4. 发明授权

US5470534A Analytical system useful in diagnosis of the condition of a disease 失效
标题翻译：用于诊断疾病状况的分析系统
公开(公告)号：US5470534A
公开(公告)日：1995-11-28
申请号：US236134
申请日：1994-05-02
申请人： Kyoko Imai , Kazumichi Imai , Yasushi Nomura
发明人： Kyoko Imai , Kazumichi Imai , Yasushi Nomura
IPC分类号： C12Q1/68 , G01N33/543 , G01N35/00 , G01N35/02
CPC分类号： G01N35/0092 , G01N35/00603 , G01N35/025 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/115831 , Y10T436/12
摘要： In a first measurement stage, reaction solutions of samples are optically measured by a biochemical analyzer, and the measurement result of the analysis item which is an index of the disease status regarding the samples is compared with the check index. This check index is stored in memory beforehand. When the measurement result corresponds to the check index, the sample processing goes to a second measurement stage for measuring a specific item. In the second measurement stage, the sample is measured by an immuno-assay apparatus or a nucleic acid analyzer, and the measurement result is outputted.
摘要翻译：在第一测量阶段，通过生物化学分析仪对样品的反应溶液进行光学测量，并将作为样品疾病状态指标的分析项目的测定结果与检查指数进行比较。此检查索引预先存储在内存中。当测量结果对应于检查指数时，样本处理进入用于测量特定项目的第二测量阶段。在第二测定阶段，通过免疫分析装置或核酸分析仪测定样品，输出测定结果。

5. 发明申请

US20140200162A1 METHOD AND APPARATUS FOR NUCLEIC ACID ANALYSIS 审中-公开
标题翻译：核酸分析方法与装置
公开(公告)号：US20140200162A1
公开(公告)日：2014-07-17
申请号：US14233256
申请日：2012-05-16
申请人： Toshiro Saito , Koshin Hamasaki , Satoshi Takahashi , Muneo Maeshima , Kyoko Imai , Kazumichi Imai , Ryuji Tao
发明人： Toshiro Saito , Koshin Hamasaki , Satoshi Takahashi , Muneo Maeshima , Kyoko Imai , Kazumichi Imai , Ryuji Tao
IPC分类号： C12Q1/68 , C12N15/10
CPC分类号： C12Q1/6834 , C12N15/1065 , C12Q2525/207 , C12Q2537/125 , C12Q2537/143 , C12Q2563/143 , C12Q2563/149
摘要： A convenient method for nucleic acid analysis is provided, which enables 1000 or more types of nucleic acid to be analyzed collectively with high comprehensiveness and with a dynamic range of at least four digits. In particular, provided is a very effective analytical method especially for untranslated RNAs and microRNAs, of which the types of target nucleic acids is 10000 or lower. Nucleic acids can be analyzed conveniently and rapidly with high comprehensiveness and quantitative performance at single-molecule sensitivity and resolution by following the steps of: preparing a group of target nucleic acid fragments one molecule at a time and hybridizing the nucleic acid molecules, which have known base sequences and have been labeled with the fluorescence substances, with the group of the target nucleic acid fragments to detect the fluorescence substances labeling the hybridized nucleic acid molecules.
摘要翻译：提供了一种方便的核酸分析方法，使得能够以高全面性和至少四位数的动态范围共同分析1000种或更多种类型的核酸。特别地，提供了非常有效的分析方法，特别是对于非翻译的RNA和微小RNA，其靶核酸的类型为10000或更低。可以通过以下步骤以单分子灵敏度和分辨率的高全面性和定量性能方便快速地分析核酸：一次一个分子制备一组靶核酸片段，并将已知的核酸分子杂交碱基序列，并用荧光物质标记，用靶核酸片段组来检测标记杂交核酸分子的荧光物质。

6. 发明授权

US10294519B2 Method and apparatus for nucleic acid analysis 有权
公开(公告)号：US10294519B2
公开(公告)日：2019-05-21
申请号：US14233256
申请日：2012-05-16
申请人： Toshiro Saito , Koshin Hamasaki , Satoshi Takahashi , Muneo Maeshima , Kyoko Imai , Kazumichi Imai , Ryuji Tao
发明人： Toshiro Saito , Koshin Hamasaki , Satoshi Takahashi , Muneo Maeshima , Kyoko Imai , Kazumichi Imai , Ryuji Tao
IPC分类号： C12Q1/6834 , C12N15/10
摘要： A convenient method for nucleic acid analysis is provided, which enables 1000 or more types of nucleic acid to be analyzed collectively with high comprehensiveness and with a dynamic range of at least four digits. In particular, provided is a very effective analytical method especially for untranslated RNAs and microRNAs, of which the types of target nucleic acids is 10000 or lower. Nucleic acids can be analyzed conveniently and rapidly with high comprehensiveness and quantitative performance at single-molecule sensitivity and resolution by following the steps of: preparing a group of target nucleic acid fragments one molecule at a time and hybridizing the nucleic acid molecules, which have known base sequences and have been labeled with the fluorescence substances, with the group of the target nucleic acid fragments to detect the fluorescence substances labeling the hybridized nucleic acid molecules.

7. 发明授权

US5882863A Method of measuring nucleic acids and reagent used therefor 失效
标题翻译：测量用于其的核酸和试剂的方法
公开(公告)号：US5882863A
公开(公告)日：1999-03-16
申请号：US658398
申请日：1996-06-05
申请人： Kyoko Imai , Junko Momose , Yasushi Nomura
发明人： Kyoko Imai , Junko Momose , Yasushi Nomura
IPC分类号： C12Q1/68 , G01N33/50 , G01N33/58 , C12Q1/70 , C07H21/02 , G01N33/544
CPC分类号： C12Q1/6818 , C12Q1/6823 , C12Q1/683
摘要： A nucleic acid sample is mixed with a nucleotide reagent under hybridizing conditions. The nucleotide reagent contains nucleotides each combined at 3'- and 5'-terminals thereof with particles. After cleaving double strands of hybridization products, at least ones of particles separated from each other by the cleaving and particles held in the unreacted reagent and subjected to no cleavage are detected for measuring nucleic acids in the sample. Since the particles separated from each other by the cleaving and the particles held in the unreacted reagent and subjected to no cleavage are different in size of particle masses from each other, these two groups of particles can be discriminated and detected. Therefore, a labeling substance in the unreacted reagent is no longer required to be washed and separated, enabling nucleic acids to be quickly measured with high sensitivity.
摘要翻译：在杂交条件下将核酸样品与核苷酸试剂混合。核苷酸试剂含有在3'和5'末端与颗粒结合的核苷酸。在切割双链杂交产物之后，检测至少一个通过切割彼此分离的颗粒和保持在未反应试剂中的颗粒并且不进行切割，以测量样品中的核酸。由于通过裂开彼此分离的颗粒和保持在未反应试剂中的颗粒彼此不分裂，所以可以鉴别和检测这两组颗粒。因此，不再需要清洗和分离未反应试剂中的标记物质，能够以高灵敏度快速测定核酸。

8. 发明授权

US5128241A Microcapsule immunoassay and reagents therefor 失效
标题翻译： MICROCAPSULE免疫和其他试剂
公开(公告)号：US5128241A
公开(公告)日：1992-07-07
申请号：US140117
申请日：1987-12-31
申请人： Kyoko Imai , Yasushi Nomura
发明人： Kyoko Imai , Yasushi Nomura
IPC分类号： G01N33/53 , G01N33/543 , G01N33/544 , G01N33/74
CPC分类号： G01N33/5432 , G01N33/74 , Y10S435/966 , Y10S435/975 , Y10S436/821 , Y10S436/829
摘要： Microcapsule-reagents are prepared by previously reacting at least a part of an antigen or antibody attached to microcapsules encapsulating a labeling substance with an antibody or antigen which is specifically reactive therewith, and then the reagent thus prepared is reacted with a sample containing an antigen or antibody in the presence of a complement, whereby highly sensitive immunoassay of the antigen or antibody in the sample can be realized even when the antigen or antibody attached to the microcapsules has a lowered activity or has only low reactivity with the antibody or antigen in the sample.

9. 发明授权

US5055415A Method for immunoassay procedure for the detection of antigen by reacting with antibody which increases its electrical charge and electrophoretic mobility 失效
标题翻译：通过与增加其电荷和电泳迁移率的抗体反应检测抗原的免疫测定方法
公开(公告)号：US5055415A
公开(公告)日：1991-10-08
申请号：US177347
申请日：1988-04-01
申请人： Kyoko Imai , Yasushi Nomura
发明人： Kyoko Imai , Yasushi Nomura
IPC分类号： G01N27/26 , G01N27/447 , G01N33/53 , G01N33/531 , G01N33/561 , G01N33/74 , G01N33/78
CPC分类号： G01N33/53 , G01N33/531 , G01N33/561 , G01N33/743 , G01N33/78 , Y10S436/806 , Y10S436/819
摘要： A method for immunoassay for an antigen involves the following steps: reacting a sample possibly containing an antigen to be determined, a definite amount of a conjugate of the antigen and a charged substance and a definite amount of labeled antibody specific for antigen; allowing the reaction products to electrophoretically migrate towards a carrier bearing an attached antibody specific for the charged substance, so that when the reaction products contact the carrier any reaction product of labeled antibody and antigen passes through the carrier and any reaction product of the labeled antibody and conjugate binds to the carrier attached antibody specific for the charged substance; determining the amount of labeled antibody thereby bound to the carrier and relating the determined amount of labeled antibody to the amount of antigen in the sample.
摘要翻译：用于抗原的免疫测定方法包括以下步骤：使可能含有待测抗原的样品，确定量的抗原与带电物质的缀合物和一定量的抗原特异性标记抗体反应; 允许反应产物电泳迁移到携带具有针对带电物质的附着抗体的载体，使得当反应产物与载体接触时，标记的抗体和抗原的任何反应产物通过载体和标记抗体的任何反应产物和缀合物结合对于带电物质特异性的载体附着的抗体; 确定由此结合到载体上的标记抗体的量，并将确定的标记抗体量与样品中的抗原量相关联。

10. 发明授权

US5083283A Method of determining calibration curve and apparatus using calibaration curve 失效
标题翻译：使用校准曲线确定校准曲线和装置的方法
公开(公告)号：US5083283A
公开(公告)日：1992-01-21
申请号：US323490
申请日：1989-03-14
申请人： Kyoko Imai , Yasushi Nomura , Hiroshi Umetsu
发明人： Kyoko Imai , Yasushi Nomura , Hiroshi Umetsu
IPC分类号： G01N33/53 , G01N21/27 , G01N33/536 , G01N33/543 , G01N35/00 , G12B13/00
CPC分类号： G01N21/274 , G12B13/00 , G01N33/53 , G01N35/00
摘要： A method of determining a calibration curve used in deciding the components of living organism by means of the least-squares method by using a plurality of measured data at different concentrations obtained by measuring reaction solutions of a plurality of standard substances having different concentrations. At least a single set of measured data Y(i) is weighted in a predetermined manner, the measured data Y(i) being obtained from the standard substance reaction solution at a specific concentration X(i) near a limit value used in deciding the living organism components. With the weighting, a calibration curve having a high precision at a portion near the limit value is realized resulting in a correct and highly reliable decision.
摘要翻译：通过使用通过测量具有不同浓度的多种标准物质的反应溶液获得的不同浓度的多个测量数据，通过最小二乘法确定用于决定活生物体组分的校准曲线的方法。至少一组测量数据Y（i）以预定的方式加权，测量数据Y（i）从标准物质反应溶液获得，其特定浓度X（i）接近用于决定活体组分。通过加权，实现在接近极限值的部分具有高精度的校准曲线，从而得到正确和高度可靠的决定。

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