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1. 发明申请

US20060177942A1 Handling method of body fluid sample and analysis apparatus using the same 审中-公开
公开(公告)号：US20060177942A1
公开(公告)日：2006-08-10
申请号：US11390210
申请日：2006-03-28
申请人： Shigeki Matsubara , Kyoko Imai , Ryuji Tao
发明人： Shigeki Matsubara , Kyoko Imai , Ryuji Tao
IPC分类号： B01L3/02
CPC分类号： G01N35/026 , G01N35/00603 , G01N35/02 , G01N35/025 , G01N35/1009 , G01N35/1065 , G01N35/1083 , G01N2035/00326 , G01N2035/103 , G01N2035/1076 , G01N2035/1086 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/12 , Y10T436/2575
摘要： Sample sampling to an analysis apparatus 200 or 820 for analyzing a biochemical analysis item is performed by a pipetting device 202 or 840 which uses a repetitively used pipette nozzle, and sample sampling to an analysis apparatus 100 or 810 for analyzing an immune analysis item is performed by a pipetting device 102 or 830 which uses a disposable nozzle tip. A sample bottle containing a sample to be analyzed on both of a biochemical analysis item and an immune analysis item is sample-pipetted by the nozzle tip first, and then transported so as to be sample-pipetted by the pipette nozzle.

2. 发明授权

US06752960B1 Automatic analysis apparatus 有权
标题翻译：自动分析仪
公开(公告)号：US06752960B1
公开(公告)日：2004-06-22
申请号：US09666882
申请日：2000-09-20
申请人： Shigeki Matsubara , Kyoko Imai , Ryuji Tao
发明人： Shigeki Matsubara , Kyoko Imai , Ryuji Tao
IPC分类号： G01N3500
CPC分类号： G01N35/1004 , G01N35/00603 , G01N2035/00326 , G01N2035/0465 , Y10T436/113332 , Y10T436/114165
摘要： An automatic analysis apparatus, in which analysis results of immunoassay analysis items are not influenced by carry-overs between samples even when the same sample container is conveyed both to a biochemical analysis unit and an immunoassay analysis unit to permit sample dispensing. The immunoassay and biochemical analysis units are arranged along a rack conveyor. A carry-over avoidance level is set on a screen every analysis item before start of an analyzing operation. When a sample given an instruction to analyze only analysis items having low carry-over avoidance levels is to be dispensed in the biochemical analysis unit, a dispenser nozzle is subjected to ordinary cleaning by water. When a sample given an instruction to analyze analysis items having high carry-over avoidance levels is to be dispensed in the biochemical analysis unit, a dispenser nozzle is cleaned with a detergent solution and water.
摘要翻译：即使将相同的样品容器输送到生物化学分析单元和免疫分析单元以允许样品分配，免疫测定分析项目的分析结果也不会影响样品之间的分析结果。免疫测定和生化分析单元沿着齿条输送机布置。在开始分析操作之前，每个分析项目在屏幕上设置结转回避级别。当给出仅分析具有低遗留回避水平的分析项目的指令的样本将被分配在生物化学分析单元中时，分配器喷嘴经受水的普通清洁。当给生物化学分析单元分配具有高遗留回避水平的分析项目的分析指标的样本时，用清洁剂溶液和水清洗分配器喷嘴。

3. 发明授权

US4977776A Gas mixing device and gas analyzer making use of the same 失效
公开(公告)号：US4977776A
公开(公告)日：1990-12-18
申请号：US404404
申请日：1989-09-08
申请人： Isao Shindo , Ryuji Tao , Kyoichi Ozawa
发明人： Isao Shindo , Ryuji Tao , Kyoichi Ozawa
IPC分类号： G01N1/00 , B01F3/02 , B01F5/06 , B01F13/00 , B01F15/04 , G01N27/26 , G01N27/27 , G01N33/483
CPC分类号： B01F15/0412 , B01F13/0059 , B01F3/02 , B01F3/026 , B01F5/064 , Y10T137/87684
摘要： A gas mixing device of a blood gas analyzer has a substrate made of a material such as silicon and a plate having a flat smooth surface, made of a material such as glass. The plate is bonded to the substrate. The substrate has a plurality of fine elongated grooves extending between inlet and outlet ports formed in the plate. Different gases are introduced through the respective inlet ports, and combined with each other in the gas mixing device. The levels of flow resistance in branch grooves are so determined that the different gases are mixed at predetermined mixing ratios for delivery to the outlet ports. Further, the analyzer includes the gas mixing device and a measuring unit equipped with a plurality of gas measuring electrodes. The mixture gas from the gas mixing device is made to bubble through a buffer solution in a reservoir for producing a standard liquid measuring unit that is delivered at predetermined time intervals to the analyzer for calibration.

4. 发明授权

US4905497A Gas mixing device and gas analyzer making use of the same 失效
标题翻译：气体混合装置和气体分析仪使用相同
公开(公告)号：US4905497A
公开(公告)日：1990-03-06
申请号：US201738
申请日：1988-06-03
申请人： Isao Shindo , Ryuji Tao , Kyoichi Ozawa
发明人： Isao Shindo , Ryuji Tao , Kyoichi Ozawa
IPC分类号： G01N1/00 , B01F3/02 , B01F5/06 , B01F13/00 , B01F15/04 , G01N27/26 , G01N27/27 , G01N33/483
CPC分类号： B01F15/0412 , B01F13/0059 , B01F3/02 , B01F3/026 , B01F5/064 , Y10T137/87684
摘要： A gas mixing device of a blood gas analyzer has a substrate made of a material such as silicon and a plate having a flat smooth surface, made of a material such as glass. The plate is bonded to the substrate. The substrate has a plurality of fine elongated grooves extending between inlet and outlet ports formed in the plate. Different gases are introduced through the respective inlet ports, and combined with each other in the gas mixing device. The levels of flow resistance in branch grooves are so determined that the different gases are mixed at predetermined mixing ratios for delivery to the outlet ports. Further, the analyzer includes the gas mixing device and a measuring unit equipped with a plurality of gas measuring electrodes. The mixture gas from the gas mixing device is made to bubble through a buffer solution in a reservoir for producing a standard liquid measuring unit that is delivered at predetermined time intervals to the analyzer for calibration.

5. 发明授权

US10294519B2 Method and apparatus for nucleic acid analysis 有权
公开(公告)号：US10294519B2
公开(公告)日：2019-05-21
申请号：US14233256
申请日：2012-05-16
申请人： Toshiro Saito , Koshin Hamasaki , Satoshi Takahashi , Muneo Maeshima , Kyoko Imai , Kazumichi Imai , Ryuji Tao
发明人： Toshiro Saito , Koshin Hamasaki , Satoshi Takahashi , Muneo Maeshima , Kyoko Imai , Kazumichi Imai , Ryuji Tao
IPC分类号： C12Q1/6834 , C12N15/10
摘要： A convenient method for nucleic acid analysis is provided, which enables 1000 or more types of nucleic acid to be analyzed collectively with high comprehensiveness and with a dynamic range of at least four digits. In particular, provided is a very effective analytical method especially for untranslated RNAs and microRNAs, of which the types of target nucleic acids is 10000 or lower. Nucleic acids can be analyzed conveniently and rapidly with high comprehensiveness and quantitative performance at single-molecule sensitivity and resolution by following the steps of: preparing a group of target nucleic acid fragments one molecule at a time and hybridizing the nucleic acid molecules, which have known base sequences and have been labeled with the fluorescence substances, with the group of the target nucleic acid fragments to detect the fluorescence substances labeling the hybridized nucleic acid molecules.

6. 发明授权

US08496877B2 Automatic analyzer 有权
标题翻译：自动分析仪
公开(公告)号：US08496877B2
公开(公告)日：2013-07-30
申请号：US13529395
申请日：2012-06-21
申请人： Isao Yamazaki , Ryuji Tao , Katsuaki Takahashi
发明人： Isao Yamazaki , Ryuji Tao , Katsuaki Takahashi
IPC分类号： G01N21/00 , G01N30/04 , G01N35/00 , G01N35/08
CPC分类号： G01N21/75 , G01N35/0092 , G01N35/025 , G01N35/1002 , G01N35/1083 , G01N2035/0094 , G01N2035/1076 , Y10T436/11 , Y10T436/113332 , Y10T436/115831 , Y10T436/116664 , Y10T436/119163 , Y10T436/12
摘要： An automatic analyzer according to the present invention is compact, mounting great number of reagents, having high processing ability. Reagent disks are arranged at inside and outside of a reaction disk. A reagent probe can inject a reagent into the position which is common position of both reagent disks. One of plural reagent probes approaches to one of reagent disks at one cycle. Plural reagent probes alternatively approach to the reagent disk. Therefore, the first reagents and the second reagents can be placed on both reagent disks. The mounting number of reagents can be increased without enlarging an analyzer. The cycle time can be shortened to make an automatic analyzer to have high processing ability.
摘要翻译：根据本发明的自动分析仪是紧凑的，安装大量试剂，具有高处理能力。试剂盘布置在反应盘的内部和外部。试剂探针可以将试剂注入到两个试剂盘的共同位置的位置。多个试剂探针之一在一个循环中接近一个试剂盘。多个试剂探针交替接近试剂盘。因此，可以将第一试剂和第二试剂置于两个试剂盘上。可以在不扩大分析仪的情况下增加试剂的安装数量。可以缩短循环时间，使自动分析仪具有较高的处理能力。

7. 发明授权

US07105351B2 Handling method of body fluid sample and analysis apparatus using the same 有权
公开(公告)号：US07105351B2
公开(公告)日：2006-09-12
申请号：US10103993
申请日：2002-03-25
申请人： Shigeki Matsubara , Kyoko Imai , Ryuji Tao
发明人： Shigeki Matsubara , Kyoko Imai , Ryuji Tao
IPC分类号： G01N35/10 , G01N1/14
CPC分类号： G01N35/026 , G01N35/00603 , G01N35/02 , G01N35/025 , G01N35/1009 , G01N35/1065 , G01N35/1083 , G01N2035/00326 , G01N2035/103 , G01N2035/1076 , G01N2035/1086 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/12 , Y10T436/2575
摘要： Sample sampling to an analysis apparatus 200 or 820 for analyzing a biochemical analysis item is performed by a pipetting device 202 or 840 which uses a repetitively used pipette nozzle, and sample sampling to an analysis apparatus 100 or 810 for analyzing an immune analysis item is performed by a pipetting device 102 or 830 which uses a disposable nozzle tip. A sample bottle containing a sample to be analyzed on both of a biochemical analysis item and an immune analysis item is sample-pipetted by the nozzle tip first, and then transported so as to be sample-pipetted by the pipette nozzle.

8. 发明申请

US20060177941A1 Handling method of body fluid sample and analysis apparatus using the same 审中-公开
公开(公告)号：US20060177941A1
公开(公告)日：2006-08-10
申请号：US11390174
申请日：2006-03-28
申请人： Shigeki Matsubara , Kyoko Imai , Ryuji Tao
发明人： Shigeki Matsubara , Kyoko Imai , Ryuji Tao
IPC分类号： B01L3/02
CPC分类号： G01N35/026 , G01N35/00603 , G01N35/02 , G01N35/025 , G01N35/1009 , G01N35/1065 , G01N35/1083 , G01N2035/00326 , G01N2035/103 , G01N2035/1076 , G01N2035/1086 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/12 , Y10T436/2575
摘要： Sample sampling to an analysis apparatus 200 or 820 for analyzing a biochemical analysis item is performed by a pipetting device 202 or 840 which uses a repetitively used pipette nozzle, and sample sampling to an analysis apparatus 100 or 810 for analyzing an immune analysis item is performed by a pipetting device 102 or 830 which uses a disposable nozzle tip. A sample bottle containing a sample to be analyzed on both of a biochemical analysis item and an immune analysis item is sample-pipetted by the nozzle tip first, and then transported so as to be sample-pipetted by the pipette nozzle.

9. 发明申请

US20050287039A1 Handling method of body fluid sample and analysis apparatus using the same 审中-公开
标题翻译：体液样品的处理方法及使用其的分析装置
公开(公告)号：US20050287039A1
公开(公告)日：2005-12-29
申请号：US11218617
申请日：2005-09-06
申请人： Shigeki Matsubara , Kyoko Imai , Ryuji Tao
发明人： Shigeki Matsubara , Kyoko Imai , Ryuji Tao
IPC分类号： G01N35/00 , G01N35/02 , G01N35/10
CPC分类号： G01N35/026 , G01N35/00603 , G01N35/02 , G01N35/025 , G01N35/1009 , G01N35/1065 , G01N35/1083 , G01N2035/00326 , G01N2035/103 , G01N2035/1076 , G01N2035/1086 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/12 , Y10T436/2575
摘要： Sample sampling to an analysis apparatus 200 or 820 for analyzing a biochemical analysis item is performed by a pipetting device 202 or 840 which uses a repetitively used pipette nozzle, and sample sampling to an analysis apparatus 100 or 810 for analyzing an immune analysis item is performed by a pipetting device 102 or 830 which uses a disposable nozzle tip. A sample bottle containing a sample to be analyzed on both of a biochemical analysis item and an immune analysis item is sample-pipetted by the nozzle tip first, and then transported so as to be sample-pipetted by the pipette nozzle.
摘要翻译：对用于分析生物化学分析项目的分析装置200或820进行样品采样由使用重复使用的移液管喷嘴的移液装置202或840进行，并且对分析装置100或810进行样本采样以分析免疫分析项目通过使用一次性喷嘴头的移液装置102或830。在生物化学分析项目和免疫分析项目中含有要分析的样品的样品瓶首先由喷嘴尖端吸取样品，然后运输，以便由移液管喷嘴进行采样。

10. 发明授权

US06413475B2 Automatic analysis apparatus with liquid level detection function 有权
标题翻译：具有液位检测功能的自动分析仪
公开(公告)号：US06413475B2
公开(公告)日：2002-07-02
申请号：US09181642
申请日：1998-10-29
申请人： Masato Ishizawa , Akira Inagaki , Ryuji Tao
发明人： Masato Ishizawa , Akira Inagaki , Ryuji Tao
IPC分类号： G01N2722
CPC分类号： G01N35/1009 , G01F23/26 , G01N2035/1025 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要： An automatic analysis apparatus with a liquid level detection function includes a pipetting device for pipetting a liquid sample from a sample cup to a reaction container by using a pipetting probe that serves as a first capacitor electrode. A sample cup holding means serves as a second capacitor electrode having a ground potential. The conductor material is arranged along a direction in which the pipetting probe moves down for pipetting and is separate from the pipetting device. The conductor material has the same ground potential as that of the sample cup holding means and also serves as a second electrode whereby at any one time either of the sample cup holding means and the conductive material serves as a second capacitor electrode in combination with the first capacitor electrode. An a electrical detector is provided for detecting a change of electrode static capacitance between the pipetting probe and the sample cup holding means and between the pipetting probe and the conductive material as of level detection of the liquid sample. Measurement means are also provided for measuring an ingredient of the reaction container.
摘要翻译：具有液位检测功能的自动分析装置包括：移液装置，用于通过使用用作第一电容器电极的移液探头，将液体样品从样品杯移液到反应容器。样品杯保持装置用作具有接地电位的第二电容器电极。导体材料沿着移液探针向下移动用于移液的方向布置，并且与吸移装置分离。导体材料具有与样品杯保持装置相同的接地电位，并且还用作第二电极，由此在样品杯保持装置和导电材料中的任一个作为第二电容器电极与第一电极组合电容电极。提供了一种电检测器，用于在液体样品的液位检测时检测移液探针和样品杯保持装置之间以及移液探针和导电材料之间的电极静电容的变化。还提供测量装置用于测量反应容器的成分。

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