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1. 发明申请

US20130157893A1 METHOD FOR PREDICTING THERAPEUTIC EFFECT OF IMMUNOTHERAPY ON CANCER PATIENT, AND GENE SET AND KIT TO BE USED IN THE METHOD 审中-公开
标题翻译：预防免疫治疗对癌症患者的治疗效果的方法，以及方法中使用的基因组和试剂盒
公开(公告)号：US20130157893A1
公开(公告)日：2013-06-20
申请号：US13807418
申请日：2011-03-30
申请人： Kyogo Itoh , Masanori Noguchi , Satoru Kuhara , Akira Yamada , Shigeki Shichijo , Nobukazu Komatsu , Kosuke Tashiro
发明人： Kyogo Itoh , Masanori Noguchi , Satoru Kuhara , Akira Yamada , Shigeki Shichijo , Nobukazu Komatsu , Kosuke Tashiro
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q1/686 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/574 , G01N2800/52
摘要： Provided is a gene set which is useful for predicting the therapeutic effect of an immunotherapy on a cancer patient. Also provided is a method for examining whether an immunotherapy is efficacious or not, said method comprising quantifying the expression amount of each of the genes constituting the aforesaid gene set. This examination method is useful for determining a therapeutic strategy for the cancer patient.
摘要翻译：提供了可用于预测免疫治疗对癌症患者的治疗效果的基因组。还提供了检查免疫治疗是否有效的方法，所述方法包括定量构成上述基因组的每个基因的表达量。该检查方法可用于确定癌症患者的治疗策略。

2. 发明申请

US20050019790A1 Fixation of nucleotide derivatives to solid carrier 审中-公开
标题翻译：核苷酸衍生物固定于固体载体
公开(公告)号：US20050019790A1
公开(公告)日：2005-01-27
申请号：US10777585
申请日：2004-02-12
申请人： Yoshihide Iwaki , Yoshihiko Makino , Hiroshi Shinoki , Satoru Kuhara , Kosuke Tashiro , Shigeru Muta
发明人： Yoshihide Iwaki , Yoshihiko Makino , Hiroshi Shinoki , Satoru Kuhara , Kosuke Tashiro , Shigeru Muta
IPC分类号： G01N33/53 , B01J19/00 , C12M1/00 , C12N15/09 , C40B40/06 , C40B60/14 , G01N33/566 , G01N37/00 , C12Q1/68 , B05D3/00 , C12M1/34
CPC分类号： B01J19/0046 , B01J2219/00351 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01J2219/00722 , C40B40/06 , C40B60/14
摘要： A micro-array for analysis of DNA is prepared by the steps of spotting onto a solid carrier in its predetermined area in which plural reactive groups are fixed an aqueous solution which contains a thickening agent and probe molecules (e.g., DNA fragments) having a group reactive with the reactive group of the solid carrier to produce covalent bonding; spotting onto the solid carrier in a different area having the same reactive groups an aqueous solution (same or different); incubating the aqueous solution-spotted solid carrier to produce the covalent bondings; and washing the solid carrier with an aqueous medium to remove the thickening agent from the solid carrier. An electrostatic bonding can be utilized in place of the covalent bonding.
摘要翻译：用于分析DNA的微阵列通过以下步骤制备：将固定载体固定在其中固定有多个反应性基团的预定区域的固体载体上，所述固定载体含有增稠剂的水溶液和具有基团的探针分子（例如，DNA片段）与固体载体的反应性基团反应产生共价键; 在具有相同反应性基团的不同区域的固体载体上发现水溶液（相同或不同）; 孵育水溶液点固体载体以产生共价键; 并用水介质洗涤固体载体以从固体载体中除去增稠剂。可以使用静电键来代替共价键。

3. 发明授权

US07430475B2 Biological discovery using gene regulatory networks generated from multiple-disruption expression libraries 有权
标题翻译：使用由多重中断表达文库生成的基因调控网络的生物学发现
公开(公告)号：US07430475B2
公开(公告)日：2008-09-30
申请号：US10259723
申请日：2002-09-26
申请人： Seiyo Imoto , Takao Goto , Satoru Miyano , Kosuke Tashiro , Michiel de Hoon , Christopher J. Savoie , Saturo Kuhara
发明人： Seiyo Imoto , Takao Goto , Satoru Miyano , Kosuke Tashiro , Michiel de Hoon , Christopher J. Savoie , Saturo Kuhara
IPC分类号： G06F19/00 , C12Q1/68
CPC分类号： G06F19/12 , G06F19/20 , G06F19/24
摘要： Embodiments of this invention include application of new inferential methods to analysis of complex biological information, including gene networks. In some embodiments, disruptant data and/or drug induction/inhibition data are obtained simultaneously for a number of genes in an organism. New methods include modifications of Boolean inferential methods and application of those methods to determining relationships between expressed genes in organisms. Additional new methods include modifications of Bayesian inferential methods and application of those methods to determining cause and effect relationships between expressed genes, and in some embodiments, for determining upstream effectors of regulated genes. Additional modifications of Bayesian methods include use of heterogeneous variance and different curve fitting methods, including spline functions, to improve estimation of graphs of networks of expressed genes. Other embodiments include the use of bootstrapping methods and determination of edge effects to more accurately provide network information between expressed genes. Methods of this invention were validated using information obtained from prior studies, as well as from newly carried out studies of gene expression.
摘要翻译：本发明的实施例包括应用新的推理方法来分析复杂的生物信息，包括基因网络。在一些实施方案中，针对生物体中的许多基因同时获得破坏性数据和/或药物诱导/抑制数据。新方法包括布尔推理方法的修改和这些方法的应用以确定生物体中表达的基因之间的关系。其他新方法包括贝叶斯推理方法的修改和这些方法的应用以确定表达基因之间的因果关系，并且在一些实施方案中用于确定受调节基因的上游受体。贝叶斯方法的另外的修改包括使用异质方差和不同的曲线拟合方法，包括样条函数，以改进表达基因网络图的估计。其他实施例包括使用自举方法和确定边缘效应以更准确地提供表达基因之间的网络信息。使用从先前研究获得的信息以及从新开展的基因表达研究来验证本发明的方法。

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