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1. 发明授权

US08563325B1 Coaxial microreactor for particle synthesis 有权
标题翻译：用于颗粒合成的同轴微反应器
公开(公告)号：US08563325B1
公开(公告)日：2013-10-22
申请号：US12893915
申请日：2010-09-29
申请人： Michael Bartsch , Michael P. Kanouff , Scott M. Ferko , Robert W. Crocker , Karl Wally
发明人： Michael Bartsch , Michael P. Kanouff , Scott M. Ferko , Robert W. Crocker , Karl Wally
IPC分类号： B01L3/00
CPC分类号： B01L3/502776 , B01L3/502707 , B01L2200/0636 , B01L2300/0816 , B01L2300/0867 , B01L2300/123 , B01L2400/0478 , B01L2400/0622
摘要： A coaxial fluid flow microreactor system disposed on a microfluidic chip utilizing laminar flow for synthesizing particles from solution. Flow geometries produced by the mixing system make use of hydrodynamic focusing to confine a core flow to a small axially-symmetric, centrally positioned and spatially well-defined portion of a flow channel cross-section to provide highly uniform diffusional mixing between a reactant core and sheath flow streams. The microreactor is fabricated in such a way that a substantially planar two-dimensional arrangement of microfluidic channels will produce a three-dimensional core/sheath flow geometry. The microreactor system can comprise one or more coaxial mixing stages that can be arranged singly, in series, in parallel or nested concentrically in parallel.
摘要翻译：同轴流体微反应器系统设置在微流体芯片上，利用层流从溶液中合成颗粒。由混合系统产生的流动几何形状利用流体动力学聚焦来将核心流动限制在流动通道横截面的小轴向对称的，中心定位的和空间上良好限定的部分，以提供反应物核心与反应物核心之间的高度均匀的扩散混合鞘流。以这样的方式制造微反应器，使得微流体通道的基本上平面的二维布置将产生三维芯/鞘流几何形状。微反应器系统可以包括一个或多个同轴混合阶段，其可以单独地，并行排列，并联或同心地平行布置。

2. 发明授权

US07452507B2 Portable apparatus for separating sample and detecting target analytes 有权
标题翻译：用于分离样品和检测目标分析物的便携式设备
公开(公告)号：US07452507B2
公开(公告)日：2008-11-18
申请号：US10633871
申请日：2003-08-04
申请人： Ronald F. Renzi , Karl Wally , Robert W. Crocker , James F. Stamps , Stewart K. Griffiths , Julia A. Fruetel , Brent A. Horn , Isaac R. Shokair , Daniel D. Yee , Victoria A. VanderNoot , Boyd J. Wiedenman , Jason A. A. West , Scott M. Ferko
发明人： Ronald F. Renzi , Karl Wally , Robert W. Crocker , James F. Stamps , Stewart K. Griffiths , Julia A. Fruetel , Brent A. Horn , Isaac R. Shokair , Daniel D. Yee , Victoria A. VanderNoot , Boyd J. Wiedenman , Jason A. A. West , Scott M. Ferko
IPC分类号： G01N21/64 , B01D59/42 , G01N21/76
CPC分类号： G01N21/645 , B01L3/5027 , B01L3/502715 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/10 , B01L2300/0672 , B01L2300/0816 , G01N2021/6482
摘要： Portable devices and methods for determining the presence of a target analyte using a portable device are provided. The portable device is preferably hand-held. A sample is injected to the portable device. A microfluidic separation is performed within the portable device and at least one separated component detected by a detection module within the portable device, in embodiments of the invention. A target analyte is identified, based on the separated component, and the presence of the target analyte is indicated on an output interface of the portable device, in accordance with embodiments of the invention.
摘要翻译：提供了便携式设备和用于使用便携式设备确定目标分析物的存在的方法。便携式设备优选地是手持式的。将样品注入便携式设备。在本发明的实施例中，在便携式设备内执行微流体分离以及由便携式设备内的检测模块检测到的至少一个分离的部件。基于分离的组分鉴定目标分析物，并且根据本发明的实施方案，在便携式设备的输出界面上指示目标分析物的存在。

3. 发明授权

US06664550B2 Apparatus to collect, classify, concentrate, and characterize gas-borne particles 有权
标题翻译：收集，分类，集中和表征气体颗粒的装置
公开(公告)号：US06664550B2
公开(公告)日：2003-12-16
申请号：US10137983
申请日：2002-04-30
申请人： Daniel J. Rader , John R. Torczynski , Karl Wally , John E. Brockmann
发明人： Daniel J. Rader , John R. Torczynski , Karl Wally , John E. Brockmann
IPC分类号： G01N2164
CPC分类号： G01N1/2202 , G01N1/24 , G01N1/405 , G01N2001/2223
摘要： An aerosol lab-on-a-chip (ALOC) integrates one or more of a variety of particle collection, classification, concentration (enrichment), an characterization processes onto a single substrate or layered stack of such substrates. By mounting a UV laser diode laser light source on the substrate, or substrates tack, so that it is located down-stream of the sample inlet port and at right angle the sample particle stream, the UV light source can illuminate individual particles in the stream to induce a fluorescence response in those particles having a fluorescent signature such as biological particles, some of said particles. An illuminated particle having a fluorescent signal above a threshold signal would trigger a sorter module that would separate that particle from the particle stream.
摘要翻译：气溶胶实验室（ALOC）将各种颗粒收集，分类，浓缩（浓缩），表征过程中的一种或多种集成到单个底物或这种底物的分层堆叠上。通过将UV激光二极管激光光源安装在基板上或基板上，使得其位于样品入口的下游并且与样品颗粒流成直角，则UV光源可以照射流中的各个颗粒在具有荧光特征的那些颗粒中诱导荧光响应，例如生物颗粒，一些所述颗粒。具有高于阈值信号的荧光信号的照射粒子将触发分离器模块，其将该颗粒与粒子流分离。

4. 发明授权

US06386015B1 Apparatus to collect, classify, concentrate, and characterize gas-borne particles 失效
标题翻译：收集，分类，集中和表征气体颗粒的装置
公开(公告)号：US06386015B1
公开(公告)日：2002-05-14
申请号：US09469718
申请日：1999-12-21
申请人： Daniel J. Rader , John R. Torczynski , Karl Wally , John E. Brockmann
发明人： Daniel J. Rader , John R. Torczynski , Karl Wally , John E. Brockmann
IPC分类号： G01N100
CPC分类号： G01N1/2202 , G01N1/24 , G01N1/405 , G01N2001/2223
摘要： An aerosol lab-on-a-chip (ALOC) integrates one or more of a variety of aerosol collection, classification, concentration (enrichment), and characterization processes onto a single substrate or layered stack of such substrates. By taking advantage of modern micro-machining capabilities, an entire suite of discrete laboratory aerosol handling and characterization techniques can be combined in a single portable device that can provide a wealth of data on the aerosol being sampled. The ALOC offers parallel characterization techniques and close proximity of the various characterization modules helps ensure that the same aerosol is available to all devices (dramatically reducing sampling and transport errors). Micro-machine fabrication of the ALOC significantly reduces unit costs relative to existing technology, and enables the fabrication of small, portable ALOC devices, as well as the potential for rugged design to allow operation in harsh environments. Miniaturization also offers the potential of working with smaller particle sizes and lower pressure drops (leading to reduction of power consumption).
摘要翻译：气溶胶实验室（ALOC）将一种或多种各种气溶胶收集，分级，浓缩（浓缩）和表征过程集成到单个基底或这种基底的分层堆叠上。通过利用现代微加工能力，可以将一整套独立的实验室气溶胶处理和表征技术组合在一个便携式设备中，可以为所采样的气溶胶提供丰富的数据。 ALOC提供并行表征技术，并且各种表征模块的紧密接近有助于确保相同的气溶胶可用于所有设备（显着降低采样和传输误差）。 ALOC的微机械制造相对于现有技术显着降低了单位成本，并且能够制造小型便携式ALOC装置，并且具有坚固的设计以允许在恶劣环境中操作的潜力。小型化还提供了使用更小粒径和更低压降（导致功耗降低）的潜力。

5. 发明授权

US5866623A Method for immobilizing particulate materials in a packed bed 失效
标题翻译：将颗粒物料固定在填充床中的方法
公开(公告)号：US5866623A
公开(公告)日：1999-02-02
申请号：US34536
申请日：1998-03-03
申请人： William R. Even, Jr. , Stephen E. Guthrie , Thomas N. Raber , Karl Wally , LeRoy L. Whinnery , Thomas Zifer
发明人： William R. Even, Jr. , Stephen E. Guthrie , Thomas N. Raber , Karl Wally , LeRoy L. Whinnery , Thomas Zifer
IPC分类号： C08J9/00 , C08J9/36 , C08J9/40 , C08J9/42
CPC分类号： C08J9/0004
摘要： The present invention pertains generally to immobilizing particulate matter contained in a "packed" bed reactor so as to prevent powder migration, compaction, coalescence, or the like. More specifically, this invention relates to a technique for immobilizing particulate materials using a microporous foam-like polymer such that a) the particulate retains its essential chemical nature, b) the local movement of the particulate particles is not unduly restricted, c) bulk powder migration and is prevented, d) physical and chemical access to the particulate is unchanged over time, and e) very high particulate densities are achieved. The immobilized bed of the present invention comprises a vessel for holding particulate matter, inlet and an outlet ports or fittings, a loosely packed bed of particulate material contained within the vessel, and a three dimensional porous matrix for surrounding and confining the particles thereby fixing the movement of individual particle to a limited local position. The established matrix is composed of a series of cells or chambers comprising walls surrounding void space, each wall forming the wall of an adjacent cell; each wall containing many holes penetrating through the wall yielding an overall porous structure and allowing useful levels of gas transport.
摘要翻译：本发明通常涉及固定包装在“填充”床反应器中的颗粒物质，以防止粉末迁移，压实，聚结等。更具体地说，本发明涉及一种使用微孔泡沫状聚合物固定微粒材料的技术，使得a）颗粒保持其基本化学性质，b）颗粒的局部运动不受过度限制，c）散装粉末迁移并被防止，d）物理和化学物质进入颗粒物随时间不变，e）达到非常高的颗粒密度。本发明的固定床包括用于保持颗粒物质的容器，入口和出口或配件，容纳在容器内的松散填充的颗粒材料床，以及三维多孔基质，用于围绕和限制颗粒，从而固定单个颗粒运动到有限的局部位置。所建立的矩阵由围绕空隙的壁的一系列单元或室组成，每个壁形成相邻单元的壁; 每个壁都包含穿透壁的许多孔，产生整体的多孔结构并允许有用的气体输送水平。

6. 发明授权

US07022287B2 Single particle electrochemical sensors and methods of utilization 有权
公开(公告)号：US07022287B2
公开(公告)日：2006-04-04
申请号：US10141806
申请日：2002-05-08
申请人： Joseph Schoeniger , Albert W. Flounders , Robert C. Hughes , Antonio J. Ricco , Karl Wally , Stanley H. Kravitz , Richard P. Janek
发明人： Joseph Schoeniger , Albert W. Flounders , Robert C. Hughes , Antonio J. Ricco , Karl Wally , Stanley H. Kravitz , Richard P. Janek
IPC分类号： G01N15/06
CPC分类号： G01N33/5438 , G01N27/22
摘要： The present invention discloses an electrochemical device for detecting single particles, and methods for using such a device to achieve high sensitivity for detecting particles such as bacteria, viruses, aggregates, immuno-complexes, molecules, or ionic species. The device provides for affinity-based electrochemical detection of particles with single-particle sensitivity. The disclosed device and methods are based on microelectrodes with surface-attached, affinity ligands (e.g., antibodies, combinatorial peptides, glycolipids) that bind selectively to some target particle species. The electrodes electrolyze chemical species present in the particle-containing solution, and particle interaction with a sensor element modulates its electrolytic activity. The devices may be used individually, employed as sensors, used in arrays for a single specific type of particle or for a range of particle types, or configured into arrays of sensors having both these attributes.

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