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1. 发明申请

US20110119776A1 METHODS OF DIAGNOSING AND PROGNOSING LUNG CANCER 审中-公开
标题翻译：诊断和预防肺癌的方法
公开(公告)号：US20110119776A1
公开(公告)日：2011-05-19
申请号：US12449404
申请日：2008-02-04
申请人： Kwok-Kin Wong , Bruce Johnson , Pasi Janne , Hongbin Ji , Nabeel Bardeesy , Norman Sharpless
发明人： Kwok-Kin Wong , Bruce Johnson , Pasi Janne , Hongbin Ji , Nabeel Bardeesy , Norman Sharpless
IPC分类号： A01K67/033 , G01N33/574 , C12Q1/68 , C40B40/06 , C40B30/04
CPC分类号： G01N33/57423 , G01N2333/9121
摘要： The present invention provides methods of detecting cancer using biomarkers.
摘要翻译：本发明提供使用生物标志物检测癌症的方法。

2. 发明授权

US08168602B2 Compositions, kits and methods for identification, assessment, prevention and therapy of cancer 失效
标题翻译：用于癌症鉴别，评估，预防和治疗的组合物，试剂盒和方法
公开(公告)号：US08168602B2
公开(公告)日：2012-05-01
申请号：US11816601
申请日：2006-02-17
申请人： Ronald A. DePinho , Giovanni Tonon , Kwok-Kin Wong , Lynda Chin
发明人： Ronald A. DePinho , Giovanni Tonon , Kwok-Kin Wong , Lynda Chin
IPC分类号： A61K31/70 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6886 , A61K48/00 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136
摘要： The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human cancer. A variety of chromosomal regions (MCRs) and markers corresponding thereto, are provided, wherein alterations in the copy number of one or more of the MCRs and/or alterations in the amount, structure, and/or activity of one or more of the markers is correlated with the presence of cancer.
摘要翻译：本发明涉及用于检测，表征，预防和治疗人类癌症的组合物，试剂盒和方法。提供了多种染色体区域（MCR）和与之对应的标记物，其中一个或多个MCR的拷贝数和/或一个或多个标记物的量，结构和/或活性的变化的改变与癌症的存在相关。

3. 发明申请

US20100166744A1 USE OF ANTI-EGFR ANTIBODIES IN TREATMENT OF EGFR MUTANT MEDIATED DISEASE 有权
标题翻译：使用抗EGFR抗体治疗EGFR突变介导的疾病
公开(公告)号：US20100166744A1
公开(公告)日：2010-07-01
申请号：US12449129
申请日：2008-01-24
申请人： Kwok-Kin Wong
发明人： Kwok-Kin Wong
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： C07K16/2863 , A61K2039/505
摘要： The present invention relates to the treatment of EGFR-mediated disease, particularly cancer, which is resistant to tyrosine kinase inhibitor therapies. Methods for treatment of cancer and reduction of tumor growth in individuals with secondary EGFR mutations, particularly tyrosine kinase domain mutations, resistant to standard therapy are provided. The invention provides methods for the treatment of tyrosine kinase inhibitor resistant cancers with anti-EGFR antibodies. Methods for treatment of recurrent lung cancer, including non-small cell lung carcinoma which is resistant to tyrosine kinase inhibitors, with the antibody anti-EGFR mAb806 are described.
摘要翻译：本发明涉及对酪氨酸激酶抑制剂治疗具有抗性的EGFR介导的疾病，特别是癌症的治疗。提供了治疗癌症的方法和减少具有继发性EGFR突变，特别是酪氨酸激酶结构域突变的个体的肿瘤生长，其对标准治疗具有抗性。本发明提供了用抗EGFR抗体治疗酪氨酸激酶抑制剂抗性癌症的方法。描述了用抗体抗EGFR mAb806治疗复发性肺癌，包括对酪氨酸激酶抑制剂具有抗性的非小细胞肺癌的方法。

4. 发明授权

US09808461B2 Protection of renal tissues from ischemia through inhibition of the proliferative kinases CDK4 and CDK6 有权
公开(公告)号：US09808461B2
公开(公告)日：2017-11-07
申请号：US13988158
申请日：2011-11-17
申请人： Derek P. DiRocco , Norman E. Sharpless , Jay C. Strum , John E. Bisi , Patrick J. Roberts , Benjamin D. Humphreys , Kwok-Kin Wong
发明人： Derek P. DiRocco , Norman E. Sharpless , Jay C. Strum , John E. Bisi , Patrick J. Roberts , Benjamin D. Humphreys , Kwok-Kin Wong
IPC分类号： A61K31/497 , A61K31/519 , A61K31/192 , A61K31/436 , A61K31/616 , A61K38/13 , A61K31/505
CPC分类号： A61K31/519 , A61K31/192 , A61K31/436 , A61K31/505 , A61K31/616 , A61K38/13 , A61K2300/00
摘要： The presently disclosed subject matter relates to methods and compositions for protecting cells and or tissues from damage due to ischemia. In particular, the presently disclosed subject matter relates to the protective action of cyclin dependent kinase 4/6 (CDK4/6) inhibitors administered to subjects that have been exposed to, or that are at risk of, ischemia.

5. 发明授权

US09090693B2 Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease 有权
标题翻译：使用抗EGFR抗体治疗EGFR突变介导的疾病
公开(公告)号：US09090693B2
公开(公告)日：2015-07-28
申请号：US12449129
申请日：2008-01-24
申请人： Kwok-Kin Wong
发明人： Kwok-Kin Wong
IPC分类号： C07K16/28 , A61K39/00
CPC分类号： C07K16/2863 , A61K2039/505
摘要： The present invention relates to the treatment of EGFR-mediated disease, particularly cancer, which is resistant to tyrosine kinase inhibitor therapies. Methods for treatment of cancer and reduction of tumor growth in individuals with secondary EGFR mutations, particularly tyrosine kinase domain mutations, resistant to standard therapy are provided. The invention provides methods for the treatment of tyrosine kinase inhibitor resistant cancers with anti-EGFR antibodies. Methods for treatment of recurrent lung cancer, including non-small cell lung carcinoma which is resistant to tyrosine kinase inhibitors, with the antibody anti-EGFR mAb806 are described.
摘要翻译：本发明涉及对酪氨酸激酶抑制剂治疗具有抗性的EGFR介导的疾病，特别是癌症的治疗。提供了治疗癌症的方法和减少具有继发性EGFR突变，特别是酪氨酸激酶结构域突变的个体的肿瘤生长，其对标准治疗具有抗性。本发明提供了用抗EGFR抗体治疗酪氨酸激酶抑制剂抗性癌症的方法。描述了用抗体抗EGFR mAb806治疗复发性肺癌，包括对酪氨酸激酶抑制剂具有抗性的非小细胞肺癌的方法。

6. 发明申请

US20130303543A1 PROTECTION OF RENAL TISSUES FROM ISCHEMIA THROUGH INHIBITION OF THE PROLIFERATIVE KINASES CDK4 AND CDK6 有权
标题翻译：通过抑制增殖型CDK4和CDK6来保护ISCHEMIA的肾组织
公开(公告)号：US20130303543A1
公开(公告)日：2013-11-14
申请号：US13988158
申请日：2011-11-17
申请人： Derek Paul DiRocco , Norman Edward Sharpless , Jay Copeland Strum , John Emerson Bisi , Patrick Joseph Roberts , Benjamin Duane Humphreys , Kwok-Kin Wong
发明人： Derek Paul DiRocco , Norman Edward Sharpless , Jay Copeland Strum , John Emerson Bisi , Patrick Joseph Roberts , Benjamin Duane Humphreys , Kwok-Kin Wong
IPC分类号： A61K31/519
CPC分类号： A61K31/519 , A61K31/192 , A61K31/436 , A61K31/505 , A61K31/616 , A61K38/13 , A61K2300/00
摘要： The presently disclosed subject matter relates to methods and compositions for protecting cells and or tissues from damage due to ischemia. In particular, the presently disclosed subject matter relates to the protective action of cyclin dependent kinase 4/6 (CDK4/6) lithibitors administered to subjects that have been exposed to, or that are at risk of, ischemia.
摘要翻译：目前公开的主题涉及用于保护细胞和/或组织免受缺血损伤的方法和组合物。特别地，目前公开的主题涉及施用于已经暴露于或处于缺血风险中的受试者的细胞周期蛋白依赖性激酶4/6（CDK4 / 6）锂化合物的保护作用。

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