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1. 发明授权

US06503714B1 Method of detecting a substance to be analyzed 失效
标题翻译：检测待分析物质的方法
公开(公告)号：US06503714B1
公开(公告)日：2003-01-07
申请号：US09713031
申请日：2000-11-16
申请人： Kurt Weindel , Christoph Seidel , Gerhard Lassonczyk
发明人： Kurt Weindel , Christoph Seidel , Gerhard Lassonczyk
IPC分类号： C12Q168
CPC分类号： C12Q1/6813 , C12Q1/6816
摘要： The invention concerns a method of detecting a substance to be analyzed in a sample by contacting the sample with a probe which contains nucleobases and two or more non-nucleosidic marker-promoting groups in conditions in which the substance to be analyzed binds indirectly or directly to the probe. The method enables the binding product to be detected. The probe is preferably branched.
摘要翻译：本发明涉及通过使样品与包含核碱基和两个或多个非核苷酸标志物促进基团的探针在待分析的物质间接或直接结合的条件下接触样品来检测待分析物质的方法，探针。该方法能够检测结合产物。探针优选是支链的。

2. 发明授权

US06214549B1 Method of detecting a substance to be analyzed 失效
标题翻译：检测待分析物质的方法
公开(公告)号：US06214549B1
公开(公告)日：2001-04-10
申请号：US09051079
申请日：1998-09-10
申请人： Kurt Weindel , Christoph Seidel , Gerhard Lassonczyk
发明人： Kurt Weindel , Christoph Seidel , Gerhard Lassonczyk
IPC分类号： C12Q168
CPC分类号： C12Q1/6813 , C12Q1/6816
摘要： The invention concerns a method of detecting a substance to be analyzed in a sample by contacting the sample with a probe which contains nucleobases and two or more non-nucleosidic marker-promoting groups in conditions in which the substance to be analyzed binds indirectly or directly to the probe. The method enables the binding product to be detected. The probe is preferably branched.
摘要翻译：本发明涉及通过使样品与包含核碱基和两个或多个非核苷酸标志物促进基团的探针在待分析的物质间接或直接结合的条件下接触样品来检测待分析物质的方法，探针。该方法能够检测结合产物。探针优选是支链的。

3. 发明授权

US07560231B2 Mannitol and glucitol derivatives 有权
标题翻译：甘露醇和葡萄糖醇衍生物
公开(公告)号：US07560231B2
公开(公告)日：2009-07-14
申请号：US10729570
申请日：2003-12-05
申请人： Frank Bergmann , Herbert Von Der Eltz , Christoph Seidel , Kurt Weindel
发明人： Frank Bergmann , Herbert Von Der Eltz , Christoph Seidel , Kurt Weindel
IPC分类号： C12Q1/68 , C07H21/00 , C07F9/06 , C07D327/00
CPC分类号： C07H21/00 , C07F9/6561 , C07H5/04 , C07H5/06
摘要： The present invention is related to compounds comprising mannitol or glucitol derivatives which may be used to build up oligomeric compounds. The invention is further related to uses of these oligomeric compounds for hybridization and as probes. In addition, methods for the detection of nucleic acids are disclosed wherein the oligomeric compounds are used.
摘要翻译：本发明涉及可用于构建低聚化合物的包含甘露糖醇或葡萄糖醇衍生物的化合物。本发明还涉及这些寡聚化合物用于杂交和作为探针的用途。此外，公开了用于检测核酸的方法，其中使用寡聚化合物。

4. 发明申请

US20090098528A1 Method for determining early HCV seroconversion 审中-公开
标题翻译：确定早期HCV血清学转换的方法
公开(公告)号：US20090098528A1
公开(公告)日：2009-04-16
申请号：US11974030
申请日：2007-10-11
申请人： Christoph Seidel , Ursula-Henrike Wienhues , Urban Schmitt , Manfred Motz , Michael Wiedmann , Barbara Upmeier , Erwin Soutscheck
发明人： Christoph Seidel , Ursula-Henrike Wienhues , Urban Schmitt , Manfred Motz , Michael Wiedmann , Barbara Upmeier , Erwin Soutscheck
IPC分类号： C12Q1/70
CPC分类号： C07K14/005 , A61K38/00 , C12N2770/24222 , G01N33/56983 , G01N33/5767 , Y10S436/82
摘要： The present invention concerns a polypeptide which is composed of the amino acids 1207±10 to 1488±10 of a hepatitis C virus and of less than 20 foreign amino acids and the use of this polypeptide as an antigen in an immunological test.
摘要翻译：本发明涉及由免疫学试验中由丙型肝炎病毒的氨基酸1207±10至1488±10和小于20个外来氨基酸组成的多肽，以及该多肽作为抗原的用途。

5. 发明授权

US07348423B2 Nucleic acids encoding fusion peptides 有权
标题翻译：编码融合肽的核酸
公开(公告)号：US07348423B2
公开(公告)日：2008-03-25
申请号：US10969624
申请日：2004-10-20
申请人： Eva Hoess , Thomas Meier , Gabriele Pestlin , Friedrich Popp , Klaus Reichert , Rainer Schmuck , Bernd Schneidinger , Christoph Seidel , Wilhelm Tischer
发明人： Eva Hoess , Thomas Meier , Gabriele Pestlin , Friedrich Popp , Klaus Reichert , Rainer Schmuck , Bernd Schneidinger , Christoph Seidel , Wilhelm Tischer
IPC分类号： A61K39/21
CPC分类号： C07K14/005 , C07K2319/00 , C12N2740/15022 , C12N2740/16122 , C12P21/02
摘要： A process is disclosed for the production of an antifusogenic peptide by producing a fusion peptide of a length of about 14 to 70 amino acids in a prokaryotic host cell, comprising the steps, under such conditions that inclusion bodies of said fusion peptide are formed, of: (a) expressing in said host cell a nucleic acid encoding said fusion peptide consisting of a first peptide which is an antifusogenic peptide of a length of about 10 to 50 amino acids and a second peptide of a length of about 4 to 30 amino acids, said first peptide being N-terminally linked to said second peptide; (b) cultivating said host cell to produce said inclusion bodies; and (c) recovering said antifusogenic peptide from said inclusion bodies, wherein said recovered antifusogenic peptide consists of said fusion peptide or a peptide comprising the antifusogenic peptide of about 10 to 50 amino acids and which is a fragment cleaved from said fusion peptide. Inclusion bodies of the peptides are disclosed. Also disclosed is a nucleic acid encoding the fusion peptide consisting of a first peptide which is an antifusogenic peptide selected from the group of SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, and said sequences further consisting of glycine at the C terminal end, N-terminally linked to the second peptide.
摘要翻译：公开了通过在原核宿主细胞中产生约14至70个氨基酸长度的融合肽来生产抗融合肽的方法，包括以下步骤：在形成所述融合肽的包涵体的条件下，（a）在所述宿主细胞中表达编码所述融合肽的核酸，所述融合肽由长度为约10至50个氨基酸的抗融合肽的第一肽和长度为约4-30个氨基酸的第二个肽组成所述第一肽与所述第二肽N-末端连接; （b）培养所述宿主细胞以产生所述包涵体; 和（c）从所述包涵体中回收所述抗融合肽，其中所述回收的抗融合肽由所述融合肽或包含约10至50个氨基酸的抗融合肽的肽组成，并且是从所述融合肽切割的片段。公开了肽的包涵体。还公开了编码由第一肽组成的融合肽的核酸，第一肽是选自SEQ ID NO：7，SEQ ID NO：8，SEQ ID NO：9，SEQ ID NO：10的抗融合肽，所述序列进一步由C末端的甘氨酸组成，N-末端与第二肽连接。

6. 发明授权

US07264938B2 Method of detecting native proBNP 有权
公开(公告)号：US07264938B2
公开(公告)日：2007-09-04
申请号：US11271138
申请日：2005-11-10
申请人： Anneliese Borgya , Andreas Gallusser , Michael Grol , Klaus Hallermayer , Volker Klemt , Christoph Seidel
发明人： Anneliese Borgya , Andreas Gallusser , Michael Grol , Klaus Hallermayer , Volker Klemt , Christoph Seidel
IPC分类号： G01N33/53 , G01N33/577 , C07K16/26 , C12N5/20 , C12P21/08 , G01N33/543
CPC分类号： C07K16/26 , A61K39/00 , C07K14/58 , C07K2317/10 , C07K2317/34 , Y10S435/975 , Y10S436/811
摘要： The present invention relates to antibodies specifically binding to native proBNP, a method for specific detection of native proBNP, a method of correlating the level of native proBNP to the diagnosis of heart failure, a kit for detection of native proBNP and to a hybridoma cell line producing an antibody to native proBNP.

7. 发明申请

US20060110775A1 Method of detecting native proBNP 有权
公开(公告)号：US20060110775A1
公开(公告)日：2006-05-25
申请号：US11271138
申请日：2005-11-10
申请人： Anneliese Borgya , Andreas Gallusser , Michael Grol , Klaus Hallermayer , Volker Klemt , Christoph Seidel
发明人： Anneliese Borgya , Andreas Gallusser , Michael Grol , Klaus Hallermayer , Volker Klemt , Christoph Seidel
IPC分类号： G01N33/53
CPC分类号： C07K16/26 , A61K39/00 , C07K14/58 , C07K2317/10 , C07K2317/34 , Y10S435/975 , Y10S436/811
摘要： The present invention relates to antibodies specifically binding to native proBNP, a method for specific detection of native proBNP, a method of correlating the level of native proBNP to the diagnosis of heart failure, a kit for detection of native proBNP and to a hybridoma cell line producing an antibody to native proBNP.

8. 发明授权

US5846738A Synthetic standard for immunoassays 失效
标题翻译：免疫测定合成标准
公开(公告)号：US5846738A
公开(公告)日：1998-12-08
申请号：US762695
申请日：1996-12-12
申请人： Christoph Seidel , Peter Bialk , Herbert Von der Eltz
发明人： Christoph Seidel , Peter Bialk , Herbert Von der Eltz
IPC分类号： G01N33/53 , A61K38/00 , C07K14/47 , G01N1/00 , G01N33/531 , G01N33/541 , G01N33/68 , G01N33/86 , G01N33/96
CPC分类号： C07K14/4716 , G01N33/531 , G01N33/6887 , G01N33/86 , G01N33/96 , A61K38/00 , G01N2333/4712 , G01N2333/75 , Y10S435/961 , Y10S435/967 , Y10S435/973 , Y10S530/806 , Y10T436/10
摘要： A conjugate of at least two binding sites that bind specifically to the analyte-specific binding region of the receptor that is used for detection in a test, wherein the binding sites are linked by at least one soluble carrier substance and the conjugate is a product of a synthetic or recombinant production, dissolved in an aqueous solution in an exactly known amount is particularly suitable as a stable calibrator in a test for the detection of an analyte.
摘要翻译：至少两个结合位点的缀合物，其特异性结合于用于检测的受体的分析物特异性结合区域，其中所述结合位点通过至少一种可溶性载体物质连接，所述缀合物是以完全已知的量溶解在水溶液中的合成或重组生产特别适合作为检测分析物的测试中的稳定校准物。

9. 发明授权

US5688659A Streptolysin O peptide antigens and methods for the determination of streptolysin antibodies 失效
标题翻译：链球菌素O肽抗原和测定链球菌溶血素抗体的方法
公开(公告)号：US5688659A
公开(公告)日：1997-11-18
申请号：US482576
申请日：1995-06-07
申请人： Christoph Seidel , Geoffrey Burns , Wolf-Dieter Engel
发明人： Christoph Seidel , Geoffrey Burns , Wolf-Dieter Engel
IPC分类号： A61K39/09 , A61K39/00 , A61P31/04 , C07K1/04 , C07K7/06 , C07K7/08 , C07K14/195 , C07K14/315 , C07K14/41 , C07K16/00 , G01N33/53 , G01N33/543 , G01N33/557 , G01N33/569
CPC分类号： C07K14/315 , A61K39/00 , Y10S436/804
摘要： SLO peptide antigens are described. These peptide antigens are suitable for the determination of SLO antibodies, as immunogens for the production of antibodies against SLO and as vaccines for the production of vaccines against SLO.
摘要翻译：描述了SLO肽抗原。这些肽抗原适用于测定SLO抗体，作为产生针对SLO的抗体的免疫原，以及用于生产针对SLO的疫苗的疫苗。

10. 发明授权

US07811770B2 Method of detecting a subfraction of proBNP 有权
$Method of detecting a subfraction of proBNP$
标题翻译：检测proBNP亚分离的方法
公开(公告)号：US07811770B2
公开(公告)日：2010-10-12
申请号：US11644565
申请日：2006-12-22
申请人： Anneliese Borgya , Andreas Gallusser , Michael Grol , Klaus Hallermayer , Volker Klemt , Christoph Seidel
发明人： Anneliese Borgya , Andreas Gallusser , Michael Grol , Klaus Hallermayer , Volker Klemt , Christoph Seidel
IPC分类号： G01N33/53 , G01N33/577 , C07K16/26 , C12N5/20 , C12P21/08 , G01N33/543
CPC分类号： C07K16/26 , A61K39/00 , C07K14/58 , C07K2317/10 , C07K2317/34 , Y10S435/975 , Y10S436/811
摘要： The present invention relates to antibodies specifically binding to native proBNP, a method for specific detection of native proBNP, a method of correlating the level of native proBNP to the diagnosis of heart failure, a kit for detection of native proBNP and to a hybridoma cell line producing an antibody to native proBNP.
摘要翻译：本发明涉及特异性结合天然proBNP的抗体，特异性检测天然proBNP的方法，将天然proBNP水平与心力衰竭诊断相关联的方法，用于检测天然proBNP的试剂盒和杂交瘤细胞系产生对天然proBNP的抗体。

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