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1. 发明授权

US5453514A Pyrazole derivatives and compositions and methods of use as maillard reaction inhibitors 失效
标题翻译：吡唑衍生物和作为美拉德反应抑制剂的组合物和方法
公开(公告)号：US5453514A
公开(公告)日：1995-09-26
申请号：US178395
申请日：1993-12-23
申请人： Kunihiro Niigata , Tatsuya Maruyama , Hisataka Shikama , Toshiyuki Takasu , Masako Umeda , Eiko Hirasaki , Satoshi Hayashibe , Takenori Kimura
发明人： Kunihiro Niigata , Tatsuya Maruyama , Hisataka Shikama , Toshiyuki Takasu , Masako Umeda , Eiko Hirasaki , Satoshi Hayashibe , Takenori Kimura
IPC分类号： C07D231/06 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/38 , C07D231/56 , C07D405/04 , C07D405/06 , C07D409/04 , A61K31/41 , A61K31/415 , C07D231/54
CPC分类号： C07D231/14 , C07D231/06 , C07D231/12 , C07D231/16 , C07D231/38 , C07D231/56 , C07D405/04 , C07D405/06 , C07D409/04
摘要： A Maillard reaction inhibitor containing, as an active ingredient, an amidinoheterocyclic derivative or its pharmaceutically acceptable salt, which is useful for the prevention and/or cure of various complications of diabetes and maturity-onset disorders. The amidinoheterocyclic derivatives are also useful as Maillard reaction inhibitors for cosmetics, external endermic medicines, foods, drinks, luxury grocery items and functional foods.
摘要翻译：一种美拉德反应抑制剂，其含有作为活性成分的脒基杂环衍生物或其药学上可接受的盐，其可用于预防和/或治愈糖尿病和成熟发作障碍的各种并发症。脒基杂环衍生物也可用作美拉德反应抑制剂，用于化妆品，外用外用药品，食品，饮料，奢侈品杂货和功能性食品。

2. 发明授权

US08399663B2 Salt of 1,3,5-triazine-2,4,6-triamine derivative 失效
标题翻译： 1,3,5-三嗪-2,4,6-三胺衍生物的盐
公开(公告)号：US08399663B2
公开(公告)日：2013-03-19
申请号：US12753415
申请日：2010-04-02
申请人： Junya Ohmori , Makoto Kasai , Takenori Kimura , Noritaka Hamada , Ryo Mizoguchi , Satoshi Miyamoto , Noriyuki Kawano
发明人： Junya Ohmori , Makoto Kasai , Takenori Kimura , Noritaka Hamada , Ryo Mizoguchi , Satoshi Miyamoto , Noriyuki Kawano
IPC分类号： C07D403/12 , A61K31/53 , A61P25/28
CPC分类号： A61K31/53 , C07D403/12
摘要： Anytime obtained is uniform crystal of N-(4-fluorophenyl)-N′-phenyl-N″-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine (compound A) and/or N,N′-bis (4-fluorophenyl)-N″-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine (compound B) as a medicament or a starting material for the preparation of the medicament, and provided are a fumarate of the compound A and/or the compound B having excellent stability and a novel crystal thereof. A salt of the compound A and/or the compound B with fumaric acid enables uniform crystal to be anytime obtained, and thus, it is a compound that is very useful as a medicament or a starting material for the preparation of the medicament having excellent stability.
摘要翻译：得到的N-（4-氟苯基）-N'-苯基-N“ - （嘧啶-2-基甲基）-1,3,5-三嗪-2,4,6-三胺（化合物A）和 /或N，N'-二（4-氟苯基）-N“ - （嘧啶-2-基甲基）-1,3,5-三嗪-2,4,6-三胺（化合物B）作为药物或起始物用于制备药物的材料，并且提供具有优异的稳定性和新颖结晶的化合物A和/或化合物B的富马酸盐。化合物A和/或化合物B与富马酸的盐能够随时获得均匀的结晶，因此，作为制备具有优异稳定性的药物的药物或原料非常有用的化合物。

3. 发明授权

US06972287B1 Method of inhibiting amyloid protein aggregation and imaging amyloid deposits 失效
标题翻译：抑制淀粉样蛋白聚集和成像淀粉样沉积物的方法
公开(公告)号：US06972287B1
公开(公告)日：2005-12-06
申请号：US10009611
申请日：2000-05-31
申请人： Corinne Elizabeth Augelli-Szafran , Mark Robert Barvian , Christopher Franklin Bigge , Shelly Ann Glase , Shunichiro Hachiya , John Steven Kiely , Takenori Kimura , Yingjie Lai , Annette Theresa Sakkab , Mark James Suto , Larry Craswell Walker , Tomoyuki Yasunaga , Nian Zhuang
发明人： Corinne Elizabeth Augelli-Szafran , Mark Robert Barvian , Christopher Franklin Bigge , Shelly Ann Glase , Shunichiro Hachiya , John Steven Kiely , Takenori Kimura , Yingjie Lai , Annette Theresa Sakkab , Mark James Suto , Larry Craswell Walker , Tomoyuki Yasunaga , Nian Zhuang
IPC分类号： A61K31/196 , A61K31/402 , A61K31/4164 , C07C229/58 , C07C229/62 , C07C229/64 , C07C233/43 , C07C311/51 , C07D209/44 , C07D213/82 , C07D217/02 , C07D233/88 , C07D257/04 , C07D295/135 , C07D317/58 , C07D413/06 , C07D401/10 , A61K31/41 , A61P25/28 , C07D403/10 , C07D413/10
CPC分类号： C07D213/82 , A61K31/196 , A61K31/402 , A61K31/4164 , C07C229/58 , C07C229/62 , C07C229/64 , C07C233/43 , C07C311/51 , C07D209/44 , C07D217/02 , C07D233/88 , C07D257/04 , C07D295/135 , C07D317/58 , C07D413/06
摘要： The present invention provides a method of treating Alzheimer's disease using a compound of Formula (I). Also provided is a method of inhibiting the aggregation of amyloid proteins using a compound of the Formula (I) and a method of imaging amyloid deposits, as well as new compounds of Formula (I).
摘要翻译：本发明提供使用式（I）的化合物治疗阿尔茨海默病的方法。还提供了使用式（I）化合物和淀粉样沉积物成像方法以及式（I）的新化合物抑制淀粉样蛋白聚集的方法。

4. 发明授权

US07666873B2 N-phenyl-(2R,5S)dimethylpiperazine derivative 有权
标题翻译： N-苯基 - （2R，5S）二甲基哌嗪衍生物
公开(公告)号：US07666873B2
公开(公告)日：2010-02-23
申请号：US11861327
申请日：2007-09-26
申请人： Nobuaki Taniguchi , Masakazu Imamura , Masahiko Hayakawa , Kenichi Kawaguchi , Takenori Kimura , Isao Kinoyama , Hiroyuki Kaizawa , Minoru Okada , Takashi Furutani
发明人： Nobuaki Taniguchi , Masakazu Imamura , Masahiko Hayakawa , Kenichi Kawaguchi , Takenori Kimura , Isao Kinoyama , Hiroyuki Kaizawa , Minoru Okada , Takashi Furutani
IPC分类号： A61K31/497 , C07D401/00
CPC分类号： C07D213/75 , C07D213/84 , C07D239/42 , C07D295/215
摘要： The present invention relates to a novel N-phenyl-(2R,5S)dimethylpiperazine derivatives useful as antiandrogenic agent which exhibits a sufficient prostate gland reducing effect as compared with conventional compounds and are excellent in oral activity. The compound of the present application is useful in preventing or treating prostate cancer, benign prostatic hyperplasia, and the like. The present invention also provides a novel intermediate useful in producing the compound of the present invention.
摘要翻译：本发明涉及用作抗雄激素剂的新型N-苯基 - （2R，5S）二甲基哌嗪衍生物，其与常规化合物相比表现出足够的前列腺减少效果，口服活性优异。本申请的化合物可用于预防或治疗前列腺癌，良性前列腺增生等。本发明还提供了可用于制备本发明化合物的新型中间体。

5. 发明授权

US6090804A Thiophene derivative and pharmaceutical composition thereof 失效
标题翻译：噻吩衍生物及其药物组合物
公开(公告)号：US6090804A
公开(公告)日：2000-07-18
申请号：US214228
申请日：1998-12-30
申请人： Takenori Kimura , Takeshi Murakami , Junya Ohmori , Takuma Morita , Shin-ichi Tsukamoto
发明人： Takenori Kimura , Takeshi Murakami , Junya Ohmori , Takuma Morita , Shin-ichi Tsukamoto
IPC分类号： A61K31/4245 , C07D333/24 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04 , C07D521/00 , A61K31/55 , C07D403/00 , C07D405/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D333/24 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04
摘要： Thiophene derivatives represented by the following general formula (I) or pharmaceutically acceptable salts thereof. Said compounds act as an anti-PCP agonist and therefore are useful as psychotropic or antischizophrenic agents and so on. ##STR1## (In the above formula, R.sub.1 is a formula --A.sub.1 --X.sub.1 --R.sub.3 ; R.sub.2 is a formula --A.sub.2 --X.sub.2 --R.sub.4 or does not exist; B ring is a 7- to 10-membered nitrogen-containing cycloalkyl ring; Ar ring is an aryl or heteroaryl ring; A.sub.1, A.sub.2 and A.sub.3 may be the same or different from one another and each represents a bond or a lower alkylene group; X.sub.1 and X.sub.2 may be the same or different from each other and each represents a bond or a formula --O--, --S--or the like; R.sub.3 and R.sub.4 may be the same or different from each other and each represents a hydrogen atom, a cyclic imido group or a lower alkyl group, a cycloalkyl group, an aryl group or an aralkyl group; with the proviso that, when Ar ring is thiazole ring, either one of A.sub.1 and A.sub.2 is a lower alkylene group. Also, when Ar ring is a benzene ring, a case in which one of R.sub.1 and R.sub.2 is methyl group or a halogen group and the other is a hydrogen atom is excluded.)
摘要翻译： PCT No.PCT / JP97 / 02255 Sec。 371日期1998年12月30日第 102（e）1998年12月30日日期PCT 1997年6月30日PCT公布。公开号WO98 / 00420 日期1998年1月8日由以下通式（I）表示的噻吩衍生物或其药学上可接受的盐。所述化合物作为抗PCP激动剂，因此可用作精神药物或抗精神分裂药物等。（在上式中，R 1为式-A 1 -X 1 -R 3; R 2为式-A 2 -X 2 -R 4或不存在; B环为7至10元含氮环烷基环; Ar环是芳基或杂芳基环; A 1，A 2和A 3可以彼此相同或不同，并且各自表示键或低级亚烷基; X 1和X 2可以彼此相同或不同，并且各自表示键或式-O-，-S-等; R 3和R 4可以相同或不同，表示氢原子，环状亚氨基或低级烷基，环烷基，芳基或芳烷基;条件是当Ar环是噻唑环时，A1和A2中的任一个是低级亚烷基，当Ar环是苯环时，其中R1和R2之一是甲基或卤素基团，另一个为氢原子。）

6. 发明授权

US09406921B2 Prismatic secondary battery 有权
标题翻译：棱镜二次电池
公开(公告)号：US09406921B2
公开(公告)日：2016-08-02
申请号：US13880765
申请日：2011-10-28
申请人： Takayuki Hattori , Takenori Kimura , Yasuhiro Yamauchi , Toshiyuki Nohma
发明人： Takayuki Hattori , Takenori Kimura , Yasuhiro Yamauchi , Toshiyuki Nohma
IPC分类号： H01M2/26 , H01M2/02
CPC分类号： H01M2/26 , H01M2/0217 , H01M2/263 , H01M2/266
摘要： A prismatic secondary battery is provided with a negative/positive electrode collector (18), which are disposed on either one of a wound negative/positive electrode substrate exposed portion (15), and a negative/positive electrode collector receiving member (19) which is disposed on another surface. At least one of the negative/positive electrode collector has a recess portion (30) formed in part on a surface on the side not facing the negative/positive electrode substrate exposed portions so as to be thinner than the thickness of the other portion. Resistance welding is carried out in this recessed part, thereby a large welding nugget is formed between the negative/positive electrode exposed portion and the negative/positive electrode collector.
摘要翻译：棱镜二次电池设置有负极/正极集电体（18），其设置在卷绕的负极/正极基板露出部分（15）和负极/正极集电体接收部件（19）中的任一个上，负极/正极集电体接收部件被布置在另一个表面上。负极/正极集电体中的至少一个具有凹部（30），该凹部（30）部分地形成在不面向负极/正极基板露出部分的一侧的表面上，以便比另一部分的厚度薄。在该凹部进行电阻焊接，在负极/正极露出部和负极/正极集电体之间形成大的焊接熔核。

7. 发明授权

US08460811B2 Prismatic sealed secondary battery 有权
标题翻译： Prismatic密封二次电池
公开(公告)号：US08460811B2
公开(公告)日：2013-06-11
申请号：US13218697
申请日：2011-08-26
申请人： Takayuki Hattori , Takenori Kimura , Yasuhiro Yamauchi , Toshiyuki Nohma
发明人： Takayuki Hattori , Takenori Kimura , Yasuhiro Yamauchi , Toshiyuki Nohma
IPC分类号： H01M10/36
CPC分类号： H01M2/0217 , H01M2/263 , H01M2/266 , H01M10/049
摘要： In a prismatic sealed secondary battery according to an embodiment of the present invention, at least one of positive electrode substrate exposed portions and negative electrode substrate exposed portions of an electrode assembly is split into two groups, and therebetween are disposed intermediate members that are made of a resin material and hold one or more connecting conductive members. The two split substrate exposed portions are electrically connected to collector members and to at least one of the connecting conductive members by resistance-welding. Voids are formed in resin material portions of the intermediate members that are located around the resistance-welded portions of the connecting conductive members. Therefore, lowered resistance between the substrate exposed portions and the collector members and stabilized quality of the welds are realized and the manufacturing yield of the prismatic sealed secondary battery is improved.
摘要翻译：在根据本发明实施例的方形密封二次电池中，电极组件的正极基板暴露部分和负电极基板暴露部分中的至少一个被分成两组，它们之间设置有中间部件，树脂材料并且保持一个或多个连接导电构件。两个分离的衬底暴露部分通过电阻焊接电连接到集电器构件和至少一个连接导电构件。在位于连接导电构件的电阻焊接部分周围的中间构件的树脂材料部分中形成有空隙。因此，实现了基板暴露部分与集电体之间的电阻降低，并且焊接质量稳定，提高了棱柱密封二次电池的制造成品率。

8. 发明申请

US20120028088A1 PRISMATIC SEALED SECONDARY BATTERY 有权
标题翻译：专用密封二次电池
公开(公告)号：US20120028088A1
公开(公告)日：2012-02-02
申请号：US13192292
申请日：2011-07-27
申请人： Takayuki Hattori , Takenori Kimura , Yasuhiro Yamauchi , Toshiyuki Nohma
发明人： Takayuki Hattori , Takenori Kimura , Yasuhiro Yamauchi , Toshiyuki Nohma
IPC分类号： H01M10/36 , H01M2/12 , H01M2/26
CPC分类号： H01M2/024 , H01M2/0217 , H01M2/263 , H01M2/30
摘要： The positive electrode substrate exposed portions or the negative electrode substrate exposed portions, or both, of an electrode assembly is split into two groups, and therebetween is disposed an intermediate member made of a resin material and holding one or more connecting conductive members. Collector members for the substrate exposed portions split into two groups is electrically joined by a resistance welding method to the substrate exposed portions split into two groups, together with the connecting conductive member(s) of the intermediate member. The resin material portion of the intermediate member protrudes, in the extension direction of the substrate exposed portions split into two groups, beyond the ends of the substrate exposed portions split into two groups and the ends of the collector member to a prismatic outer can. This structure enables enhanced resistance between the substrate exposed portions and the collector member and curbs variation in the welding strength.
摘要翻译：电极组件的正极基板暴露部分或负电极基板暴露部分或两者被分成两组，并且在它们之间设置由树脂材料制成并保持一个或多个连接导电部件的中间部件。通过电阻焊接方法将基板暴露部分分成两组的集电体部件与中间部件的连接导电部件一起被分成两组的基板暴露部分。中间构件的树脂材料部分在基板暴露部分的分成两组的延伸方向上突出超过分成两组的基板暴露部分的端部和集电体构件的端部到棱柱形外罐。这种结构使得能够增强基板暴露部分和集电体部件之间的电阻，并且限制焊接强度的变化。

9. 发明授权

US08722252B2 Current carrying block for resistance welding, and method for manufacturing sealed battery and sealed battery each using the current carrying block 有权
标题翻译：用于电阻焊接的承载块，以及使用电流承载块的密封电池和密封电池的制造方法
公开(公告)号：US08722252B2
公开(公告)日：2014-05-13
申请号：US12878479
申请日：2010-09-09
申请人： Takenori Kimura , Taiki Kamifuji , Kousuke Yamamoto , Yoshinori Yokoyama
发明人： Takenori Kimura , Taiki Kamifuji , Kousuke Yamamoto , Yoshinori Yokoyama
IPC分类号： H01M2/16 , H01M4/02 , H01M6/00 , H01M10/00
CPC分类号： H01M10/05 , B23K11/11 , H01M2/22 , H01M10/0587 , Y10T29/49108 , Y10T29/4911
摘要： In a sealed battery, a metal current carrying block 24A having a protrusion 24b on each of the two opposing faces is placed between positive or negative electrode substrate exposed portions that are divided into two so as to bring the protrusion 24b on each of the two opposing faces into contact with the positive or negative electrode substrate exposed portions that are stacked, a pair of electrodes 31 and 32 for resistance welding are brought into contact with positive electrode collector members 16 or negative electrode collector members that are each placed on the outermost surfaces of the positive electrode substrate exposed portions 14 or negative electrode substrate exposed portions, and resistance welding is performed with pressure applied between the pair of electrodes 31 and 32 for resistance welding.
摘要翻译：在密封电池中，在两个相对面的每一个上具有突出部24b的金属电流承载块24A被放置在正电极基板暴露部分和负电极基板暴露部分之间，其被分成两部分，以使突出部24b在两个相对的与正极或负极基板的暴露部分接触，用于电阻焊接的一对电极31和32与正极集电部件16或负极集电体部件接触，所述正极集电部件16或负极集电体部件分别放置在正极基板暴露部分14或负电极基板暴露部分，并且在施加在用于电阻焊接的一对电极31和32之间的压力下进行电阻焊接。

10. 发明申请

US20120015225A1 PRISMATIC SEALED SECONDARY BATTERY AND MANUFACTURING METHOD FOR THE SAME 审中-公开
标题翻译：专用密封二次电池及其制造方法
公开(公告)号：US20120015225A1
公开(公告)日：2012-01-19
申请号：US13181793
申请日：2011-07-13
申请人： Takayuki Hattori , Takenori Kimura , Yasuhiro Yamauchi , Toshiyuki Nohma
发明人： Takayuki Hattori , Takenori Kimura , Yasuhiro Yamauchi , Toshiyuki Nohma
IPC分类号： H01M10/36 , H01M10/04 , H01M10/02
CPC分类号： H01M10/0431 , H01M2/0217 , H01M2/263 , H01M10/0413 , Y10T29/49108
摘要： A prismatic sealed secondary battery according to an embodiment of the present invention includes an electrode assembly having stacked or wound positive and negative electrode substrate exposed portions and a pair of collector members electrically joined to the respective electrode substrate exposed portions. At least one of the electrode substrate exposed portions is split into two groups, and therebetween is disposed an intermediate member made of resin material and holding a plurality of connective conducting members. The collector member for the substrate exposed portions split into two groups is disposed on at least one of the outermost faces of the substrate exposed portions, and is electrically joined by a resistance welding method to the substrate exposed portions, together with the connecting conductive members of the intermediate member. This configuration lowers resistance of the electrode substrate exposed portions and the collector members and curbs variation in the welding strength.
摘要翻译：根据本发明实施例的方形密封二次电池包括具有层叠或卷绕的正极和负极基板暴露部分的电极组件和电连接到各个电极基板暴露部分的一对集电体部件。电极基板露出部中的至少一个被分成两组，并且在它们之间设置由树脂材料制成的中间部件并且保持多个连接导电部件。用于基板暴露部分分成两组的集电体构件设置在基板暴露部分的至少一个最外表面上，并且通过电阻焊接方法与基板暴露部分电连接，连接导电部件中间构件。这种结构降低了电极基板暴露部分和集电体部件的阻力，并且限制了焊接强度的变化。

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