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1. 发明授权

US5223219A Analytical cartridge and system for detecting analytes in liquid samples 失效
标题翻译：用于检测液体样品中分析物的分析盒和系统
公开(公告)号：US5223219A
公开(公告)日：1993-06-29
申请号：US867162
申请日：1992-04-10
申请人： Kumar Subramanian , Jeffrey Sugarman , Bernhard B. Sterling , Fred Voss , Marina Saltman
发明人： Kumar Subramanian , Jeffrey Sugarman , Bernhard B. Sterling , Fred Voss , Marina Saltman
IPC分类号： B01L3/00 , G01N21/03 , G01N21/78 , G01N33/66 , G01N33/72 , G01N33/92
CPC分类号： G01N21/03 , B01L3/5027 , B01L2200/027 , B01L2200/082 , B01L2300/069 , B01L2300/0816 , B01L2400/0406 , B01L2400/0457 , B01L3/5023 , B01L3/502746 , G01N2021/0346 , G01N2021/035 , G01N21/474 , Y10S366/01
摘要： A diagnosis system, which comprises a monitor, comprising a detector providing multiple reflectance readings in an array of individual locations, registering an analytical cartridge in the monitor at a fixed location and orientation relative to the array, and determines and displays analytical results from reflectance readings; and an analytical cartridge, comprising a liquid impervious housing, a sample application site in the housing located outside the monitor when the cartridge is registered in the monitor by the means for registering, one or more reflectance reading sites in the housing that register with one or more of the locations in the array, a capillary pathway in the housing leading from the sample application site to each of the reflectance reading sites, and a reflectance matrix located in at least one of the reflectance reading sites. In some embodiments of the invention, control features that optimize accuracy of measurement by controlling when and if sample reaches reflectance reading sites and by drawing excess sample away from undesirable locations in the cartridge are present. One control element balances the liquid-holding capacities of the application site, the sample-transporting capillary passageway that leads to the reflectance reading site, and the porous matrices from which the reflectance reading will be made, so that excess sample is excluded from entry into the cartridge while sample volumes that are below the minimum necessary for accurate operation do not reach the matrix, thereby avoiding false readings.
摘要翻译：一种诊断系统，其包括监视器，其包括检测器，其在各个位置的阵列中提供多个反射读数，以相对于阵列的固定位置和取向将分析盒注册在监视器中，并且确定并显示来自反射读数的分析结果 ; 以及分析盒，包括不透液体的壳体，当所述盒通过所述记录装置登记在所述监视器中时，位于所述显示器外部的壳体中的样品施加位置，所述壳体中的一个或多个反射率读数位置与一个或多个阵列中更多的位置，从样品应用位点引导到每个反射率读取位置的壳体中的毛细管路径，以及位于至少一个反射读取位置的反射矩阵。在本发明的一些实施例中，存在通过控制样品到达反射率读取位置以及通过将多余的样品远离盒中不期望的位置的时间和时间来优化测量精度的控制特征。一个控制元件平衡施加部位的液体保持能力，导致反射率读取位置的样品输送毛细管通道和将从其进行反射率读数的多孔基质，使得过量样品被排除进入当低于准确操作所需最小值的样品体积未达到基质时，墨盒的墨盒不会被误读。

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