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1. 发明申请

US20050075268A1 Photochemical internalization for delivery of molecules into the cytosol 有权
标题翻译：用于将分子递送到细胞质中的光化学内化
公开(公告)号：US20050075268A1
公开(公告)日：2005-04-07
申请号：US10433136
申请日：2001-11-29
申请人： Kristian Berg , Lina Prasmickaite , Anders Hogset , Pal Selbo
发明人： Kristian Berg , Lina Prasmickaite , Anders Hogset , Pal Selbo
IPC分类号： C12N15/09 , A61K31/197 , A61K35/76 , A61K38/00 , A61K39/00 , A61K39/395 , A61K41/00 , A61K45/00 , A61K47/42 , A61K47/48 , A61K48/00 , A61P35/00 , A61P37/04 , C12N5/06 , C12N5/10 , C12N15/87 , A61K31/00
CPC分类号： A61K39/0011 , A61K41/0057 , A61K2039/5154 , A61K2039/5156 , C12N15/87
摘要： The present invention provides a method for introducing a molecule into the cytosol of a cell in which the cell is contacted with a photosentistising agent, the cell is irradiated with light of a wavelength effective to activate the photosentisitising agent and, substantially at the same time or after the irradiation, the cell is contacted with the molecule to be introduced, particularly for use in cancer treatment, gene therapy and vaccination.
摘要翻译：本发明提供了一种将细胞引入细胞的细胞溶质中的方法，其中细胞与光敏剂接触，细胞用有效激活光敏剂的波长的光照射，并且基本上同时或照射后，细胞与待导入的分子接触，特别是用于癌症治疗，基因治疗和疫苗接种。

2. 发明授权

US09737594B2 Method of stimulating an immune response 有权
公开(公告)号：US09737594B2
公开(公告)日：2017-08-22
申请号：US13542017
申请日：2012-07-05
申请人： Kristian Berg , Torunn E. Tjelle , Anders Hogset , Lina Prasmickaite
发明人： Kristian Berg , Torunn E. Tjelle , Anders Hogset , Lina Prasmickaite
IPC分类号： A61K39/00 , C12N5/09 , A61N5/06 , C12N13/00 , C12N15/85
CPC分类号： A61K39/0011 , A61K2039/5152 , A61K2039/5156 , A61N5/0613 , C12N5/0693 , C12N13/00 , C12N15/85 , C12N2501/999
摘要： The present invention provides a method of stimulating an immune response to an antigenic molecule, by contacting a cell with the antigenic molecule and with a photosensitizing agent, irradiating the cell, and thereby presenting the antigenic molecule, or part thereof, on the surface of said cell and stimulating an immune response.

3. 发明授权

US08008077B2 Photochemical internalization for delivery of molecules into the cytosol 有权
标题翻译：用于将分子递送到细胞质中的光化学内化
公开(公告)号：US08008077B2
公开(公告)日：2011-08-30
申请号：US11746394
申请日：2007-05-09
申请人： Kristian Berg , Lina Prasmickaite , Anders Hogset , Pal Kristian Selbo
发明人： Kristian Berg , Lina Prasmickaite , Anders Hogset , Pal Kristian Selbo
IPC分类号： C12N15/00 , C12N15/87 , A61K48/00
CPC分类号： A61K39/0011 , A61K41/0057 , A61K2039/5154 , A61K2039/5156 , C12N15/87
摘要： The present invention provides a method for introducing a molecule into the cytosol of a cell in which the cell is contacted with a photosensitising agent, the cell is irradiated with light of a wavelength effective to activate the photosensitising agent and, substantially at the same time or after the irradiation, the cell is contacted with the molecule to be introduced, particularly for use in cancer treatment, gene therapy and vaccination.
摘要翻译：本发明提供了一种将细胞引入细胞与光敏剂接触的细胞质中的方法，该细胞用有效激活光敏剂的波长的光照射，并且基本上同时或照射后，细胞与待导入的分子接触，特别是用于癌症治疗，基因治疗和疫苗接种。

4. 发明申请

US20130330363A1 METHOD OF VACCINATION 有权
标题翻译：接种方法
公开(公告)号：US20130330363A1
公开(公告)日：2013-12-12
申请号：US13542017
申请日：2012-07-05
申请人： Kristian Berg , Torunn E. Tjelle , Anders Hogset , Lina Prasmickaite
发明人： Kristian Berg , Torunn E. Tjelle , Anders Hogset , Lina Prasmickaite
IPC分类号： A61K39/00 , C12N15/85 , A61N5/06 , C12N13/00
CPC分类号： A61K39/0011 , A61K2039/5152 , A61K2039/5156 , A61N5/0613 , C12N5/0693 , C12N13/00 , C12N15/85 , C12N2501/999
摘要： The present invention provides a method of expressing an antigenic molecule or a part thereof on the surface of an antigen-presenting cell, said method comprising introducing a molecule into the cell cytosol by photochemical internalisation, wherein said molecule, or a part thereof, is subsequently presented on the surface of said cell. Methods of vaccination comprising this method, together with compositions comprising said cells and uses involving said cells expressing antigenic molecules are also provided.
摘要翻译：本发明提供了在抗原呈递细胞表面上表达抗原性分子或其一部分的方法，所述方法包括通过光化学内化将分子引入细胞溶质中，其中所述分子或其一部分随后呈现在所述细胞的表面上。还提供了包含该方法的疫苗接种方法，以及包含所述细胞的组合物和涉及所述表达抗原性分子的细胞的用途。

5. 发明授权

US09026203B2 Photosensitizing compositions 有权
标题翻译：光敏组合物
公开(公告)号：US09026203B2
公开(公告)日：2015-05-05
申请号：US13390404
申请日：2010-08-16
申请人： Jo Klaveness , Anders Hogset
发明人： Jo Klaveness , Anders Hogset
IPC分类号： A61K31/409 , A61M37/00 , C07D487/22 , A61K41/00
CPC分类号： A61K41/0071
摘要： The invention relates to pharmaceutically acceptable salts of amphiphilic photosensitizing agents which have a water solubility of at least 0.5 mg/ml and to their use in methods of photochemical internalization. Such salts may be formed from a pharmaceutically acceptable base, for example an organic amine such as an amino alcohol, or from a pharmaceutically acceptable acid, for example a sulphonic acid or a sulphonic acid derivative. Due to their increased water solubility, such salts are particularly suitable for use in the preparation of parenteral pharmaceutical preparations, e.g. for use as solutions for injection or infusion.
摘要翻译：本发明涉及两亲性光敏剂的药学上可接受的盐，它们的水溶解度至少为0.5mg / ml，并且它们在光化学内化方法中的用途。这样的盐可以由药学上可接受的碱形成，例如有机胺如氨基醇，或由药学上可接受的酸，例如磺酸或磺酸衍生物形成。由于其水溶性增加，这些盐特别适合用于制备肠胃外药物制剂，例如，用作注射或输注的溶液。

6. 发明申请

US20120226217A1 PHOTOSENSITIZING COMPOSITIONS 有权
标题翻译：光敏组合物
公开(公告)号：US20120226217A1
公开(公告)日：2012-09-06
申请号：US13390404
申请日：2010-08-16
申请人： Jo Klaveness , Anders Hogset
发明人： Jo Klaveness , Anders Hogset
IPC分类号： A61K31/409 , A61M37/00 , C07D487/22
CPC分类号： A61K41/0071
摘要： The invention relates to pharmaceutically acceptable salts of amphiphilic photosensitizing agents which have a water solubility of at least 0.5 mg/ml and to their use in methods of photochemical internalization. Such salts may be formed from a pharmaceutically acceptable base, for example an organic amine such as an amino alcohol, or from a pharmaceutically acceptable acid, for example a sulphonic acid or a sulphonic acid derivative. Due to their increased water solubility, such salts are particularly suitable for use in the preparation of parenteral pharmaceutical preparations, e.g. for use as solutions for injection or infusion.
摘要翻译：本发明涉及两亲性光敏剂的药学上可接受的盐，它们的水溶解度至少为0.5mg / ml，并且它们在光化学内化方法中的用途。这样的盐可以由药学上可接受的碱形成，例如有机胺如氨基醇，或由药学上可接受的酸例如磺酸或磺酸衍生物形成。由于其水溶性增加，这些盐特别适合用于制备肠胃外药物制剂，例如，用作注射或输注的溶液。

7. 发明申请

US20120253264A1 PHOTOCHEMICAL INTERNALIZATION METHOD 审中-公开
标题翻译：光化学内在化方法
公开(公告)号：US20120253264A1
公开(公告)日：2012-10-04
申请号：US13390360
申请日：2010-08-16
申请人： Jo Klaveness , Anders Hogset
发明人： Jo Klaveness , Anders Hogset
IPC分类号： A61M37/00
CPC分类号： A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0034 , A61K9/006 , A61K9/107 , A61K9/2054 , A61K9/4858 , A61K41/0071
摘要： The invention relates to methods of introducing drugs into cells which are located in body cavities. In particular, it provides a photosensitizing agent for use in a method of introducing a drug molecule into the cytosol of a cell located within a body cavity, said method comprising the step of contacting said cell with said photosensitizing agent and said drug molecule, and irradiating the cell with light of a wavelength effective to activate the photosensitizing agent. Such methods are particularly suitable for use in the delivery of cytotoxic drugs in the treatment of cancer, especially bladder cancer, ovarian cancer, cervical cancer, lung cancer, brain cancer, colorectal cancer and cancers of the oral and nasal cavity.
摘要翻译：本发明涉及将药物引入位于体腔内的细胞中的方法。特别地，本发明提供一种用于将药物分子引入体腔内的细胞质的细胞溶质的方法中的光敏剂，所述方法包括使所述细胞与所述光敏剂和所述药物分子接触的步骤，以及照射具有有效激活光敏剂的波长的光的电池。这些方法特别适用于递送细胞毒性药物治疗癌症，特别是膀胱癌，卵巢癌，子宫颈癌，肺癌，脑癌，结肠直肠癌和口腔和鼻腔癌。

8. 发明申请

US20050002865A1 Diagnostic/therapeutic agents 审中-公开
标题翻译：诊断/治疗剂
公开(公告)号：US20050002865A1
公开(公告)日：2005-01-06
申请号：US10734730
申请日：2003-12-15
申请人： Jo Klaveness , Pal Rongved , Anders Hogset , Helge Tolleshaug , Alan Cuthbertson , Aslak Godal , Lars Hoff , Geir Gogstad , Klaus Bryn , Anne Naevestad , Dagfinn Lovhaug , Halldis Hellebust , Magne Solbakken
发明人： Jo Klaveness , Pal Rongved , Anders Hogset , Helge Tolleshaug , Alan Cuthbertson , Aslak Godal , Lars Hoff , Geir Gogstad , Klaus Bryn , Anne Naevestad , Dagfinn Lovhaug , Halldis Hellebust , Magne Solbakken
IPC分类号： A61K47/48 , A61K49/00 , A61K49/08 , A61K49/18 , A61K49/22 , A61K51/04 , A61K51/08 , A61K51/12
CPC分类号： A61K51/1255 , A61K47/542 , A61K47/62 , A61K47/6925 , A61K49/0002 , A61K49/0043 , A61K49/0047 , A61K49/0054 , A61K49/0056 , A61K49/0058 , A61K49/0091 , A61K49/223 , A61K51/065 , A61K51/1227 , Y10S977/928 , Y10S977/929 , Y10S977/93
摘要： Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.
摘要翻译：靶向诊断和/或治疗活性剂，例如超声造影剂，其包含在包含含气体或气体产生材料的报道分子的含水载体液体中的悬浮液，所述试剂能够与靶形成至少两种结合对。

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