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1. 发明申请

US20060148066A1 Electrospun nanofibrous membrane assembly for use in capturing chemical and/or biological analytes 审中-公开
标题翻译：用于捕获化学和/或生物分析物的Electrospun纳米纤维膜组件
公开(公告)号：US20060148066A1
公开(公告)日：2006-07-06
申请号：US11029548
申请日：2005-01-05
申请人： Kris Senecal , Andre Senecal , Philip Pivarnik , Charlene Mello , Jason Soares , Heidi Schreuder-Gibson
发明人： Kris Senecal , Andre Senecal , Philip Pivarnik , Charlene Mello , Jason Soares , Heidi Schreuder-Gibson
IPC分类号： C12M1/34
CPC分类号： B01D39/1623 , B01D2239/0216 , B01D2239/025 , D04H1/4291 , D04H1/4334 , D04H1/4358 , D04H1/4382
摘要： A membrane assembly adapted for use in capturing an analyte of interest, the membrane assembly comprising in one embodiment (a) an electrospun nanofibrous membrane, the electrospun nanofibrous membrane comprising a random mat of electrospun nanofibers, at least some of the electrospun nanofibers including one or more types of functional groups; and (b) at least one molecular recognition element immobilized on the random mat via a functional group, the molecular recognition element being adapted to selectively bind the analyte of interest. The membrane assembly may be incorporated into a sensor.
摘要翻译：一种适于用于捕获感兴趣分析物的膜组件，所述膜组件包括在一个实施方案中（a）电纺丝纳米纤维膜，所述电纺丝纳米纤维膜包含电纺丝纳米纤维的无规毡，至少一些所述电纺丝纳米纤维包括一个或多个更多类型的功能组; 和（b）经由官能团固定在无规毡上的至少一种分子识别元件，所述分子识别元件适于选择性地结合感兴趣的分析物。膜组件可以结合到传感器中。

2. 发明申请

US20070231833A1 Labeled antimicrobial peptides and method of using the same to detect microorganisms of interest 审中-公开
标题翻译：标记的抗微生物肽及其使用方法来检测感兴趣的微生物
公开(公告)号：US20070231833A1
公开(公告)日：2007-10-04
申请号：US11135130
申请日：2005-05-23
申请人： Steven Arcidiacono , Charlene Mello , Philip Pivarnik , Andre Senecal
发明人： Steven Arcidiacono , Charlene Mello , Philip Pivarnik , Andre Senecal
IPC分类号： G01N33/53
CPC分类号： C12Q1/04 , G01N33/54326
摘要： Labeled antimicrobial peptides and method of using the same to detect a microorganism of interest. In one embodiment, the method involves adding immuno-capture beads to a sample, the immuno-capture beads including capture antibodies coupled to a paramagnetic bead, the capture antibodies being specific for the type of microorganism of interest. After mixing, the target microorganism binds to the capture antibodies. Next, the beads are collected by positioning a magnet close to the sample, and the unbound material is removed from the sample. Then, a solution containing fluorescently-labeled antimicrobial peptide is added to the sample, the labeled peptide binding in great numbers to the immuno-captured microorganism. After removing unbound peptide, the beads are suspended in solution and a magnetic probe is used to collect the beads in a small volume. With the beads thus drawn together, the solution is excited with a laser. Such excitation causes the label to fluoresce, which fluorescence is then detected.
摘要翻译：标记的抗微生物肽及其使用方法来检测感兴趣的微生物。在一个实施方案中，所述方法包括向样品中加入免疫捕获珠，所述免疫捕获珠包括偶联到顺磁珠的捕获抗体，所述捕获抗体对所关注的微生物类型是特异性的。混合后，靶微生物与捕获抗体结合。接下来，通过将磁体靠近样品定位收集珠子，并且从样品中去除未结合的材料。然后，将含有荧光标记的抗微生物肽的溶液加入到样品中，标记的肽大量结合到免疫捕获的微生物。除去未结合的肽后，将珠悬浮在溶液中，并使用磁性探针以小体积收集珠粒。将珠子拉在一起，用激光激发溶液。这种激发使标签发荧光，然后检测到荧光。

3. 发明授权

US06753454B1 Electrospun fibers and an apparatus therefor 有权
标题翻译：电纺纤维及其设备
公开(公告)号：US06753454B1
公开(公告)日：2004-06-22
申请号：US09571841
申请日：2000-05-16
申请人： Daniel J. Smith , Darrell H. Reneker , Albert T. McManus , Heidi L. Schreuder-Gibson , Charlene Mello , Michael S. Sennett
发明人： Daniel J. Smith , Darrell H. Reneker , Albert T. McManus , Heidi L. Schreuder-Gibson , Charlene Mello , Michael S. Sennett
IPC分类号： A61F1300
CPC分类号： D01D5/0084 , A61L15/225 , A61L15/42 , D01D5/0076 , D01F1/10 , Y10S977/788 , Y10S977/961
摘要： A novel fiber comprising a substantially homogeneous mixture of a hydrophilic polymer and a polymer which is at least weakly hydrophobic is disclosed. The fiber optionally contains a pH adjusting compound. A method of making the fiber comprises electrospinning fibers of the substantially homogeneous polymer solution. A method of treating a wound or other area of a patient requiring protection from contamination comprises electrospinning the substantially homogeneous polymer solution to form a dressing. An apparatus for electrospinning a wound dressing is discosed.
摘要翻译：公开了一种包含亲水性聚合物和至少具有弱疏水性的聚合物的基本上均匀的混合物的新型纤维。纤维任选地含有pH调节化合物。制造纤维的方法包括基本均匀的聚合物溶液的静电纺丝纤维。治疗需要保护免受污染的患者的伤口或其他区域的方法包括电纺丝基本均匀的聚合物溶液以形成敷料。摆放用于静电伤口敷料的装置。

4. 发明授权

US6124129A Compositions and methods for controlling genetically engineered organisms 失效
标题翻译：用于控制转基因生物的组合物和方法
公开(公告)号：US6124129A
公开(公告)日：2000-09-26
申请号：US19966
申请日：1998-02-06
申请人： Przemyslaw Szafranski , Charlene Mello , Takeshi Sano , Cassandra L. Smith , David L. Kaplan , Charles R. Cantor
发明人： Przemyslaw Szafranski , Charlene Mello , Takeshi Sano , Cassandra L. Smith , David L. Kaplan , Charles R. Cantor
IPC分类号： C07K14/36 , C12N1/21 , C12N15/72 , C12N15/74 , C12N1/20
CPC分类号： C07K14/36 , C12N15/72 , C12N15/74
摘要： Compositions and methods for the control of genetically engineered organisms are described. A more effective cell suicide approach is contemplated based on the conditional expression of the lethal Streptomyces avidinii streptavidin gene. Toxicity of streptavidin is derived from its exceptionally high binding affinity for an essential prosthetic group, D-biotin. The general requirement for biotin through the living world makes streptavidin-based conditional lethal designs applicable to a broad range of containment strategies.
摘要翻译：描述了用于控制转基因生物的组合物和方法。基于致死性链霉菌链霉亲和素链霉亲和素基因的条件表达考虑了更有效的细胞自杀方法。链霉抗生物素蛋白的毒性源自其对必需的假基团D-生物素的极高的结合亲和力。生物素通过生活世界的一般要求使基于链霉亲和素的条件致命设计适用于广泛的遏制策略。

5. 发明申请

US20050158821A1 Methods for the purification and aqueous fiber spinning of spider silks and other structural proteins 失效
标题翻译：蜘蛛丝和其他结构蛋白的纯化和水性纤维纺丝的方法
公开(公告)号：US20050158821A1
公开(公告)日：2005-07-21
申请号：US10426124
申请日：2003-04-29
申请人： Charlene Mello , Steven Arcidiacono , Michelle Butler
发明人： Charlene Mello , Steven Arcidiacono , Michelle Butler
IPC分类号： C12N15/09 , C07K1/12 , C07K1/14 , C07K14/245 , C07K14/435 , C12P21/02 , D01F4/00 , C12P21/06 , B32B25/02 , B32B25/10
CPC分类号： C07K1/14 , C07K14/245 , C07K14/43518 , Y10T428/249938
摘要： Methods are described for the purification and spinning of recombinant and non-recombinant proteins. Specifically, the lysis of bacteria and purification of silk proteins occur in a single solution of organic acid. Bacterial proteins are hydrolyzed while the silk protein remains intact. Silk proteins remain soluble as they are concentrated into a aqueous-based mixture for fiber spinning.
摘要翻译：描述了重组和非重组蛋白质的纯化和纺丝的方法。具体来说，细菌的裂解和丝蛋白的纯化发生在单一的有机酸溶液中。当丝蛋白保持完整时，细菌蛋白质被水解。当丝素蛋白质浓缩成纤维纺丝的水性混合物时，丝蛋白质仍然是可溶的。

6. 发明授权

US06287844B1 Compositions and methods for controlling genetically engineered organisms 失效
标题翻译：用于控制转基因生物的组合物和方法
公开(公告)号：US06287844B1
公开(公告)日：2001-09-11
申请号：US09019966
申请日：1998-02-06
申请人： Przemyslaw Szafranski , Charlene Mello , Takeshi Sano , Cassandra L. Smith , David L. Kaplan , Charles R. Cantor
发明人： Przemyslaw Szafranski , Charlene Mello , Takeshi Sano , Cassandra L. Smith , David L. Kaplan , Charles R. Cantor
IPC分类号： C12N120
CPC分类号： C07K14/36 , C12N15/72 , C12N15/74
摘要： Compositions and methods for the control of genetically engineered organisms are described. A more effective cell suicide approach is contemplated based on the conditional expression of the lethal Streptomyces avidinii streptavidin gene. Toxicity of streptavidin is derived from its exceptionally high binding affinity for an essential prosthetic group, D-biotin. The general requirement for biotin through the living world makes streptavidin-based conditional lethal designs applicable to a broad range of containment strategies.
摘要翻译：描述了用于控制转基因生物的组合物和方法。基于致死性链霉菌链霉亲和素链霉亲和素基因的条件表达考虑了更有效的细胞自杀方法。链霉抗生物素蛋白的毒性源自其对必需的假基团D-生物素的极高的结合亲和力。生物素通过生活世界的一般要求使基于链霉亲和素的条件致命设计适用于广泛的遏制策略。

7. 发明授权

US08415131B2 M13 bacteriophage as a chemoaddressable nanoparticle for biological and medical applications 有权
标题翻译： M13噬菌体作为用于生物和医学应用的化学可接地纳米颗粒
公开(公告)号：US08415131B2
公开(公告)日：2013-04-09
申请号：US12604575
申请日：2009-10-23
申请人： Qian Wang , Kai Li , Charlene Mello
发明人： Qian Wang , Kai Li , Charlene Mello
IPC分类号： C12Q1/70 , C12N7/00 , C12N7/06 , C07C245/00 , C07D249/16
CPC分类号： G01N21/6486 , C12N7/00 , C12N2795/14142 , C12N2795/14145 , C12N2810/10 , C12N2810/405
摘要： Reactive and modified M13 bacteriophages, and methods of making and using the same, are generally provided. The reactive M13 bacteriophage can include a alkyne functional group covalently attached to the M13 bacteriophage. The modified M13 bacteriophage can include a substituent covalently attached to the M13 bacteriophage via a 1,2,3-triazole linkage. Dual-modified M13 bacteriophages are also generally provided, and can include a cancer-targeting substituent covalently attached to the M13 bacteriophage and a fluorescent group covalently attached to the M13 bacteriophage. The modified M13 bacteriophages can not only be employed as a fluorescent probe for cancer imaging, but also can be used as biomaterials for cell alignment and scaffolding.
摘要翻译：通常提供活性和改良的M13噬菌体及其制备和使用方法。反应性M13噬菌体可以包括共价连接到M13噬菌体上的炔官能团。修饰的M13噬菌体可以包括通过1,2,3-三唑键共价连接到M13噬菌体上的取代基。也通常提供双重修饰的M13噬菌体，并且可以包括共价连接到M13噬菌体的癌靶向取代基和共价连接到M13噬菌体的荧光基团。修饰的M13噬菌体不仅可以用作癌症成像的荧光探针，还可以用作细胞比对和脚手架的生物材料。

8. 发明授权

US06620917B1 Method for the purification and aqueous fiber spinning of spider silks and other structural proteins 失效
标题翻译：蜘蛛丝和其他结构蛋白的纯化和水性纤维纺丝方法
公开(公告)号：US06620917B1
公开(公告)日：2003-09-16
申请号：US09490291
申请日：2000-01-20
申请人： Charlene Mello , Steven Arcidiacono , Michelle M. Butler
发明人： Charlene Mello , Steven Arcidiacono , Michelle M. Butler
IPC分类号： C07K100
CPC分类号： C07K1/14 , C07K14/245 , C07K14/43518 , Y10T428/249938
摘要： Methods are described for the purification and spinning of recombinant and non-recombinant proteins. Specifically, the lysis of bacteria and purification of silk proteins occur in a single solution of organic acid. Bacterial proteins are hydrolyzed while the silk protein remains intact. Silk proteins remain soluble as they are concentrated into a aqueous-based mixture for fiber spinning.
摘要翻译：描述了重组和非重组蛋白质的纯化和纺丝的方法。具体来说，细菌的裂解和丝蛋白的纯化发生在单一的有机酸溶液中。当丝蛋白保持完整时，细菌蛋白质被水解。当丝素蛋白质浓缩成纤维纺丝的水性混合物时，丝蛋白质仍然是可溶的。

9. 发明申请

US20100190233A1 M13 Bacteriophage as A Chemoaddressable Nanoparticle for Biological and Medical Applications 有权
标题翻译： M13噬菌体作为用于生物和医学应用的化学可接地纳米颗粒
公开(公告)号：US20100190233A1
公开(公告)日：2010-07-29
申请号：US12604575
申请日：2009-10-23
申请人： Qian Wang , Kai Li , Charlene Mello
发明人： Qian Wang , Kai Li , Charlene Mello
IPC分类号： C12N7/00 , C12N5/09
CPC分类号： G01N21/6486 , C12N7/00 , C12N2795/14142 , C12N2795/14145 , C12N2810/10 , C12N2810/405
摘要： Reactive and modified M13 bacteriophages, and methods of making and using the same, are generally provided. The reactive M13 bacteriophage can include a alkyne functional group covalently attached to the M13 bacteriophage. The modified M13 bacteriophage can include a substituent covalently attached to the M13 bacteriophage via a 1,2,3-triazole linkage. Dual-modified M13 bacteriophages are also generally provided, and can include a cancer-targeting substituent covalently attached to the M13 bacteriophage and a fluorescent group covalently attached to the M13 bacteriophage. The modified M13 bacteriophages can not only be employed as a fluorescent probe for cancer imaging, but also can be used as biomaterials for cell alignment and scaffolding.
摘要翻译：通常提供活性和改良的M13噬菌体及其制备和使用方法。反应性M13噬菌体可以包括共价连接到M13噬菌体上的炔官能团。修饰的M13噬菌体可以包括通过1,2,3-三唑键共价连接到M13噬菌体上的取代基。也通常提供双重修饰的M13噬菌体，并且可以包括共价连接到M13噬菌体的癌靶向取代基和共价连接到M13噬菌体的荧光基团。修饰的M13噬菌体不仅可以用作癌症成像的荧光探针，还可以用作细胞比对和脚手架的生物材料。

10. 发明授权

US07335739B2 Methods for the purification and aqueous fiber spinning of spider silks and other structural proteins 失效
标题翻译：蜘蛛丝和其他结构蛋白的纯化和水性纤维纺丝的方法
公开(公告)号：US07335739B2
公开(公告)日：2008-02-26
申请号：US10426124
申请日：2003-04-29
申请人： Charlene Mello , Steven Arcidiacono , Michelle M. Butler
发明人： Charlene Mello , Steven Arcidiacono , Michelle M. Butler
IPC分类号： A61K38/17 , C07K1/14
CPC分类号： C07K1/14 , C07K14/245 , C07K14/43518 , Y10T428/249938
摘要： Methods are described for the purification and spinning of recombinant and non-recombinant proteins. Specifically, the lysis of bacteria and purification of silk proteins occur in a single solution of organic acid. Bacterial proteins are hydrolyzed while the silk protein remains intact. Silk proteins remain soluble as they are concentrated into a aqueous-based mixture for fiber spinning.
摘要翻译：描述了重组和非重组蛋白质的纯化和纺丝的方法。具体来说，细菌的裂解和丝蛋白的纯化发生在单一的有机酸溶液中。当丝蛋白保持完整时，细菌蛋白质被水解。当丝素蛋白质浓缩成纤维纺丝的水性混合物时，丝蛋白质仍然是可溶的。

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