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1. 发明授权

US07208524B2 5-amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation 失效
标题翻译： 5-脒基-2-羟基苯磺酰胺衍生物，含有它们的药物组合物及其制备中间体
公开(公告)号：US07208524B2
公开(公告)日：2007-04-24
申请号：US10398383
申请日：2001-10-02
申请人： Kosuke Okazaki , Masahiko Uchida , Harunobu Mukaiyama , Hiroaki Kobayashi , Yuichiro Kai , Hideki Takeuchi , Kenji Yokoyama , Yoshihiro Terao , Yuji Hoyano , Hiroaki Shiohara , Norihiko Kikuchi
发明人： Kosuke Okazaki , Masahiko Uchida , Harunobu Mukaiyama , Hiroaki Kobayashi , Yuichiro Kai , Hideki Takeuchi , Kenji Yokoyama , Yoshihiro Terao , Yuji Hoyano , Hiroaki Shiohara , Norihiko Kikuchi
IPC分类号： A61K31/195 , A61K31/18 , C07C59/52 , C07C307/06
CPC分类号： A61K31/18 , A61K31/40 , A61K31/421 , A61K31/445 , A61K31/5377 , A61K31/55 , A61K31/553 , C07C311/29 , C07C311/37 , C07C317/32 , C07C2601/14
摘要： The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R1 is a hydrogen atom or an optionally substituted lower alkyl group; R2 is a di(lower alkyl)amino group, a lower alkyl group, a cycloalkyl group, an optionally substituted aryl group, an optionally substituted heterocycloalkyl group, or an optionally substituted aromatic heterocyclic group; T is an oxygen atom, a sulfur atom, a sulfonyl group etc.; Q is a hydrogen atom or an optionally substituted lower alkyl group; and Z is a hydrogen atom, a hydroxy group etc., or a pharmaceutically acceptable salt thereof, which exert a potent and selective activated blood coagulation factor X inhibitory activity and is useful as an agent for the prevention or treatment of a disease occurred associating an activated blood coagulation factor X, a pharmaceutical composition comprising the same, a pharmaceutical use thereof and an intermediate thereof.
摘要翻译：本发明涉及由以下通式表示的5-脒基-2-羟基苯磺酰胺衍生物：其中R 1是氢原子或任选取代的低级烷基; R 2是二（低级烷基）氨基，低级烷基，环烷基，任选取代的芳基，任选取代的杂环烷基或任选取代的芳族杂环基; T是氧原子，硫原子，磺酰基等; Q是氢原子或任意取代的低级烷基; Z是氢原子，羟基等，或其药学上可接受的盐，其具有有效和选择性的活化凝血因子X抑制活性，并且可用作预防或治疗疾病的药剂，活化凝血因子X，包含其的药物组合物，其药物用途及其中间体。

2. 发明申请

US20060116361A1 5-Amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation 失效
公开(公告)号：US20060116361A1
公开(公告)日：2006-06-01
申请号：US10398383
申请日：2001-10-02
申请人： Kosuke Okazaki , Masahiko Uchida , Harunobu Mukaiyama , Hiroaki Kobayashi , Yuichiro Kai , Hideki Takeuchi , Kenji Yokoyama , Yoshihiro Terao , Yuji Hoyano , Hiroaki Shiohara , Norihiko Kikuchi
发明人： Kosuke Okazaki , Masahiko Uchida , Harunobu Mukaiyama , Hiroaki Kobayashi , Yuichiro Kai , Hideki Takeuchi , Kenji Yokoyama , Yoshihiro Terao , Yuji Hoyano , Hiroaki Shiohara , Norihiko Kikuchi
IPC分类号： A61K31/44 , A61K31/40 , A61K31/195
CPC分类号： A61K31/18 , A61K31/40 , A61K31/421 , A61K31/445 , A61K31/5377 , A61K31/55 , A61K31/553 , C07C311/29 , C07C311/37 , C07C317/32 , C07C2601/14
摘要： The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R1 is a hydrogen atom or an optionally substituted lower alkyl group; R2 is a di(lower alkyl)amino group, a lower alkyl group, a cycloalkyl group, an optionally substituted aryl group, an optionally substituted heterocycloalkyl group, or an optionally substituted aromatic heterocyclic group; T is an oxygen atom, a sulfur atom, a sulfonyl group etc.; Q is a hydrogen atom or an optionally substituted lower alkyl group; and Z is a hydrogen atom, a hydroxy group etc., or a pharmaceutically acceptable salt thereof, which exert a potent and selective activated blood coagulation factor X inhibitory activity and is useful as an agent for the prevention or treatment of a disease occurred associating an activated blood coagulation factor X, a pharmaceutical composition comprising the same, a pharmaceutical use thereof and an intermediate thereof.

3. 发明授权

US07589126B2 5-amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation 失效
标题翻译： 5-脒基-2-羟基苯磺酰胺衍生物，含有它们的药物组合物及其制备中间体
公开(公告)号：US07589126B2
公开(公告)日：2009-09-15
申请号：US11553573
申请日：2006-10-27
申请人： Kosuke Okazaki , Masahiko Uchida , Harunobu Mukaiyama , Hiroaki Kobayashi , Yuichiro Kai , Hideki Takeuchi , Kenji Yokoyama , Yoshihiro Terao , Yuji Hoyano , Hiroaki Shiohara , Norihiko Kikuchi
发明人： Kosuke Okazaki , Masahiko Uchida , Harunobu Mukaiyama , Hiroaki Kobayashi , Yuichiro Kai , Hideki Takeuchi , Kenji Yokoyama , Yoshihiro Terao , Yuji Hoyano , Hiroaki Shiohara , Norihiko Kikuchi
IPC分类号： A61K31/195 , A61K31/18
CPC分类号： A61K31/18 , A61K31/40 , A61K31/421 , A61K31/445 , A61K31/5377 , A61K31/55 , A61K31/553 , C07C311/29 , C07C311/37 , C07C317/32 , C07C2601/14
摘要： The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R1 is a hydrogen atom or an optionally substituted lower alkyl group; R2 is a di(lower alkyl)amino group, a lower alkyl group, a cycloalkyl group, an optionally substituted aryl group, an optionally substituted heterocycloalkyl group, or an optionally substituted aromatic heterocyclic group; T is an oxygen atom, a sulfur atom, a sulfonyl group etc.; Q is a hydrogen atom or an optionally substituted lower alkyl group; and Z is a hydrogen atom, a hydroxy group etc., or a pharmaceutically acceptable salt thereof, which exert a potent and selective activated blood coagulation factor X inhibitory activity and is useful as an agent for the prevention or treatment of a disease occurred associating an activated blood coagulation factor X, a pharmaceutical composition comprising the same, a pharmaceutical use thereof and an intermediate thereof.
摘要翻译：本发明涉及由下列通式表示的5-脒基-2-羟基苯磺酰胺衍生物：其中R 1是氢原子或任意取代的低级烷基; R2是二（低级烷基）氨基，低级烷基，环烷基，任选取代的芳基，任选取代的杂环烷基或任选取代的芳族杂环基; T是氧原子，硫原子，磺酰基等; Q是氢原子或任意取代的低级烷基; Z是氢原子，羟基等，或其药学上可接受的盐，其具有有效和选择性的活化凝血因子X抑制活性，并且可用作预防或治疗疾病，活化凝血因子X，包含其的药物组合物，其药物用途及其中间体。

4. 发明授权

US07217832B2 5-amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation 失效
公开(公告)号：US07217832B2
公开(公告)日：2007-05-15
申请号：US11359430
申请日：2006-02-23
申请人： Kosuke Okazaki , Masahiko Uchida , Harunobu Mukaiyama , Hiroaki Kobayashi , Yuichiro Kai , Hideki Takeuchi , Kenji Yokoyama , Yoshihiro Terao , Yuji Hoyano , Hiroaki Shiohara , Norihiko Kikuchi
发明人： Kosuke Okazaki , Masahiko Uchida , Harunobu Mukaiyama , Hiroaki Kobayashi , Yuichiro Kai , Hideki Takeuchi , Kenji Yokoyama , Yoshihiro Terao , Yuji Hoyano , Hiroaki Shiohara , Norihiko Kikuchi
IPC分类号： C07D265/30 , C07D271/113 , C07D277/30 , C07C255/53 , C07C255/63
CPC分类号： A61K31/18 , A61K31/40 , A61K31/421 , A61K31/445 , A61K31/5377 , A61K31/55 , A61K31/553 , C07C311/29 , C07C311/37 , C07C317/32 , C07C2601/14
摘要： The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R1 is a hydrogen atom or an optionally substituted lower alkyl group; R2 is a di(lower alkyl)amino group, a lower alkyl group, a cycloalkyl group, an optionally substituted aryl group, an optionally substituted heterocycloalkyl group, or an optionally substituted aromatic heterocyclic group; T is an oxygen atom, a sulfur atom, a sulfonyl group etc.; Q is a hydrogen atom or an optionally substituted lower alkyl group; and Z is a hydrogen atom, a hydroxy group etc., or a pharmaceutically acceptable salt thereof, which exert a potent and selective activated blood coagulation factor X inhibitory activity and is useful as an agent for the prevention or treatment of a disease occurred associating an activated blood coagulation factor X, a pharmaceutical composition comprising the same, a pharmaceutical use thereof and an intermediate thereof.

5. 发明申请

US20070105829A1 5-AMIDINO-2-HYDROXYBENZENESULFONAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES FOR THEIR PREPARATION 失效
标题翻译： 5-氨基-2-羟基苯甲酰胺衍生物，含有它们的药物组合物及其制备中间体
公开(公告)号：US20070105829A1
公开(公告)日：2007-05-10
申请号：US11553573
申请日：2006-10-27
申请人： Kosuke OKAZAKI , Masahiko Uchida , Harunobu Mukaiyama , Hiroaki Kobayashi , Yuichiro Kai , Hideki Takeuchi , Kenji Yokoyama , Yoshihiro Terao , Yuji Hoyano , Hiroaki Shiohara , Norihiko Kikuchi
发明人： Kosuke OKAZAKI , Masahiko Uchida , Harunobu Mukaiyama , Hiroaki Kobayashi , Yuichiro Kai , Hideki Takeuchi , Kenji Yokoyama , Yoshihiro Terao , Yuji Hoyano , Hiroaki Shiohara , Norihiko Kikuchi
IPC分类号： A61K31/553 , A61K31/55 , A61K31/5377 , A61K31/445 , A61K31/421 , A61K31/40 , A61K31/18
CPC分类号： A61K31/18 , A61K31/40 , A61K31/421 , A61K31/445 , A61K31/5377 , A61K31/55 , A61K31/553 , C07C311/29 , C07C311/37 , C07C317/32 , C07C2601/14
摘要： The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R1 is a hydrogen atom or an optionally substituted lower alkyl group; R2 is a di(lower alkyl)amino group, a lower alkyl group, a cycloalkyl group, an optionally substituted aryl group, an optionally substituted heterocycloalkyl group, or an optionally substituted aromatic heterocyclic group; T is an oxygen atom, a sulfur atom, a sulfonyl group etc.; Q is a hydrogen atom or an optionally substituted lower alkyl group; and Z is a hydrogen atom, a hydroxy group etc., or a pharmaceutically acceptable salt thereof, which exert a potent and selective activated blood coagulation factor X inhibitory activity and is useful as an agent for the prevention or treatment of a disease occurred associating an activated blood coagulation factor X, a pharmaceutical composition comprising the same, a pharmaceutical use thereof and an intermediate thereof.
摘要翻译：本发明涉及由以下通式表示的5-脒基-2-羟基苯磺酰胺衍生物：其中R 1是氢原子或任选取代的低级烷基; R 2是二（低级烷基）氨基，低级烷基，环烷基，任选取代的芳基，任选取代的杂环烷基或任选取代的芳族杂环基; T是氧原子，硫原子，磺酰基等; Q是氢原子或任意取代的低级烷基; Z是氢原子，羟基等，或其药学上可接受的盐，其具有有效和选择性的活化凝血因子X抑制活性，并且可用作预防或治疗疾病的药剂，活化凝血因子X，包含其的药物组合物，其药物用途及其中间体。

6. 发明申请

US20060205812A1 5-Amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation 失效
标题翻译： 5-脒基-2-羟基苯磺酰胺衍生物，含有它们的药物组合物及其制备中间体
公开(公告)号：US20060205812A1
公开(公告)日：2006-09-14
申请号：US11359430
申请日：2006-02-23
申请人： Kosuke Okazaki , Masahiko Uchida , Harunobu Mukaiyama , Hiroaki Kobayashi , Yuichiro Kai , Hideki Takeuchi , Kenji Yokoyama , Yoshihiro Terao , Yuji Hoyano , Hiroaki Shiohara , Norihiko Kikuchi
发明人： Kosuke Okazaki , Masahiko Uchida , Harunobu Mukaiyama , Hiroaki Kobayashi , Yuichiro Kai , Hideki Takeuchi , Kenji Yokoyama , Yoshihiro Terao , Yuji Hoyano , Hiroaki Shiohara , Norihiko Kikuchi
IPC分类号： A61K31/24 , A61K31/195 , C07C311/47
CPC分类号： A61K31/18 , A61K31/40 , A61K31/421 , A61K31/445 , A61K31/5377 , A61K31/55 , A61K31/553 , C07C311/29 , C07C311/37 , C07C317/32 , C07C2601/14
摘要： The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R1 is a hydrogen atom or an optionally substituted lower alkyl group; R2 is a di(lower alkyl)amino group, a lower alkyl group, a cycloalkyl group, an optionally substituted aryl group, an optionally substituted heterocycloalkyl group, or an optionally substituted aromatic heterocyclic group; T is an oxygen atom, a sulfur atom, a sulfonyl group etc.; Q is a hydrogen atom or an optionally substituted lower alkyl group; and Z is a hydrogen atom, a hydroxy group etc., or a pharmaceutically acceptable salt thereof, which exert a potent and selective activated blood coagulation factor X inhibitory activity and is useful as an agent for the prevention or treatment of a disease occurred associating an activated blood coagulation factor X, a pharmaceutical composition comprising the same, a pharmaceutical use thereof and an intermediate thereof.
摘要翻译：本发明涉及由以下通式表示的5-脒基-2-羟基苯磺酰胺衍生物：其中R 1是氢原子或任选取代的低级烷基; R 2是二（低级烷基）氨基，低级烷基，环烷基，任选取代的芳基，任选取代的杂环烷基或任选取代的芳族杂环基; T是氧原子，硫原子，磺酰基等; Q是氢原子或任意取代的低级烷基; Z是氢原子，羟基等，或其药学上可接受的盐，其具有有效和选择性的活化凝血因子X抑制活性，并且可用作预防或治疗疾病，活化凝血因子X，包含其的药物组合物，其药物用途及其中间体。

7. 发明申请

US20050085541A1 Novel thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof 失效
标题翻译：新型甲状腺激素受体配体，含有该甲状腺激素受体配体的药物组合物及其应用
公开(公告)号：US20050085541A1
公开(公告)日：2005-04-21
申请号：US10502737
申请日：2003-01-28
申请人： Hiroaki Shiohara , Tetsuya Nakamura , Norihiko Kikuchi , Tomonaga Ozawa , Makio Kitazawa
发明人： Hiroaki Shiohara , Tetsuya Nakamura , Norihiko Kikuchi , Tomonaga Ozawa , Makio Kitazawa
IPC分类号： A61K31/19 , A61K31/22 , A61K31/223 , A61K31/225 , A61K31/27 , A61K31/341 , A61K31/351 , A61K31/40 , A61K31/426 , A61K31/44 , A61K31/4406 , A61K31/50 , A61K31/5375 , A61K31/54 , A61P1/16 , A61P3/04 , A61P3/10 , A61P5/14 , A61P5/16 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , A61P17/00 , A61P17/06 , A61P19/10 , A61P25/24 , A61P27/06 , A61P35/00 , A61P37/08 , A61P43/00 , C07C59/72 , C07C233/25 , C07C233/56 , C07C235/66 , C07C309/65 , C07C311/29 , C07C317/22 , C07C323/41 , C07C323/67 , C07D209/08 , C07D213/75 , C07D213/76 , C07D237/14 , C07D249/12 , C07D253/075 , C07D257/04 , C07D257/06 , C07D271/06 , C07D271/07 , C07D277/24 , C07D277/34 , C07D295/13 , C07D295/192 , C07D295/26 , C07D307/12 , C07D309/06 , C07D403/12 , C07D413/12 , C07D417/12 , A61K31/24 , A61K31/12 , A61K31/165 , A61K31/18
CPC分类号： C07D213/75 , A61K31/19 , A61K31/22 , A61K31/223 , A61K31/225 , A61K31/27 , A61K31/341 , A61K31/351 , A61K31/40 , A61K31/426 , A61K31/44 , A61K31/4406 , A61K31/50 , A61K31/5375 , A61K31/54 , C07C59/72 , C07C233/25 , C07C233/56 , C07C235/66 , C07C309/65 , C07C311/29 , C07C317/22 , C07C323/41 , C07C323/67 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D209/08 , C07D213/76 , C07D237/14 , C07D249/12 , C07D253/075 , C07D257/04 , C07D257/06 , C07D271/07 , C07D277/34 , C07D295/13 , C07D295/192 , C07D295/26 , C07D307/12 , C07D309/06 , C07D403/12 , C07D413/12 , C07D417/12
摘要： The present invention provides a compound represented by general formula (I): or pharmaceutically acceptable salts thereof, wherein W is O, S(O)m, CH2 and the like; R1 is halogen, lower alkyl, halo-lower alkyl, CN and the like; R3 is hydrogen and the like; R4 is hydrogen, halogen, alkyl, halo-lower alkyl, substituted alkyl, aryl, aralkyl, alkoxy, substituted alkoxy, alkanoyl, aroyl, —CONR7(R8), —S(O)mR9, —SO2NR7(R8) and the like; R5 is hydrogen, halogen, alkyl, substituted alkyl and the like; A is —N(R6)CO-A1-COR10 and the like; pharmaceutical compositions containing them and their uses, which have a high affinity to human thyroid hormone receptors, in particular human thyroid hormone receptor β.
摘要翻译：本发明提供由通式（I）表示的化合物或其药学上可接受的盐，其中W为O，S（O）m，CH 2等 ; R 1是卤素，低级烷基，卤代低级烷基，CN等; R 3是氢等; R 4是氢，卤素，烷基，卤代低级烷基，取代的烷基，芳基，芳烷基，烷氧基，取代的烷氧基，烷酰基，芳酰基，-CONR 7 S（O）m R 9，-SO 2 NR 7，S（O）（R 8 S 8）等; R 5是氢，卤素，烷基，取代的烷基等; A是-N（R 6）CO-A 1 -COR 10等; 含有它们的药物组合物及其用途，其对人甲状腺激素受体，特别是甲状腺激素受体β具有高亲和力。

8. 发明授权

US07230031B2 Thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof 失效
标题翻译：甲状腺激素受体配体，含有其的药物组合物及其用途
公开(公告)号：US07230031B2
公开(公告)日：2007-06-12
申请号：US10502737
申请日：2003-01-28
申请人： Hiroaki Shiohara , Tetsuya Nakamura , Norihiko Kikuchi , Tomonaga Ozawa , Makio Kitazawa
发明人： Hiroaki Shiohara , Tetsuya Nakamura , Norihiko Kikuchi , Tomonaga Ozawa , Makio Kitazawa
IPC分类号： A61K31/19 , C07C303/00
CPC分类号： C07D213/75 , A61K31/19 , A61K31/22 , A61K31/223 , A61K31/225 , A61K31/27 , A61K31/341 , A61K31/351 , A61K31/40 , A61K31/426 , A61K31/44 , A61K31/4406 , A61K31/50 , A61K31/5375 , A61K31/54 , C07C59/72 , C07C233/25 , C07C233/56 , C07C235/66 , C07C309/65 , C07C311/29 , C07C317/22 , C07C323/41 , C07C323/67 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D209/08 , C07D213/76 , C07D237/14 , C07D249/12 , C07D253/075 , C07D257/04 , C07D257/06 , C07D271/07 , C07D277/34 , C07D295/13 , C07D295/192 , C07D295/26 , C07D307/12 , C07D309/06 , C07D403/12 , C07D413/12 , C07D417/12
摘要： The present invention provides a compound represented by general formula (I): or pharmaceutically acceptable salts thereof, wherein W is O, S(O)m, CH2 and the like; R1 is halogen, lower alkyl, halo-lower alkyl, CN and the like; R3 is hydrogen and the like; R4 is hydrogen, halogen, alkyl, halo-lower alkyl, substituted alkyl, aryl, aralkyl, alkoxy, substituted alkoxy, alkanoyl, aroyl, —CONR7(R8), —S(O)mR9, —SO2NR7(R8) and the like; R5 is hydrogen, halogen, alkyl, substituted alkyl and the like; A is —N(R6)CO—A1—COR10 and the like; pharmaceutical compositions containing them and their uses, which have a high affinity to human thyroid hormone receptors, in particular human thyroid hormone receptor β.
摘要翻译：本发明提供由通式（I）表示的化合物或其药学上可接受的盐，其中W为O，S（O）m，CH 2等 ; R 1是卤素，低级烷基，卤代低级烷基，CN等; R 3是氢等; R 4是氢，卤素，烷基，卤代低级烷基，取代的烷基，芳基，芳烷基，烷氧基，取代的烷氧基，烷酰基，芳酰基，-CONR 7 S（O）m R 9，-SO 2 NR 7，S（O）（R 8 S 8）等; R 5是氢，卤素，烷基，取代的烷基等; A是-N（R 6）CO-A 1 -COR 10等; 含有它们的药物组合物及其用途，其对人甲状腺激素受体，特别是甲状腺激素受体β具有高亲和力。

9. 发明授权

US07795236B2 Purine nucleoside derivative modified in 8-position and medical use thereof 失效
标题翻译： 8位修饰的嘌呤核苷衍生物及其用途
公开(公告)号：US07795236B2
公开(公告)日：2010-09-14
申请号：US11717741
申请日：2007-03-13
申请人： Kazuya Tatani , Yoshinori Nonaka , Norihiko Kikuchi
发明人： Kazuya Tatani , Yoshinori Nonaka , Norihiko Kikuchi
IPC分类号： A01N43/04 , A61K31/70 , C07H19/00 , C07H19/16
CPC分类号： A61K45/06 , A61K31/7076 , C07H19/167 , C07H19/173
摘要： The present invention provides an 8-modified purinenucleoside derivative which is useful for diseases associated with an abnormality of plasma uric acid level. An 8-modified purinenucleoside derivative represented by the following formula (I), a prodrug thereof or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof, is useful for the prevention or treatment of gout, hyperuricemia, urinary lithiasis, hyperuricemic nephropathy or the like.In the formula, n is 1 or 2; RA is a hydrogen atom or a hydroxyl group; R1 is a hydrogen atom, a hydroxyl group, a thiol group, an amino group or a chlorine atom; ring J represents an optionally substituted 2-naphthyl group, or a group represented by the following general formula (II) wherein Y represents a single bond or a connecting group; ring Z represents an optionally substituted aryl group or heteroaryl group or the like; and R2 to R4, P1 and Q represents a halogen atom, a cyano group or the like.
摘要翻译：本发明提供了可用于与血浆尿酸水平异常相关的疾病的8-修饰的嘌呤核苷衍生物。由下式（I）表示的8-修饰的嘌呤核苷衍生物，其前体药物或其药学上可接受的盐或其水合物或溶剂合物可用于预防或治疗痛风，高尿酸血症，尿结石病，高尿酸性肾病或类似。在该式中，n为1或2; RA是氢原子或羟基; R1是氢原子，羟基，硫醇基，氨基或氯原子; 环J表示任选取代的2-萘基，或由以下通式（II）表示的基团，其中Y表示单键或连接基团; 环Z表示任选取代的芳基或杂芳基等; R2和R4，P1和Q表示卤原子，氰基等。

10. 发明申请

US20060082040A1 Clamp device and clamp method for heat-treated article 有权
标题翻译：热处理制品的夹紧装置和夹紧方法
公开(公告)号：US20060082040A1
公开(公告)日：2006-04-20
申请号：US10541331
申请日：2004-10-04
申请人： Satoshi Shimizu , Norihiko Kikuchi , Tatsushi Yurudume , Hisao Hoshino , Takao Minagawa , Hiroyuki Osaka , Makoto Noudou , Shigeki Kishihara , Shingo Shikuwa
发明人： Satoshi Shimizu , Norihiko Kikuchi , Tatsushi Yurudume , Hisao Hoshino , Takao Minagawa , Hiroyuki Osaka , Makoto Noudou , Shigeki Kishihara , Shingo Shikuwa
IPC分类号： B23Q3/02
CPC分类号： C21D1/42 , C21D1/09 , C21D1/673 , C21D9/0025 , C21D9/0068 , Y02P10/253
摘要： A heat treatment operation can be executed, suppressing a wave-shaped deformation at a non heat-treatment region of an article to be heat treated. To an elongated-shaped article to be heat treated (10) to which a raised portion (11) extending in the longitudinal direction is formed, a hardening region as being a heat-treated region defined to be extended in a longitudinal direction at a part of the raised portion (11) and a non-hardening region as being non heat-treated region defined to be extended in the longitudinal direction at flange portion (13) and other parts of the raised portion (11) are arranged side by side in a width direction orthogonal to the longitudinal direction. The flange portion (13) is clamped by a first and a second clamping means (22), (23) arranged in the longitudinal direction, and one first clamping means (22) is a tight clamping means holding fixedly the flange portion (13) and a plurality of second clamping means (23) are loose clamping means clamping loosely the flange portion (13), allowing the article to be heat treated (10) to be convex on the side of the heated hardening region.
摘要翻译：可以进行热处理操作，抑制待热处理物品的非热处理区域的波状变形。对于形成有沿长度方向延伸的凸部（11）进行热处理的细长型制品（10），形成作为热处理区域的硬化区域，其被定义为在纵向方向上延伸的部分的突出部（11）的非热硬化区域和非凸部（11）的其他部分在长度方向上被限定为非热处理区域的非硬化区域并排配置在与纵向正交的宽度方向。凸缘部分（13）由沿纵向布置的第一和第二夹紧装置（22），（23）夹持，一个第一夹紧装置（22）是固定地保持凸缘部分（13）的紧固装置，并且多个第二夹紧装置（23）是松弛地夹紧凸缘部分（13）的松紧夹紧装置，允许制品在加热硬化区域一侧被热处理（10）凸起。

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