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1. 发明授权

US5891029A Method of and device for positioning a living body for biological measurement and apparatus for measurement of biological information 失效
标题翻译：用于定位用于生物测量的生物体的方法和装置以及用于测量生物信息的装置
公开(公告)号：US5891029A
公开(公告)日：1999-04-06
申请号：US776775
申请日：1997-02-07
申请人： Koji Matsuoka , Yoshio Mitsumura , Harumi Uenoyama , Kexin Xu
发明人： Koji Matsuoka , Yoshio Mitsumura , Harumi Uenoyama , Kexin Xu
IPC分类号： A61B10/00 , A61B5/00 , A61B5/107 , A61B5/145 , A61B5/1455
CPC分类号： A61B5/1455 , A61B5/1078 , A61B5/14532
摘要： To secure a highly accurate measurement value of biological information with minimized variation by positioning a target part of a living body with good reproducibility and by positioning the target part of the living body easily with high reproducibility without pressing blood vessels in the living body. The concentration of a particular component in the living body is measured by the use of a transmitted or reflected spectrum obtained by projecting light onto the target part of the living body. A biological information measuring template 2 includes a shape memory medium 6 having a contact surface which, when the target part is pressed to the contact surface, undergoes change according to the shape of the target part, to thereby store the shape. The target part 1 of the living body is arranged at a store portion of the shape memory medium and is illuminated by light. The spectrum of light transmitted through or reflected from the target part 1 is arithmetically processed in an arithmetic control means 4 to calculate the concentration of the particular component in the living body, a result of calculation being outputted to an output unit 5.
摘要翻译： PCT No.PCT / JP96 / 01551 Sec。 371日期1997年2月7日 102（e）1997年2月7日PCT PCT 1996年6月7日PCT公布。 WO96 / 41568 PCT出版物日期1996年12月27日为了通过将生物体的目标部分定位好，具有良好的再现性，并且以高再现性容易地定位生物体的目标部分，而不会迫使生物信息的目标部分活体。通过使用通过将光投射到生物体的目标部分而获得的透射或反射光谱来测量生物体中特定成分的浓度。生物信息测量模板2包括：形状记忆介质6，具有接触面，当接触面按压目标部分时，根据目标部位的形状发生变化，从而存储形状。生物体的目标部分1布置在形状记忆介质的存储部分并被光照射。通过算术控制装置4对目标部分1透射或反射的光的光谱进行算术处理，以计算生物体中特定成分的浓度，计算结果输出到输出部5。

2. 发明授权

US6147749A Method and apparatus for measuring concentration by light projection 失效
标题翻译：用于通过光投影测量浓度的方法和装置
公开(公告)号：US6147749A
公开(公告)日：2000-11-14
申请号：US817085
申请日：1997-04-29
申请人： Hiroko Kubo , Yoshio Mitsumura , Harumi Uenoyama , Kexin Xu
发明人： Hiroko Kubo , Yoshio Mitsumura , Harumi Uenoyama , Kexin Xu
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1455 , G01N21/27 , G01N33/48 , G01N21/00
CPC分类号： G01N21/27 , A61B5/14532 , A61B5/1455 , A61B5/6825 , A61B5/6842 , A61B5/6843
摘要： To project measuring light with good reproducibility onto the measuring part of a measured object so that measurement conditions can always be constant. An optical measuring apparatus is equipped with a spectroscopic analyzer that detects the spectral intensity of the reflected light of measuring light projected onto a human hand. Spectroscopic analyzer moves in the direction" of the X-axis, Y axis, and Z axis, and around the Z axis by a moving mechanism. During the registration of the measuring part of the human hand, a CCD camera takes a picture of the human hand, and the operator selects a part having a feature from the pattern of the taken image. During the spectrometry, the CCD camera again takes a picture of the human hand. The optical measuring apparatus then detects the registered feature part on the currently taken image, moves spectroscopic analyzer by moving mechanism, and projects measuring light onto the registered feature part.
摘要翻译： PCT No.PCT / JP96 / 02223 Sec。 371日期1997年4月7日 102（e）日期1997年4月7日PCT 1996年8月7日PCT PCT。出版物WO97 / 06423 日期1997年2月20日将测量对象的重复性重新测量投影到测量对象的测量部位，以便测量条件始终保持不变。光学测量装置配备有光谱分析仪，其检测投射到人手上的测量光的反射光的光谱强度。光谱分析仪通过移动机构沿X轴，Y轴和Z轴方向移动，Z轴周围移动，在人体测量部位的配准期间，CCD摄像机拍摄人手，操作员从拍摄图像的图案中选择具有特征的部分，在光谱测定期间，CCD照相机再次拍摄人手的照片，然后光学测量装置检测当前拍摄的注册特征部分图像，通过移动机构移动光谱分析仪，并将测量光投射到注册的特征部分上。

3. 发明授权

US5475234A Apparatus and method for measuring concentrations of components using pulsed light of different wavelengths and performing a time resolved measurement 失效
标题翻译：使用不同波长的脉冲光测量组分浓度并执行时间分辨测量的装置和方法
公开(公告)号：US5475234A
公开(公告)日：1995-12-12
申请号：US280811
申请日：1994-07-26
申请人： Kexin Xu , Yutaka Yamasaki , Harumi Uenoyama , Takeshi Sakura
发明人： Kexin Xu , Yutaka Yamasaki , Harumi Uenoyama , Takeshi Sakura
IPC分类号： G01N15/06 , A61B5/00 , G01N21/27 , G01N21/49 , G01N21/85
CPC分类号： A61B5/1455 , A61B5/14532 , G01N21/49 , G01N2021/1789 , G01N2021/1791 , G01N2021/4797 , G01N21/359
摘要： An apparatus and method for measuring component concentrations which enables accurate measurement of concentrations of component within an object in a non-destructive, non-invasive, and bloodless procedure. The apparatus comprises a light irradiator 1 for projecting pulse laser of different wavelengths toward an object 12 by means of a variable wavelength laser generating unit 11, a photodetector 2 for performing a time resolved measurement of the quantity of transmitted light from the object which is subject to changes with lapse of time after the generation of the pulse laser, and an arithmetic unit 3 for calculating concentrations of components in the object 12 and outputting the calculation result such that the relationship between time lapse and measured quantity of light is converted into a relationship between an optical path length representing the distance of light travel within the object 12 and a change in the measured quantity of light relative to a change in unit concentration so that the optical path length and the quantity of light which is measured when the change in the quantity of light is at a peak are stored in memory for each wavelength, the quantity of light being used as a basis for the calculation.
摘要翻译：一种用于测量组分浓度的装置和方法，其能够在非破坏性，非侵入性和无血液过程中精确测量物体内的组分的浓度。该装置包括用于通过可变波长激光产生单元11将不同波长的脉冲激光投射到物体12的光照射器1，用于对来自被摄体的物体的透射光进行时间分辨测量的光电检测器2 在产生脉冲激光之后经过时间的变化，以及用于计算对象12中的分量的浓度的运算单元3，并输出计算结果，使得时间流逝和测量光量之间的关系被转换为关系在表示物体12内的光行进距离的光路长度与测量的光量相对于单位浓度的变化的变化之间，使得光路长度和当光线长度变化时所测量的光量光量处于峰值时，存储在每个波长的存储器中，光量为我们作为计算的基础。

4. 发明授权

US5602647A Apparatus and method for optically measuring concentrations of components 失效
标题翻译：用于光学测量组分浓度的装置和方法
公开(公告)号：US5602647A
公开(公告)日：1997-02-11
申请号：US562785
申请日：1995-11-27
申请人： Kexin Xu , Yutaka Yamasaki , Harumi Uenoyama , Takeshi Sakura
发明人： Kexin Xu , Yutaka Yamasaki , Harumi Uenoyama , Takeshi Sakura
IPC分类号： G01N21/27 , G01J3/42 , G01N21/03 , G01N21/31 , G01N21/39 , G01N21/59 , G01N21/00
CPC分类号： G01N21/0303 , G01N21/31 , G01J3/42 , G01N2021/3129 , G01N21/39 , G01N21/59 , G01N2201/066 , G01N2201/0668
摘要： An apparatus and method for optically measuring concentrations of components allow enhancement in measurement accuracy of concentration. The apparatus includes a cell, a light irradiator, a photodetector, and an arithmetic unit. The cell presents different optical path lengths at different locations and is to contain a sample therein. The light irradiator, which includes a variable-wavelength laser generator and a measuring system composed of convex lenses, outputs a collimated, enlarged laser beam, and makes the laser beam incident upon the cell. The photodetector comprises a multiplicity of photodetectors arranged in parallel to the surface of the cell, so that it can detect intensity of rays of transmitted light that have traveled over different optical path lengths at positions of an equal distance from the cell. The arithmetic unit, receiving a signal from the individual photodetectors, calculates concentrations of components in the sample based on optimum optical path lengths for different wavelengths and values of transmitted light at positions of the optimum optical path lengths, and further outputs calculation results.
摘要翻译：用于光学测量组分浓度的装置和方法允许增强浓度的测量精度。该装置包括单元，光照射器，光电检测器和运算单元。细胞在不同位置呈现不同的光程长度，并且其中包含样品。包括可变波长激光发生器和由凸透镜组成的测量系统的光照射器输出准直的，放大的激光束，并使激光束入射到电池上。光电检测器包括与电池表面平行设置的多个光电检测器，使得其可以检测在距离电池相等距离的位置处已经在不同光程长度上行进的透射光的光强。运算单元接收来自各个光电检测器的信号，根据最佳光程长度的不同波长的最佳光路长度和最佳光路长度位置处的透射光值，计算样品中的成分浓度，并进一步输出计算结果。

5. 发明授权

US5815260A Urogenous component measuring apparatus for qualitatively/quantitatively measuring a plurality of urogenous components 失效
标题翻译：用于定性/定量测量多个泌尿生成分的泌尿成分测量装置
公开(公告)号：US5815260A
公开(公告)日：1998-09-29
申请号：US733637
申请日：1996-10-17
申请人： Xiaoming Dou , Harumi Uenoyama , Yung Xiang Wang , Koji Matsuoka
发明人： Xiaoming Dou , Harumi Uenoyama , Yung Xiang Wang , Koji Matsuoka
IPC分类号： A61B10/00 , G01N21/65
CPC分类号： A61B10/007 , G01N21/65
摘要： A concave urine collector is set under a front end portion of a stool body, so that urine can be collected in a bowl. Single fiber holes are set on a front end and a left side of the urine collector respectively, while condenser lenses for condensing light on the bowl side, an excitation light fiber member carrying excitation light from an excitation light source and a Raman light receiving fiber member for receiving Raman light are set in the fiber holes respectively. The excitation light fiber member is connected with the excitation light source, and the Raman light receiving fiber member communicates with a spectro-detector. A Raman signal separated into its spectral components detected by the spectro-detector is data-processed by a data processing part, and outputted from a data output part as a measurement result.
摘要翻译：将尿液收集器设置在粪便体的前端部的下方，能够将尿液收集在碗内。单个纤维孔分别设置在尿液收集器的前端和左侧，而聚光透镜用于聚光在碗侧，来自激发光源的激发光和拉曼光接收纤维部件用于接收拉曼光的光纤分别设置在光纤孔中。激发光纤部件与激发光源连接，拉曼光接收光纤部件与分光检测器连通。分离成其由光谱检测器检测的光谱分量的拉曼信号由数据处理部分进行数据处理，并作为测量结果从数据输出部分输出。

6. 发明授权

US5754288A Optical measuring method of expiration components 失效
标题翻译：过期组分的光学测量方法
公开(公告)号：US5754288A
公开(公告)日：1998-05-19
申请号：US694342
申请日：1996-08-08
申请人： Hiroshi Yamamoto , Harumi Uenoyama , Xiaoming Dou , Yung Xiang Wang , Kentaro Shimada
发明人： Hiroshi Yamamoto , Harumi Uenoyama , Xiaoming Dou , Yung Xiang Wang , Kentaro Shimada
IPC分类号： G01J3/44 , G01N21/65 , G01N33/497
CPC分类号： G01N21/65 , G01J3/44
摘要： As to respective expiration components to be measured, wavelengths having excellent correlations between component concentrations and Raman spectral intensity values are previously selected as measuring wavelengths which are specific to the components, an expiration specimen is irradiated with Raman excitation light, Raman spectra at the measuring wavelength which is specific to nitrogen and those at the measuring wavelengths previously selected for the components to be measured respectively are measured, Raman spectral intensity ratios of the components to the Raman spectral intensity of nitrogen are obtained, and the respective expiration components are quantitatively analyzed through a calibration curve which is previously prepared as to the Raman spectral intensity ratios of the respective components to nitrogen and concentrations. It is possible to provide a measuring method utilizing Raman spectroscopy, which can directly determine intra- expiratory components in a short time with no requirement for expendable items.
摘要翻译：对于要测量的各个到期组分，预先选择组分浓度和拉曼光谱强度值之间具有优异相关性的波长作为测定组分特有的波长，用拉曼激发光照射呼出样品，在测量波长处照射拉曼光谱测量分别对于氮和特定于测量波长的测量波长的测量波长，并获得组分与氮的拉曼光谱强度的拉曼光谱强度比，并通过一个校准曲线，其预先制备了各组分对氮和浓度的拉曼光谱强度比。可以提供使用拉曼光谱的测量方法，其可以在短时间内直接确定呼气成分，而不需要消耗品。

7. 发明授权

US5696580A Method of and apparatus for measuring absorbance, component concentration or specific gravity of liquid sample 失效
标题翻译：用于测量液体样品的吸光度，组分浓度或比重的方法和仪器
公开(公告)号：US5696580A
公开(公告)日：1997-12-09
申请号：US434717
申请日：1995-05-04
申请人： Hiroko Kubo , Xu Kexin , Harumi Uenoyama
发明人： Hiroko Kubo , Xu Kexin , Harumi Uenoyama
IPC分类号： G01N21/03 , G01N21/41 , G01N21/00
CPC分类号： G01N21/4133 , G01N21/0303
摘要： A measuring beam is incident upon a triangular cell storing a liquid sample, and transmitted light thereof is received by a linear sensor so that both transmitted light intensity and a position of the beam are detected. A refractive index calculating part calculates refractive indices from the position detected by the linear sensor, while an absorbance calculating part calculates absorbance values dependent on component concentration values correcting influence by transmittance change at the triangular cell through the transmitted light intensity values and the refractive indices of the sample calculated at the refractive index calculating part. A component concentration calculating part performs a multivariate analytical operation on the basis of the absorbance values dependent on the component concentration values at a plurality of measuring wavelengths calculated at the absorbance calculating part.
摘要翻译：测量光束入射在存储液体样品的三角形单元上，并且其透射光被线性传感器接收，从而检测透射光强度和光束位置。折射率计算部分从由线性传感器检测的位置计算折射率，而吸光度计算部分通过透射光强度值和透射光强度值来计算依赖于三角形单元的透射率变化校正影响的成分浓度值的吸光度值，在折射率计算部分计算的样本。成分浓度计算部根据在吸光度计算部计算出的多个测定波长的成分浓度值的吸光度值，进行多变量分析。

8. 发明授权

US5332479A Biosensor and method of quantitative analysis using the same 失效
标题翻译：生物传感器和定量分析方法采用相同的方法
公开(公告)号：US5332479A
公开(公告)日：1994-07-26
申请号：US883367
申请日：1992-05-15
申请人： Harumi Uenoyama , Hisashi Okuda
发明人： Harumi Uenoyama , Hisashi Okuda
IPC分类号： G01N27/327 , C12Q1/00 , G01N27/416 , G01N27/26
CPC分类号： C12Q1/004 , Y10S435/817
摘要： A biosensor which electrochemically detects a material which relates to a reaction of a specific compound in a liquid sample with a biologically active substance or its related substance, in which the biologically active material or an optionally used mediator is placed at a part which is remote from a position of an electrode which acts as electrochemical detector means, and optionally the biological active material or the mediator is covered with a polymer layer.
摘要翻译：电化学检测与液体样品中的特定化合物与生物活性物质或其相关物质的反应相关的材料的生物传感器，其中生物活性物质或任选使用的介体放置在远离充当电化学检测器装置的电极的位置，以及任选的生物活性材料或介体的聚合物层被覆盖。

9. 发明授权

US06887430B1 Apparatus for immune analysis 失效
标题翻译：免疫分析仪器
公开(公告)号：US06887430B1
公开(公告)日：2005-05-03
申请号：US08985816
申请日：1999-03-12
申请人： Xiaoming Dou , Yoshinori Yamaguchi , Harumi Uenoyama
发明人： Xiaoming Dou , Yoshinori Yamaguchi , Harumi Uenoyama
IPC分类号： G01N21/55 , G01N21/17
CPC分类号： G01N21/7703 , G01N21/552
摘要： A total reflection cell has a total reflection prism on at least one surface thereof. A mixed solution containing a gold colloid labelled antibody which is adsorbed on a gold colloid is stored in the total reflection cell, and a sample solution containing an antigen causing antigen-antibody reaction with the antibody is added thereto for forming a gold colloid labelled immune complex. A measuring beam is introduced into the total reflection prism from an incident optical system at an angle θ of incidence causing total reflection and an outgoing beam from the total reflection prism is received by a measuring optical system, thereby measuring absorption by the gold colloid labelled immune complex and carrying out qualification and determination of the antigen.
摘要翻译：全反射单元在其至少一个表面上具有全反射棱镜。将含有被吸附在金胶体上的金胶体标记抗体的混合溶液储存在全反射池中，向其中加入含抗原抗体与抗体反应的抗原的样品溶液，形成金胶体标记的免疫复合物。测量光束从入射光学系统以入射角度θ被引入全反射棱镜，从而引起全反射，并且来自全反射棱镜的输出光束被测量光学系统接收，从而测量金胶体标记的免疫吸收复杂并进行抗原的鉴定和鉴定。

10. 发明授权

US06612986B2 Dispersed-type testing/measuring system and dispersed-type health care system 有权
标题翻译：分散型测试/测量系统和分散式保健系统
公开(公告)号：US06612986B2
公开(公告)日：2003-09-02
申请号：US09800691
申请日：2001-03-07
申请人： Shigeru Doi , Harumi Uenoyama , Yoshinori Yamaguchi
发明人： Shigeru Doi , Harumi Uenoyama , Yoshinori Yamaguchi
IPC分类号： A61B500
CPC分类号： G06F19/3418 , G06F19/00 , G16H10/40 , G16H40/20 , G16H40/63 , Y10S128/904
摘要： A dispersed-type testing/measuring system provides for example a simplified terminal unit to be installed at a patient's home. The dispersed-type testing/measuring system has a central controlling unit 20 and a plurality of terminal units 30 each accessible to the central controlling unit via a communication line 15. Each terminal unit 30 includes a crude data collecting portion 40, and a data transmitting means 45 for sending the data collected by the crude data collecting portion 40 to the central controlling unit 20. The central controlling unit 20 includes a measurement data calculating means 210 for generating measurement data by making calculation on the crude data sent from each terminal unit 30.
摘要翻译：分散型测试/测量系统例如提供了要安装在患者家中的简化终端单元。分散式测试/测量系统具有中央控制单元20和多个终端单元30，每个终端单元可访问中央控制每个终端单元30包括原始数据收集部分40和用于将粗原始数据收集部分40收集的数据发送到中央控制单元20的数据发送装置45.中央控制单元20包括测量数据计算装置210，用于通过对从每个终端单元30发送的原始数据进行计算来产生测量数据。

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