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1. 发明授权

US5754288A Optical measuring method of expiration components 失效
标题翻译：过期组分的光学测量方法
公开(公告)号：US5754288A
公开(公告)日：1998-05-19
申请号：US694342
申请日：1996-08-08
申请人： Hiroshi Yamamoto , Harumi Uenoyama , Xiaoming Dou , Yung Xiang Wang , Kentaro Shimada
发明人： Hiroshi Yamamoto , Harumi Uenoyama , Xiaoming Dou , Yung Xiang Wang , Kentaro Shimada
IPC分类号： G01J3/44 , G01N21/65 , G01N33/497
CPC分类号： G01N21/65 , G01J3/44
摘要： As to respective expiration components to be measured, wavelengths having excellent correlations between component concentrations and Raman spectral intensity values are previously selected as measuring wavelengths which are specific to the components, an expiration specimen is irradiated with Raman excitation light, Raman spectra at the measuring wavelength which is specific to nitrogen and those at the measuring wavelengths previously selected for the components to be measured respectively are measured, Raman spectral intensity ratios of the components to the Raman spectral intensity of nitrogen are obtained, and the respective expiration components are quantitatively analyzed through a calibration curve which is previously prepared as to the Raman spectral intensity ratios of the respective components to nitrogen and concentrations. It is possible to provide a measuring method utilizing Raman spectroscopy, which can directly determine intra- expiratory components in a short time with no requirement for expendable items.
摘要翻译：对于要测量的各个到期组分，预先选择组分浓度和拉曼光谱强度值之间具有优异相关性的波长作为测定组分特有的波长，用拉曼激发光照射呼出样品，在测量波长处照射拉曼光谱测量分别对于氮和特定于测量波长的测量波长的测量波长，并获得组分与氮的拉曼光谱强度的拉曼光谱强度比，并通过一个校准曲线，其预先制备了各组分对氮和浓度的拉曼光谱强度比。可以提供使用拉曼光谱的测量方法，其可以在短时间内直接确定呼气成分，而不需要消耗品。

2. 发明授权

US5815260A Urogenous component measuring apparatus for qualitatively/quantitatively measuring a plurality of urogenous components 失效
标题翻译：用于定性/定量测量多个泌尿生成分的泌尿成分测量装置
公开(公告)号：US5815260A
公开(公告)日：1998-09-29
申请号：US733637
申请日：1996-10-17
申请人： Xiaoming Dou , Harumi Uenoyama , Yung Xiang Wang , Koji Matsuoka
发明人： Xiaoming Dou , Harumi Uenoyama , Yung Xiang Wang , Koji Matsuoka
IPC分类号： A61B10/00 , G01N21/65
CPC分类号： A61B10/007 , G01N21/65
摘要： A concave urine collector is set under a front end portion of a stool body, so that urine can be collected in a bowl. Single fiber holes are set on a front end and a left side of the urine collector respectively, while condenser lenses for condensing light on the bowl side, an excitation light fiber member carrying excitation light from an excitation light source and a Raman light receiving fiber member for receiving Raman light are set in the fiber holes respectively. The excitation light fiber member is connected with the excitation light source, and the Raman light receiving fiber member communicates with a spectro-detector. A Raman signal separated into its spectral components detected by the spectro-detector is data-processed by a data processing part, and outputted from a data output part as a measurement result.
摘要翻译：将尿液收集器设置在粪便体的前端部的下方，能够将尿液收集在碗内。单个纤维孔分别设置在尿液收集器的前端和左侧，而聚光透镜用于聚光在碗侧，来自激发光源的激发光和拉曼光接收纤维部件用于接收拉曼光的光纤分别设置在光纤孔中。激发光纤部件与激发光源连接，拉曼光接收光纤部件与分光检测器连通。分离成其由光谱检测器检测的光谱分量的拉曼信号由数据处理部分进行数据处理，并作为测量结果从数据输出部分输出。

3. 发明授权

US5870188A Measuring method and measuring apparatus by light scattering 失效
标题翻译：光散射测量方法和测量装置
公开(公告)号：US5870188A
公开(公告)日：1999-02-09
申请号：US715974
申请日：1996-09-19
申请人： Yukihiro Ozaki , Yoshinori Yamaguchi , Xiaoming Dou , Harumi Uenoyama
发明人： Yukihiro Ozaki , Yoshinori Yamaguchi , Xiaoming Dou , Harumi Uenoyama
IPC分类号： G01J3/44
CPC分类号： G01J3/4412
摘要： An excitation beam from a laser is passed through a bandpass filter, and applied to a sample by a collimator lens. An optical adjusting part comprising a camera lens and a converging lens is provided for receiving scattered light from the sample, so that the camera lens receives the scattered light and converts the same to a parallel beam. The converging lens has chromatic aberration, and receives and converges the parallel beam from the camera lens. An inlet slit of a spectroscope is provided as an inlet port on a converging position by the converging lens. This inlet slit is a circular hole having a diameter of about 200 .mu.m. The inlet slit is arranged on a position for converging anti-Stokes-Raman scattered light through the chromatic aberration of the converging lens.
摘要翻译：来自激光器的激发光束通过带通滤光器，并通过准直透镜施加到样品。提供包括相机镜头和会聚透镜的光学调节部件，用于接收来自样品的散射光，使得相机镜头接收散射光并将其转换成平行光束。会聚透镜具有色差，并且从相机透镜接收和收敛平行光束。分光镜的入口狭缝由会聚透镜设置在聚光位置上的入口。该入口狭缝是直径约200μm的圆形孔。入口狭缝布置在通过会聚透镜的色差会聚反斯托克斯 - 拉曼散射光的位置。

4. 发明授权

US06887430B1 Apparatus for immune analysis 失效
标题翻译：免疫分析仪器
公开(公告)号：US06887430B1
公开(公告)日：2005-05-03
申请号：US08985816
申请日：1999-03-12
申请人： Xiaoming Dou , Yoshinori Yamaguchi , Harumi Uenoyama
发明人： Xiaoming Dou , Yoshinori Yamaguchi , Harumi Uenoyama
IPC分类号： G01N21/55 , G01N21/17
CPC分类号： G01N21/7703 , G01N21/552
摘要： A total reflection cell has a total reflection prism on at least one surface thereof. A mixed solution containing a gold colloid labelled antibody which is adsorbed on a gold colloid is stored in the total reflection cell, and a sample solution containing an antigen causing antigen-antibody reaction with the antibody is added thereto for forming a gold colloid labelled immune complex. A measuring beam is introduced into the total reflection prism from an incident optical system at an angle θ of incidence causing total reflection and an outgoing beam from the total reflection prism is received by a measuring optical system, thereby measuring absorption by the gold colloid labelled immune complex and carrying out qualification and determination of the antigen.
摘要翻译：全反射单元在其至少一个表面上具有全反射棱镜。将含有被吸附在金胶体上的金胶体标记抗体的混合溶液储存在全反射池中，向其中加入含抗原抗体与抗体反应的抗原的样品溶液，形成金胶体标记的免疫复合物。测量光束从入射光学系统以入射角度θ被引入全反射棱镜，从而引起全反射，并且来自全反射棱镜的输出光束被测量光学系统接收，从而测量金胶体标记的免疫吸收复杂并进行抗原的鉴定和鉴定。

5. 发明授权

US5750410A Method of and apparatus for immune analysis 失效
标题翻译：免疫分析方法和装置
公开(公告)号：US5750410A
公开(公告)日：1998-05-12
申请号：US592522
申请日：1996-01-26
申请人： Xiaoming Dou , Yoshinori Yamaguchi , Harumi Uenoyama
发明人： Xiaoming Dou , Yoshinori Yamaguchi , Harumi Uenoyama
IPC分类号： G01N21/55 , G01N33/58 , G01N33/553
CPC分类号： G01N21/77 , G01N21/552 , G01N33/585 , Y10S435/962
摘要： A total reflection cell has a total reflection prism on at least one surface thereof. A mixed solution containing a gold colloid labelled antibody which is adsorbed on a gold colloid is stored in the total reflection cell, and a sample solution containing an antigen causing antigen-antibody reaction with the antibody is added thereto for forming a gold colloid labelled immune complex. A measuring beam is introduced into the total reflection prism from an incident optical system at an angle .theta. of incidence causing total reflection and an outgoing beam from the total reflection prism is received by a measuring optical system, thereby measuring absorption by the gold colloid labelled immune complex and carrying out qualification and determination of the antigen.
摘要翻译：全反射单元在其至少一个表面上具有全反射棱镜。将含有被吸附在金胶体上的金胶体标记抗体的混合溶液储存在全反射池中，向其中加入含抗原抗体与抗体反应的抗原的样品溶液，形成金胶体标记的免疫复合物。测量光束从入射光学系统以入射角度θ被引入全反射棱镜，从而引起全反射，并且来自全反射棱镜的输出光束被测量光学系统接收，从而测量金胶体标记的免疫吸收复杂并进行抗原的鉴定和鉴定。

6. 发明授权

US5741660A Method of measuring enzyme reaction by Raman scattering 失效
标题翻译：通过拉曼散射测量酶反应的方法
公开(公告)号：US5741660A
公开(公告)日：1998-04-21
申请号：US594205
申请日：1996-01-30
申请人： Xiaoming Dou , Yutaka Yamasaki , Harumi Uenoyama , Yoshinori Yamaguchi
发明人： Xiaoming Dou , Yutaka Yamasaki , Harumi Uenoyama , Yoshinori Yamaguchi
IPC分类号： C12Q1/26 , G01N21/65
CPC分类号： G01N21/65 , C12Q1/26 , G01N2021/651
摘要： As to reaction solutions in which the amount of each potassium ferricyanate, glucose oxidase and glucose substrate are set at a constant value while glucose concentrations are varied, intensity changes of peaks at a shift wavenumber of 2081 cm.sup.-1 in light scattering spectra are measured every 10 seconds, the maximum values of the intensity changes of the peaks at the respective glucose concentrations obtained, for obtaining a calibration curve from correlations between the maximum values of the reaction velocities and the glucose concentrations. The calibration curve is employed for carrying out quantitative measurement of an unknown sample.
摘要翻译：对于在葡萄糖浓度变化时将铁氰化钾，葡萄糖氧化酶和葡萄糖底物的量设定为恒定值的反应溶液，每个测量光散射光谱中在2081cm -1的位移波数处的峰的强度变化 10秒，获得所得各葡萄糖浓度下峰的强度变化的最大值，以从反应速度的最大值与葡萄糖浓度之间的相关性获得校准曲线。采用校准曲线进行未知样品的定量测量。

7. 发明授权

US5712167A Method of measuring Amadori compound by light scattering 失效
标题翻译：通过光散射测量阿马多利化合物的方法
公开(公告)号：US5712167A
公开(公告)日：1998-01-27
申请号：US682219
申请日：1996-07-17
申请人： Yoshinori Yamaguchi , Xiaoming Dou , Masayuki Yagi , Harumi Uenoyama
发明人： Yoshinori Yamaguchi , Xiaoming Dou , Masayuki Yagi , Harumi Uenoyama
IPC分类号： G01N21/65 , G01N21/47
CPC分类号： G01N21/65 , Y10T436/173845
摘要： In order to quantitatively measure an Amadori compound by a simple optical method utilizing light scattering, a sample containing an Amadori compound which is stored in a cell is irradiated with excitation light from an He--Ne laser unit so that scattered light from the sample is received and separated into its spectral components for obtaining a light scattering spectrum, and a light scattering peak existing at 820 to 840 cm.sup.-1, 1655 to 1660 cm.sup.-1, 2000 to 2020 cm.sup.-1, 2080 to 2100 cm.sup.-1, 2460 to 2470 cm.sup.-1 or 2530 to 2600 cm.sup.-1 in shift wavenumber with respect to the excitation wavelength in the light scattering spectrum is detected by a detector. The saccharide concentration or the saccharification ratio of the Amadori compound is measured by a calibration curve through the peak intensity or the peak integral value of the light scattering peak.
摘要翻译：为了通过使用光散射的简单光学方法定量测量阿马多利化合物，将来自He-Ne激光单元的激发光照射存储在电池中的含有Amadori化合物的样品，从而接收来自样品的散射光并分离成其光谱分量以获得光散射光谱，以及存在于820至840cm -1，1655至1660cm -1，2000至2020cm -1，2080至2100cm -1，2460至通过检测器检测相对于光散射光谱中的激发波长的2470cm -1或2530〜2600cm -1的位移波数。阿马多利化合物的糖浓度或糖化率通过校准曲线通过峰光强度或光散射峰的峰值积分值来测量。

8. 发明授权

US5617205A Spectral measuring method and spectral measuring apparatus 失效
标题翻译：光谱测量方法和光谱测量仪器
公开(公告)号：US5617205A
公开(公告)日：1997-04-01
申请号：US672027
申请日：1996-06-26
申请人： Xiaoming Dou , Yoshinori Yamaguchi , Harumi Uenoyama , Yung X. Wang
发明人： Xiaoming Dou , Yoshinori Yamaguchi , Harumi Uenoyama , Yung X. Wang
IPC分类号： G01N21/63 , G01J3/44 , G01N21/65 , G01N21/64
CPC分类号： G01J3/44
摘要： Excitation light from a light source is divided into a sample beam and a correction beam by a half mirror, so that the sample beam is converged on a sample in a sample part by convergent lenses. Condenser lenses are provided in order to converge scattered light from the sample on an inlet slit of a spectroscope, and a holographic notch filter which is set to include the wavelength of the excitation light in its notch region is arranged in order to remove the same wavelength component as the excitation light from the scattered light for selecting target light. The target light and the correction beam are guided onto the same optical axis by a half mirror, to be incident upon a polychrometer through the inlet slit and simultaneously detected. The detected value of the target light is corrected by a simultaneously detected intensity of the correction beam.
摘要翻译：来自光源的激发光被半反射镜分为采样光束和校正光束，使得样品光束通过会聚透镜会聚在样品部分中的样品上。提供了冷凝器透镜，以便将来自样品的散射光聚集在分光器的入口狭缝上，并且布置被设置为包括其切口区域中的激发光的波长的全息陷波滤波器，以便去除相同的波长作为来自用于选择目标光的散射光的激发光的分量。目标光和校正光束通过半反射镜被引导到相同的光轴上，并通过入口狭缝入射到多个温度计上并同时检测。通过校正光束的同时检测的强度校正目标光的检测值。

9. 发明授权

US5481113A Apparatus and method for measuring concentrations of components with light scattering 失效
标题翻译：用于测量具有光散射的组分浓度的装置和方法
公开(公告)号：US5481113A
公开(公告)日：1996-01-02
申请号：US284213
申请日：1994-08-02
申请人： Xiaoming Dou , Harumi Uenoyama
发明人： Xiaoming Dou , Harumi Uenoyama
IPC分类号： G01N21/35 , G01N21/65 , G01N33/02 , G01N33/487 , G01N33/497 , G01N21/47
CPC分类号： G01N33/497 , G01N21/65 , G01N21/359
摘要： An apparatus and a method for measuring concentrations of components with light scattering allows measurement of concentrations of components in a measuring object to be accomplished in non-destructive fashion by using light in near-infrared wavelength ranges with good transmissivity and relatively low light quantum energy. The apparatus is composed of a light irradiator (1) for irradiating excited light in a near-infrared wavelength range to a measuring object (16), a photodetector (2) for receiving and spectrally separating Raman scattered light derived from the measuring object (16), and an arithmetic unit (3) for calculating concentration of a component in the measuring object (16) from intensity of the Raman scattered light and outputting a calculation result.
摘要翻译：用光散射测量组分浓度的装置和方法允许通过使用具有良好的透射率和相对低的光量子能的近红外波长范围内的光，以非破坏性的方式测量测量对象中的组分的浓度。该装置由用于将近红外波长范围的激发光照射到测量对象（16）的光照射器（1），用于接收和分光从测量对象（16）导出的拉曼散射光的光电检测器）和用于从拉曼散射光的强度计算测量对象（16）中的分量的浓度并输出计算结果的运算单元（3）。

10. 发明授权

US5796476A Method of optically measuring component in solution 失效
标题翻译：在溶液中光学测量组分的方法
公开(公告)号：US5796476A
公开(公告)日：1998-08-18
申请号：US672026
申请日：1996-06-26
申请人： Yung Xiang Wang , Xiaoming Dou
发明人： Yung Xiang Wang , Xiaoming Dou
IPC分类号： G01N21/64 , G01N21/65 , G01J3/44
CPC分类号： G01N21/64 , G01N21/65
摘要： A sample solution containing protein is irradiated with excitation light of a single wavelength which is emitted from a light source, so that light scattered from the sample solution is received and separated into its spectral components in a spectroscope, thereby obtaining light scattering spectra. Protein is quantitatively measured through intensity of a light scattering spectrum in a shift wavenumber of 100 to 3100 cm.sup.-1 with respect to the excitation wavelength among the light scattering spectra or an integral value in a proper range therein. As to a body fluid sample, the sample is irradiated with excitation light and Raman scattering spectral intensity values are measured at a plurality of wavenumbers in an arbitrary wavenumber range, and a plurality of components in the sample are analyzed simultaneously by multivariate regression analysis.
摘要翻译：用从光源发出的单波长的激发光照射含有蛋白质的样品溶液，使从样品溶液散射的光被接收并在分光镜中分离成其光谱成分，从而得到光散射光谱。通过相对于光散射光谱中的激发波长的偏移波数为100〜3100cm -1的光散射光谱的强度或其中适当范围内的积分值，定量测定蛋白质。对于体液样品，用激发光照射样品，并且在任意波数范围内的多个波数处测量拉曼散射光谱强度值，并且通过多元回归分析同时分析样品中的多个组分。

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