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1. 发明授权

US07976837B2 Method of preventing and treating brain infarction 失效
标题翻译：预防和治疗脑梗死的方法
公开(公告)号：US07976837B2
公开(公告)日：2011-07-12
申请号：US11573429
申请日：2005-06-17
申请人： Koji Abe , Junichi Kawagoe
发明人： Koji Abe , Junichi Kawagoe
IPC分类号： A61K38/48
CPC分类号： C07K14/705 , A61K45/06
摘要： The present invention is intended to clarify the relationship between PAR-2 and cerebral infarction and thereby provide an efficient method of preventing and treating cerebral infarction, as well as a pharmaceutical composition therefore. Namely, the present invention relates to a method of preventing and treating cerebral infarction by activating PAR-2 and/or promoting expression of PAR-2 gene. The present invention further relates to a pharmaceutical composition for preventing and treating cerebral infarction, comprising one, or two or more of the active ingredients selected from the group consisting of a PAR-2 activator and/or a PAR-2 gene expression promoter; as well as a pharmaceutically acceptable carrier. It further relates to a method of screening an active ingredient for preventing and treating cerebral infarction using as an indicator the PAR-2 activation promoted by a test substance.
摘要翻译：本发明旨在阐明PAR-2与脑梗死之间的关系，从而提供预防和治疗脑梗塞的有效方法，以及由此产生的药物组合物。即，本发明涉及通过激活PAR-2和/或促进PAR-2基因的表达来预防和治疗脑梗死的方法。本发明还涉及一种预防和治疗脑梗塞的药物组合物，其包含一种或两种以上选自PAR-2激活剂和/或PAR-2基因表达启动子的活性成分; 以及药学上可接受的载体。本发明还涉及一种筛选用于预防和治疗脑梗死的活性成分的方法，所述方法使用由测试物质促进的PAR-2活化作为指标。

2. 发明申请

US20090263374A1 METHOD OF PREVENTING AND TREATING BRAIN INFARCTION 失效
标题翻译：预防和治疗脑梗塞的方法
公开(公告)号：US20090263374A1
公开(公告)日：2009-10-22
申请号：US11573429
申请日：2005-06-17
申请人： Koji Abe , Junichi Kawagoe
发明人： Koji Abe , Junichi Kawagoe
IPC分类号： A61K38/48 , A61K38/16 , A61K38/06 , A61K38/07 , A61K38/08 , C12Q1/68 , A61P25/00
CPC分类号： C07K14/705 , A61K45/06
摘要： The present invention is intended to clarify the relationship between PAR-2 and cerebral infarction and thereby provide an efficient method of preventing and treating cerebral infarction, as well as a pharmaceutical composition therefore. Namely, the present invention relates to a method of preventing and treating cerebral infarction by activating PAR-2 and/or promoting expression of PAR-2 gene. The present invention further relates to a pharmaceutical composition for preventing and treating cerebral infarction, comprising one, or two or more of the active ingredients selected from the group consisting of a PAR-2 activator and/or a PAR-2 gene expression promoter; as well as a pharmaceutically acceptable carrier. It further relates to a method of screening an active ingredient for preventing and treating cerebral infarction using as an indicator the PAR-2 activation promoted by a test substance.
摘要翻译：本发明旨在阐明PAR-2与脑梗死之间的关系，从而提供预防和治疗脑梗塞的有效方法，以及由此产生的药物组合物。即，本发明涉及通过激活PAR-2和/或促进PAR-2基因的表达来预防和治疗脑梗死的方法。本发明还涉及一种预防和治疗脑梗塞的药物组合物，其包含一种或两种以上选自PAR-2激活剂和/或PAR-2基因表达启动子的活性成分; 以及药学上可接受的载体。本发明还涉及一种筛选用于预防和治疗脑梗死的活性成分的方法，所述方法使用由测试物质促进的PAR-2活化作为指标。

3. 发明授权

US09371268B2 Method for producing asymmetric chain carbonate 有权
标题翻译：生产不对称链碳酸酯的方法
公开(公告)号：US09371268B2
公开(公告)日：2016-06-21
申请号：US13061329
申请日：2009-08-31
申请人： Koji Abe , Akikazu Ito
发明人： Koji Abe , Akikazu Ito
IPC分类号： C07C69/96 , C07C68/00
CPC分类号： C07C68/00 , C07C69/96
摘要： An asymmetric chain carbonate can be produced in a single-step reaction comprising a step of reacting methyl nitrite, carbon monoxide, and 0.05-1.5 moles of an aliphatic alcohol having 2-6 carbon atoms or an alicyclic alcohol having 5-6 carbon atoms per one mole of methyl nitrile in a gaseous phase in the presence of a solid catalyst comprising a platinum group metal or a compound thereof placed on a support.
摘要翻译：可以在单步反应中制备不对称链碳酸酯，其包括使亚硝酸甲酯，一氧化碳和0.05-1.5摩尔具有2-6个碳原子的脂族醇或具有5-6个碳原子的脂环族醇反应的步骤在含有铂族金属或其化合物的固体催化剂存在下，在气相中加入1摩尔甲基腈。

4. 发明授权

US09364400B2 Water-in-oil emulsified sunscreen cosmetic 有权
标题翻译：油包水乳化防晒化妆品
公开(公告)号：US09364400B2
公开(公告)日：2016-06-14
申请号：US14002124
申请日：2012-08-09
申请人： Yosuke Ikebe , Koji Abe
发明人： Yosuke Ikebe , Koji Abe
IPC分类号： A61Q17/04 , A61K8/06 , A61K8/895 , A61K8/81 , A61K8/894 , A61K8/02
CPC分类号： A61K8/064 , A61K8/0254 , A61K8/8152 , A61K8/894 , A61K8/895 , A61K2800/612 , A61Q17/04
摘要： The present invention provides a water-in-oil emulsified sunscreen cosmetic characteristically comprising the following (a) through (g): (a) Ultraviolet absorbent (b) Silicone backbone powder (c) Methyl polymethacrylate powder (d) Hydrophobicized platelike powder (e) Surfactant (f) Oil component (g) Water The object of the present invention is to provide a water-in-oil emulsified sunscreen cosmetic that manifests a superior texture during use, a high ultraviolet protection effect, and superior stability.
摘要翻译：本发明提供一种油包水乳化防晒化妆品，其特征在于包括以下（a）至（g）：（a）紫外线吸收剂（b）硅酮骨架粉末（c）聚甲基丙烯酸甲酯粉末（d）疏水性扁平粉末）表面活性剂（f）油成分（g）水本发明的目的是提供一种油包水乳化防晒化妆品，其在使用中表现出优异的质地，高的紫外线防护效果和优异的稳定性。

5. 发明授权

US09362595B2 Nonaqueous electrolytic solution and energy storage device using same 有权
标题翻译：非水电解液及储能装置使用
公开(公告)号：US09362595B2
公开(公告)日：2016-06-07
申请号：US14111451
申请日：2012-03-26
申请人： Koji Abe , Kazuhiro Miyoshi , Yuichi Kotou
发明人： Koji Abe , Kazuhiro Miyoshi , Yuichi Kotou
IPC分类号： H01M10/056 , H01M10/0567 , H01M10/0569 , H01M10/0525 , H01G11/06 , H01G11/60 , H01M10/48 , H01G11/64
CPC分类号： H01M10/0569 , H01G11/06 , H01G11/60 , H01G11/64 , H01M10/0525 , H01M10/0567 , H01M10/48 , H01M2200/20 , H01M2220/20 , Y02E60/122 , Y02E60/13 , Y02T10/7011 , Y02T10/7022
摘要： The present invention is to provide a nonaqueous electrolytic solution prepared by dissolving an electrolyte salt in a nonaqueous solvent, wherein the nonaqueous solvent includes 0.01 to 40% by volume of an ester having two alkyl groups at the α-position carbon of the carbonyl group and being represented by the following general formula (I), and an energy storage device. (in the above formula, R1 is an alkyl group, an alkenyl group or an alkynyl group in which at least one of the hydrogen atoms may be substituted with a halogen atom, R2 and R3 are an alkyl group in which at least one of the hydrogen atoms may be substituted with a halogen atom, and R2 and R3 may be linked to each other to form a ring. However, when R2 and R3 do not form a ring, R3 is an alkyl group in which at least one of the hydrogen atoms may be substituted with a halogen atom.).
摘要翻译：本发明提供一种通过将电解质盐溶解在非水溶剂中制备的非水电解液，其中非水溶剂包括0.01至40体积％的在羰基的α-位碳上具有两个烷基的酯，由以下通式（I）表示，以及储能装置。（在上式中，R 1是其中至少一个氢原子可以被卤素原子取代的烷基，烯基或炔基，R 2和R 3是烷基，其中至少一个氢原子可以被卤素原子取代，R2和R3可以彼此连接形成环，但是当R2和R3不形成环时，R3是烷基，其中至少一个氢原子可以被卤素原子取代）。

6. 发明授权

US09236635B2 Non-aqueous electrolyte and electricity storage device using same 有权
标题翻译：非水电解质和蓄电装置使用相同
公开(公告)号：US09236635B2
公开(公告)日：2016-01-12
申请号：US14237492
申请日：2012-08-07
申请人： Koji Abe , Kei Shimamoto
发明人： Koji Abe , Kei Shimamoto
IPC分类号： H01M10/0567 , H01M10/0569 , H01M10/0525 , H01M4/131 , H01M4/505 , H01M4/52 , H01M4/58 , H01M4/583 , H01M4/38 , H01M4/485 , C07C309/65 , H01M10/052 , C07C69/65 , C07D327/00 , H01M10/0568
CPC分类号： H01M10/0567 , C07C69/65 , C07C309/65 , C07D327/00 , H01M4/13 , H01M4/131 , H01M4/386 , H01M4/387 , H01M4/485 , H01M4/505 , H01M4/52 , H01M4/525 , H01M4/5825 , H01M4/583 , H01M4/587 , H01M10/052 , H01M10/0525 , H01M10/0568 , H01M10/0569 , Y02E60/122 , Y02T10/7011
摘要： The present invention provides a nonaqueous electrolytic solution capable of improving electrochemical characteristics in a broad temperature range, such as low-temperature cycle properties and low-temperature discharge properties after high-temperature storage, and provides an energy storage device using the nonaqueous electrolytic solution. The invention includes (1) a nonaqueous electrolytic solution of an electrolyte salt dissolved in a nonaqueous solvent, which comprises from 0.001 to 10% by mass of a compound represented by the following general formula (I), and (2) an energy storage device comprising a positive electrode, a negative electrode, and a nonaqueous electrolytic solution of an electrolyte salt dissolved in a nonaqueous solvent, wherein the nonaqueous electrolytic solution is the nonaqueous electrolytic solution of (1). (In the formula, Y represents a group —C(═O)— or a group —S(═O)2—; R3 and R4 each independently represent an aryl group having from 6 to 10 carbon atoms in which at least one hydrogen atom is substituted with a halogen atom, or R3 and R4 bonding to each other represent a cycloalkanediyl group or a benzenediyl group, having from 5 to 12 carbon atoms. R represents —C(R1)(R2)— or -L-; R1 and R2 each independently represent a hydrogen atom, a halogen atom, or an alkyl group having from 1 to 4 carbon atoms; and L represents a divalent linking group having from 1 to 6 carbon atoms and optionally substituted with a halogen atom).
摘要翻译：本发明提供一种能够在高温保存后的低温循环特性和低温放电性等宽温度范围内提高电化学特性的非水电解液，提供使用该非水电解液的储能装置。本发明包括（1）溶解在非水溶剂中的电解质盐的非水电解液，其含有0.001〜10质量％的下述通式（I）表示的化合物，和（2）能量储存装置包括正极，负极和溶解在非水溶剂中的电解质盐的非水电解液，其中非水电解液是（1）的非水电解液。（在该式中，Y表示基团-C（= O） - 或基团-S（= O）2 - ; R 3和R 4各自独立地表示具有6至10个碳原子的芳基，其中至少一个氢原子被卤素原子取代，或者R 3和R 4彼此键合表示具有5至12个碳原子的环烷二基或苯二基，R表示-C（R 1）（R 2） - 或-L-; R 1 和R 2各自独立地表示氢原子，卤素原子或具有1〜4个碳原子的烷基; L表示具有1〜6个碳原子并且任选被卤素原子取代的二价连接基团）。

7. 发明授权

US08948652B2 Image forming apparatus and process unit that form images by using photosensitive bodies and developing units 有权
标题翻译：通过使用感光体和显影单元形成图像的图像形成装置和处理单元
公开(公告)号：US08948652B2
公开(公告)日：2015-02-03
申请号：US13426756
申请日：2012-03-22
申请人： Koji Abe
发明人： Koji Abe
IPC分类号： G03G21/18
CPC分类号： G03G15/0194 , G03G21/1619 , G03G21/1676 , G03G2215/0141 , G03G2221/1684
摘要： In an image forming apparatus, photosensitive bodies are mounted in a first frame. Developing units are detachably mounted in the first frame. A second frame is movable relative to the first frame. Each developing unit is movable relative to the first frame between a separate position, at which a developing roller is separate from a photosensitive body, and a contact position, at which the developing roller is in contact with the photosensitive body. The second frame moves relative to the first frame, thereby moving the developing units relative to the first frame between the separate positions and the contact positions. The second frame positions each developing unit relative to the first frame in a direction to move the developing roller toward the corresponding photosensitive body when the developing unit is in the contact position.
摘要翻译：在图像形成装置中，感光体安装在第一框架中。显影单元可拆卸地安装在第一框架中。第二框架可相对于第一框架移动。每个显影单元可以在显影辊与感光体分开的分离位置与显影辊与感光体接触的接触位置之间相对于第一框架移动。第二框架相对于第一框架移动，从而相对于第一框架在分开的位置和接触位置之间移动显影单元。当显影单元处于接触位置时，第二框架在使显影辊朝向相应感光体的方向上相对于第一框架定位每个显影单元。

8. 发明授权

US08790630B2 Pure chlorine dioxide solution, and gel-like composition and foaming composition each comprising the same 有权
标题翻译：纯二氧化氯溶液，以及各自包含其的凝胶状组合物和发泡组合物
公开(公告)号：US08790630B2
公开(公告)日：2014-07-29
申请号：US13618585
申请日：2012-09-14
申请人： Koji Abe
发明人： Koji Abe
IPC分类号： A61L9/00 , A61K33/14 , A61K8/18
CPC分类号： C02F1/50 , A01N59/00 , A61L2/18 , A61L2/22 , A61L9/012 , A61L9/14 , C01B11/022 , C02F1/76 , C02F2303/04 , C02F2303/12 , A01N25/04 , A01N25/16 , A01N2300/00
摘要： A pure chlorine dioxide solution includes a chlorine dioxide gas dissolved therein, a chlorite, and a pH adjuster which is an acid or a salt thereof having a buffering property whose pH is 2.5 to 6.8 as a 5% aqueous solution at 25° C.
摘要翻译：纯二氧化氯溶液包括溶解于其中的二氧化氯气体，亚氯酸盐和pH调节剂，其是在25℃下作为5％水溶液的pH为2.5至6.8的缓冲性质的酸或其盐。

9. 发明申请

US20140120144A1 Thin Film Supporting Hyaluronic Acid Or Derivative Thereof And Thin Film Cosmetic 审中-公开
标题翻译：薄膜支持透明质酸或其衍生物和薄膜化妆品
公开(公告)号：US20140120144A1
公开(公告)日：2014-05-01
申请号：US14125649
申请日：2012-06-14
申请人： Koji Abe , Satoshi Yamaki , Eriko Takeoka , Tomoko Kimura , Naomi Kunisawa , Shinji Takeoka , Toshinori Fujie , Kohki Kabata , Akihiro Saito
发明人： Koji Abe , Satoshi Yamaki , Eriko Takeoka , Tomoko Kimura , Naomi Kunisawa , Shinji Takeoka , Toshinori Fujie , Kohki Kabata , Akihiro Saito
IPC分类号： A61K8/02 , A61Q19/00
CPC分类号： A61K8/0216 , A61K8/0212 , A61K8/735 , A61K8/85 , A61Q19/00 , A61Q19/08 , Y10T156/10
摘要： The present invention provides a thin film having an excellent manageability, moisture-retaining effect, and unevenness correction effect and a thin film cosmetic. The thin film of the present invention is a laminate of (a) a base film supporting hyaluronic acid or a derivative thereof and (b) a carrier, wherein the thickness of film (a) is 10 to 500 nm.
摘要翻译：本发明提供了具有优异的易控性，保湿效果和不均匀性校正效果的薄膜以及薄膜化妆品。本发明的薄膜是（a）支撑透明质酸或其衍生物的底膜和（b）载体的层压体，其中膜（a）的厚度为10〜500nm。

10. 发明授权

US08673508B2 Nonaqueous electrolyte for lithium battery and lithium battery using same 有权
标题翻译：锂电池和锂电池的非水电解液使用相同
公开(公告)号：US08673508B2
公开(公告)日：2014-03-18
申请号：US12935691
申请日：2009-03-18
申请人： Koji Abe , Kazuhiro Miyoshi
发明人： Koji Abe , Kazuhiro Miyoshi
IPC分类号： H01M10/056 , H01M6/14
CPC分类号： H01M10/0568 , H01M10/0569
摘要： A nonaqueous electrolytic solution for lithium battery comprises an electrolyte salt dissolved in a nonaqueous solvent and contains a carboxylate compound represented by the following general formula (I) in an amount of from 0.01 to 10% by mass of the nonaqueous electrolytic solution. (In the formula R1 and R2 each independently represent a hydrogen atom, or an alkyl group having from 1 to 6 carbon atoms; R3 represents a hydrogen atom, a methyl group, or a group —CH2CO2CR1R2C≡CH (R1 and R2 have the same meaning as above).) A lithium battery uses the nonaqueous electrolytic solution having excellent cycle property and storage property.
摘要翻译：用于锂电池的非水电解液包含溶解在非水溶剂中的电解质盐，并且含有由以下通式（I）表示的羧酸盐化合物，其量为非水电解液的0.01至10质量％。（式中，R 1和R 2各自独立地表示氢原子或碳原子数1〜6的烷基，R 3表示氢原子，甲基或-CH 2 CO 2 CR 1 R 2 C = CH（R 1和R 2相同如上所述）。锂电池使用具有优异的循环性能和储存性能的非水电解液。

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