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1. 发明申请

US20100312255A1 METHOD OF PRODUCING MEDICAL INSTRUMENT 有权
标题翻译：生产医用仪器的方法
公开(公告)号：US20100312255A1
公开(公告)日：2010-12-09
申请号：US12864074
申请日：2008-12-17
申请人： Kohsuke Satake , Kazuharu Niwa , Ryo Matsushita , Yasuhiko Suzuki , Hiroko Nomura , Kazuhiko Nakada
发明人： Kohsuke Satake , Kazuharu Niwa , Ryo Matsushita , Yasuhiko Suzuki , Hiroko Nomura , Kazuhiko Nakada
IPC分类号： A61F9/007 , B05D3/10
CPC分类号： A61F2/1664 , A61F2/0077 , A61F2/1675 , A61L29/085 , A61L31/10 , C09D101/14 , C09D101/32
摘要： A method of producing a medical instrument whereby a highly hydrophilic and lubricant coating layer having a high durability can be formed by a simple technique and thus highly hydrophilic and lubricant properties can be imparted to a surface of a medical instrument. An intraocular lens insertion instrument having been subjected to a surface treatment as described above is also provided. The method comprises the steps of: preparing a coating solution by mixing at least a water-insoluble polymer having carboxyl group and a polyfunctional reactive compound with an organic solvent; applying this solution on the surface of the medical instrument; conducting crosslinking; and performing a chemical reaction process whereby the coating layer is made hydrophilic. The intraocular lens insertion instrument is made hydrophilic by forming the coating layer as described above on an inner surface of an insertion tube portion, crosslinking and then performing the chemical reaction process.
摘要翻译：通过简单的技术可以形成具有高耐久性的高亲水性和润滑性涂层的医疗器械的制造方法，能够赋予医疗器械表面更高的亲水性和润滑性。还提供了如上所述进行了表面处理的眼内透镜插入器具。该方法包括以下步骤：通过将至少具有羧基的水不溶性聚合物和多官能反应性化合物与有机溶剂混合来制备涂布溶液; 将该溶液施用在医疗器械的表面上; 进行交联; 并进行化学反应过程，由此使涂层成为亲水性。通过在插入管部的内表面上形成如上所述的涂层，进行交联，然后进行化学反应处理，使眼内透镜插入器具亲水。

2. 发明授权

US07662937B2 Polymerizable dye and ophthalmic lens containing the same 有权
标题翻译：可聚合染料和含有它的眼科镜片
公开(公告)号：US07662937B2
公开(公告)日：2010-02-16
申请号：US11910758
申请日：2006-03-03
申请人： Kohsuke Satake , Kazuharu Niwa
发明人： Kohsuke Satake , Kazuharu Niwa
IPC分类号： C09B43/18 , G02C7/04
CPC分类号： C09B69/106 , C09B43/20
摘要： A novel benzophenone type polymerizable dye containing a urethane bond and an ophthalmic lens containing the said polymerizable dye are disclosed. The benzophenone type polymerizable dye is shown by the following general formula (1) (wherein R1 and R2 are respectively and independently a hydrogen atom, a hydroxyl group, a carboxylic group, a C1 to C8 alkyl group, a C1 to C8 alkoxy group, a sulfonic acid group or a benzyloxy group, and m and n are respectively and independently an integer of 0 to 18. R3 is any of a polymerizable functional group of a vinyl group, an acryloyl group or a methacryloyl group).
摘要翻译：公开了含有氨基甲酸酯键的新型二苯甲酮型可聚合染料和含有所述可聚合染料的眼用透镜。二苯甲酮型聚合性染料由以下通式（1）表示（其中，R1和R2分别独立地为氢原子，羟基，羧基，C1〜C8烷基，C1〜C8烷氧基，磺酸基或苄氧基，m和n分别为0〜18的整数.R 3为乙烯基，丙烯酰基或甲基丙烯酰基的聚合性官能团中的任意一种。

3. 发明申请

US20090082553A1 Novel Polymerizable Dye and Ophthalmic Lens Containing the Same 有权
标题翻译：新型可聚合染料和含有其的眼科镜片
公开(公告)号：US20090082553A1
公开(公告)日：2009-03-26
申请号：US11910758
申请日：2006-03-03
申请人： Kohsuke Satake , Kazuharu Niwa
发明人： Kohsuke Satake , Kazuharu Niwa
IPC分类号： C09B29/03 , G02C7/10
CPC分类号： C09B69/106 , C09B43/20
摘要： A novel benzophenone type polymerizable dye containing a urethane bond and an ophthalmic lens containing the said polymerizable dye are disclosed. The benzophenone type polymerizable dye is shown by the following general formula (1) (wherein R1 and R2 are respectively and independently a hydrogen atom, a hydroxyl group, a carboxylic group, a C1 to C8 alkyl group, a C1 to C8 alkoxy group, a sulfonic acid group or a benzyloxy group, and m and n are respectively and independently an integer of 0 to 18. R3 is any of a polymerizable functional group of a vinyl group, an acryloyl group or a methacryloyl group).
摘要翻译：公开了含有氨基甲酸酯键的新型二苯甲酮型可聚合染料和含有所述可聚合染料的眼用透镜。二苯甲酮型聚合性染料由以下通式（1）表示（其中，R1和R2分别独立地为氢原子，羟基，羧基，C1〜C8烷基，C1〜C8烷氧基，磺酸基或苄氧基，m和n分别为0〜18的整数.R 3为乙烯基，丙烯酰基或甲基丙烯酰基的聚合性官能团中的任意一种。

4. 发明授权

US08523878B2 Method of producing medical instrument 有权
标题翻译：医疗器械生产方法
公开(公告)号：US08523878B2
公开(公告)日：2013-09-03
申请号：US12864074
申请日：2008-12-17
申请人： Kohsuke Satake , Kazuharu Niwa , Ryo Matsushita , Yasuhiko Suzuki , Hiroko Nomura , Kazuhiko Nakada
发明人： Kohsuke Satake , Kazuharu Niwa , Ryo Matsushita , Yasuhiko Suzuki , Hiroko Nomura , Kazuhiko Nakada
IPC分类号： A61F9/00 , A61F2/16 , A61L33/00
CPC分类号： A61F2/1664 , A61F2/0077 , A61F2/1675 , A61L29/085 , A61L31/10 , C09D101/14 , C09D101/32
摘要： A method of producing a medical instrument whereby a highly hydrophilic and lubricant coating layer having a high durability can be formed by a simple technique and thus highly hydrophilic and lubricant properties can be imparted to a surface of a medical instrument. An intraocular lens insertion instrument having been subjected to a surface treatment as described above is also provided. The method includes preparing a coating solution by mixing at least a water-insoluble polymer having carboxyl group and a polyfunctional reactive compound with an organic solvent; applying this solution on the surface of the medical instrument; conducting crosslinking; and performing a chemical reaction process. The coating layer is made hydrophilic. The intraocular lens insertion instrument is made hydrophilic by forming the coating layer as described above on an inner surface of an insertion tube portion, crosslinking and then performing the chemical reaction process.
摘要翻译：通过简单的技术可以形成具有高耐久性的高亲水性和润滑性涂层的医疗器械的制造方法，能够赋予医疗器械表面更高的亲水性和润滑性。还提供了如上所述进行了表面处理的眼内透镜插入器具。该方法包括通过将至少具有羧基的水不溶性聚合物和多官能反应性化合物与有机溶剂混合来制备涂布溶液; 将该溶液施用在医疗器械的表面上; 进行交联; 并进行化学反应过程。使涂层成为亲水性。通过在插入管部的内表面上形成如上所述的涂层，进行交联，然后进行化学反应处理，使眼内透镜插入器具亲水。

5. 发明申请

US20090030514A1 INTRAOCULAR LENS 有权
标题翻译：内窥镜
公开(公告)号：US20090030514A1
公开(公告)日：2009-01-29
申请号：US11912499
申请日：2005-05-20
申请人： Kazuharu Niwa , Yutaka Kumazawa , Atsushi Kobayashi
发明人： Kazuharu Niwa , Yutaka Kumazawa , Atsushi Kobayashi
IPC分类号： A61F2/16
CPC分类号： A61F2/1613 , A61F2002/1683
摘要： An intraocularlens of novel structure by which the outer circumferential part of an optical portion can be pressed stably against a posterior capsule under worn state and crisis of secondary cataract can be suppressed more advantageously. A pair of coupling portions (14, 14) are formed to hold an optical portion (12) between them in one direction perpendicular to the optical axis, wherein the outer fringe parts of the coupling portions (14, 14) are made thicker than the outer fringe part of the optical portion (12), a pair of supporting portions (16, 16) are formed to project from the outer fringe parts of the coupling portions (14, 14) and a edge contour part (32) is formed continuously on the outer fringe parts of the optical portion (12) and respective posterior surfaces (20, 24) of the coupling portions (14, 14) so as to extend smoothly along the entire circumference thereof.
摘要翻译：新型结构的眼内透镜可以更有利地抑制光学部分的外圆周部分在佩戴状态下被稳定地压靠在后囊上，并且可以更有利地抑制二次白内障的危机。形成一对联接部分（14,14），以在垂直于光轴的一个方向上在其间保持光学部分（12），其中联接部分（14,14）的外边缘部分比光学部分（12）的外边缘部分，一对支撑部分（16,16）形成为从连接部分（14,14）的外边缘部分突出，并且连续地形成边缘轮廓部分（32）在所述光学部分（12）的外边缘部分和所述联接部分（14,14）的各个后表面（20,24）之间沿着其整个圆周平滑地延伸。

6. 发明授权

US06326448B1 Soft intraocular lens material 有权
标题翻译：软性眼内透镜材料
公开(公告)号：US06326448B1
公开(公告)日：2001-12-04
申请号：US09252222
申请日：1999-02-18
申请人： Tatsuya Ojio , Kazuharu Niwa , Tohru Kawaguchi
发明人： Tatsuya Ojio , Kazuharu Niwa , Tohru Kawaguchi
IPC分类号： C08F12606
CPC分类号： A61L27/50 , A61L27/16 , A61L2430/16 , C08L39/06 , C08L33/06 , C08L33/26 , C08L33/14
摘要： A soft intraocular lens material which consists essentially of a polymer obtained by polymerizing polymerizable components containing a hydrophilic monomer, and which has a water absorptivity of from 1.5 to 4.5 wt %.
摘要翻译：一种软性眼内透镜材料，其基本上由通过聚合含有亲水性单体的可聚合组分获得的聚合物组成，并且其吸水率为1.5至4.5重量％。

7. 发明授权

US06320008B2 Polymeric colorant and colored material for ocular lens using the colorant 有权
标题翻译：使用着色剂的聚合物着色剂和用于眼镜片的着色材料
公开(公告)号：US06320008B2
公开(公告)日：2001-11-20
申请号：US09836906
申请日：2001-04-17
申请人： Akira Tsuzuki , Kazuharu Niwa , Tatsuya Ojio
发明人： Akira Tsuzuki , Kazuharu Niwa , Tatsuya Ojio
IPC分类号： C08F12600
CPC分类号： A61L27/50 , A61L2430/16 , C08F220/14 , C08F220/30 , C08F220/34 , G02B1/043
摘要： A polymeric colorant represented by the following formula: A1—N═N—A2—O—(CH2)n-X wherein, A1 represents an aryl group which may have a substituent group, A2 represents an arylene group which may have a substituent group, X represents one of an acryloyloxy group, a methacryloyloxy group, a vinylphenyl group, a vinylphenyloxy group, and a vinylphenylalkyloxy group whose alkyl portion has 1-5 carbon atoms, and n is an integer of 1-5, and a colored material for an ocular lens which uses to the polymeric colorant is also disclosed.
摘要翻译：由下式表示的聚合物着色剂：其中，A 1表示可以具有取代基的芳基，A 2表示可以具有取代基的亚芳基，X表示丙烯酰氧基，甲基丙烯酰氧基，乙烯基苯基，乙烯基苯氧基和烷基部分具有1-5个碳原子的乙烯基苯基烷氧基，n为1-5的整数，并且还公开了用于该聚合物着色剂的用于眼用透镜的着色材料。

8. 发明授权

US6015511A Method for producing an intraocular lens 有权
标题翻译：眼内透镜的制造方法
公开(公告)号：US6015511A
公开(公告)日：2000-01-18
申请号：US150902
申请日：1998-09-10
申请人： Akihiro Yasuda , Kazuharu Niwa
发明人： Akihiro Yasuda , Kazuharu Niwa
IPC分类号： A61F2/16 , B29D11/02 , B29D11/00
CPC分类号： B29D11/023 , B29C2793/00
摘要： An intraocular lens of one-piece body consisting of supporting portions 34 and an optical portion 32 is formed by forming an annular supporting-portion-forming blank 2 composed of a polymerization product for supporting portion 34, which has a thickness to form the supporting portion 34 for an intraocular lens and has a through hole 4 formed by concentrically drilling the central portion on the basis of the outer diameter of the blank; forming a composite-lens-forming blank 24 by filling in the through hole a monomer composition 16 for forming another polymerization product 22 for the optical portion followed by polymerizing it whereby the polymerization product 22 is formed integrally in the through hole; and processing the blank 24 on the basis of its outer diameter.
摘要翻译：由支撑部分34和光学部分32组成的一体式人造眼镜透镜通过形成由用于支撑部分34的聚合产物构成的环形支撑部分成形坯料2而形成，该坯料具有形成支撑部分的厚度 34，其具有通过基于坯料的外径同心钻孔中心部而形成的通孔4; 通过在通孔中填充单体组合物16形成复合透镜成形坯料24，形成用于光学部分的另一聚合产物22，随后聚合，由此聚合产物22一体地形成在通孔中; 并且基于其外径来处理坯件24。

9. 发明授权

US09398950B2 Intraocular lens insertion tool 有权
公开(公告)号：US09398950B2
公开(公告)日：2016-07-26
申请号：US14342822
申请日：2012-09-13
申请人： Kazuharu Niwa , Yasuhiko Suzuki , Masayoshi Tanaka
发明人： Kazuharu Niwa , Yasuhiko Suzuki , Masayoshi Tanaka
IPC分类号： A61F2/16
摘要： An intraocular lens insertion tool including: a cylindrical tool body provided with a placement part at which is placed an intraocular lens having an optical part, and a pair of support parts extending from either side of the optical part; and a plunger for pushing out the intraocular lens; the intraocular lens insertion tool being provided in a state in which the intraocular lens is preset in the placement part, wherein at least one of the front support part extending toward a tip end of the tool body and the rear support part extending toward a rear end of the tool body is pre-deformed by abutting against an abutting projection disposed inside the placement part.

10. 发明申请

US20130093994A1 COLORED CONTACT LENS 有权
标题翻译：彩色接触镜
公开(公告)号：US20130093994A1
公开(公告)日：2013-04-18
申请号：US13704876
申请日：2011-06-17
申请人： Ichiro Ando , Yuji Goto , Ryo Matsushita , Kazuharu Niwa
发明人： Ichiro Ando , Yuji Goto , Ryo Matsushita , Kazuharu Niwa
IPC分类号： G02C7/04
CPC分类号： G02C7/046 , B41M5/0047 , B41M5/0064 , B41M5/0088 , G02C7/021 , G02C7/04 , G02C2202/16
摘要： Provided is a colored contact lens in which a colored band is disposed at a boundary part between a dark part and a white part of an eye, and a density is gradually changed from the dark part to the white part of the eye such that the density of this colored band decreases from an inner circumference side to an outer circumference side. As a result, a novel colored contact lens is provided with which it is possible to bring out beauty of the white part of the eye, which has been ignored by conventional technology, while an impression is maintained that is as natural and elegant as possible by avoiding an artificial impression such as that found in conventional technology.
摘要翻译：提供一种彩色隐形眼镜，其中着色带设置在眼睛的黑暗部分和白色部分之间的边界部分处，并且密度从眼睛的黑暗部分逐渐变为白色部分，使得密度该彩色带从内周侧向外周侧减小。结果，提供了一种新颖的彩色隐形眼镜，可以通过传统技术忽视的眼睛的白色部分的美丽，同时保持尽可能自然和优雅的印象避免了人造印象，例如在传统技术中发现的印象。

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