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1. 发明授权

US08103349B2 Neural electrode treatment 有权
标题翻译：神经电极治疗
公开(公告)号：US08103349B2
公开(公告)日：2012-01-24
申请号：US12638266
申请日：2009-12-15
申请人： Adrianus P. Donders , Koen J. Weijand , Mark B. Knudson
发明人： Adrianus P. Donders , Koen J. Weijand , Mark B. Knudson
IPC分类号： A61N1/06 , A61N1/36
CPC分类号： A61N1/36146 , A61N1/36053 , A61N1/36085 , A61N1/36114
摘要： An apparatus for applying a signal to a nerve for the treatment of a disorder includes a first electrode and a second electrode. Each of the electrodes is adapted to be secured to a nerve of a patient. A signal generator is electrically connected to each of the first and second electrodes. The signal generator is adapted to create a signal having a first waveform at the first electrode and a second waveform at the second electrode. The waveforms have parameters selected to block propagation of neural action potentials. The waveforms have a repeating pattern of cycles of pulses with a delay period between at least selected ones of said pulses. In one embodiment, the first and second waveforms are out of phase for a cycle of one of the waveforms to occur during a delay period of the other of the waveforms.
摘要翻译：用于向神经施加信号以用于治疗病症的装置包括第一电极和第二电极。每个电极适于固定到患者的神经。信号发生器电连接到第一和第二电极中的每一个。信号发生器适于产生在第一电极处具有第一波形的信号和在第二电极处的第二波形。波形具有选择的参数以阻止神经动作电位的传播。这些波形具有脉冲周期的重复模式，其中所述脉冲中的至少一个选择之间具有延迟周期。在一个实施例中，在另一个波形的延迟周期期间，波形中的一个波形的周期是第一和第二波形异相。

2. 发明授权

US07672727B2 Neural electrode treatment 有权
标题翻译：神经电极治疗
公开(公告)号：US07672727B2
公开(公告)日：2010-03-02
申请号：US11205415
申请日：2005-08-17
申请人： Adrianus P. Donders , Koen J. Weijand , Mark B. Knudson
发明人： Adrianus P. Donders , Koen J. Weijand , Mark B. Knudson
IPC分类号： A61N1/06 , A61N1/36
CPC分类号： A61N1/36146 , A61N1/36053 , A61N1/36085 , A61N1/36114
摘要： An apparatus for applying a signal to a nerve for the treatment of a disorder includes a first electrode and a second electrode. Each of the electrodes is adapted to be secured to a nerve of a patient. A signal generator is electrically connected to each of the first and second electrodes. The signal generator is adapted to create a signal having a first waveform at the first electrode and a second waveform at the second electrode. The waveforms have parameters selected to block propagation of neural action potentials. The waveforms have a repeating pattern of cycles of pulses with a delay period between at least selected ones of said pulses. In one embodiment, the first and second waveforms are out of phase for a cycle of one of the waveforms to occur during a delay period of the other of the waveforms.
摘要翻译：用于向神经施加信号以用于治疗病症的装置包括第一电极和第二电极。每个电极适于固定到患者的神经。信号发生器电连接到第一和第二电极中的每一个。信号发生器适于产生在第一电极处具有第一波形的信号和在第二电极处的第二波形。波形具有选择的参数以阻止神经动作电位的传播。这些波形具有脉冲周期的重复模式，其中延迟周期至少在所选择的脉冲之间。在一个实施例中，在另一个波形的延迟周期期间，波形中的一个波形的周期是第一和第二波形异相。

3. 发明申请

US20100094375A1 NEURAL ELECTRODE TREATMENT 有权
标题翻译：神经电极治疗
公开(公告)号：US20100094375A1
公开(公告)日：2010-04-15
申请号：US12638266
申请日：2009-12-15
申请人： Adrianus P. Donders , Koen J. Weijand , Mark B. Knudson
发明人： Adrianus P. Donders , Koen J. Weijand , Mark B. Knudson
IPC分类号： A61N1/36
CPC分类号： A61N1/36146 , A61N1/36053 , A61N1/36085 , A61N1/36114
摘要： An apparatus for applying a signal to a nerve for the treatment of a disorder includes a first electrode and a second electrode. Each of the electrodes is adapted to be secured to a nerve of a patient. A signal generator is electrically connected to each of the first and second electrodes. The signal generator is adapted to create a signal having a first waveform at the first electrode and a second waveform at the second electrode. The waveforms have parameters selected to block propagation of neural action potentials. The waveforms have a repeating pattern of cycles of pulses with a delay period between at least selected ones of said pulses. In one embodiment, the first and second waveforms are out of phase for a cycle of one of the waveforms to occur during a delay period of the other of the waveforms.
摘要翻译：用于向神经施加信号以用于治疗病症的装置包括第一电极和第二电极。每个电极适于固定到患者的神经。信号发生器电连接到第一和第二电极中的每一个。信号发生器适于产生在第一电极处具有第一波形的信号和在第二电极处的第二波形。波形具有选择的参数以阻止神经动作电位的传播。这些波形具有脉冲周期的重复模式，其中延迟周期至少在所选择的脉冲之间。在一个实施例中，在另一个波形的延迟周期期间，波形中的一个波形的周期是第一和第二波形异相。

4. 发明申请

US20080154333A1 NEURAL BLOCKING THERAPY 有权
标题翻译：神经阻滞治疗
公开(公告)号：US20080154333A1
公开(公告)日：2008-06-26
申请号：US12045394
申请日：2008-03-10
申请人： Mark B. Knudson , Adrianus P. Donders , Timothy R. Conrad
发明人： Mark B. Knudson , Adrianus P. Donders , Timothy R. Conrad
IPC分类号： A61N1/05
CPC分类号： A61N1/36071 , A61N1/0531 , A61N1/0534 , A61N1/0551 , A61N1/36064 , A61N1/36067
摘要： A method and apparatus are disclosed for treating a variety of conditions include treating a disorder associated with neural activity near a region of a brain. In such condition, the method includes placing an electrode to create a field near said region, creating said field with parameters selected to at least partially block neural activity within said field. For treating a tissue sensation, the method includes identifying a target area of tissue to be treated and placing an electrode to create a field near the target area, and creating the field with parameters selected to at least partially block neural activity within the target area. For treating a condition associated with neural activity of a spinal cord, the method includes placing an electrode to create a field near a nerve associated with the spinal cord, and creating the field with parameters selected to at least partially block neural activity within the nerve.
摘要翻译：公开了用于治疗各种病症的方法和装置，包括治疗与脑区域附近的神经活动相关的病症。在这种情况下，该方法包括放置电极以在所述区域附近产生场，产生具有选择以至少部分地阻止所述场内的神经活动的参数的所述场。为了治疗组织感觉，所述方法包括识别待治疗的组织的靶区域并放置电极以在目标区域附近产生场，以及创建具有选择以至少部分阻断目标区域内的神经活动的参数的场。为了治疗与脊髓的神经活动相关的病症，所述方法包括放置电极以产生与脊髓相关的神经附近的场，以及创建具有选择以至少部分阻断神经内的神经活动的参数的场。

5. 发明申请

US20110307023A1 NEURAL MODULATION DEVICES AND METHODS 有权
标题翻译：神经调制装置及方法
公开(公告)号：US20110307023A1
公开(公告)日：2011-12-15
申请号：US13154846
申请日：2011-06-07
申请人： Katherine S. Tweden , Jonathan J. Waataja , Adrianus P. Donders , Mark B. Knudson
发明人： Katherine S. Tweden , Jonathan J. Waataja , Adrianus P. Donders , Mark B. Knudson
IPC分类号： A61N1/36 , A61M37/00
CPC分类号： A61N1/36007 , A61N1/0509 , A61N1/0551 , A61N1/36053 , A61N1/36085 , A61N1/36117 , A61N1/36171 , A61N1/36178 , A61N1/37235 , A61N1/3787
摘要： A system for designing a therapy or for treating a gastrointestinal disorder or a condition associated with excess weight in a subject comprising at least one electrode configured to be implanted within a body of the patient and placed at a vagus nerve, the electrode also configured to apply therapy to the vagus nerve upon application of a therapy cycle to the electrode; an implantable neuroregulator for placement in the body of the patient beneath the skin layer, the implantable neuroregulator being configured to generate a therapy cycle, wherein the therapy cycle comprises an on time during which an electrical signal is delivered, the electrical signal comprising: a) a set of pulses applied at a first selected frequency of about 150-10,000 Hz, wherein each pulse of the set of pulses has a pulse width of at least 0.01 milliseconds and less than the period of the first selected frequency.
摘要翻译：一种用于设计用于治疗或治疗与受试者相关的胃肠疾病或与体重过重相关的病症的系统，所述系统包括至少一个被配置成植入患者体内并置于迷走神经的电极，所述电极还被配置为施加在向电极施加治疗周期时对迷走神经进行治疗; 可植入神经调节器，用于放置在皮肤层下面的患者体内，所述可植入神经调节器被配置为产生治疗周期，其中所述治疗周期包括传递电信号的接通时间，所述电信号包括：a）以大约150-10,000Hz的第一选定频率施加的一组脉冲，其中脉冲组的每个脉冲具有至少0.01毫秒且小于第一选定频率的周期的脉冲宽度。

6. 发明授权

US08798754B2 Neural blocking therapy 有权
标题翻译：神经阻滞治疗
公开(公告)号：US08798754B2
公开(公告)日：2014-08-05
申请号：US12045394
申请日：2008-03-10
申请人： Mark B. Knudson , Adrianus P. Donders , Timothy R. Conrad
发明人： Mark B. Knudson , Adrianus P. Donders , Timothy R. Conrad
IPC分类号： A61N1/36
CPC分类号： A61N1/36071 , A61N1/0531 , A61N1/0534 , A61N1/0551 , A61N1/36064 , A61N1/36067
摘要： A method and apparatus are disclosed for treating a variety of conditions include treating a disorder associated with neural activity near a region of a brain. In such condition, the method includes placing an electrode to create a field near said region, creating said field with parameters selected to at least partially block neural activity within said field. For treating a tissue sensation, the method includes identifying a target area of tissue to be treated and placing an electrode to create a field near the target area, and creating the field with parameters selected to at least partially block neural activity within the target area. For treating a condition associated with neural activity of a spinal cord, the method includes placing an electrode to create a field near a nerve associated with the spinal cord, and creating the field with parameters selected to at least partially block neural activity within the nerve.
摘要翻译：公开了用于治疗各种病症的方法和装置，包括治疗与脑区域附近的神经活动相关的病症。在这种情况下，该方法包括放置电极以在所述区域附近产生场，产生具有选择以至少部分地阻止所述场内的神经活动的参数的所述场。为了治疗组织感觉，所述方法包括识别待治疗的组织的靶区域并放置电极以在目标区域附近产生场，以及创建具有选择以至少部分阻断目标区域内的神经活动的参数的场。为了治疗与脊髓的神经活动相关的病症，所述方法包括放置电极以产生与脊髓相关的神经附近的场，以及创建具有选择以至少部分阻断神经内的神经活动的参数的场。

7. 发明授权

US08825164B2 Neural modulation devices and methods 有权
标题翻译：神经调制装置及方法
公开(公告)号：US08825164B2
公开(公告)日：2014-09-02
申请号：US13154846
申请日：2011-06-07
申请人： Katherine S. Tweden , Jonathan J. Waataja , Adrianus P. Donders , Mark B. Knudson
发明人： Katherine S. Tweden , Jonathan J. Waataja , Adrianus P. Donders , Mark B. Knudson
IPC分类号： A61N1/06 , A61N1/36
CPC分类号： A61N1/36007 , A61N1/0509 , A61N1/0551 , A61N1/36053 , A61N1/36085 , A61N1/36117 , A61N1/36171 , A61N1/36178 , A61N1/37235 , A61N1/3787
摘要： A system for designing a therapy or for treating a gastrointestinal disorder or a condition associated with excess weight in a subject comprising at least one electrode configured to be implanted within a body of the patient and placed at a vagus nerve, the electrode also configured to apply therapy to the vagus nerve upon application of a therapy cycle to the electrode; an implantable neuroregulator for placement in the body of the patient beneath the skin layer, the implantable neuroregulator being configured to generate a therapy cycle, wherein the therapy cycle comprises an on time during which an electrical signal is delivered, the electrical signal comprising: a) a set of pulses applied at a first selected frequency of about 150-10,000 Hz, wherein each pulse of the set of pulses has a pulse width of at least 0.01 milliseconds and less than the period of the first selected frequency.
摘要翻译：一种用于设计用于治疗或治疗与受试者相关的胃肠疾病或与体重过重相关的病症的系统，所述系统包括至少一个被配置成植入患者体内并置于迷走神经的电极，所述电极还被配置为施加在向电极施加治疗周期时对迷走神经进行治疗; 可植入神经调节器，用于放置在皮肤层下面的患者体内，所述可植入神经调节器被配置为产生治疗周期，其中所述治疗周期包括传递电信号的接通时间，所述电信号包括：a）以大约150-10,000Hz的第一选定频率施加的一组脉冲，其中脉冲组的每个脉冲具有至少0.01毫秒且小于第一选定频率的周期的脉冲宽度。

8. 发明授权

US09392971B2 Device and method for treating cardiac disorders by modulating autonomic response 有权
标题翻译：通过调节自主反应来治疗心脏疾病的装置和方法
公开(公告)号：US09392971B2
公开(公告)日：2016-07-19
申请号：US13515630
申请日：2010-12-03
申请人： Samuel J. Asirvatham , Mark B. Knudson
发明人： Samuel J. Asirvatham , Mark B. Knudson
IPC分类号： A61N1/05 , A61N1/20 , A61B18/14 , A61B5/00 , A61B5/04 , A61M25/00 , A61M25/04 , A61M25/10 , A61B5/02 , A61B5/0215 , A61B5/0402 , A61B18/02 , A61B18/00 , A61N1/06
CPC分类号： A61B18/1492 , A61B5/02 , A61B5/0215 , A61B5/04001 , A61B5/0402 , A61B5/4035 , A61B18/02 , A61B2018/00083 , A61B2018/00214 , A61B2018/0022 , A61B2018/00351 , A61B2018/00434 , A61B2018/00577 , A61B2018/00839 , A61B2018/00994 , A61B2218/002 , A61M25/007 , A61M25/04 , A61M25/10 , A61M2025/105 , A61N1/0587 , A61N1/06 , A61N1/20 , A61N1/36114
摘要： A method and device for modulating the autonomic nervous system adjacent a pericardial space to treat cardiac arrhythmia includes a treatment source arranged to supply a treatment medium, a catheter having an end sized for insertion into the pericardial space, a medium delivery assembly having a distal end arranged to be positioned by the catheter into the pericardium, with the distal end of the delivery assembly comprising a delivery tip arranged to extend away from the distal end of the catheter into the pericardial space. A connector operatively couples the delivery tip of the medium delivery assembly to the treatment source, and the delivery tip of the medium delivery assembly including a plurality of delivery points for delivering the treatment medium at a plurality of treatment areas within the pericardial space. The device performs modulation or ablation of the autonomic nervous system at selected treatment areas within the pericardium.
摘要翻译：用于调节毗邻心包空间以治疗心律不齐的自主神经系统的方法和装置包括：设置成供应治疗介质的治疗源，具有尺寸用于插入心包空间的端部的导管，具有远端的介质递送组件布置成由导管定位成心包，其中输送组件的远端包括布置成远离导管的远端延伸到心包空间中的输送尖端。连接器将介质输送组件的输送末端可操作地连接到治疗源，并且介质递送组件的输送末端包括用于在心包空间内的多个治疗区域处递送治疗介质的多个递送点。该装置在心包内的选定治疗区域进行自主神经系统的调制或消融。

9. 发明授权

US08768469B2 Systems for regulation of blood pressure and heart rate 有权
标题翻译：调节血压和心率的系统
公开(公告)号：US08768469B2
公开(公告)日：2014-07-01
申请号：US12537019
申请日：2009-08-06
申请人： Katherine S. Tweden , Richard R. Wilson , Mark B. Knudson , Dennis Dong-Won Kim , Deepak Bhole
发明人： Katherine S. Tweden , Richard R. Wilson , Mark B. Knudson , Dennis Dong-Won Kim , Deepak Bhole
IPC分类号： A61N1/00
CPC分类号： A61N1/36117 , A61N1/36053 , A61N1/36114 , A61N1/36139 , A61N1/37211 , A61N1/3787
摘要： A method and apparatus for treating a condition associated with impaired blood pressure and/or heart rate in a subject comprising applying an electrical treatment signal, wherein the electrical treatment signal is selected to at least partially block nerve impulses, or in some embodiments, to augment nerve impulses.
摘要翻译：一种用于治疗与受试者中受损的血压和/或心率相关的病症的方法和装置，包括施加电治疗信号，其中所述电治疗信号被选择为至少部分阻断神经冲动，或在一些实施例中增加神经冲动

10. 发明授权

US07986995B2 Bulimia treatment 有权
标题翻译：暴食症治疗
公开(公告)号：US07986995B2
公开(公告)日：2011-07-26
申请号：US11656121
申请日：2007-01-22
申请人： Mark B. Knudson , Richard R. Wilson , Katherine S. Tweden , Timothy R. Conrad
发明人： Mark B. Knudson , Richard R. Wilson , Katherine S. Tweden , Timothy R. Conrad
IPC分类号： A61N1/18
CPC分类号： A61N1/36053 , A61F5/0026 , A61N1/05 , A61N1/321 , A61N1/36007 , A61N1/36071 , A61N1/36082 , A61N1/37235
摘要： At least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient is treated by a method that includes positioning an electrode on a vagus nerve. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. In some embodiments, the disorder is bulimia. The signal may be a blocking or a stimulation signal. In some embodiments, the signal is selected to, at least in part, downregulate neural activity on the vagus nerve.
摘要翻译：通过包括将电极定位在迷走神经上的方法来治疗至少部分地由支配患者的多个器官中的至少一个的迷走神经活动表征的患者的多种病症中的至少一种。将电信号施加到电极，以通过选择用于治疗病症的量来调节迷走神经活性。在一些实施方案中，该疾病是贪食症。该信号可以是阻塞或刺激信号。在一些实施方案中，所述信号被选择为至少部分地下调迷走神经的神经活动。

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