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1. 发明授权

US5629185A Process for disintegrating cell dispersions or cell suspensions by means of ultrasonication for the purpose of isolating cell constituents 失效
标题翻译：为了分离细胞成分，通过超声波分解细胞分散液或细胞悬浮液的方法
公开(公告)号：US5629185A
公开(公告)日：1997-05-13
申请号：US256973
申请日：1994-08-01
申请人： Klaus Stanzl , Leonhard Zastrow , Joachim Roding , Karin Golz
发明人： Klaus Stanzl , Leonhard Zastrow , Joachim Roding , Karin Golz
IPC分类号： C12N13/00 , C12M3/08 , C12N1/06 , C12M1/42
CPC分类号： C12N1/066 , C12M47/06
摘要： A process capable of being continuously carried out, for disintegrating cell material in the form of dispersions or suspensions in water for the purpose of obtaining cell constituent. Selected parameters permit avoidance of use of solid ultrasonication activators and the establishment of a particular geometry form for the acoustic irradiation container. The parameters include sonotrode immersion angle, length of immersion, ratio of extent of immersion of the sonotrode relative to the acoustic irradiation volume and the ratio of extent of immersion to the solid matter content of the medium to be sonicated.
摘要翻译： PCT No.PCT / EP93 / 03406 Sec。 371日期1994年8月1日 102（e）日期1994年8月1日PCT提交1993年12月3日PCT公布。 WO94 / 13783 PCT出版物日期1994年6月23日为了获得细胞成分，能够连续地进行以分散体或悬浮液形式的细胞材料分解的方法。选择的参数允许避免使用固体超声波激活剂和建立声辐射容器的特定几何形状。参数包括超声波浸入角度，浸渍长度，超声波探针的浸入程度相对于声辐照体积的比例以及待超声处理的介质的浸渍程度与固体物质含量的比例。

2. 发明授权

US5667772A Preparation containing a fluorocarbon emulsion and usable as cosmetics or dermatics 失效
标题翻译：含有碳氟化合物乳液并可用作化妆品或皮肤的制剂
公开(公告)号：US5667772A
公开(公告)日：1997-09-16
申请号：US654026
申请日：1996-05-28
申请人： Leonhard Zastrow , Klaus Stanzl , Joachim Roding
发明人： Leonhard Zastrow , Klaus Stanzl , Joachim Roding
IPC分类号： A61K8/70 , A61Q1/02 , A61Q1/08 , A61Q1/10 , A61Q1/12 , A61Q5/02 , A61Q5/12 , A61Q15/00 , A61Q17/04 , A61Q19/00 , A61Q19/04 , A61Q19/10 , A61K7/48
CPC分类号： A61K8/0212 , A61K8/22 , A61K8/70 , A61Q19/00 , A61Q1/02 , A61Q1/08 , A61Q1/10 , A61Q1/12 , A61Q15/00 , A61Q17/04 , A61Q19/002 , A61Q19/04 , A61Q19/10 , A61Q5/00 , A61Q5/02 , Y10S514/844 , Y10S514/845 , Y10S514/846 , Y10S514/847 , Y10S514/944 , Y10S514/945
摘要： The invention relates to preparations for the improved release of oxygen into the skin and to the use of same as cosmetics/dermatics. The preparations according to this invention contain, as the essential component, fluorocarbon emulsions consisting of nonionic emulsifiers and an oxygen-loaded fluorocarbon or fluorocarbon mixture, the fluorocarbon content being in the range from 0.05 to 100% by weight/volume. They are prepared by emulsifying the corresponding components and incorporating the resulting emulsion in known carriers for, for example, ointments, creams, lotions, waters, alcoholic extracts, pastes, powders, gels, tinctures or masks.
摘要翻译：本发明涉及将氧气释放到皮肤中以及使用它们作为化妆品/皮肤用品的制剂。根据本发明的制剂含有由非离子乳化剂和含氧碳氟化合物或碳氟化合物混合物组成的碳氟化合物乳液作为必要组分，氟碳含量为0.05-100重量％/体积。它们通过乳化相应的组分并将所得乳液并入已知的载体例如软膏，霜剂，洗剂，水，醇提取物，糊剂，粉末，凝胶，酊剂或掩模中来制备。

3. 发明授权

US5686102A Pharmacological composition for topical administration 失效
标题翻译：用于局部给药的药理组合物
公开(公告)号：US5686102A
公开(公告)日：1997-11-11
申请号：US674851
申请日：1996-07-03
申请人： Udo Gross , Joachim Roding , Klaus Stanzl , Leonhard Zastrow
发明人： Udo Gross , Joachim Roding , Klaus Stanzl , Leonhard Zastrow
IPC分类号： A61K8/14 , A61K8/70 , A61K9/127 , A61Q19/00 , A61K7/00
CPC分类号： A61K8/14 , A61K8/70 , A61K9/0014 , A61K9/127 , A61Q19/00 , Y10S514/944 , Y10S514/969
摘要： The invention relates to pharmaceutical compositions which are incorporated into the skin with the aid of novel microaggregates as carriers. The object of the invention is to make available pharmacological active compounds in a biologically and chemically inert carrier for therapeutic and diagnostic administration to the skin or for systemic administration, and in this way to make deeper penetration into the skin or transdermal transport possible. According to the invention, this is effected by means of a pharmaceutical composition for topical administration, which contains asymmetric lamellar aggregates, consisting of phospholipids, pharmacological active compounds and fluorocarbons or fluorocarbon mixtures, the proportion of fluorocarbon being in the range from 1 to 100% weight/volume, in a pharmaceutical excipient which is suitable for topical administration. Preparation is effected by emulsification of the appropriate constituents and use in ointments, creams, lotions, pastes, gels, powders or on a dressing or plaster or by means of a spray.
摘要翻译：本发明涉及借助于新的微团聚体作为载体并入皮肤中的药物组合物。本发明的目的是在生物和化学惰性的载体中制备可用的药理学活性化合物，用于治疗和诊断给予皮肤或全身给药，并且以这种方式使得能够更深入地渗入皮肤或透皮传递。根据本发明，这是通过用于局部给药的药物组合物实现的，其包含由磷脂，药理活性化合物和碳氟化合物或碳氟化合物混合物组成的不对称层状聚集体，碳氟化合物的比例在1至100％重量/体积，适用于局部给药的药物赋形剂。制备通过乳化适当的组分并用于软膏，乳膏，洗剂，糊剂，凝胶，粉末或敷料或膏药或通过喷雾剂进行。

4. 发明授权

US5641509A Preparation for topical use 失效
标题翻译：局部使用准备
公开(公告)号：US5641509A
公开(公告)日：1997-06-24
申请号：US640116
申请日：1996-04-30
申请人： Udo Gross , Joachim Roding , Klaus Stanzl , Leonhard Zastrow
发明人： Udo Gross , Joachim Roding , Klaus Stanzl , Leonhard Zastrow
IPC分类号： A61K8/14 , A61K8/70 , A61K8/72 , A61Q1/10 , A61Q17/04 , A61K9/127 , A61K7/00
CPC分类号： B82Y5/00 , A61K8/14 , A61K8/70 , A61K8/72 , A61Q1/10 , A61Q17/04 , Y10S514/944 , Y10S514/969
摘要： The invention relates to a preparation for topical use, having light protection properties and in a special application form. In the known light protection agents containing the naturally occurring active compound melanin, the problem is inadequate transport of the melanin to its site of action. According to the invention, this problem is solved by a preparation for topical use which is characterised in that it contains melanin, dissolved or dispersed in one or more fluorocarbons, which are present as asymmetric lamellar phospholipid aggregates in an aqueous system together with a phospholipid, with a particle size of the aggregates in the range from 200 to 3000 nm.
摘要翻译：本发明涉及局部使用的制剂，具有防光性能和特殊应用形式。在已知的含有天然存在的活性化合物黑色素的防晒剂中，问题是黑色素运送到其作用部位的问题。根据本发明，这个问题是通过局部使用的制剂来解决的，其特征在于它含有溶解或分散在一种或多种碳氟化合物中的黑色素，它们与磷脂一起在水性体系中作为不对称层状磷脂聚集体存在，聚集体的粒度在200〜3000nm的范围内。

5. 发明授权

US5637318A Dermatological agent for assisting the transport of oxygen in the skin 失效
标题翻译：用于辅助皮肤中氧气运输的皮肤病药
公开(公告)号：US5637318A
公开(公告)日：1997-06-10
申请号：US674850
申请日：1996-07-03
申请人： Udo Gross , Joachim Roding , Klaus Stanzl , Leonhard Zastrow
发明人： Udo Gross , Joachim Roding , Klaus Stanzl , Leonhard Zastrow
IPC分类号： A61K9/06 , A61K8/00 , A61K8/11 , A61K8/14 , A61K8/55 , A61K8/58 , A61K9/08 , A61K9/107 , A61K9/127 , A61K9/14 , A61K9/70 , A61K31/02 , A61K31/025 , A61K31/08 , A61K31/13 , A61K31/34 , A61K31/535 , A61K31/66 , A61K38/16 , A61K47/24 , A61P3/00 , A61Q19/00 , A61K7/00
CPC分类号： A61K9/127 , A61K31/02 , A61K31/025 , A61K31/08 , A61K31/13 , A61K31/34 , A61K31/535 , Y10S514/964 , Y10S514/969
摘要： The invention relates to a dermatological agent for assisting the transport of oxygen in the skin, a process for its preparation and the use thereof. The problem with the known dermatological agents is the inadequate supply of oxygen to the skin and the adjoining tissue. The object of the invention is therefore to get through the horny layer of the skin and the epidermis by penetration processes in order to increase the oxygen concentration in the dermal area and adjoining tissue and to activate metabolic processes. According to the invention, this is effected by means of a dermatological agent containing asymmetric lamellar aggregates, consisting of phospholipids and oxygen-laden fluorocarbon or fluorocarbon mixture, the amount of fluorocarbon being in the range from 0.2 to 100% weight/volume, in a carrier which is suitable for dermatological use. Preparation is effected by emulsification of the corresponding constituents, and use in ointments, creams, lotions, waters, alcoholic extracts, pastes, powders, gels, tinctures or on dressings and plasters or in a spray.
摘要翻译： PCT No.PCT / DE93 / 00572 Sec。 371日期1994年12月22日第 102（e）日期1994年12月22日PCT提交1993年6月24日PCT公布。公开号WO94 / 00109 日期1994年1月6日本发明涉及一种用于辅助皮肤中氧气输送的皮肤病药，其制备方法及其用途。已知皮肤病学药剂的问题是氧气供应不足于皮肤和邻接的组织。因此，本发明的目的是通过渗透过程渗透皮肤和表皮的角质层，以增加皮肤区域和毗邻组织中的氧浓度并激活代谢过程。根据本发明，这通过含有由磷脂和含氧碳氟化合物或碳氟化合物混合物组成的不对称层状聚集体的皮肤病学试剂来实现，碳氟化合物的量在0.2至100重量/体积的范围内，适用于皮肤病学用途的载体。制剂通过乳化相应的成分进行，并用于软膏，霜剂，洗剂，水，酒精提取物，糊剂，粉末，凝胶，酊剂，敷料和膏药或喷雾剂中。

6. 发明授权

US5643601A Phospholipid-and fluorocarbon-containing cosmetic 失效
标题翻译：含磷脂和含碳氟化合物的化妆品
公开(公告)号：US5643601A
公开(公告)日：1997-07-01
申请号：US674849
申请日：1996-07-03
申请人： Udo Gross , Joachim Roding , Klaus Stanzl , Leonhard Zastrow
发明人： Udo Gross , Joachim Roding , Klaus Stanzl , Leonhard Zastrow
IPC分类号： A61K8/14 , A61K8/70 , A61Q1/10 , A61Q5/00 , A61Q19/00 , A61K9/127 , A61K7/00
CPC分类号： A61Q19/00 , A61K8/0212 , A61K8/14 , A61K8/22 , A61K8/70 , A61Q1/02 , A61Q1/10 , A61Q15/00 , A61Q17/04 , A61Q19/002 , A61Q19/10 , A61Q5/00 , A61Q5/02 , Y10S514/944 , Y10S514/969
摘要： The invention relates to a cosmetic for assisting the transport of oxygen in the skin, a process for its preparation and the use thereof. The problem with the known cosmetics is the inadequate oxygen supply to the skin and the adjoining tissue. The object of the invention is therefore to get through the horny layer of the skin and the epidermis by penetration processes in order to increase the oxygen concentration in the dermal area and adjoining tissue and to activate metabolic processes. According to the invention, this is effected by a cosmetic containing asymmetric lamellar aggregates, consisting of phospholipids and oxygen-laden fluorocarbon or fluorocarbon mixture, the amount of fluorocarbon being in the range from 0.2 to 100% weight/volume, in a carrier suitable for dermatological use. Preparation is effected by emulsification of the corresponding constituents, and use in ointments, creams, lotions, waters, alcoholic extracts, pastes, powders, gels, tinctures or on dressings and plasters or in a spray.
摘要翻译：本发明涉及一种用于辅助皮肤中氧气输送的化妆品，其制备方法及其用途。已知化妆品的问题是对皮肤和相邻组织的氧气供应不足。因此，本发明的目的是通过渗透过程渗透皮肤和表皮的角质层，以增加皮肤区域和毗邻组织中的氧浓度并激活代谢过程。根据本发明，这是通过包含不对称层状聚集体的化妆品来实现的，该组合物由磷脂和含氧碳氟化合物或氟碳混合物组成，碳氟化合物的量在0.2至100重量/体积的范围内，适用于皮肤用药。制剂通过乳化相应的成分进行，并用于软膏，霜剂，洗剂，水，酒精提取物，糊剂，粉末，凝胶，酊剂，敷料和膏药或喷雾剂中。

7. 发明申请

US20070092460A1 Silylated compounds as precursors for self-tanning compositions 审中-公开
标题翻译：甲硅烷基化合物作为自鞣组合物的前体
公开(公告)号：US20070092460A1
公开(公告)日：2007-04-26
申请号：US11637322
申请日：2006-12-12
申请人： Thomas Ehlis , Dietmar Huglin , Joachim Roding
发明人： Thomas Ehlis , Dietmar Huglin , Joachim Roding
IPC分类号： A61K8/89
CPC分类号： A61Q19/04 , A61K8/585 , C07F7/1804
摘要： The use of silylated compounds as precursors of skin self-tanning substances in self-tanning compositions is described.
摘要翻译：描述了在自鞣组合物中使用甲硅烷基化合物作为皮肤自鞣物质的前体。

8. 发明申请

US20100324152A1 USE OF 1,2-DECANEDIOL FOR SEBUM REDUCTION AND COSMETIC AND/OR DERMATOLOGICAL FORMULATIONS COMPRISING 1,2-DECANEDIOL 审中-公开
标题翻译：使用1,2-癸醇用于减少和减少包含1,2-癸醇的化妆和/或皮肤配方
公开(公告)号：US20100324152A1
公开(公告)日：2010-12-23
申请号：US12446190
申请日：2007-10-12
申请人： Gerhard Schmaus , Sabine Lange , Joachim Roding
发明人： Gerhard Schmaus , Sabine Lange , Joachim Roding
IPC分类号： A61K31/045 , C07C31/18
CPC分类号： A61K8/345 , A61Q19/008 , A61Q19/10
摘要： The present invention relates to a use of 1,2-decanediol for reduction of the sebum concentration of the skin, a cosmetic and/or dermatological formulation for topical application comprising 1,2-decanediol, a method for reduction of the sebum concentration of the skin and a use of 1,2-decanediol and a method for assisting the penetration of one, two, three, four or more active compounds into areas of the skin with increased sebum production.
摘要翻译：本发明涉及1,2-癸二醇用于降低皮肤的皮脂浓度，用于局部施用的化妆品和/或皮肤病学制剂，包括1,2-癸二醇，降低皮脂含量的方法皮肤和1,2-癸二醇的使用以及一种辅助将一种，两种，三种，四种或更多种活性化合物渗入皮肤区域并增加皮脂产生的方法。

9. 发明申请

US20060292191A1 Use of nanodispersions in pharmaceutical end formulations 有权
标题翻译：在药物末端制剂中使用纳米分散体
公开(公告)号：US20060292191A1
公开(公告)日：2006-12-28
申请号：US11446844
申请日：2006-06-05
申请人： Andreas Supersaxo , Hans Weder , Dietmar Huglin , Joachim Roding
发明人： Andreas Supersaxo , Hans Weder , Dietmar Huglin , Joachim Roding
IPC分类号： A61K9/00
CPC分类号： A61K9/1075 , A61K9/4858 , A61K9/4866 , Y10S514/846 , Y10S514/937 , Y10S514/938 , Y10S514/941 , Y10S514/947
摘要： A nanodispersion comprises (a) a membrane-forming molecule, (b) a coemulsifier and (c) a lipophilic component, in pharmaceutical end formulations, the nanodispersion being obtainable by (α) mixing the components (a), (b) and (c) until a homogeneous clear liquid is obtained, and (β) adding the liquid obtained in step (α) to the water phase of the pharmaceutical end formulations, where steps (α) and (β) may be carried out without high energy mixing or homogenization. The nanodispersions prepared according to this invention are suitable as transport vehicles for pharmaceutical active agents.
摘要翻译：纳米分散体包含（a）在药物末端制剂中的成膜分子，（b）共乳化剂和（c）亲脂性组分，所述纳米分散体可通过（α）混合组分（a），（b）和（ c）直到获得均匀的透明液体，和（β）将步骤（α）中获得的液体加入到药物末端制剂的水相中，其中步骤（α）和（β）可以在没有高能量混合的情况下进行或均质化。根据本发明制备的纳米分散体适合用作药物活性剂的运输工具。

10. 发明授权

US5741513A Alcoholic aqueous gel-like phospholipid composition, its use and topical preparations containing it 失效
标题翻译：酒精含水凝胶状磷脂组合物，其用途和含有其的局部制剂
公开(公告)号：US5741513A
公开(公告)日：1998-04-21
申请号：US478884
申请日：1995-06-07
申请人： Miklos Ghyczy , Joachim Roding , Hans Lautenschlager , Walter Hameister , Jorg Hager
发明人： Miklos Ghyczy , Joachim Roding , Hans Lautenschlager , Walter Hameister , Jorg Hager
IPC分类号： A61K8/14 , A61K8/42 , A61K8/64 , A61Q19/00 , A61K9/127
CPC分类号： A61K8/14 , A61K8/42 , A61K8/64 , A61Q19/00 , B82Y5/00 , A61Q5/00 , Y10S514/944 , Y10T428/2984
摘要： An alcoholic, aqueous gel-like phospholipid composition is disclosed which contains, as alcohols, ethanol, 1-propanol or 2-propanol, which is characterized in that this composition is a liposomal gel composed of 15.00 to 30.00 parts by weight of a phospholipid concentrate, 14.00 to 20.00 parts by weight of alcohol and 50 to 71.00 parts by weight of an aqueous solution as the remainder. The use of this phospholipid composition for the preparation of liposomal solutions by dilution with a solution and topical preparations which contain these solutions are additionally disclosed.
摘要翻译：公开了一种醇，水性凝胶状磷脂组合物，其含有醇，乙醇，1-丙醇或2-丙醇，其特征在于该组合物是由15.00至30.00重量份的磷脂浓缩物组成的脂质体凝胶，14.00至20.00重量份的醇和50至71.00重量份的其余水溶液。另外公开了通过用溶液稀释制备脂质体溶液并使用这种磷脂组合物和含有这些溶液的局部制剂。

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