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1. 发明授权

US5795450A Apparatus for producing hydrogen and oxygen 失效
标题翻译：用于生产氢气和氧气的设备
公开(公告)号：US5795450A
公开(公告)日：1998-08-18
申请号：US811263
申请日：1997-03-04
申请人： Kiyoshi Hirai , Shinichi Yasui , Hiroko Kobayashi , Mamoru Nagao , Takashi Sasaki , Hiroyuki Harada
发明人： Kiyoshi Hirai , Shinichi Yasui , Hiroko Kobayashi , Mamoru Nagao , Takashi Sasaki , Hiroyuki Harada
IPC分类号： C25B9/20 , C25B9/00 , C25B15/08
CPC分类号： C25B9/206
摘要： A simple and efficient apparatus for producing hydrogen and oxygen is disclosed, wherein resistance to the flow of deionized water, oxygen gas, and hydrogen gas does not increase, and the amount of electric energy required for electrolysis can be reduced. A bipolar-type apparatus for producing hydrogen and oxygen, wherein a main water feeding path is formed in the approximate center of electrode plates in the axial direction, and an anode chamber and a cathode chamber are formed on opposing surfaces of the electrode plates to store porous conductors. A secondary water feeding path for the anode chamber directs water from the main water feeding path to the anode chamber. On the cathode side of the apparatus, a hydrogen gas collecting chamber is formed, a plurality of radial hydrogen gas paths are formed from the cathode chamber to the hydrogen gas collecting chamber, and a hydrogen gas discharging path are formed to axially hydrogen gas collecting chambers in each electrode plate. On the anode side of the apparatus, an oxygen gas path is formed from the anode chamber to the oxygen gas collecting chamber, and an oxygen gas discharging path is formed to axially connect to the oxygen gas collecting chambers in each electrode plate.
摘要翻译：公开了一种用于生产氢气和氧气的简单有效的装置，其中对去离子水，氧气和氢气的流动的抵抗力不增加，并且可以减少电解所需的电能量。一种用于生产氢和氧的双极型装置，其中主轴线在电极板的大致中心沿轴向形成，并且阳极室和阴极室形成在电极板的相对表面上以存储多孔导体。用于阳极室的二次供水路径将水从主供水路径引导到阳极室。在该装置的阴极侧，形成氢气收集室，从阴极室向氢气收集室形成多个径向氢气路径，并将氢气排出路径形成为轴向氢气收集室在每个电极板中。在设备的阳极侧，从阳极室到氧气收集室形成氧气通道，并且形成氧气排放路径以轴向连接到每个电极板中的氧气收集室。

2. 发明授权

US5783051A Apparatus for producing hydrogen and oxygen 失效
标题翻译：用于生产氢气和氧气的设备
公开(公告)号：US5783051A
公开(公告)日：1998-07-21
申请号：US811348
申请日：1997-03-04
申请人： Kiyoshi Hirai , Shinichi Yasui , Hiroko Kobayashi , Mamoru Nagao , Takashi Sasaki , Akira Asari , Hiroyuki Harada
发明人： Kiyoshi Hirai , Shinichi Yasui , Hiroko Kobayashi , Mamoru Nagao , Takashi Sasaki , Akira Asari , Hiroyuki Harada
IPC分类号： C25B11/02 , C25B1/06 , C25B1/12 , C25B9/00 , C25B9/08 , C25B9/18 , C25B9/20
CPC分类号： C25B1/12 , C25B9/206 , Y02E60/366
摘要： An apparatus for producing hydrogen and oxygen having a pressure vessel surrounding a bipolar-type water electrolytic cell The electrolytic cell contains a plurality of joined solid electrolyte membrane units, and each solid electrolyte membrane unit contains a solid electrolyte membrane, porous conductors in contact with opposing surfaces of the solid electrolyte membrane, and bipolar-type electrode plates in contact with each porous conductor, wherein each electrode plate is capable of performing as an anode and a cathode. A gap is present between the interior of the pressure vessel and the exterior of the water electrolytic cell to form a water pressure regulating chamber, and water of a preselected pressure can be fed into the water pressure regulating chamber such that the pressure differential between the pressure inside the water electrolytic cell and the pressure inside the water pressure regulating chamber is maintained within the pressure differential tolerance range of the water electrolytic cell.
摘要翻译：一种用于生产氢和氧的装置，具有围绕双极型水电解槽的压力容器。电解槽包含多个接合的固体电解质膜单元，并且每个固体电解质膜单元包含固体电解质膜，与相对的接触的多孔导体固体电解质膜的表面和与每个多孔导体接触的双极型电极板，其中每个电极板能够作为阳极和阴极进行。在压力容器的内部和水电解池的外部之间存在间隙以形成水压调节室，并且可以将预选压力的水供给到水压调节室中，使得压力在水电解池内部，水压力调节室内的压力保持在水电解槽的压差范围内。

3. 发明授权

US5796799A Control apparatus for oxygen concentration of water in atomic reactor 失效
标题翻译：原子反应堆水中氧浓度控制装置
公开(公告)号：US5796799A
公开(公告)日：1998-08-18
申请号：US548091
申请日：1995-10-25
申请人： Hiroko Kobayashi , Takashi Sasaki , Kiyoshi Hirai , Shinichi Yasui , Mamoru Nagao , Hiroyuki Harada
发明人： Hiroko Kobayashi , Takashi Sasaki , Kiyoshi Hirai , Shinichi Yasui , Mamoru Nagao , Hiroyuki Harada
IPC分类号： G21D1/00 , G21C19/317 , G21D3/08
CPC分类号： G21C17/022 , C25B1/10 , C25B11/04 , C25B15/02 , G21C19/307 , G21D3/08 , B01D2311/2684 , Y02E30/40 , Y02E60/366 , Y02E70/10
摘要： An apparatus for controlling dissolved oxygen concentration in primary and secondary cooling water in boiling water and pressurized water atomic reactors is disclosed. The apparatus contains an electrolytic cell having an anode chamber and a cathode chamber separated from one another by a diaphragm of a solid polymer electrolyte membrane. The diaphragm contains: (a) an ion exchange membrane and (b) a pair of multilayered electrodes chemically plated to both surfaces of the ion exchange membrane. The electrolytic cell is operatively connected to a circular route for cooling water in the reactor, and hydrogen gas generated through electrolysis of deionized water in the cathode side of the cell is introduced into the circular route for the cooling water to control the dissolved oxygen concentration of the cooling water.
摘要翻译：公开了一种用于控制沸水和加压水原子反应堆中的一次和二次冷却水中的溶解氧浓度的装置。该装置包含具有通过固体聚合物电解质膜的隔膜彼此分离的阳极室和阴极室的电解池。隔膜包含：（a）离子交换膜和（b）一对化学镀在离子交换膜的两个表面上的多层电极。电解池可操作地连接到循环路径，用于冷却反应器中的水，并且将通过电解阴极侧的去离子水产生的氢气引入冷却水的循环路径中以控制溶解氧浓度冷却水。

4. 发明授权

US5690797A Hydrogen and oxygen gas generating system 失效
标题翻译：氢气和氧气发生系统
公开(公告)号：US5690797A
公开(公告)日：1997-11-25
申请号：US588336
申请日：1996-01-18
申请人： Hiroyuki Harada , Takashi Sasaki , Kiyoshi Hirai , Shinichi Yasui , Hiroko Kobayashi , Mamoru Nagao
发明人： Hiroyuki Harada , Takashi Sasaki , Kiyoshi Hirai , Shinichi Yasui , Hiroko Kobayashi , Mamoru Nagao
IPC分类号： C25B1/04 , C25B1/12 , C25B15/00 , C25B15/02 , C25B9/00 , C25B15/08
CPC分类号： C25B15/08 , C25B1/12 , C25B15/02 , Y02E60/366
摘要： A hydrogen/oxygen gas generating system includes a deionized water container and a cell for water electrolysis having anode and cathode compartments, the cell being submerged in deionized water in the container. Oxygen gas generated in the anode compartment is channeled to an oxygen gas separating chamber defined in the container at its top whereas hydrogen gas generated in the cathode compartment is channeled to a gas/liquid separator. The pressures of these gases are detected, and in accordance with the detected gas pressures, a first gas piping line for delivering oxygen gas outward from the oxygen gas separating chamber and a second gas piping line for delivering hydrogen gas outward from the separator are controlled such that the differential pressure between the gases may fall in a limited range. Water level in the oxygen gas separating chamber and water level in the gas/liquid separator are detected, and the detected levels are utilized to control the pressures and the supply of deionized water into the container. The system can generate hydrogen and oxygen gases of high purity under high pressure in a safe manner without a need for gas compressors.
摘要翻译：氢气/氧气发生系统包括去离子水容器和具有阳极和阴极隔室的水电解池，该电池被浸没在容器中的去离子水中。在阳极室中产生的氧气被引导到位于其顶部的容器中限定的氧气分离室，而在阴极室中产生的氢气被引导至气/液分离器。检测这些气体的压力，并且根据检测到的气体压力，将用于从氧气分离室向外输送氧气的第一气体管线和用于从分离器向外输送氢气的第二气体管线被控制为气体之间的压差可能落在有限的范围内。检测氧气分离室中的水位和气/液分离器中的水位，并且使用检测到的水平来控制去离子水进入容器的压力和供应。该系统可以安全地在高压下产生高纯度的氢气和氧气，无需气体压缩机。

5. 发明授权

US5888361A Apparatus for producing hydrogen and oxygen 失效
标题翻译：用于生产氢气和氧气的设备
公开(公告)号：US5888361A
公开(公告)日：1999-03-30
申请号：US850280
申请日：1997-05-05
申请人： Kiyoshi Hirai , Shinichi Yasui , Hiroko Kobayashi , Teruyuki Morioka , Akiko Miyake , Hiroyuki Harada
发明人： Kiyoshi Hirai , Shinichi Yasui , Hiroko Kobayashi , Teruyuki Morioka , Akiko Miyake , Hiroyuki Harada
IPC分类号： C25B1/04 , C25B9/08 , C25B9/18 , C25B15/00 , C25B9/00 , C25B15/02
CPC分类号： C25B9/18 , C25B1/04 , C25B15/00 , C25B9/08 , Y02E60/366
摘要： A simply configured cooling mechanism for an apparatus for producing hydrogen and oxygen is disclosed. The configuration makes it possible to freely select the type of heat exchanger, without any restrictions, in order to improve cooling efficiency. In particular, a heat exchanger for cooling deionized water in a deionized water tank, which contains an electrolytic cell, is installed outside the tank. An inlet to the heat exchanger is connected to a deionized water flow outlet from the tank that is below the level of the deionized water the tank by a pipe, and an outlet from the heat exchanger to tank is connected to a deionized water flow inlet that is positioned in the tank below the deionized water flow outlet.
摘要翻译：公开了用于产生氢和氧的设备的简单配置的冷却机构。该结构使得可以在没有任何限制的情况下自由地选择热交换器的类型，以便提高冷却效率。特别地，用于冷却含有电解池的去离子水箱中的去离子水的热交换器安装在罐外。热交换器的入口通过管连接到来自罐的去离子水流出口，其通过管道位于罐的去离子水水平以下，并且从热交换器到罐的出口连接到去离子水流入口，被定位在去离子水流出口下方的罐中。

6. 发明授权

US08652739B2 Electrostatic image developing toner, electrostatic image developer, toner cartridge, process cartridge, image forming apparatus and image forming method 有权
标题翻译：静电图像显影调色剂，静电图像显影剂，调色剂盒，处理盒，成像设备和图像形成方法
公开(公告)号：US08652739B2
公开(公告)日：2014-02-18
申请号：US13024115
申请日：2011-02-09
申请人： Hiroko Kobayashi , Yasuhiro Arima
发明人： Hiroko Kobayashi , Yasuhiro Arima
IPC分类号： G03G13/20 , G03G13/08 , G03G21/00
CPC分类号： G03G9/0975 , G03G5/08214 , G03G9/08782 , G03G9/091 , G03G9/09716 , G03G9/09725 , G03G9/09741 , G03G15/08 , G03G15/0855 , G03G15/0865
摘要： The present invention provides a toner for developing an electrostatic charge image including toner particles having residual ammonium ions and silica particles containing a chlorine compound as an external additive.
摘要翻译：本发明提供一种用于显影静电荷图像的调色剂，其包括具有残留铵离子的调色剂颗粒和含有氯化合物作为外部添加剂的二氧化硅颗粒。

7. 发明授权

US07244730B2 2-iminopyrrolidine derivatives 有权
标题翻译： 2-亚氨基吡咯烷衍生物
公开(公告)号：US07244730B2
公开(公告)日：2007-07-17
申请号：US10475188
申请日：2002-04-19
申请人： Shuichi Suzuki , Makoto Kotake , Mitsuaki Miyamoto , Tetsuya Kawahara , Akiharu Kajiwara , Ieharu Hishinuma , Kazuo Okano , Syuhei Miyazawa , Richard Clark , Fumihiro Ozaki , Nobuaki Sato , Masanobu Shinoda , Atsushi Kamada , Itaru Tsukada , Fumiyoshi Matsuura , Yoshimitsu Naoe , Taro Terauchi , Yoshiaki Oohashi , Osamu Ito , Hiroshi Tanaka , Takashi Musya , Motoji Kogushi , Tsutomu Kawada , Toshiyuki Matsuoka , Hiroko Kobayashi , Ken-ichi Chiba , Akifumi Kimura , Naoto Ono
发明人： Shuichi Suzuki , Makoto Kotake , Mitsuaki Miyamoto , Tetsuya Kawahara , Akiharu Kajiwara , Ieharu Hishinuma , Kazuo Okano , Syuhei Miyazawa , Richard Clark , Fumihiro Ozaki , Nobuaki Sato , Masanobu Shinoda , Atsushi Kamada , Itaru Tsukada , Fumiyoshi Matsuura , Yoshimitsu Naoe , Taro Terauchi , Yoshiaki Oohashi , Osamu Ito , Hiroshi Tanaka , Takashi Musya , Motoji Kogushi , Tsutomu Kawada , Toshiyuki Matsuoka , Hiroko Kobayashi , Ken-ichi Chiba , Akifumi Kimura , Naoto Ono
IPC分类号： A61K31/535 , A61K31/40 , C07D265/30 , C07D241/04 , C07D209/44
CPC分类号： C07D209/44
摘要： A 2-iminopyrrolidine derivative represented by the formula: {wherein ring B represents a benzene ring, pyridine ring, etc.; R101–R103 represent hydrogen, halogen, C1-6 alkyl, etc.; R5 represents hydrogen, C1-6 alkyl, C1-6 alkoxy-C1-6 alkyl, etc.; R6 represents hydrogen, C1-6 alkyl, C1-6 alkyloxycarbonyl, etc.; Y1 represents a single bond, —CH2—, etc.; Y2 represents a single bond, —CO—, etc.; and Ar represents hydrogen, a group represented by the formula: [wherein R10—R14 represent hydrogen, C1-6 alkyl, hydroxyl, C1-6 alkoxy, etc.; and R11 and R12 or R12 and R13 may bond together to form a 5- to 8-membered heterocyclic ring], etc.}, or a salt thereof.
摘要翻译：由下式表示的2-亚氨基吡咯烷衍生物：其中环B表示苯环，吡啶环等; R 101为-O-，卤素，C 1-6烷基等; R 5表示氢，C 1-6烷基，C 1-6烷氧基-C 1-6烷基等等 R 6表示氢，C 1-6烷基，C 1-6烷氧基羰基等; Y 1表示单键，-CH 2 - 等; Y 2表示单键，-CO-等; 和Ar表示氢，由下式表示的基团：其中R 10 -R 14表示氢，C 1-6烷基，羟基 C 1-6烷氧基等; 并且R 11和R 12或R 12和R 13可以键合在一起形成5-8个 - 杂环]等，或其盐。

8. 发明授权

US07871984B2 Methylated CpG polynucleotide 失效
标题翻译：甲基化CpG多核苷酸
公开(公告)号：US07871984B2
公开(公告)日：2011-01-18
申请号：US10553948
申请日：2004-04-23
申请人： Yukio Sato , Hiroko Kobayashi
发明人： Yukio Sato , Hiroko Kobayashi
IPC分类号： A01N43/04
CPC分类号： C12N15/117 , C07H21/02 , C07H21/04 , C12N2310/336
摘要： It is an object of the present invention to provide a polynucleotide, which can effectively suppress the immunoreactivity caused by DNA having a CpG motif and which can be used for preventing and/or treating immune-mediated diseases such as arthritis. The present invention provides a polynucleotide comprising a CpG motif wherein guanine is methylated, and a pharmaceutical composition comprising the above-mentioned polynucleotide.
摘要翻译：本发明的目的是提供一种多核苷酸，其可以有效地抑制由具有CpG基序的DNA引起的免疫反应性，其可用于预防和/或治疗免疫介导的疾病如关节炎。本发明提供了包含CpG基序的多核苷酸，其中鸟嘌呤被甲基化，和包含上述多核苷酸的药物组合物。

9. 发明申请

US20050245592A1 2-Iminopyrrolidine derivatives 审中-公开
标题翻译： 2-亚氨基吡咯烷衍生物
公开(公告)号：US20050245592A1
公开(公告)日：2005-11-03
申请号：US11158941
申请日：2005-06-22
申请人： Shuichi Suzuki , Makoto Kotake , Mitsuaki Miyamoto , Tetsuya Kawahara , Akiharu Kajiwara , Ieharu Hishinuma , Kazuo Okano , Syuhei Miyazawa , Richard Clark , Fumihiro Ozaki , Nobuaki Sato , Masanobu Shinoda , Atsushi Kamada , Itaru Tsukada , Fumiyoshi Matsuura , Yoshimitsu Naoe , Taro Terauchi , Yoshiaki Oohashi , Osamu Ito , Hiroshi Tanaka , Takashi Musha , Motoji Kogushi , Tsutomu Kawata , Toshiyuki Matsuoka , Hiroko Kobayashi , Ken-ichi Chiba , Akifumi Kimura , Naoto Ono
发明人： Shuichi Suzuki , Makoto Kotake , Mitsuaki Miyamoto , Tetsuya Kawahara , Akiharu Kajiwara , Ieharu Hishinuma , Kazuo Okano , Syuhei Miyazawa , Richard Clark , Fumihiro Ozaki , Nobuaki Sato , Masanobu Shinoda , Atsushi Kamada , Itaru Tsukada , Fumiyoshi Matsuura , Yoshimitsu Naoe , Taro Terauchi , Yoshiaki Oohashi , Osamu Ito , Hiroshi Tanaka , Takashi Musha , Motoji Kogushi , Tsutomu Kawata , Toshiyuki Matsuoka , Hiroko Kobayashi , Ken-ichi Chiba , Akifumi Kimura , Naoto Ono
IPC分类号： A61K20060101 , A61K31/403 , A61K31/4035 , A61K31/4178 , A61K31/4184 , A61K31/422 , A61K31/437 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/538 , A61P20060101 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P19/10 , A61P25/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07D20060101 , C07D207/22 , C07D207/24 , C07D207/26 , C07D207/263 , C07D207/267 , C07D207/34 , C07D209/44 , C07D209/52 , C07D209/54 , C07D209/62 , C07D209/96 , C07D213/73 , C07D213/74 , C07D233/46 , C07D233/66 , C07D233/88 , C07D233/90 , C07D235/30 , C07D249/14 , C07D261/14 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D409/04 , C07D409/06 , C07D409/10 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/10 , C07D471/04 , C07D487/04 , C07D491/10 , C07D498/04 , C07D521/00 , C07D209/48 , C07D471/02
CPC分类号： C07D209/44
摘要： A 2-iminopyrrolidine derivative represented by the formula: {wherein ring B represents a benzene ring, pyridine ring, etc.; R101-R103 represent hydrogen, halogen, C1-6 alkyl, etc.; R5 represents hydrogen, C1-6 alkyl, C1-6 alkoxy-C1-6 alkyl, etc.; R6 represents hydrogen, C1-6 alkyl, C1-6 alkyloxycarbonyl, etc.; Y1 represents a single bond, —CH2—, etc.; Y2 represents a single bond, —CO—, etc.; and Ar represents hydrogen, a group represented by the formula: [wherein R10-R14 represent hydrogen, C1-6 alkyl, hydroxyl, C1-6 alkoxy, etc.; and R11 and R12 or R12 and R13 may bond together to form a 5- to 8-membered heterocyclic ring], etc.}, or a salt thereof.
摘要翻译：由下式表示的2-亚氨基吡咯烷衍生物：其中环B表示苯环，吡啶环等; R 101为-O-，卤素，C 1-6烷基等; R 5表示氢，C 1-6烷基，C 1-6烷氧基-C 1-6烷基等等 R 6表示氢，C 1-6烷基，C 1-6烷氧基羰基等; Y 1表示单键，-CH 2 - 等; Y 2表示单键，-CO-等; 和Ar表示氢，由下式表示的基团：其中R 10 -R 14表示氢，C 1-6烷基，羟基 C 1-6烷氧基等; 并且R 11和R 12或R 12和R 13可以键合在一起形成5-8个 - 杂环]等，或其盐。

10. 发明申请

US20110312000A1 MONOCLONAL ANTIBODY AND USE THEREOF 失效
标题翻译：单克隆抗体及其用途
公开(公告)号：US20110312000A1
公开(公告)日：2011-12-22
申请号：US13105730
申请日：2011-05-11
申请人： Hiroko Kobayashi , Masahiro Hasegawa , Tsutomu Seito
发明人： Hiroko Kobayashi , Masahiro Hasegawa , Tsutomu Seito
IPC分类号： G01N33/577
CPC分类号： G01N33/6893 , A61K2039/505 , C07K16/18 , C07K16/24 , C07K2317/74 , G01N2333/51 , G01N2333/52
摘要： The purpose of the invention is to provide an antibody which recognizes OPN N-half but does not recognize the full-length OPN, and its use. A monoclonal antibody which is characterized in that it recognizes a protein or polypeptide in which the C-terminal amino acid sequence is YGLR (SEQ ID NO: 1) and it substantially does not recognize a protein or polypeptide which has an amino acid sequence of YGLR outside of the C-terminal, as well as a method for measuring OPN N-half utilizing the said antibody, a method for diagnosing diseases relating to OPN N-half, a method for judging the severity of said disease, and a method for treating said diseases, are provided.
摘要翻译：本发明的目的是提供一种识别OPN N半但不识别全长OPN的抗体及其用途。一种单克隆抗体，其特征在于其识别C末端氨基酸序列是YGLR（SEQ ID NO：1）的蛋白质或多肽，并且其基本上不识别具有YGLR的氨基酸序列的蛋白质或多肽 C端以外的方法，以及利用所述抗体测定OPN N-half的方法，用于诊断与OPN N一半有关的疾病的方法，所述疾病的严重程度的判定方法及治疗方法说疾病是提供的。

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