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1. 发明申请

US20130064437A1 HANDLING A SPECIMEN IMAGE 审中-公开
标题翻译：处理样本图像
公开(公告)号：US20130064437A1
公开(公告)日：2013-03-14
申请号：US13698905
申请日：2011-05-16
申请人： Kirsten Meetz , Thomas Buelow , Ingwer Curt Carlsen , Martin Bergtholdt
发明人： Kirsten Meetz , Thomas Buelow , Ingwer Curt Carlsen , Martin Bergtholdt
IPC分类号： G06K9/46
CPC分类号： G06T7/33 , G06T2207/10081 , G06T2207/10088 , G06T2207/10116 , G06T2207/10132 , G06T2207/10136 , G06T2207/30004 , G06T2207/30068 , G06T2207/30096
摘要： A system for handling a specimen image is disclosed. An image input (1) is configured to receive a body image representing at least a portion of a living body and a specimen image representing a dissected portion of the living body. An alignment unit (2) is configured to compute an alignment of the specimen image with the body image, based on image content of the specimen image and/or the body image. A border detector (3) is operatively connected to the alignment unit (2) and configured to detect at least part of an outer border of the dissected portion in the specimen image.
摘要翻译：公开了一种处理标本图像的系统。图像输入（1）被配置为接收表示生物体的至少一部分的身体图像和表示生物体的解剖部分的标本图像。对准单元（2）被配置为基于标本图像和/或身体图像的图像内容来计算样本图像与身体图像的对准。边界检测器（3）可操作地连接到对准单元（2）并且被配置为检测样本图像中的解剖部分的外部边界的至少一部分。

2. 发明申请

US20100316279A1 SCANNING METHOD AND SYSTEM 有权
标题翻译：扫描方法与系统
公开(公告)号：US20100316279A1
公开(公告)日：2010-12-16
申请号：US12809080
申请日：2008-12-26
申请人： Kirsten Meetz , Ingwer Curt Carlsen
发明人： Kirsten Meetz , Ingwer Curt Carlsen
IPC分类号： G06K9/00
CPC分类号： A61B6/504 , A61B6/501
摘要： To improve the scanning effect, a scanning method is provided, which comprises the steps of performing at least one of an nCT scan and a CTA scan on an object so as to obtain a set of images; detecting characteristics of a region of interest based on the set of images; and performing a CTP scan on the region of interest by adopting the characteristics to obtain a CTP image. By deriving the characteristics of the region of interest, e.g. a lesion or an area covering the lesion, before performing the CTP scan, and by adapting the subsequent CTP scan based on the characteristics of the region of interest, the drawback introduced by a limited scan area of the CTP scanner is mitigated, or even overcome.
摘要翻译：为了提高扫描效果，提供了扫描方法，其包括以下步骤：对物体执行nCT扫描和CTA扫描中的至少一个以获得一组图像; 基于所述图像集来检测感兴趣区域的特征; 并通过采用特征来获得CTP图像来对感兴趣区域进行CTP扫描。通过导出感兴趣区域的特征，例如，病变或覆盖病变的区域，在执行CTP扫描之前，并且通过基于感兴趣区域的特征适应随后的CTP扫描，减轻CTP扫描器的有限扫描区域引入的缺点，甚至克服。

3. 发明授权

US09757083B2 Scanning method and system 有权
公开(公告)号：US09757083B2
公开(公告)日：2017-09-12
申请号：US12809080
申请日：2008-12-26
申请人： Kirsten Meetz , Ingwer Curt Carlsen
发明人： Kirsten Meetz , Ingwer Curt Carlsen
IPC分类号： A61B6/00
CPC分类号： A61B6/504 , A61B6/501
摘要： To improve the scanning effect, a scanning method is provided, which comprises the steps of performing at least one of an nCT scan and a CTA scan on an object so as to obtain a set of images; detecting characteristics of a region of interest based on the set of images; and performing a CTP scan on the region of interest by adopting the characteristics to obtain a CTP image. By deriving the characteristics of the region of interest, e.g. a lesion or an area covering the lesion, before performing the CTP scan, and by adapting the subsequent CTP scan based on the characteristics of the region of interest, the drawback introduced by a limited scan area of the CTP scanner is mitigated, or even overcome.

4. 发明申请

US20110286652A1 SYSTEM FOR PROVIDING LUNG VENTILATION INFORMATION 有权
标题翻译：提供肺通气信息的系统
公开(公告)号：US20110286652A1
公开(公告)日：2011-11-24
申请号：US13146885
申请日：2010-01-25
申请人： Sven Kabus , Cristian Lorenz , Nicole Schadewaldt , Roland Opfer , Ingwer Curt Carlsen , Steffen Renisch , Joerg Sabczynski , Hans Barschdorf , Jens Von Berg , Thomas Blaffert , Tobias Klinder
发明人： Sven Kabus , Cristian Lorenz , Nicole Schadewaldt , Roland Opfer , Ingwer Curt Carlsen , Steffen Renisch , Joerg Sabczynski , Hans Barschdorf , Jens Von Berg , Thomas Blaffert , Tobias Klinder
IPC分类号： G06K9/00
CPC分类号： A61B6/5235 , A61B5/08 , A61B6/541 , G06T7/33 , G06T2207/10081 , G06T2207/30061
摘要： A system for displaying lung ventilation information, the system comprising an input (12) and a processing unit (15). The input being provided for receiving multiple CT images (71) of a lung, each CT image (71) corresponding to one phase of at least two different phases in a respiratory cycle. The processing unit (15) being configured to compare CT images (71) corresponding to different phases in the respiratory cycle for determining a deformation vector field for each phase, to generate for each phase a ventilation image (72) based on the corresponding deformation vector field, to spatially align the ventilation images (72), and to generate for at least one common position (62) in each one of the aligned ventilation images (72), a function (81) of a time course of a ventilation value for said common position (62), each ventilation value in the function (81) being based on the deformation vector fields corresponding to the aligned ventilation images (73).
摘要翻译：一种用于显示肺通气信息的系统，所述系统包括输入（12）和处理单元（15）。所述输入被提供用于接收肺的多个CT图像（71），每个CT图像（71）对应于呼吸周期中的至少两个不同相的一个相。所述处理单元（15）被配置为比较对应于呼吸周期中的不同相位的CT图像（71），以确定每个相位的变形矢量场，以根据相应的变形矢量为每个阶段生成通气图像（72）在空间上对准通气图像（72），并且为每个对齐的通气图像（72）中的至少一个公共位置（62）产生一个通风值的时间过程的功能（81），用于所述公共位置（62）中，所述功能（81）中的每个换气值基于对应于对齐的通气图像（73）的变形矢量场。

5. 发明申请

US20100183206A1 ADJUSTING ACQUISITION PROTOCOLS FOR DYNAMIC MEDICAL IMAGING USING DYNAMIC MODELS 有权
标题翻译：使用动态模型调整动态医学成像采集协议
公开(公告)号：US20100183206A1
公开(公告)日：2010-07-22
申请号：US12665441
申请日：2008-06-19
申请人： Ingwer Curt Carlsen , Daniel Bystrov
发明人： Ingwer Curt Carlsen , Daniel Bystrov
IPC分类号： G06K9/00
CPC分类号： A61B6/032 , A61B5/7285 , A61B6/037 , A61B6/488 , A61B6/541 , G06T7/149 , G06T7/215 , G06T2207/10076 , G06T2207/30004
摘要： The invention relates to automatically adjusting an acquisition protocol for dynamic medical imaging, such as dynamic CT, MRI or PET imaging. The protocols are adjusted based on anatomic and dynamic models (10, 12, 14) which are individualized or fitted to each patient based on a scout scan (6, 8). The adjustment can compensate for changes in the patient due to patient motion (e.g. breathing or heartbeat) or flow of contrast or tracing agent during the sequence. This ensures that changes in the reconstructed images are indicative of pathological changes in the patient and not caused by patient motion or changes in scanning parameters or timing. The dynamic model can be a motion model (12) used to predict the motion of anatomic/physiologic features, typically organs, during scanning, or a haemodynamic model (14) used to predict flow of the contrast agent allowing for precise timing of the scanning sequence.
摘要翻译：本发明涉及自动调整用于动态医学成像的采集协议，例如动态CT，MRI或PET成像。基于解剖和动态模型（10,12,14）调整协议，这些解剖和动态模型基于侦察扫描（6,8）对每个患者进行个性化或拟合。该调整可以补偿由于患者运动（例如呼吸或心跳）或对比剂或跟踪剂在序列期间的流动引起的患者的变化。这确保重建图像中的改变指示患者的病理变化，而不是由患者运动或扫描参数或时间的变化引起的。动态模型可以是用于预测解剖/生理特征（通常是器官）在扫描期间的运动的运动模型（12）或用于预测造影剂的流动的血液动力学模型（14），其允许扫描的精确定时序列。

6. 发明申请

US20120123801A1 PET/CT BASED MONITORING SYSTEM SUPPORTED BY A CLINICAL GUIDELINE NAVIGATOR 审中-公开
标题翻译：基于PET / CT的监测系统由临床导向导管支持
公开(公告)号：US20120123801A1
公开(公告)日：2012-05-17
申请号：US13260533
申请日：2010-02-11
申请人： Roland Opfer , Lilla Boroczky , Ingwer Curt Carlsen , Pradyumna Dutta , Steffen Renisch , Joerg Sabczynski , Paola Karina Tulipano
发明人： Roland Opfer , Lilla Boroczky , Ingwer Curt Carlsen , Pradyumna Dutta , Steffen Renisch , Joerg Sabczynski , Paola Karina Tulipano
IPC分类号： G06Q50/24
CPC分类号： G16H10/60 , A61B6/037 , A61B6/508 , G06F19/00 , G06F19/321 , G06Q50/24
摘要： An oncology monitoring system comprises: an image analysis module (42, 44) configured to perform an oncological monitoring operation based on images of a subject, for example acquired by positron emission tomography (PET) and computed tomography (CT); and a clinical guideline support module (10). The clinical guideline support module is configured to: display a graphical flow diagram (GFD) of a clinical therapy protocol for treating the subject comprising graphical blocks (B0, B1 B2, B3, B4, B5, B21, B211, B22, B221, B222, B223, B23, B231, B232) representing therapeutic or monitoring operations of the clinical therapy protocol including at least one monitoring operation performed by the image analysis module; annotate a graphical block of the graphical flow diagram with subject-specific information pertaining to a therapeutic or monitoring operation represented by the graphical block; and display an annotation (POP) of a graphical block (B211) responsive to selection of the graphical block by a user.
摘要翻译：肿瘤监测系统包括：图像分析模块（42,44），其被配置为基于例如通过正电子发射断层摄影（PET）和计算机断层摄影（CT）获取的对象的图像执行肿瘤监测操作; 和临床指南支持模块（10）。临床指南支持模块被配置为：显示用于治疗受试者的临床治疗方案的图形流程图（GFD），包括图形块（B0，B1B2，B3，B4，B5，B21，B211，B22，B221，B222 ，B223，B23，B231，B232），其代表包括图像分析模块执行的至少一个监视操作的临床治疗方案的治疗或监视操作; 注释图形流程图的图形块，其具有与由图形块表示的治疗或监视操作有关的主题特定信息; 以及响应于用户对所述图形块的选择来显示图形块（B211）的注释（POP）。

7. 发明申请

US20110046979A1 METHOD AND SYSTEM FOR PERSONALIZED GUIDELINE-BASED THERAPY AUGMENTED BY IMAGING INFORMATION 审中-公开
标题翻译：基于图像信息的个性化导向治疗方法与系统
公开(公告)号：US20110046979A1
公开(公告)日：2011-02-24
申请号：US12989805
申请日：2009-05-04
申请人： Paola Karina Tulipano , Lilla Boroczky , Michael C. Lee , Victor Paulus Marcellus Vloemans , Ingwer Curt Carlsen , Roland Opfer , Charles Lagor
发明人： Paola Karina Tulipano , Lilla Boroczky , Michael C. Lee , Victor Paulus Marcellus Vloemans , Ingwer Curt Carlsen , Roland Opfer , Charles Lagor
IPC分类号： G06Q50/00 , G06F17/30
CPC分类号： G06Q50/22 , G06F19/325 , G16H50/20 , G16H50/70
摘要： When treating a patient, clinical decision support system (CDSS) guidelines are employed to assist a physician in generating a treatment plan. These plans are generated using both imaging and non-imaging data. To accomplish this, the CDSS is interfaced with imaging systems (CADx, CAD, PACS etc.). A data-mining operation is performed to identify relevant patients with similar attributes such as diagnosis, medical history, treatment, etc from imaging and non-imaging data. Natural language processing is employed to extract and encode relevant non-imaging (textual) data from relevant patients' records. Additionally, an image of a current patient is compared to reference images in a patient database to identify relevant patients. Relevant patients are then identified to a user, and the user selects a relevant patient to view detailed information related to medical history, treatment, guidelines, efficacy, and the like.
摘要翻译：在治疗患者时，采用临床决策支持系统（CDSS）指南来协助医生生成治疗计划。这些计划是使用成像和非成像数据生成的。为了实现这一点，CDSS与成像系统（CADx，CAD，PACS等）接口。进行数据挖掘操作，以从成像和非成像数据中识别具有类似属性的相关患者，如诊断，病史，治疗等。采用自然语言处理技术从相关患者记录中提取和编码相关非成像（文本）数据。此外，将当前患者的图像与患者数据库中的参考图像进行比较以识别相关患者。然后将相关患者识别给用户，并且用户选择相关患者以查看与病史，治疗，指南，疗效等相关的详细信息。

8. 发明申请

US20080317382A1 Adaptive Point-Based Elastic Image Registration 审中-公开
标题翻译：自适应点弹性图像配准
公开(公告)号：US20080317382A1
公开(公告)日：2008-12-25
申请号：US12093052
申请日：2006-11-09
申请人： Astrid Ruth Franz , Ingwer Curt Carlsen , Steffen Renisch , Hans-Aloys Wischmann
发明人： Astrid Ruth Franz , Ingwer Curt Carlsen , Steffen Renisch , Hans-Aloys Wischmann
IPC分类号： G06K9/32
CPC分类号： G06T3/0081
摘要： A point-based elastic registration method for registering a first image and a second image. Initially, a single control point is randomly placed (S2) with the source image region and optimal parameter settings in respect thereof are determined (S3) for performing elastic deformation (S4) in respect of the first image so as to optimise a similarity measure. Additional control points are then added (S6) one-by-one, and the elastic deformation process repeated each time (S8) in respect of the new control point set, until a predetermined stopping criterion is met, e.g. the resultant improvement in the similarity measure no longer exceeds some predetermined threshold value. Thus, a high speed, high quality registration method is provided without having to specify the number of control points initially.
摘要翻译：一种用于登记第一图像和第二图像的基于点的弹性配准方法。首先，单个控制点与源图像区域随机放置（S2），并且确定相对于第一图像执行弹性变形（S4）的最佳参数设置（S3），以便优化相似性度量。然后逐个添加附加的控制点（S6），并且相对于新的控制点集合每次重复弹性变形过程（S8），直到达到预定的停止标准为止。所得到的相似性度量的改善不再超过某个预定阈值。因此，提供高速，高质量的登记方法，而不必首先指定控制点的数量。

9. 发明授权

US10311971B2 PET/CT based monitoring system supported by a clinical guideline navigator 有权
公开(公告)号：US10311971B2
公开(公告)日：2019-06-04
申请号：US13260533
申请日：2010-02-11
申请人： Roland Johannes Opfer , Lilla Boroczky , Ingwer Curt Carlsen , Pradyumna Dutta , Steffen Renisch , Joerg Sabczynski , Paola Karina Tulipano
发明人： Roland Johannes Opfer , Lilla Boroczky , Ingwer Curt Carlsen , Pradyumna Dutta , Steffen Renisch , Joerg Sabczynski , Paola Karina Tulipano
IPC分类号： G16H30/20 , G16H20/40 , A61B6/03 , G06F19/00 , G06Q50/24 , G16H10/60 , A61B6/00
摘要： An oncology monitoring system comprises: an image analysis module (42, 44) configured to perform an oncological monitoring operation based on images of a subject, for example acquired by positron emission tomography (PET) and computed tomography (CT); and a clinical guideline support module (10). The clinical guideline support module is configured to: display a graphical flow diagram (GFD) of a clinical therapy protocol for treating the subject comprising graphical blocks (B0, B1, B2, B3, B4, B5, B21, B211, B22, B221, B222, B223, B23, B231, B232) representing therapeutic or monitoring operations of the clinical therapy protocol including at least one monitoring operation performed by the image analysis module; annotate a graphical block of the graphical flow diagram with subject-specific information pertaining to a therapeutic or monitoring operation represented by the graphical block; and display an annotation (POP) of a graphical block (B211) responsive to selection of the graphical block by a user.

10. 发明授权

US08798343B2 System for providing lung ventilation information 有权
标题翻译：提供肺通气信息的系统
公开(公告)号：US08798343B2
公开(公告)日：2014-08-05
申请号：US13146885
申请日：2010-01-25
申请人： Sven Kabus , Cristian Lorenz , Nicole Schadewaldt , Roland Opfer , Ingwer Curt Carlsen , Steffen Renisch , Joerg Sabczynski , Hans Barschdorf , Jens Von Berg , Thomas Blaffert , Tobias Klinder
发明人： Sven Kabus , Cristian Lorenz , Nicole Schadewaldt , Roland Opfer , Ingwer Curt Carlsen , Steffen Renisch , Joerg Sabczynski , Hans Barschdorf , Jens Von Berg , Thomas Blaffert , Tobias Klinder
IPC分类号： G06K9/00
CPC分类号： A61B6/5235 , A61B5/08 , A61B6/541 , G06T7/33 , G06T2207/10081 , G06T2207/30061
摘要： A system for displaying lung ventilation information, the system comprising an input (12) and a processing unit (15). The input being provided for receiving multiple CT images (71) of a lung, each CT image (71) corresponding to one phase of at least two different phases in a respiratory cycle. The processing unit (15) being configured to compare CT images (71) corresponding to different phases in the respiratory cycle for determining a deformation vector field for each phase, to generate for each phase a ventilation image (72) based on the corresponding deformation vector field, to spatially align the ventilation images (72), and to generate for at least one common position (62) in each one of the aligned ventilation images (72), a function (81) of a time course of a ventilation value for said common position (62), each ventilation value in the function (81) being based on the deformation vector fields corresponding to the aligned ventilation images (73).
摘要翻译：一种用于显示肺通气信息的系统，所述系统包括输入（12）和处理单元（15）。所述输入被提供用于接收肺的多个CT图像（71），每个CT图像（71）对应于呼吸周期中的至少两个不同相的一个相。所述处理单元（15）被配置为比较对应于呼吸周期中的不同相位的CT图像（71），以确定每个相位的变形矢量场，以根据相应的变形矢量为每个阶段生成通气图像（72）在空间上对准通气图像（72），并且为每个对齐的通气图像（72）中的至少一个公共位置（62）产生功能（81），其中通风值的时间过程为所述公共位置（62）中，所述功能（81）中的每个换气值基于对应于对齐的通气图像（73）的变形矢量场。

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