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1. 发明授权

US07005430B2 Fused purine derivatives 失效
标题翻译：融合嘌呤衍生物
公开(公告)号：US07005430B2
公开(公告)日：2006-02-28
申请号：US10149423
申请日：2000-12-22
申请人： Kimihisa Ueno , Akira Ogawa , Yoshihisa Ohta , Yuji Nomoto , Kotaro Takasaki , Hideaki Kusaka , Hiroshi Yano , Chiharu Nakagawa , Satoshi Nakanishi
发明人： Kimihisa Ueno , Akira Ogawa , Yoshihisa Ohta , Yuji Nomoto , Kotaro Takasaki , Hideaki Kusaka , Hiroshi Yano , Chiharu Nakagawa , Satoshi Nakanishi
IPC分类号： C07D487/14 , C07D473/24 , C07D473/22 , A61K31/519 , A61P3/10
CPC分类号： C07D487/14
摘要： A condensed purine derivative represented by Formula (I): wherein X—Y-Z represents R1N—C═O or N═C—W, R2 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted aromatic heterocyclic group, a substituted or unsubstituted alicyclic heterocyclic group or the like, n represents an integer of from 0 to 3, V1 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted aromatic heterocyclic group, V2 represents a substituted lower alkyl group or a substituted or unsubstituted aromatic heterocyclic group, and when V1 represents a hydrogen atom, a lower alkyl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted aryl group, and for example, X—Y-Z represents R1aN—C═O and R2 represents a substituted lower alkyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted alicyclic heterocyclic group, a halogen atom, a lower alkylthio group, —NR7R8, —CO2H, a lower alkoxycarbonyl group, —COHal, —CONR9R10 or —CHO, V2 may represent a lower alkyl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted aryl group; or a pharmacologically acceptable salt thereof.
摘要翻译：由式（I）表示的稠合嘌呤衍生物：化学式id =“CHEM-US-00001”num =“000”

2. 发明申请

US20060252780A1 Fused pyrimidine derivatives 审中-公开
标题翻译：融合嘧啶衍生物
公开(公告)号：US20060252780A1
公开(公告)日：2006-11-09
申请号：US10554254
申请日：2004-04-23
申请人： Takao Nakajima , Kimihisa Ueno , Yuji Nomoto , Yuichi Matsumoto , Hiroshi Yano , Satoshi Nakanishi , Kotaro Takasaki , Hideaki Kusaka
发明人： Takao Nakajima , Kimihisa Ueno , Yuji Nomoto , Yuichi Matsumoto , Hiroshi Yano , Satoshi Nakanishi , Kotaro Takasaki , Hideaki Kusaka
IPC分类号： A61K31/519 , C07D487/14
CPC分类号： C07D487/14
摘要： A fused pyrimidine derivative is presented. The derivatie has an insulin secretion stimulating activity represented by Formula (I): {wherein R1 represents a hydrogen atom, lower alkyl, or the like; n represents an integer of 0 to 3; and X1 and X2 may be the same or different and each represents a hydrogen atom, lower alkyl, or the like; and formula (II): represents formula (III): [wherein X—Y—Z represents R2C═CR3—NR4 (wherein R2, R3 and R4 may be the same or different and each represents a hydrogen atom, lower alkyl, or the like)]}, or a pharmaceutically acceptable salt thereof.
摘要翻译：提出了一种稠合的嘧啶衍生物。衍生物具有由式（I）表示的胰岛素分泌刺激活性：其中R 1表示氢原子，低级烷基等; n表示0〜3的整数， X 1和X 2可以相同或不同，各自表示氢原子，低级烷基等; 和式（II）：表示式（III）：[其中XYZ表示R 2 C-CR 3 -NR 4（其中R' O 2，R 3和R 4可以相同或不同，各自表示氢原子，低级烷基等）]}，或其药学上可接受的盐。

3. 发明申请

US20100226803A1 Electric Pump 有权
公开(公告)号：US20100226803A1
公开(公告)日：2010-09-09
申请号：US12784529
申请日：2010-05-21
申请人： Fumio TAJIMA , Masashi Kitamura , Yuji Enomoto , Yuji Nomoto , Kenya Takarai
发明人： Fumio TAJIMA , Masashi Kitamura , Yuji Enomoto , Yuji Nomoto , Kenya Takarai
IPC分类号： F04D13/06 , H02K1/12 , H02K1/02 , H02K1/04
CPC分类号： F04D13/064 , B60L1/003 , B60L1/02 , B60L3/0061 , B60L11/14 , B60L2210/40 , B60L2240/34 , B60L2240/36 , B60L2240/425 , B60L2270/142 , B60L2270/145 , F04D13/0633 , H02K1/02 , H02K1/145 , H02K5/12 , H02K7/14 , H02K21/145 , Y02T10/641 , Y02T10/642 , Y02T10/70 , Y02T10/7077 , Y02T10/7241
摘要： A pump is driven by a compact electric motor in which a coil is disposed in a ring form around and along a stator core which has a plurality of claw magnetic poles that extend alternately from both ends of one member of the stator core toward the end of the other member thereof. A stator core can be made from a compressed powder core by molding with resin, with the molded portion able to serve as a partition separating pump and motor units.

4. 发明授权

US06270314B1 Water pump for an internal combustion engine 有权
标题翻译：内燃机用水泵
公开(公告)号：US06270314B1
公开(公告)日：2001-08-07
申请号：US09397149
申请日：1999-09-16
申请人： Yuji Nomoto
发明人： Yuji Nomoto
IPC分类号： F04D2916
CPC分类号： F04D29/426 , F04D29/086 , F04D29/167
摘要： A water pump for an internal combustion engine having a pump casing and a pump cover that forms a circulation cavity. A plate is positioned interface of the pump casing and the pump cover and divides the circulation cavity into an inlet passage and an outlet passage and has a seal portion that seals against the leakage between the inlet passage and the outlet passage of a gap of the interface of the pump casing and the pump cover.
摘要翻译：一种用于内燃机的水泵，其具有形成循环腔的泵壳体和泵盖。板被定位在泵壳体和泵盖的界面上，并将循环腔分成入口通道和出口通道，并且具有密封部分，该密封部分密封入口通道和出口通道之间的界面间隙的泄漏的泵壳和泵盖。

5. 发明授权

US4668683A Cardiotonic quinazoline derivatives 失效
标题翻译：强心喹唑啉衍生物
公开(公告)号：US4668683A
公开(公告)日：1987-05-26
申请号：US841656
申请日：1986-03-20
申请人： Haruki Takai , Yuji Nomoto , Tadashi Hirata , Tetsuji Ohno , Kazuhiro Kubo
发明人： Haruki Takai , Yuji Nomoto , Tadashi Hirata , Tetsuji Ohno , Kazuhiro Kubo
IPC分类号： A61K31/505 , A61P9/04 , C07D401/14 , C07D487/04 , C07D403/14
CPC分类号： C07D401/14 , C07D487/04
摘要： Quinazoline derivatives and their pharmaceutically acceptable acid addition salts having the general formula ##STR1## wherein R.sup.1 and R.sup.2 each represents hydrogen or alkyl;R.sup.3 represents alkyl or substituted alkyl;R.sup.7 and R.sup.8 each represent alkoxy;Z is oxygen or sulfur;m is zero or 1;n is zero or an integer from 1 to 5,exhibit a cardiotonic activity with little tendency to cause tachycardia.
摘要翻译：喹唑啉衍生物及其药学上可接受的具有通式（I）的酸加成盐，其中R 1和R 2各自代表氢或烷基; R3表示烷基或取代的烷基; R7和R8各自表示烷氧基; Z是氧或硫; m为零或1; n为零或1至5的整数，表现出强心剂活性，几乎不引起心动过速。

6. 发明授权

US07718808B2 Thiazole derivatives 有权
标题翻译：噻唑衍生物
公开(公告)号：US07718808B2
公开(公告)日：2010-05-18
申请号：US10584633
申请日：2004-12-24
申请人： Takao Nakajima , Masamori Sugawara , Shin-ichi Uchida , Tetsuji Ohno , Yuji Nomoto , Noriaki Uesaka , Yoshisuke Nakasato
发明人： Takao Nakajima , Masamori Sugawara , Shin-ichi Uchida , Tetsuji Ohno , Yuji Nomoto , Noriaki Uesaka , Yoshisuke Nakasato
IPC分类号： A61K31/427 , C07D417/14
CPC分类号： C07D417/06 , A61K31/427 , A61K31/438 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/5383 , A61K31/541 , A61K31/542 , A61K31/551 , A61K31/553 , A61K31/695 , C07D417/04 , C07D417/14 , C07D491/048 , C07D491/10 , C07D498/04 , C07D513/04
摘要： (Wherein n is an integer of from 0 to 3; R1 is substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, a substituted or unsubstituted alicyclic heterocyclic group, or a substituted or unsubstituted aromatic heterocyclic group; R2 is halogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, a substituted or unsubstituted alicyclic heterocyclic group, a substituted or unsubstituted aromatic heterocyclic group, —COR8, or the like; R3 and R4 may be the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl, —COR12, or the like)For example, provided are adenosine A2A receptor antagonists comprising, as the active ingredient, a thiazole derivative represented by a general formula (I), or a pharmaceutically acceptable salt thereof, and the like.
摘要翻译：本发明提供的腺苷A 2A受体拮抗剂包含作为活性成分的由通式（I）表示的噻唑衍生物或其药学上可接受的盐：......（其中n为0-3的整数; R 1为取代或取代或未取代的芳基，取代或未取代的脂环族杂环基或取代或未取代的芳族杂环基; R2为卤素，取代或未取代的低级烷基，取代或未取代的芳基，取代或未取代的脂环族杂环基，或未取代的芳族杂环基，-COR 8等; R 3和R 4可以相同或不同，各自表示氢原子，取代或未取代的低级烷基，取代或未取代的芳烷基，-COR 12等）。

7. 发明授权

US07560461B2 Quinazoline derivatives as kinase inhibitors 失效
标题翻译：喹唑啉衍生物作为激酶抑制剂
公开(公告)号：US07560461B2
公开(公告)日：2009-07-14
申请号：US11210028
申请日：2005-08-22
申请人： Anjali Pandey , Robert M. Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
发明人： Anjali Pandey , Robert M. Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
IPC分类号： A61K31/497 , A61K31/535 , C07D413/12 , C07D239/94
CPC分类号： C07D239/94 , A61K31/517 , C07D401/12 , C07D403/12
摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
摘要翻译：本发明涉及对抑制这种激酶活性的激酶磷酸化具有抑制活性的含氮杂环化合物及其药学上可接受的盐。本发明还涉及通过抑制激酶的磷酸化来抑制哺乳动物的激酶和治疗疾病状态的方法。在一个特定方面，本发明提供了抑制PDGF受体的磷酸化以阻止异常细胞生长和细胞游动的含氮杂环化合物及其药学上可接受的盐，以及预防或治疗细胞增殖性疾病如动脉硬化，血管重建，癌症和肾小球硬化症。

8. 发明授权

US07329655B2 Nitrogenous heterocyclic compounds 失效
标题翻译：含氮杂环化合物
公开(公告)号：US07329655B2
公开(公告)日：2008-02-12
申请号：US10344625
申请日：2001-08-17
申请人： Anjali Pandey , Robert M. Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
发明人： Anjali Pandey , Robert M. Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
IPC分类号： A61K31/54 , C07D417/14 , C07D413/14 , C07D43/14
CPC分类号： C07D401/12 , C07D239/94 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomeruloscierosis.
摘要翻译：本发明涉及对抑制这种激酶活性的激酶磷酸化具有抑制活性的含氮杂环化合物及其药学上可接受的盐。本发明还涉及通过抑制激酶的磷酸化来抑制哺乳动物的激酶和治疗疾病状态的方法。在一个特定方面，本发明提供了抑制PDGF受体的磷酸化以阻止异常细胞生长和细胞游动的含氮杂环化合物及其药学上可接受的盐，以及预防或治疗细胞增殖性疾病如动脉硬化，血管重建，癌症和肾小球硬化。

9. 发明申请

US20070225308A1 2-Amino Quinazoline Derivative 审中-公开
标题翻译： 2-氨基喹唑啉衍生物
公开(公告)号：US20070225308A1
公开(公告)日：2007-09-27
申请号：US10592955
申请日：2005-03-15
申请人： Yoshisuke Nakasato , Eri Atsumi , Yumiko Uochi , Takashi Sakuma , Mariko Kurasawa , Eiichi Fuse , Yuji Nomoto
发明人： Yoshisuke Nakasato , Eri Atsumi , Yumiko Uochi , Takashi Sakuma , Mariko Kurasawa , Eiichi Fuse , Yuji Nomoto
IPC分类号： C07D239/84 , A61K31/517 , C07D401/02
CPC分类号： C07D239/84 , C07D401/04 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/14
摘要： The present invention provides a compound represented by Formula (I) (wherein R1 and R2 are the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl and the like, R3 represents substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic group and the like, R4 and R5 are the same or different, and each represents a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl and the like, proviso that they are not simultaneously hydrogen atoms, and R6 represents hydroxy or substituted or unsubstituted lower alkoxy), or a pharmaceutically acceptable salt thereof and the like.
摘要翻译：本发明提供由式（I）表示的化合物（其中R 1和R 2相同或不同，各自表示氢原子，取代或未取代的低级烷基等，R 3表示取代或未取代的芳基，取代或未取代的芳香族杂环基等，R 4，R 5，它们各自表示氢原子，卤素，取代或未取代的低级烷基，取代或未取代的芳基等，条件是它们不同时为氢原子，R 6表示羟基或取代或未取代的低级烷氧基），或其药学上可接受的盐等。

10. 发明授权

US5749707A Water pumps 失效
标题翻译：水泵
公开(公告)号：US5749707A
公开(公告)日：1998-05-12
申请号：US713352
申请日：1996-09-13
申请人： Yuji Nomoto
发明人： Yuji Nomoto
IPC分类号： F04D29/24 , F04B49/00
CPC分类号： F04D29/242
摘要： A water pump comprises an impeller including a rotor main body and vanes arranged to protrude from an end face of the rotor main body and disposed radially. Each vane has an inlet portion which faces an inlet port of a housing and has an inner end which is substantially perpendicular to the direction of cooling water flowing from the inlet port to the inner periphery of each vane. The inlet portion of the vane has a circular arc with an inclination angle which is substantially identical to an inflow angle of cooling water.
摘要翻译：一种水泵，包括：叶轮，其包括转子主体和布置成从转子主体的端面突出并且径向设置的叶片。每个叶片具有面向壳体的入口的入口部分，并且具有基本上垂直于从入口到每个叶片的内周边的冷却水的方向的内端。叶片的入口部分具有与冷却水的流入角基本相同的倾斜角的圆弧。

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