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1. 发明授权

US06599521B1 Absorbent articles for the inhibition of exoprotein production from Gram positive bacteria 失效
标题翻译：用于抑制革兰氏阳性菌产生外源蛋白的吸收制品
公开(公告)号：US06599521B1
公开(公告)日：2003-07-29
申请号：US09724190
申请日：2000-11-28
申请人： Kim L. Resheski-Wedepohl , Rae Ellen Syverson , David C. Potts , Matthew D. Young , Ali Yahiaoui
发明人： Kim L. Resheski-Wedepohl , Rae Ellen Syverson , David C. Potts , Matthew D. Young , Ali Yahiaoui
IPC分类号： A61F606
CPC分类号： A61F13/8405 , A61K31/702 , A61L15/46 , A61L15/48 , A61L2300/232 , A61L2300/404
摘要： An absorbent article for inhibiting the production of exoproteins from Gram positive bacteria, such as potentially harmful proteins produced by Staphylococcus species, is described. The absorbent article is particularly useful for inhibiting the production of TSST-1, alpha-toxin and/or enterotoxins A, B and C from S. aureus bacterium. An alkyl polyglycoside is incorporated into the absorbent article. For example, alkyl polyglycoside may be coated on the fibers of a liquid-permeable cover of a catamenial tampon.
摘要翻译：描述了用于抑制由革兰氏阳性细菌（例如由葡萄球菌物种产生的潜在有害蛋白质）产生外来蛋白的吸收制品。吸收制品特别适用于抑制从金黄色葡萄球菌中产生TSST-1，α-毒素和/或肠毒素A，B和C. 将烷基多糖苷掺入吸收制品中。例如，烷基多糖苷可以涂覆在月经棉塞的透液性覆盖物的纤维上。

2. 发明授权

US06531435B1 Compositions for the inhibition of exoprotein production from Gram positive bacteria 失效
标题翻译：用于抑制革兰氏阳性细菌产生外源蛋白的组合物
公开(公告)号：US06531435B1
公开(公告)日：2003-03-11
申请号：US09723632
申请日：2000-11-28
申请人： Kim L. Resheski-Wedepohl , Rae Ellen Syverson
发明人： Kim L. Resheski-Wedepohl , Rae Ellen Syverson
IPC分类号： C11D322
CPC分类号： A61F13/8405 , A61K31/702 , A61L15/46 , A61L15/48 , A61L2300/232 , A61L2300/404 , Y10T442/2484 , Y10T442/2525
摘要： Compositions for use in inhibiting the production of exoproteins from Gram positive bacteria, such as harmful proteins produced by Staphylococcus species, are described. The compositions are particularly useful for inhibiting the production of TSST-1, alpha-toxin and/or enterotoxins A, B and C from S. aureus bacteria. The compositions include alkyl polyglycoside and a pharmaceutically acceptable carrier. The alkyl polyglycoside typically has an HLB of at least 10 and/or an average number of carbon atoms in the alkyl chain of 8 to 12.
摘要翻译：描述了用于抑制革兰氏阳性细菌（例如由葡萄球菌物种产生的有害蛋白质）产生外来蛋白的组合物。所述组合物特别可用于抑制来自金黄色葡萄球菌的TSST-1，α-毒素和/或肠毒素A，B和C的产生。组合物包括烷基多糖苷和药学上可接受的载体。烷基多糖苷通常具有至少10的HLB和/或8-12的烷基链中的平均碳原子数。

3. 发明授权

US06656913B1 Inhibition of exoprotein production from gram positive bacteria 失效
标题翻译：从革兰氏阳性菌抑制外生蛋白产生
公开(公告)号：US06656913B1
公开(公告)日：2003-12-02
申请号：US09723589
申请日：2000-11-28
申请人： Kim L. Resheski-Wedepohl , Rae Ellen Syverson
发明人： Kim L. Resheski-Wedepohl , Rae Ellen Syverson
IPC分类号： A61K31047
CPC分类号： A61F13/8405 , A61K31/702 , A61L15/46 , A61L15/48 , A61L2300/232 , A61L2300/404
摘要： A method of inhibiting the production of exoproteins from Gram positive bacteria, such as harmful proteins produced by Staphylococcus species, is described. The method is particularly useful for inhibiting the production of TSST-1, alpha-toxin and/or enterotoxins A, B and C from S. aureus bacteria. The method may be based on exposing Gram positive bacteria to alkyl polyglycoside incorporated into an absorbent product. Alternatively, the methods can include causing Gram positive bacteria to come into contact with the alkyl polyglycoside in other forms, e.g., when formulated with a pharmaceutically acceptable carrier or incorporated in or on a non-absorbent substrate. Typically, the alkyl polyglycoside has an HLB of at least about 10 and an alkyl group with an average of 8 to 14 carbon atoms.
摘要翻译：描述了抑制由革兰氏阳性细菌产生外源蛋白的方法，例如由葡萄球菌物种产生的有害蛋白质。该方法对于抑制来自金黄色葡萄球菌的TSST-1，α-毒素和/或肠毒素A，B和C的产生特别有用。该方法可以基于将革兰氏阳性细菌暴露于掺入吸收产品中的烷基多糖苷。或者，所述方法可以包括使革兰氏阳性细菌以其它形式与烷基多糖苷接触，例如当与药学上可接受的载体一起配制或并入非吸收性底物中时或其上。通常，烷基多糖苷具有至少约10的HLB和平均具有8至14个碳原子的烷基。

4. 发明授权

US07056891B2 Method to produce a tampon that inhibits exoprotein production from gram positive bacteria 失效
标题翻译：产生抑制革兰氏阳性细菌产生外源蛋白的棉塞的方法
公开(公告)号：US07056891B2
公开(公告)日：2006-06-06
申请号：US10647921
申请日：2003-08-26
申请人： Kim L. Resheski-Wedepohl , Rae Ellen Syverson
发明人： Kim L. Resheski-Wedepohl , Rae Ellen Syverson
IPC分类号： A61K31/715
CPC分类号： A61F13/8405 , A61K31/702 , A61L15/46 , A61L15/48 , A61L2300/232 , A61L2300/404
摘要： A method to inhibit the production of exoproteins from Gram positive bacteria, such as harmful proteins produced by Staphylococcus species, is described. The method is particularly useful to inhibit the production of TSST-1, alpha-toxin and/or enterotoxins A, B and C from Staphylococcus aureus bacteria. The method is based on exposing Gram positive bacteria to alkyl polyglycoside incorporated into an absorbent product. Alternate methods include bringing Gram positive bacteria into contact with the alkyl polyglycoside in other forms, e.g., when formulated with a pharmaceutically acceptable carrier or incorporated in or on a non-absorbent substrate. Typically, the alkyl polyglycoside has a hydrophilic/lipophilic balance (HLB) of at least about 10 and an alkyl group with an average of 8 to 14 carbon atoms.
摘要翻译：描述了抑制由革兰氏阳性细菌产生外源蛋白的方法，例如由葡萄球菌物种产生的有害蛋白质。该方法特别有用于抑制来自金黄色葡萄球菌的TSST-1，α-毒素和/或肠毒素A，B和C的产生。该方法基于将革兰氏阳性细菌暴露于掺入吸收产品中的烷基多糖苷。替代方法包括使革兰氏阳性细菌与其它形式的烷基多糖苷接触，例如当与药学上可接受的载体配制或掺入非吸收性基质中时或非吸收性底物上时。通常，烷基多糖苷具有至少约10的亲水/亲油平衡（HLB）和平均具有8至14个碳原子的烷基。

5. 发明授权

US06676957B1 Non-absorbent substrates for the inhibition of exoprotein production from gram positive bacteria 失效
标题翻译：用于抑制革兰氏阳性细菌产生外源蛋白的非吸收性底物
公开(公告)号：US06676957B1
公开(公告)日：2004-01-13
申请号：US09724023
申请日：2000-11-28
申请人： Kim L. Resheski-Wedepohl , Rae Ellen Syverson
发明人： Kim L. Resheski-Wedepohl , Rae Ellen Syverson
IPC分类号： A61K716
CPC分类号： A61F13/8405 , A61K31/702 , A61L15/46 , A61L15/48 , A61L2300/232 , A61L2300/404 , Y10S514/841 , Y10S514/843 , Y10S514/967
摘要： Non-absorbent substrates for use in inhibiting the production of exoproteins from Gram positive bacteria, such as harmful proteins produced by Staphylococcus species, are provided. The substrates are particularly useful for inhibiting the production of TSST-1, alpha-toxin and/or enterotoxins A, B and C from S. aureus bacteria. The substrates include an alkyl polyglycoside incorporated in or on at least a portion of the substrate. The alkyl polyglycoside typically has an HLB of about 10 to 15 and/or an average number of carbon atoms in the alkyl chain of about 8 to about 12.
摘要翻译：提供了用于抑制革兰氏阳性细菌（例如由葡萄球菌物种产生的有害蛋白质）产生外来蛋白的非吸收性底物。底物对于抑制来自金黄色葡萄球菌的TSST-1，α-毒素和/或肠毒素A，B和C的产生特别有用。底物包括掺入到基质的至少一部分中或之上的烷基聚糖苷。烷基多糖苷通常具有约10至15的HLB和/或烷基链中的平均碳原子数约8至约12。

6. 发明授权

US07258867B2 Aromatic compositions as inhibitors of exoprotein production in non-absorbent articles 失效
标题翻译：芳香族组合物作为非吸收性物品中外蛋白生产的抑制剂
公开(公告)号：US07258867B2
公开(公告)日：2007-08-21
申请号：US10803345
申请日：2004-03-18
申请人： Rae Ellen Syverson , Richard A. Proctor
发明人： Rae Ellen Syverson , Richard A. Proctor
IPC分类号： A61F9/00 , A61F13/15 , A01N25/34
CPC分类号： A61K31/165 , A61K31/325 , A61L15/46 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/45 , A61L2300/802
摘要： Non-absorbent articles are disclosed. The non-absorbent articles include an effective amount of an aromatic inhibitory compound to substantially inhibit the production of exotoxins by Gram positive bacteria. The aromatic inhibitory compounds of the present invention have the general formula: wherein R1 is selected from the group consisting of H, and NH2 and salts thereof; R5 is a monovalent saturated or unsaturated aliphatic hydrocarbyl moiety; R6 is a divalent saturated or unsaturated aliphatic hydrocarbyl moiety; R7 is a trivalent saturated or unsaturated aliphatic hydrocarbyl moiety; R8 is a monovalent substituted or unsubstituted saturated or unsaturated aliphatic hydrocarbyl moiety which may or may not be interrupted with hetero atoms; R2, R3, and R4 are independently selected from the group consisting of H, OH, COOH, and —C(O)R9; R9 is hydrogen or a monovalent saturated or unsaturated aliphatic hydrocarbyl moiety.
摘要翻译：公开了非吸收性物品。非吸收性物品包括有效量的芳香族抑制化合物，以显着抑制革兰氏阳性菌产生外毒素。本发明的芳族抑制化合物具有以下通式：其中R 1选自H和NH 2及其盐; R 5是一价饱和或不饱和脂族烃基部分; R 6是二价饱和或不饱和脂族烃基部分; R 7是三价饱和或不饱和脂族烃基部分; R 8是单价取代或未取代的饱和或不饱和脂族烃基部分，其可以或不会被杂原子中断; R 2，R 3和R 4独立地选自H，OH，COOH和-C（O） 9＆lt; 9＆gt; R 9是氢或一价饱和或不饱和脂族烃基部分。

7. 发明授权

US07026354B2 Aromatic compositions for the inhibition of exoprotein production from gram positive bacteria 失效
标题翻译：用于抑制革兰氏阳性细菌产生外源蛋白的芳香族组合物
公开(公告)号：US07026354B2
公开(公告)日：2006-04-11
申请号：US09969218
申请日：2001-10-02
申请人： Rae Ellen Syverson , Richard A. Proctor
发明人： Rae Ellen Syverson , Richard A. Proctor
IPC分类号： A61K31/27 , A61K31/24 , A62D3/00 , A01N25/02
CPC分类号： A61L15/46 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/45 , A61L2300/802
摘要： Compositions including an aromatic compound for inhibiting the production of exoproteins by Gram positive bacteria are disclosed. The aromatic inhibitory compounds of the present invention have the general formula: wherein R1 is selected from the group consisting of H, —OR5, —R6C(O)H, —R6OH, —R6COOH, —OR6OH, —OR6COOH, —C(O)NH2, and NH2 and salts thereof; R5 is a monovalent saturated or unsaturated aliphatic hydrocarbyl moiety; R6 is a divalent saturated or unsaturated aliphatic hydrocarbyl moiety; R7 is a trivalent saturated or unsaturated aliphatic hydrocarbyl moiety; R8 is a monovalent substituted or unsubstituted saturated or unsaturated aliphatic hydrocarbyl moiety which may or may not be interrupted with hetero atoms; R2, R3, and R4 are independently selected from the group consisting of H, OH, COOH, and —C(O)R9; R9 is hydrogen or a monovalent saturated or unsaturated aliphatic hydrocarbyl moiety.
摘要翻译：公开了包含用于抑制革兰氏阳性细菌产生外来蛋白的芳族化合物的组合物。本发明的芳族抑制化合物具有以下通式：其中R 1选自H，-OR 5，-R 6， C（O）H，-R 6 OH，-R 6 COOH，-OR 6 OH，-OR， COOH，-C（O）NH 2和NH 2和它们的盐; R 5是单价饱和或不饱和脂族烃基部分; R 6是二价饱和或不饱和脂族烃基部分; R 7是三价饱和或不饱和脂族烃基部分; R 8是单价取代或未取代的饱和或不饱和脂族烃基部分，其可以或不会被杂原子中断; R 2，R 3和R 4独立地选自H，OH，COOH和-C（O） 9＆lt; 9＆gt; R 9是氢或一价饱和或不饱和脂族烃基部分。

8. 发明授权

US5685872A Inhibition of exoprotein using amide compositions in absorbent article 失效
标题翻译：吸收制品中使用酰胺组合物抑制外蛋白
公开(公告)号：US5685872A
公开(公告)日：1997-11-11
申请号：US487876
申请日：1995-06-07
申请人： Rae Ellen Syverson
发明人： Rae Ellen Syverson
IPC分类号： A61L15/20 , A61L15/46 , A61F13/15 , A61F13/20
CPC分类号： A61L15/20 , A61L15/46 , A61L2300/404 , A61L2300/434 , Y10S604/904
摘要： Absorbent articles, such as catamenial tampons, for absorbing body fluids are disclosed which include an effective amount of a nitrogen containing compound to substantially inhibit the production of exotoxins by Gram positive bacteria. The compound is one or more nitrogen containing compounds having the general formula ##STR1## wherein R.sub.1, inclusive of the carbonyl carbon, is an alkyl group having 8 to 18 carbon atoms and R.sub.2 and R.sub.3 can be the same or different. Moieties R.sub.2 and R.sub.3 can be selected from hydrogen and an alkyl group having 1 to about 12 carbon atoms which may contain one or more substituent groups selected from ester, ether, amine, hydroxyl, carboxyl, carboxyl salts, sulfonate, sulfonate salts and mixtures thereof. The compound is effective in substantially inhibiting the production of TSST-1 and Enterotoxin-B from S. aureus bacteria.
摘要翻译：公开了用于吸收体液的吸收制品，例如月经棉塞，其包括有效量的含氮化合物，以显着抑制革兰氏阳性细菌产生外毒素。化合物是一种或多种具有通式“IMAGE”的含氮化合物，其中R 1（包括羰基碳）是具有8至18个碳原子的烷基，R 2和R 3可以相同或不同。部分R2和R3可以选自氢和具有1至约12个碳原子的烷基，其可以含有一个或多个选自酯，醚，胺，羟基，羧基，羧基盐，磺酸盐，磺酸盐及其混合物的取代基。该化合物有效地显着抑制来自金黄色葡萄球菌的TSST-1和肠毒素-B的产生。

9. 发明授权

US07294651B2 Inhibition of exoprotein production using isoprenoid compositions 失效
标题翻译：使用类异戊二烯组合物抑制外生蛋白产生
公开(公告)号：US07294651B2
公开(公告)日：2007-11-13
申请号：US10900251
申请日：2004-07-27
申请人： Rae Ellen Syverson , Richard A. Proctor
发明人： Rae Ellen Syverson , Richard A. Proctor
IPC分类号： A61K31/05 , A61K9/00
CPC分类号： A61K45/06 , A61K9/0034 , A61K31/045 , Y10S514/967 , A61K2300/00
摘要： Methods and compositions for inhibiting the production of exotoxins are disclosed. The compositions include an effective amount of an isoprenoid inhibitory compound to substantially inhibit the production of exotoxins by Gram positive bacteria.
摘要翻译：公开了用于抑制外毒素生产的方法和组合物。组合物包括有效量的类异戊二烯抑制化合物，以显着抑制革兰氏阳性细菌产生外毒素。

10. 发明申请

US20100274071A1 Aromatic Compositions As Inhibitors Of Exoprotein Production In Non-Absorbent Articles 审中-公开
标题翻译：作为非吸收制品中外蛋白生产抑制剂的芳香族组合物
公开(公告)号：US20100274071A1
公开(公告)日：2010-10-28
申请号：US11683879
申请日：2007-03-08
申请人： Rae Ellen Syverson , Richard A. Proctor
发明人： Rae Ellen Syverson , Richard A. Proctor
IPC分类号： A61M31/00 , A61F6/06 , A61F2/02 , A61F13/26
CPC分类号： A61K31/165 , A61K31/325 , A61L15/46 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/45 , A61L2300/802
摘要： Non-absorbent articles are disclosed. The non-absorbent articles include an effective amount of an aromatic inhibitory compound to substantially inhibit the production of exotoxins by Gram positive bacteria. The aromatic inhibitory compounds of the present invention have the general formula: wherein R1 is selected from the group consisting of H, —OR5, —R6C(O)H, —R6COOH, —OR6COOH, —C(O)NH2, and NH2 and salts thereof; R5 is a monovalent saturated or unsaturated aliphatic hydrocarbyl moiety; R6 is a divalent saturated or unsaturated aliphatic hydrocarbyl moiety; R7 is a trivalent saturated or unsaturated aliphatic hydrocarbyl moiety; R8 is a monovalent substituted or unsubstituted saturated or unsaturated aliphatic hydrocarbyl moiety which may or may not be interrupted with hetero atoms; R2, R3, and R4 are independently selected from the group consisting of H, OH, COOH, and —C(O)R9; R9 is hydrogen or a monovalent saturated or unsaturated aliphatic hydrocarbyl moiety.
摘要翻译：公开了非吸收性物品。非吸收性物品包括有效量的芳香族抑制化合物，以显着抑制革兰氏阳性菌产生外毒素。本发明的芳族抑制化合物具有以下通式：其中R1选自H，-OR5，-R6C（O）H，-R6COOH，-OR6COOH，-C（O）NH2和NH2，以及的盐; R5是单价饱和或不饱和脂族烃基部分; R6是二价饱和或不饱和脂族烃基部分; R7是三价饱和或不饱和脂族烃基部分; R8是单价取代或未取代的饱和或不饱和脂族烃基部分，其可以或不会被杂原子中断; R 2，R 3和R 4独立地选自H，OH，COOH和-C（O）R 9; R9是氢或一价饱和或不饱和脂族烃基部分。

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