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1. 发明授权

US06531435B1 Compositions for the inhibition of exoprotein production from Gram positive bacteria 失效
标题翻译：用于抑制革兰氏阳性细菌产生外源蛋白的组合物
公开(公告)号：US06531435B1
公开(公告)日：2003-03-11
申请号：US09723632
申请日：2000-11-28
申请人： Kim L. Resheski-Wedepohl , Rae Ellen Syverson
发明人： Kim L. Resheski-Wedepohl , Rae Ellen Syverson
IPC分类号： C11D322
CPC分类号： A61F13/8405 , A61K31/702 , A61L15/46 , A61L15/48 , A61L2300/232 , A61L2300/404 , Y10T442/2484 , Y10T442/2525
摘要： Compositions for use in inhibiting the production of exoproteins from Gram positive bacteria, such as harmful proteins produced by Staphylococcus species, are described. The compositions are particularly useful for inhibiting the production of TSST-1, alpha-toxin and/or enterotoxins A, B and C from S. aureus bacteria. The compositions include alkyl polyglycoside and a pharmaceutically acceptable carrier. The alkyl polyglycoside typically has an HLB of at least 10 and/or an average number of carbon atoms in the alkyl chain of 8 to 12.
摘要翻译：描述了用于抑制革兰氏阳性细菌（例如由葡萄球菌物种产生的有害蛋白质）产生外来蛋白的组合物。所述组合物特别可用于抑制来自金黄色葡萄球菌的TSST-1，α-毒素和/或肠毒素A，B和C的产生。组合物包括烷基多糖苷和药学上可接受的载体。烷基多糖苷通常具有至少10的HLB和/或8-12的烷基链中的平均碳原子数。

2. 发明授权

US06656913B1 Inhibition of exoprotein production from gram positive bacteria 失效
标题翻译：从革兰氏阳性菌抑制外生蛋白产生
公开(公告)号：US06656913B1
公开(公告)日：2003-12-02
申请号：US09723589
申请日：2000-11-28
申请人： Kim L. Resheski-Wedepohl , Rae Ellen Syverson
发明人： Kim L. Resheski-Wedepohl , Rae Ellen Syverson
IPC分类号： A61K31047
CPC分类号： A61F13/8405 , A61K31/702 , A61L15/46 , A61L15/48 , A61L2300/232 , A61L2300/404
摘要： A method of inhibiting the production of exoproteins from Gram positive bacteria, such as harmful proteins produced by Staphylococcus species, is described. The method is particularly useful for inhibiting the production of TSST-1, alpha-toxin and/or enterotoxins A, B and C from S. aureus bacteria. The method may be based on exposing Gram positive bacteria to alkyl polyglycoside incorporated into an absorbent product. Alternatively, the methods can include causing Gram positive bacteria to come into contact with the alkyl polyglycoside in other forms, e.g., when formulated with a pharmaceutically acceptable carrier or incorporated in or on a non-absorbent substrate. Typically, the alkyl polyglycoside has an HLB of at least about 10 and an alkyl group with an average of 8 to 14 carbon atoms.
摘要翻译：描述了抑制由革兰氏阳性细菌产生外源蛋白的方法，例如由葡萄球菌物种产生的有害蛋白质。该方法对于抑制来自金黄色葡萄球菌的TSST-1，α-毒素和/或肠毒素A，B和C的产生特别有用。该方法可以基于将革兰氏阳性细菌暴露于掺入吸收产品中的烷基多糖苷。或者，所述方法可以包括使革兰氏阳性细菌以其它形式与烷基多糖苷接触，例如当与药学上可接受的载体一起配制或并入非吸收性底物中时或其上。通常，烷基多糖苷具有至少约10的HLB和平均具有8至14个碳原子的烷基。

3. 发明授权

US07056891B2 Method to produce a tampon that inhibits exoprotein production from gram positive bacteria 失效
标题翻译：产生抑制革兰氏阳性细菌产生外源蛋白的棉塞的方法
公开(公告)号：US07056891B2
公开(公告)日：2006-06-06
申请号：US10647921
申请日：2003-08-26
申请人： Kim L. Resheski-Wedepohl , Rae Ellen Syverson
发明人： Kim L. Resheski-Wedepohl , Rae Ellen Syverson
IPC分类号： A61K31/715
CPC分类号： A61F13/8405 , A61K31/702 , A61L15/46 , A61L15/48 , A61L2300/232 , A61L2300/404
摘要： A method to inhibit the production of exoproteins from Gram positive bacteria, such as harmful proteins produced by Staphylococcus species, is described. The method is particularly useful to inhibit the production of TSST-1, alpha-toxin and/or enterotoxins A, B and C from Staphylococcus aureus bacteria. The method is based on exposing Gram positive bacteria to alkyl polyglycoside incorporated into an absorbent product. Alternate methods include bringing Gram positive bacteria into contact with the alkyl polyglycoside in other forms, e.g., when formulated with a pharmaceutically acceptable carrier or incorporated in or on a non-absorbent substrate. Typically, the alkyl polyglycoside has a hydrophilic/lipophilic balance (HLB) of at least about 10 and an alkyl group with an average of 8 to 14 carbon atoms.
摘要翻译：描述了抑制由革兰氏阳性细菌产生外源蛋白的方法，例如由葡萄球菌物种产生的有害蛋白质。该方法特别有用于抑制来自金黄色葡萄球菌的TSST-1，α-毒素和/或肠毒素A，B和C的产生。该方法基于将革兰氏阳性细菌暴露于掺入吸收产品中的烷基多糖苷。替代方法包括使革兰氏阳性细菌与其它形式的烷基多糖苷接触，例如当与药学上可接受的载体配制或掺入非吸收性基质中时或非吸收性底物上时。通常，烷基多糖苷具有至少约10的亲水/亲油平衡（HLB）和平均具有8至14个碳原子的烷基。

4. 发明授权

US06676957B1 Non-absorbent substrates for the inhibition of exoprotein production from gram positive bacteria 失效
标题翻译：用于抑制革兰氏阳性细菌产生外源蛋白的非吸收性底物
公开(公告)号：US06676957B1
公开(公告)日：2004-01-13
申请号：US09724023
申请日：2000-11-28
申请人： Kim L. Resheski-Wedepohl , Rae Ellen Syverson
发明人： Kim L. Resheski-Wedepohl , Rae Ellen Syverson
IPC分类号： A61K716
CPC分类号： A61F13/8405 , A61K31/702 , A61L15/46 , A61L15/48 , A61L2300/232 , A61L2300/404 , Y10S514/841 , Y10S514/843 , Y10S514/967
摘要： Non-absorbent substrates for use in inhibiting the production of exoproteins from Gram positive bacteria, such as harmful proteins produced by Staphylococcus species, are provided. The substrates are particularly useful for inhibiting the production of TSST-1, alpha-toxin and/or enterotoxins A, B and C from S. aureus bacteria. The substrates include an alkyl polyglycoside incorporated in or on at least a portion of the substrate. The alkyl polyglycoside typically has an HLB of about 10 to 15 and/or an average number of carbon atoms in the alkyl chain of about 8 to about 12.
摘要翻译：提供了用于抑制革兰氏阳性细菌（例如由葡萄球菌物种产生的有害蛋白质）产生外来蛋白的非吸收性底物。底物对于抑制来自金黄色葡萄球菌的TSST-1，α-毒素和/或肠毒素A，B和C的产生特别有用。底物包括掺入到基质的至少一部分中或之上的烷基聚糖苷。烷基多糖苷通常具有约10至15的HLB和/或烷基链中的平均碳原子数约8至约12。

5. 发明授权

US06599521B1 Absorbent articles for the inhibition of exoprotein production from Gram positive bacteria 失效
标题翻译：用于抑制革兰氏阳性菌产生外源蛋白的吸收制品
公开(公告)号：US06599521B1
公开(公告)日：2003-07-29
申请号：US09724190
申请日：2000-11-28
申请人： Kim L. Resheski-Wedepohl , Rae Ellen Syverson , David C. Potts , Matthew D. Young , Ali Yahiaoui
发明人： Kim L. Resheski-Wedepohl , Rae Ellen Syverson , David C. Potts , Matthew D. Young , Ali Yahiaoui
IPC分类号： A61F606
CPC分类号： A61F13/8405 , A61K31/702 , A61L15/46 , A61L15/48 , A61L2300/232 , A61L2300/404
摘要： An absorbent article for inhibiting the production of exoproteins from Gram positive bacteria, such as potentially harmful proteins produced by Staphylococcus species, is described. The absorbent article is particularly useful for inhibiting the production of TSST-1, alpha-toxin and/or enterotoxins A, B and C from S. aureus bacterium. An alkyl polyglycoside is incorporated into the absorbent article. For example, alkyl polyglycoside may be coated on the fibers of a liquid-permeable cover of a catamenial tampon.
摘要翻译：描述了用于抑制由革兰氏阳性细菌（例如由葡萄球菌物种产生的潜在有害蛋白质）产生外来蛋白的吸收制品。吸收制品特别适用于抑制从金黄色葡萄球菌中产生TSST-1，α-毒素和/或肠毒素A，B和C. 将烷基多糖苷掺入吸收制品中。例如，烷基多糖苷可以涂覆在月经棉塞的透液性覆盖物的纤维上。

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