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1. 发明申请

US20060253198A1 Multi-lumen mold for intervertebral prosthesis and method of using same 审中-公开
标题翻译：用于椎间假体的多腔模具及其使用方法
公开(公告)号：US20060253198A1
公开(公告)日：2006-11-09
申请号：US11268786
申请日：2005-11-08
申请人： Khin Myint , Erik Martz , Benjamin Carter , Ronald Burke
发明人： Khin Myint , Erik Martz , Benjamin Carter , Ronald Burke
IPC分类号： A61F2/44
CPC分类号： A61F2/441 , A61F2002/30062 , A61F2002/30578 , A61F2002/30583 , A61F2002/30841 , A61F2002/30878 , A61F2002/4435 , A61F2002/444 , A61F2210/0004 , A61F2210/0085
摘要： A multi-lumen mold is for the in situ formation of a prosthesis in an annulus located in an intervertebral disc space of a patient. The annulus has at least two openings formed by minimally invasive techniques and at least a portion of the nucleus pulposus is removed to form a nuclear cavity. The multi-lumen mold includes a mold adapted to be located in the nuclear cavity. A first lumen having a distal end is fluidly coupled to a flexible mold at a first location. At least a second lumen having a distal end fluidly coupled to the flexible mold at a second location. The first and second lumens are adapted to extend out through the openings in the annulus when the mold is positioned in the nuclear cavity. One or more securing members can be used to secure the mold in the intervertebral disc space. The securing members can engage with the annulus, the end plates, and/or another surface of a vertebrate.
摘要翻译：多腔模具用于在位于患者的椎间盘空间中的环中原位形成假体。所述环具有通过微创技术形成的至少两个开口，并且去除髓核的至少一部分以形成核腔。多腔模具包括适于位于核腔内的模具。具有远端的第一管腔在第一位置处流体地联接到柔性模具。至少第二内腔具有在第二位置处与柔性模具流体耦合的远端。当模具定位在核腔中时，第一和第二内腔适于延伸穿过环形空间中的开口。可以使用一个或多个固定构件将模具固定在椎间盘空间中。固定构件可与环形物，端板和/或脊椎动物的另一表面接合。

2. 发明申请

US20050209602A1 Multi-stage biomaterial injection system for spinal implants 审中-公开
标题翻译：用于脊柱植入物的多级生物材料注射系统
公开(公告)号：US20050209602A1
公开(公告)日：2005-09-22
申请号：US10984566
申请日：2004-11-09
申请人： Bruce Bowman , Robert Kohler , Erik Martz , Daniel Melink , Khin Myint , Michael Ahrens , Jean-Charles Lehuec , John Sherman , Scott Hook , Dennis Johnson , Qi-Bin Bao , Robert Hudgins
发明人： Bruce Bowman , Robert Kohler , Erik Martz , Daniel Melink , Khin Myint , Michael Ahrens , Jean-Charles Lehuec , John Sherman , Scott Hook , Dennis Johnson , Qi-Bin Bao , Robert Hudgins
IPC分类号： A61B17/88 , A61B19/00 , A61F2/00 , A61F2/02 , A61F2/30 , A61F2/44 , A61F2/46
CPC分类号： A61B17/8805 , A61B17/8827 , A61B17/8836 , A61B2090/064 , A61F2/441 , A61F2/4601 , A61F2/4611 , A61F2002/30062 , A61F2002/3008 , A61F2002/30583 , A61F2002/4627 , A61F2002/465 , A61F2002/4663 , A61F2002/467 , A61F2002/4677 , A61F2002/4688 , A61F2002/4693 , A61F2002/4694 , A61F2210/0004 , A61F2210/0085 , A61F2250/0098
摘要： A method and apparatus for fluidly coupling a reservoir containing a flowable biomaterial to a mold. The flow of the flowable biomaterial into the mold is controlled in accordance with a first operating parameter. At least one injection condition is monitored. The flow of the flowable biomaterial is controlled in accordance with a second operating parameter in response to one or more of the injection conditions reaching a threshold level. The second operating parameter is maintained during at least a portion of the curing of the flowable biomaterial. In some embodiments, the second operating parameter may optionally include permitting a portion of the flowable biomaterial to be expelled from the mold.
摘要翻译：一种用于将包含可流动的生物材料的容器流体耦合到模具的方法和装置。根据第一操作参数控制可流动的生物材料流入模具的流动。至少监测一个注射条件。响应于达到阈值水平的一个或多个注入条件，可流动生物材料的流动根据第二操作参数来控制。在可流动的生物材料的固化的至少一部分期间维持第二操作参数。在一些实施例中，第二操作参数可以可选地包括允许可流动的生物材料的一部分从模具中排出。

3. 发明授权

US08029511B2 Multi-stage biomaterial injection system for spinal implants 失效
标题翻译：用于脊柱植入物的多级生物材料注射系统
公开(公告)号：US08029511B2
公开(公告)日：2011-10-04
申请号：US10984493
申请日：2004-11-09
申请人： Bruce R. Bowman , Rob Kohler , Erik Martz , Dan Melink , Khin Myint , Michael Ahrens , Jean-Charles Lehuec , John Sherman , Scott Hook , Dennis Johnson , Qi-Bin Bao , Robert Garryl Hudgins
发明人： Bruce R. Bowman , Rob Kohler , Erik Martz , Dan Melink , Khin Myint , Michael Ahrens , Jean-Charles Lehuec , John Sherman , Scott Hook , Dennis Johnson , Qi-Bin Bao , Robert Garryl Hudgins
IPC分类号： A61B17/58 , A61B17/60 , A61F2/00
CPC分类号： A61B17/8805 , A61B17/8827 , A61B17/8836 , A61B2090/064 , A61F2/441 , A61F2/4601 , A61F2/4611 , A61F2002/30062 , A61F2002/3008 , A61F2002/30583 , A61F2002/4627 , A61F2002/465 , A61F2002/4663 , A61F2002/467 , A61F2002/4677 , A61F2002/4688 , A61F2002/4693 , A61F2002/4694 , A61F2210/0004 , A61F2210/0085 , A61F2250/0098
摘要： A method and apparatus for fluidly coupling a reservoir containing a flowable biomaterial to a mold. The flow of the flowable biomaterial into the mold is controlled in accordance with a first operating parameter. At least one injection condition is monitored. The flow of the flowable biomaterial is controlled in accordance with a second operating parameter in response to one or more of the injection conditions reaching a threshold level. The second operating parameter is maintained during at least a portion of the curing of the flowable biomaterial. In some embodiments, the second operating parameter may optionally include permitting a portion of the flowable biomaterial to be expelled from the mold.
摘要翻译：一种用于将包含可流动的生物材料的容器流体耦合到模具的方法和装置。根据第一操作参数控制可流动的生物材料流入模具的流动。至少监测一个注射条件。响应于达到阈值水平的一个或多个注入条件，可流动生物材料的流动根据第二操作参数来控制。在可流动的生物材料的固化的至少一部分期间维持第二操作参数。在一些实施例中，第二操作参数可以可选地包括允许可流动的生物材料的一部分从模具中排出。

4. 发明申请

US20090076518A1 METHOD AND SYSTEM FOR STABILIZING ADJACENT VERTEBRAE 审中-公开
标题翻译：用于稳定相邻VERTEBRAE的方法和系统
公开(公告)号：US20090076518A1
公开(公告)日：2009-03-19
申请号：US12266301
申请日：2008-11-06
申请人： Bruce R. Bowman , Rob Kohler , Erik Martz , Dan Melink , Khin Myint , Michael Ahrens , Jean-Charles Lehuec , John Sherman , Scott Hook , Dennis Johnson , Qi-Bin Bao , Robert Garryl Hudgins
发明人： Bruce R. Bowman , Rob Kohler , Erik Martz , Dan Melink , Khin Myint , Michael Ahrens , Jean-Charles Lehuec , John Sherman , Scott Hook , Dennis Johnson , Qi-Bin Bao , Robert Garryl Hudgins
IPC分类号： A61B17/58 , A61B19/00
CPC分类号： A61B17/8805 , A61B17/8827 , A61B17/8836 , A61B2090/064 , A61F2/441 , A61F2/4601 , A61F2/4611 , A61F2002/30062 , A61F2002/3008 , A61F2002/30583 , A61F2002/4627 , A61F2002/465 , A61F2002/4663 , A61F2002/467 , A61F2002/4677 , A61F2002/4688 , A61F2002/4693 , A61F2002/4694 , A61F2210/0004 , A61F2210/0085 , A61F2250/0098
摘要： A method of stabilizing adjacent vertebrae including the steps of forming at least one annulotomy in an annulus. At least a portion of the nucleus material is removed through the annulotomy to form a cavity in an intervertebral disc space between the adjacent vertebrae. A reservoir containing a flowable biomaterial is fluidly coupled to the intervertebral disc space. A flowable biomaterial is delivered to the cavity. The delivery of the flowable biomaterial into the intervertebral disc space is controlled in accordance with at least a first operating parameter. The biomaterial is at least partially cured to stabilize the adjacent vertebrae.
摘要翻译：一种稳定相邻椎骨的方法，包括在环空中形成至少一个瓣膜切开术的步骤。至少一部分细胞核材料通过瓣膜切开术去除以在相邻椎骨之间的椎间盘间隙中形成空腔。包含可流动的生物材料的储存器流体耦合到椎间盘空间。可流动的生物材料被输送到空腔。根据至少第一操作参数控制可流动的生物材料输送到椎间盘空间中。生物材料至少部分固化以稳定相邻的椎骨。

5. 发明申请

US20050209601A1 Multi-stage biomaterial injection system for spinal implants 失效
公开(公告)号：US20050209601A1
公开(公告)日：2005-09-22
申请号：US10984493
申请日：2004-11-09
申请人： Bruce Bowman , Robert Kohler , Erik Martz , Daniel Melink , Khin Myint , Michael Ahrens , Jean-Charles Lehuec , John Sherman , Scott Hook , Dennis Johnson , Qi-Bin Bao , Robert Hudgins
发明人： Bruce Bowman , Robert Kohler , Erik Martz , Daniel Melink , Khin Myint , Michael Ahrens , Jean-Charles Lehuec , John Sherman , Scott Hook , Dennis Johnson , Qi-Bin Bao , Robert Hudgins
IPC分类号： A61B17/88 , A61B19/00 , A61F2/00 , A61F2/02 , A61F2/30 , A61F2/44 , A61F2/46
CPC分类号： A61B17/8805 , A61B17/8827 , A61B17/8836 , A61B2090/064 , A61F2/441 , A61F2/4601 , A61F2/4611 , A61F2002/30062 , A61F2002/3008 , A61F2002/30583 , A61F2002/4627 , A61F2002/465 , A61F2002/4663 , A61F2002/467 , A61F2002/4677 , A61F2002/4688 , A61F2002/4693 , A61F2002/4694 , A61F2210/0004 , A61F2210/0085 , A61F2250/0098
摘要： A method and apparatus for fluidly coupling a reservoir containing a flowable biomaterial to a mold. The flow of the flowable biomaterial into the mold is controlled in accordance with a first operating parameter. At least one injection condition is monitored. The flow of the flowable biomaterial is controlled in accordance with a second operating parameter in response to one or more of the injection conditions reaching a threshold level. The second operating parameter is maintained during at least a portion of the curing of the flowable biomaterial. In some embodiments, the second operating parameter may optionally include permitting a portion of the flowable biomaterial to be expelled from the mold.

6. 发明申请

US20090054990A1 MULTI-LUMEN MOLD FOR INTERVERTEBRAL PROSTHESIS AND METHOD OF USING SAME 审中-公开
标题翻译：用于椎间盘突出症的多元模具及其使用方法
公开(公告)号：US20090054990A1
公开(公告)日：2009-02-26
申请号：US12256885
申请日：2008-10-23
申请人： Khin Myint , Erik O. Martz , Benjamin F. Carter , Ronald Burke
发明人： Khin Myint , Erik O. Martz , Benjamin F. Carter , Ronald Burke
IPC分类号： A61F2/44
CPC分类号： A61F2/441 , A61F2002/30062 , A61F2002/30578 , A61F2002/30583 , A61F2002/30841 , A61F2002/30878 , A61F2002/4435 , A61F2002/444 , A61F2210/0004 , A61F2210/0085
摘要： A multi-lumen mold is for the in situ formation of a prosthesis in an intervertebral disc space located between adjacent vertebrae of a patient. The multi-lumen mold a flexible mold, a first lumen, a second lumen and a curable biomaterial. The flexible mold is shaped to be positioned in the intervertebral disc space. The first lumen and the second lumen each have a distal end is fluidly coupled to the flexible mold at a first location and a second location, respectively. The first lumen is shaped to extend out through a first opening extending through one of the adjacent vertebrae when the mold is positioned in the intervertebral disc space. The curable biomaterial is delivered into the flexible mold through at least one of the first and second lumens. The first and second locations can optionally be located on generally opposite sides of the mold, on the same side of the mold, or a variety of other configurations. One or more securing members can be used to secure the mold in the intervertebral disc space. The securing members can engage with the annulus, the end plates, and/or another surface of a vertebrae.
摘要翻译：多腔模具用于在位于患者的相邻椎骨之间的椎间盘空间中原位形成假体。多腔模具是柔性模具，第一腔，第二腔和可固化生物材料。柔性模具成形为定位在椎间盘空间中。分别具有远端的第一管腔和第二管腔分别在第一位置和第二位置处流体耦合到柔性模具。当模具定位在椎间盘空间中时，第一管腔被成形为延伸穿过相邻椎骨中的一个延伸的第一开口。可固化的生物材料通过第一和第二腔中的至少一个被输送到柔性模具中。第一和第二位置可以可选地位于模具的大致相对的两侧，在模具的同一侧，或各种其它构造。可以使用一个或多个固定构件将模具固定在椎间盘空间中。固定构件可以与圆环，端板和/或椎骨的另一表面接合。

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