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1. 发明申请

US20060074282A1 Nitric-oxide detection using Raman spectroscopy 审中-公开
标题翻译：使用拉曼光谱的一氧化氮检测
公开(公告)号：US20060074282A1
公开(公告)日：2006-04-06
申请号：US11234866
申请日：2005-09-26
申请人： Kevin Ward , R. Barbee , Ivo Filho , Roland Pittman , James Terner
发明人： Kevin Ward , R. Barbee , Ivo Filho , Roland Pittman , James Terner
IPC分类号： A61B5/00 , A61B6/00
CPC分类号： A61B5/14546 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/1455 , A61B5/412 , A61B5/445 , G01N21/658
摘要： In an emergency medicine patient, accurate measurement of change or lack thereof from non-shock, non-ischemimc, non-inflammation, non-tissue injury, non-immune dysfunction conditions is important and is provided, as practical, real-time approaches for accurately characterizing a patient's condition, using Raman spectroscopy with a high degree of accuracy, Resonance Raman spectroscopy is used to monitor tissue nitric oxide activity either in vivo or in vitro, especially as a function of its interaction with hemoglobin or other metalloproteins. Measurement times are on the order of seconds. High-accuracy measurement is achieved with Raman spectroscopy interrogation of tissue. Measurements may be non-invasive to minimally invasive. The invention may be used to monitor the effect of instituting therapies using nitric oxide or disease processes that produce nitric oxide.
摘要翻译：在紧急医学病人中，从非休克，非缺血，非炎症，非组织损伤，非免疫功能障碍状况的准确测量变化或缺乏是非常重要的，并且作为实际的实时方法提供了实时的方法使用拉曼光谱法准确地表征患者的状况，使用共振拉曼光谱法在体内或体外监测组织一氧化氮活性，特别是作为其与血红蛋白或其他金属蛋白相互作用的函数。测量次数为秒数。通过拉曼光谱询问组织实现高精度测量。测量可能是非侵入性的微创。本发明可用于监测使用一氧化氮或产生一氧化氮的疾病过程进行治疗的效果。

2. 发明申请

US20060052356A1 Pharmacological methods to modulate oxygen consumption 审中-公开
标题翻译：调节氧气消耗的药理学方法
公开(公告)号：US20060052356A1
公开(公告)日：2006-03-09
申请号：US10952525
申请日：2004-09-29
申请人： Kevin Ward , R. Barbee , Penny Reynolds , Robert Dieglemann , Rakesh Kukreja , Bruce Spiess , Melissa Evans , Eric Edwards
发明人： Kevin Ward , R. Barbee , Penny Reynolds , Robert Dieglemann , Rakesh Kukreja , Bruce Spiess , Melissa Evans , Eric Edwards
IPC分类号： A61K31/33
CPC分类号： A61K31/33
摘要： Methods of modulating oxygen consumption in tissues are provided. In particular, the methods involve the administration of agents that transiently inhibit protein synthesis. The methods are used to treat ischemia and reperfusion-related injuries by temporarily decreasing oxygen consumption needs, and/or by inhibiting inflammation that results from reperfusion.
摘要翻译：提供调节组织中耗氧量的方法。特别地，该方法包括施用瞬时抑制蛋白质合成的试剂。该方法用于通过暂时降低氧气消耗需求和/或通过抑制由再灌注引起的炎症来治疗缺血和再灌注相关的损伤。

3. 发明申请

US20100183583A1 GALK1S AS MODIFIERS OF THE PTEN/AKT PATHWAY AND METHODS OF USE 审中-公开
标题翻译： GALK1S作为PTEN / AKT途径的修饰者及其使用方法
公开(公告)号：US20100183583A1
公开(公告)日：2010-07-22
申请号：US11993191
申请日：2006-06-20
申请人： Arthur Brace , Margaret Lynn Bjerke , Susana Nieto-Bergman , Lori S. Friedman , Kevin Ward , Robert A. Blake
发明人： Arthur Brace , Margaret Lynn Bjerke , Susana Nieto-Bergman , Lori S. Friedman , Kevin Ward , Robert A. Blake
IPC分类号： A61K39/395 , G01N33/53 , C12Q1/68 , A01K67/00 , C12N5/02
CPC分类号： C12N9/14 , G01N33/574 , G01N33/6872 , G01N2333/4704 , G01N2333/9121 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要： Human GALK1 genes are identified as modulators of the PTEN/AKT pathway, and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT, comprising screening for agents that modulate the activity of GALK1 are provided.
摘要翻译：人GALK1基因被鉴定为PTEN / AKT途径的调节剂，因此是与缺陷型PTEN / AKT功能相关的疾病的治疗靶点。提供了用于鉴定PTEN / AKT调节剂的方法，包括筛选调节GALK1活性的试剂。

4. 发明申请

US20070123796A1 Method and apparatus for monitoring intra ocular and intra cranial pressure 有权
标题翻译：监测眼内和颅内压的方法和装置
公开(公告)号：US20070123796A1
公开(公告)日：2007-05-31
申请号：US10565852
申请日：2004-08-06
申请人： Martin Lenhardt , Kevin Ward
发明人： Martin Lenhardt , Kevin Ward
IPC分类号： A61B5/00
CPC分类号： A61B5/031 , A61B5/6814 , A61B5/6821 , A61B8/0808 , A61B8/4227
摘要： A method and apparatus for measuring acoustic energy applied to the head to detect increases in intracranial pressure. Acoustic eye patches are applied to a patient's eye or eyelid, and an ultrasonic sweep generator applies an acoustic signal across the patient's skull, the signal being swept across a predetermined range. The eye patches have piezoelectric film sensors for measuring the acoustic signal. In one embodiment the predetermined range is in the ultrasonic band and an analyzer determines from the output of the sensors a resonant frequency and a damping of acoustic amplitude at said resonant frequency, there being a correlation between said damping and intra cranial pressure. In another embodiment the predetermined range includes a range less than 20 kHz and the analyzer determines retinal artery pulsations, with pressure being applied to the eye until the pulsations disappear, such pressure being a measure of intra cranial pressure.
摘要翻译：一种用于测量施加到头部的声能以检测颅内压升高的方法和装置。声眼补片应用于患者的眼睛或眼睑，超声波扫描发生器在患者的颅骨上施加声学信号，该信号被扫过预定范围。眼贴具有用于测量声信号的压电膜传感器。在一个实施例中，预定范围在超声频带中，分析器根据传感器的输出确定谐振频率和在所述共振频率处的声振幅的阻尼，所述阻尼和颅内压之间存在相关性。在另一个实施例中，预定范围包括小于20kHz的范围，并且分析仪确定视网膜动脉脉动，其中施加压力施加到眼睛直到脉动消失，这种压力是颅内压的量度。

5. 发明申请

US20060185753A1 Papermaker's forming fabric with machine direction stitching yarns that form machine side knuckles 有权
标题翻译：造纸机的成形织物与机器方向缝合纱线形成机器侧关节
公开(公告)号：US20060185753A1
公开(公告)日：2006-08-24
申请号：US11207277
申请日：2005-08-19
申请人： Kevin Ward
发明人： Kevin Ward
IPC分类号： D03D25/00 , D21F1/00
CPC分类号： D21F1/0036
摘要： A papermaking fabric includes a series of repeat units, each of the repeat units including: a first set of top machine direction (MD) yarns; a second set of top MD yarns; a set of top cross machine direction (CMD) yarns interwoven with the first and second sets of top MD yarns; a set of bottom CMD yarns; and a set of pairs of MD stitching yarns interwoven with the top and bottom CMD yarns, each pair of MD stitching yarns sandwiching an immediately adjacent respective top MD yarn of the second set. The first and second sets of top MD yarns interweave only with the top CMD yarns. The top MD yarns of the first set interweave in a first sequence with the top CMD yarns in which the top MD yarns of the first set form a plurality of top side MD knuckles over the top CMD yarns, and the top MD yarns of the second set interweave with the top CMD yarns in a second sequence that differs from the first sequence that differs from the first sequence in that the top MD yarns of the second set form fewer knuckles than are present in the first sequence. Only stitching yarns interweave with the bottom CMD yarns.
摘要翻译：造纸织物包括一系列重复单元，每个重复单元包括：第一组顶部机器方向（MD）纱线; 第二组顶层MD纱线; 一组与第一和第二组顶部MD纱线交织的顶部横向（CMD）纱线; 一套底部CMD纱线; 以及与顶部和底部CMD纱线交织的一组MD缝合纱线，每对MD缝合纱线夹着紧邻第二组的顶部MD纱线。第一组和第二组顶层MD纱线仅与顶部CMD纱线交织。第一组的顶部MD纱线以第一组织的第一顺序交织，其中第一组的顶部MD纱线在顶部CMD纱线上形成多个顶侧MD关节，并且第二组织的顶部MD纱线以与第一序列不同的第一序列的第二序列设置与顶部CMD纱线交织，因为第二组织的顶部MD纱线比第一序列中存在的指节节数更少。只有缝合纱线与底部CMD纱线交织。

6. 发明授权

US06462644B1 Network of vending machines connected interactively to data-base building host 有权
标题翻译：自动售货机网络交互式连接到数据库建筑主机
公开(公告)号：US06462644B1
公开(公告)日：2002-10-08
申请号：US09195415
申请日：1998-11-19
申请人： Thomas P. Howell , Kevin Ward
发明人： Thomas P. Howell , Kevin Ward
IPC分类号： G06F704
CPC分类号： G07F9/026 , G06Q10/087
摘要： A wide area network (WAN) of vending machines connected to a host that builds a database of vending-related information received from the vending machines. Also, a communications system within each vending machine having a vending machine data acquisition unit and a multiple-communication-technology adapter to interface the data acquisition unit to multiple communication technologies including at least one wireless technology. Also, a data structure used to build the database, the data structure having data elements corresponding to an identity of a machine, recent and previous prediction information for the machine, and recent and previous refill-visit information for the machine, the elements being linked together. The multiple vending machines communicate with a communications concentrator via one of many communication technologies. The communications concentrator interfaces the multiple vending machines to a data warehouse that builds a database using the data structure mentioned above. The data warehouse is made available to one or more bottlers for analysis of individual vending machine routing needs and profitability.
摘要翻译：连接到主机的自动售货机的广域网（WAN）构建从自动售货机接收的与售货相关的信息的数据库。而且，每个售货机内的通信系统具有自动售货机数据获取单元和多通信技术适配器，以将数据采集单元与包括至少一种无线技术的多种通信技术相接合。此外，用于构建数据库的数据结构，具有与机器的身份相对应的数据元素的数据结构，用于机器的最近和之前的预测信息以及机器的最近和之前的再填充访问信息，所述元件被链接一起。多台自动售货机通过许多通信技术之一与通信集线器进行通信。通信集中器将多台自动售货机连接到使用上述数据结构构建数据库的数据仓库。数据仓库可用于一个或多个瓶装机，用于分析各个售货机路由需求和盈利能力。

7. 发明授权

US10066796B1 LED light system with elongated body with cavity, diffuser and end caps removably secured thereto 有权
公开(公告)号：US10066796B1
公开(公告)日：2018-09-04
申请号：US15184166
申请日：2016-06-16
申请人： Kevin Ward
发明人： Kevin Ward
IPC分类号： F21S4/28 , F21V15/015 , F21V29/83 , F21V3/04 , F21Y101/02 , F21Y103/00
摘要： A LED light system includes an elongated body extending from a first end to a second end; an elongated strip of a plurality of LED lights secured to the raised connector section; a light defusing cover slidingly engaged with the first slot of the first side and with the second slot of the second side, the light defusing cover having a plurality of elongated textured lines for defusing light from the plurality of LED lights, the light defusing cover being configured to cover the cavity of the elongated body; a first removable end cap removably secured to a first end and removably secured to the first side and the second side; and a second removable end cap removably secured to a second end and removably secured to the first side and the second side. The elongated body includes a first side forming a first slot and a first fastening device configured to receive a first fastener; a second side forming a second slot and a second fastening device configured to receive a second fastener; a cavity formed between the first side and the second side; and a raised connector section integrally attached to the first side and the second side.

8. 发明申请

US20180243153A1 Multiple Actuator Vibration Therapy 审中-公开
公开(公告)号：US20180243153A1
公开(公告)日：2018-08-30
申请号：US15904337
申请日：2018-02-24
申请人： Bogdan I. Epureanu , Kevin Ward , Himanshu Saxena , Mert Egilmez
发明人： Bogdan I. Epureanu , Kevin Ward , Himanshu Saxena , Mert Egilmez
IPC分类号： A61H1/00
CPC分类号： A61H1/005 , A61H1/006 , A61H2201/0142 , A61H2201/0149 , A61H2201/0207 , A61H2201/1614 , A61H2201/164 , A61H2201/1652 , A61H2203/0431 , A61H2203/0456 , A61H2230/065 , A61H2230/085 , A61H2230/201 , A61H2230/206 , A61H2230/208 , A61H2230/255 , A61H2230/405 , A61H2230/505
摘要： A method includes disposing a plurality of actuators about a subject, each actuator being configured to generate a respective vibration signal, each vibration signal applying a normal force to the subject, and controlling the plurality of actuators such that the respective vibration signal of each actuator of the plurality has a respective vibration characteristic. Each actuator is oriented such that the respective vibration signal propagates along a longitudinal axis of the subject for stimulation of the subject remote from the plurality of actuators.

9. 发明申请

US20170049618A1 METHODS AND APPARATUS FOR OPTIMIZING THERAPEUTIC TEMPERATURE CONTROL 审中-公开
标题翻译：用于优化治疗温度控制的方法和装置
公开(公告)号：US20170049618A1
公开(公告)日：2017-02-23
申请号：US15307690
申请日：2015-04-29
申请人： Kevin Ward , Kayvan Najarian , THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： Kevin Ward , Kyle Gunnerson , Kayvan Najarian
IPC分类号： A61F7/12 , A61B5/0205 , A61B5/0476 , A61M5/142 , A61B5/01 , A61B5/145 , A61B3/113 , A61F7/08 , A61B5/00 , A61B5/1455
CPC分类号： A61F7/12 , A61B3/113 , A61B5/01 , A61B5/02055 , A61B5/021 , A61B5/02405 , A61B5/0476 , A61B5/0484 , A61B5/0533 , A61B5/0816 , A61B5/14542 , A61B5/14551 , A61B5/412 , A61B5/4836 , A61B5/6852 , A61B5/7267 , A61B2505/01 , A61F7/02 , A61F7/08 , A61F2007/0093 , A61F2007/0094 , A61F2007/0096 , A61F2007/126 , A61M5/142
摘要： Vascular pressures and oximetry are optimized through administration of fluids and other support prior to manipulating temperature in a therapeutic hypothermia procedure. Temperature and active hemodynamic management are utilized, through measurement and adjustment of temperature and hemodynamic parameters through the use of an internal cooling device, such as endovascular catheter, and/or an external temperature-altering device, to ensure that temperature management is optimized, and hemodynamics and tissue resuscitation are optimized prior to and during temperature manipulation.
摘要翻译：在治疗低温手术中操纵温度之前，通过施用流体和其它支持物来优化血管压力和血压测定。通过使用诸如血管内导管的内部冷却装置和/或外部温度变化装置来测量和调节温度和血液动力学参数，以确保温度管理被优化，并利用温度和主动血液动力学管理，以及血液动力学和组织复苏在温度操作之前和期间被优化。

10. 发明申请

US20150231177A1 Methods and Compositions for Controlled and Sustained Production and Delivery of Peroxides and/or Oxygen for Biological and Industrial Applications 审中-公开
公开(公告)号：US20150231177A1
公开(公告)日：2015-08-20
申请号：US14484884
申请日：2014-09-12
申请人： Kevin Ward , Gary Huvard , Everette Carpenter , Gurbhagat Sandhu , Robert Barbee , Bruce Spiess
发明人： Kevin Ward , Gary Huvard , Everette Carpenter , Gurbhagat Sandhu , Robert Barbee , Bruce Spiess
IPC分类号： A61K33/40 , A61K31/17 , A61K9/50 , A61K47/06
CPC分类号： A61K33/40 , A01N59/00 , A61K9/5031 , A61K31/17 , A61K47/06 , A61L2/0082 , A61L2/0088 , A61L2/186 , A61L2/23 , A61L2202/24 , C01B13/0211 , C01B15/03 , C01B15/032 , C02F1/722 , A01N25/02 , A01N25/30 , A01N27/00 , A01N59/16 , A01N59/20 , A01N2300/00
摘要： Methods and compositions for the controlled and sustained release of peroxides or oxygen to aqueous environments (e.g. a patient's body or circulatory system, or for other applications) or non-aqueous environments, include a material coating or encapsulating hydrogen peroxide, inorganic peroxides or peroxide adducts. In the case of peroxide adducts, and particularly in one type of embodiment, the peroxide adducts should be able to permeate the material, but water, hydrogen peroxide and inorganic peroxides should be able to permeate the material. The methods and compositions that allow the release of oxygen, H2O2 or inorganic peroxides from peroxide adducts with movement of these moieties across a selectively permeable barrier into, preferably, an aqueous environment. In the case of hydrogen peroxide, it can be acted upon by catalase or other enzymes, or be simply degraded, or are otherwise acted upon by enzymes or catalysts embedded in the selectively permeable barrier to produce, for example, O2. Alternatively, hydrogen peroxide or inorganic peroxides can be delivered selectively to a site of action of cleaning, disinfecting or other applications.

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