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1. 发明授权

US06423489B1 Compositions and methods for treatment of Hepatitis C virus-associated diseases 失效
公开(公告)号：US06423489B1
公开(公告)日：2002-07-23
申请号：US08452841
申请日：1995-05-30
申请人： Kevin P. Anderson , Ronnie C. Hanecak , Kazuya Hoshiko , Chikateru Nozaki , Tsukasa Nishihara , Hiroshi Nakatake , Fukusaburo Hamada , Tatsuo Eto , Shinichi Furukawa , Shoji Furusako , Thomas W. Bruice , Walter F. Lima
发明人： Kevin P. Anderson , Ronnie C. Hanecak , Kazuya Hoshiko , Chikateru Nozaki , Tsukasa Nishihara , Hiroshi Nakatake , Fukusaburo Hamada , Tatsuo Eto , Shinichi Furukawa , Shoji Furusako , Thomas W. Bruice , Walter F. Lima
IPC分类号： C12Q168
CPC分类号： C12N15/1131 , C07H21/00 , C07K14/005 , C12N2310/315 , C12N2310/33 , C12N2310/3521 , C12N2310/3527 , C12N2770/24222 , C12Q1/707
摘要： Antisense oligonucleotides are provided which are complementary to and hybridizable with at least a portion of HCV RNA and which are capable of inhibiting the function of the HCV RNA. These oligonucleotides can be administered to inhibit the activity of Hepatitis C virus in vivo or in vitro. These compounds can be used either prophylactically or therapeutically to reduce the severity of diseases associated with Hepatitis C virus, and for diagnosis and detection of HCV and HCV-associated diseases. Methods of using these compounds are also disclosed.

2. 发明授权

US06391542B1 Compositions and methods for treatment of Hepatitis C virus-associated diseases 失效
标题翻译：治疗丙型肝炎病毒相关疾病的组合物和方法
公开(公告)号：US06391542B1
公开(公告)日：2002-05-21
申请号：US08650093
申请日：1996-05-17
申请人： Kevin P. Anderson , Ronnie C. Hanecak , Kazuya Hoshiko , Chikateru Nozaki , Tsukasa Nishihara , Hiroshi Nakatake , Fukusaburo Hamada , Tatsuo Eto , Shinichi Furukawa , Shoji Furasako , Thomas W. Bruice , Walter F. Lima
发明人： Kevin P. Anderson , Ronnie C. Hanecak , Kazuya Hoshiko , Chikateru Nozaki , Tsukasa Nishihara , Hiroshi Nakatake , Fukusaburo Hamada , Tatsuo Eto , Shinichi Furukawa , Shoji Furasako , Thomas W. Bruice , Walter F. Lima
IPC分类号： C12Q168
CPC分类号： C12N15/1131 , C07H21/00 , C07K14/005 , C12N2310/315 , C12N2310/33 , C12N2310/3521 , C12N2310/3527 , C12N2770/24222 , C12Q1/707
摘要： Antisense oligonucleotides are provided which are complementary to and hybridizable with at least a portion of HCV RNA and which are capable of inhibiting the function of the HCV RNA. These oligonucleotides can be administered to inhibit the activity of Hepatitis C virus in vivo or in vitro. These compounds can be used either prophylactically or therapeutically to reduce the severity of diseases associated with Hepatitis C virus, and for diagnosis and detection of HCV and HCV-associated diseases. Methods of using these compounds are also disclosed.
摘要翻译：提供反义寡核苷酸，其与至少一部分HCV RNA互补并可与其相互杂交，并能够抑制HCV RNA的功能。可以施用这些寡核苷酸来体内或体外抑制丙型肝炎病毒的活性。这些化合物可以预防性地或治疗性地用于降低与丙型肝炎病毒相关的疾病的严重性，以及HCV和HCV相关疾病的诊断和检测。还公开了使用这些化合物的方法。

3. 发明授权

US06284458B1 Compositions and methods for treatment of hepatitis C virus-associated diseases 失效
公开(公告)号：US06284458B1
公开(公告)日：2001-09-04
申请号：US08397220
申请日：1995-03-09
申请人： Kevin P. Anderson , Ronnie C. Hanecak , Kazuya Hoshiko , Chikateru Nozaki , Tsukasa Nishihara , Hiroshi Nakatake , Fukusaburo Hamada , Tatsuo Eto , Shinichi Furukawa
发明人： Kevin P. Anderson , Ronnie C. Hanecak , Kazuya Hoshiko , Chikateru Nozaki , Tsukasa Nishihara , Hiroshi Nakatake , Fukusaburo Hamada , Tatsuo Eto , Shinichi Furukawa
IPC分类号： C12Q168
CPC分类号： C12N15/1131 , C07H21/00 , C07K14/005 , C12N2310/315 , C12N2310/33 , C12N2310/3521 , C12N2310/3527 , C12N2770/24222 , C12Q1/707
摘要： Antisense oligonucleotides are provided which are complementary to and hybridizable with at least a portion of HCV RNA and which are capable of inhibiting the function of the HCV RNA. These oligonucleotides can be administered to inhibit the activity of Hepatitis C virus in vivo or in vitro. These compounds can be used either prophylactically or therapeutically to reduce the severity of diseases associated with Hepatitis C virus, and for diagnosis and detection of HCV and HCV-associated diseases. Methods of using these compounds are also disclosed.

4. 发明授权

US5059538A Recombinant plasmid inserted with herpes simplex virus gene 失效
标题翻译：用HERPES SIMPLEX病毒基因插入的重组质粒
公开(公告)号：US5059538A
公开(公告)日：1991-10-22
申请号：US896923
申请日：1986-08-15
申请人： Chikateru Nozaki , Hiroshi Nakatake , Yoichiro Kino , Tatsuo Eto , Keiichi Makizumi , Nobuya Ohtomo
发明人： Chikateru Nozaki , Hiroshi Nakatake , Yoichiro Kino , Tatsuo Eto , Keiichi Makizumi , Nobuya Ohtomo
IPC分类号： C12N15/09 , A61K39/00 , C07H21/04 , C07K14/035 , C12N15/00 , C12N15/38 , C12N15/81 , C12P21/02 , C12R1/19 , C12R1/865
CPC分类号： C12N15/81 , C07K14/005 , A61K39/00 , C12N2710/16622 , Y10S435/942
摘要： A novel recombinant plasmid inserted with a herpes simplex virus gene, which comprises a plasmid vector containing a yeast DNA sequence and an Escherichia coli DNA sequence and carrying a promoter region and a herpes simplex virus gN gene (HSVgB) gene) recombined thereto under control of the promoter, said HSVgB gene lacking an N-terminal portion of the gene including a signal sequence-encoding region and optionally further lacking the region downstream therefrom, such as a gB gene lacking a DNA sequence encoding the N-terminal 30 amino acids, and a gB gene lacking a DNA sequence encoding the N-terminal 83 amino acids. The recombinant plasmid is useful for the production of transformed yeast, which is useful for the production of HSVgB proteins suitable for producing HSV vaccine and diagnostic reagents for herpes simplex virus infections.
摘要翻译：一种插入单纯疱疹病毒基因的新型重组质粒，其包含含有酵母DNA序列和大肠杆菌DNA序列并携带启动子区域和单纯疱疹病毒gN基因（HSVgB）基因）的质粒载体，启动子，所述HSVgB基因缺失包含信号序列编码区的基因的N末端部分，并且任选地进一步缺少其下游区域，例如缺乏编码N末端30个氨基酸的DNA序列的gB基因，以及缺乏编码N-末端83个氨基酸的DNA序列的gB基因。重组质粒可用于生产转化酵母，其可用于生产适用于生产HSV疫苗的HSVgB蛋白和用于单纯疱疹病毒感染的诊断试剂。

5. 发明申请

US20050164365A1 Genetically modified ecarin and process for producing the same 审中-公开
标题翻译：转基因茄子及其生产方法
公开(公告)号：US20050164365A1
公开(公告)日：2005-07-28
申请号：US10482925
申请日：2002-07-04
申请人： Hiroshi Yonemura , Takayuki Imamura , Hiroshi Nakatake , Kenji Soejima , Chikateru Nozaki
发明人： Hiroshi Yonemura , Takayuki Imamura , Hiroshi Nakatake , Kenji Soejima , Chikateru Nozaki
IPC分类号： C12N9/64 , C12N15/12 , C07H21/04 , C12N1/21 , C12N5/06 , C12N15/74
CPC分类号： C12N9/6418
摘要： A recombinant ecarin protein that specifically activates prothrombin, said protein being efficiently prepared by the genetic engineering technique comprising the steps: (1) culturing a transformant microorganism or animal cell transformed with an expression vector in which a gene encoding ecarin is incorporated to the downstream of a promoter so as to produce and accumulate ecarin in culture supernatant or within said transformant and recovering the produced ecarin; and (2) purifying a solution containing the recovered ecarin to obtain purified ecarin. The present invention allows for production of recombinant ecarin on an industrial scale.
摘要翻译：一种特异性激活凝血酶原的重组ecarin蛋白，所述蛋白通过遗传工程技术有效地制备，包括以下步骤：（1）培养用表达载体转化的转化体微生物或动物细胞，其中将编码ecarin的基因并入到促进剂，以在培养上清液或所述转化体内产生和积累ecarin并回收所产生的ecarin; 和（2）纯化含有回收的ecarin的溶液以获得纯化的ecarin。本发明允许以工业规模生产重组ecarin。

6. 发明授权

US07635577B2 Process for producing human thrombin by gene modification technique 失效
标题翻译：通过基因修饰技术生产人凝血酶的方法
公开(公告)号：US07635577B2
公开(公告)日：2009-12-22
申请号：US10482926
申请日：2002-07-04
申请人： Hiroshi Yonemura , Tajayuki Imamura , Hiroshi Nakatake , Kenji Soejima , Chikateru Nozaki
发明人： Hiroshi Yonemura , Tajayuki Imamura , Hiroshi Nakatake , Kenji Soejima , Chikateru Nozaki
IPC分类号： C12P21/04
CPC分类号： C12N9/6424 , C12Y304/21005
摘要： A genetic recombinant human thrombin is provided. Human thrombin is efficiently prepared by the genetic engineering technique comprising the steps: (1) culturing a transfectant animal cell transfected with an expression vector in which a gene encoding human prethrombin is incorporated to the downstream of a promoter so as to produce and accumulate prethrombin in culture supernatant and recovering the produced human prethrombin; (2) treating a solution containing human prethrombin recovered in step (1) with ecarin so as to convert human prethrombin into human thrombin; and (3) purifying the solution obtained after the above activation process to obtain purified human thrombin. The present invention allows for provision of human thrombin in a large scale in a safe and economical manner due to exclusion of blood-derived components.
摘要翻译：提供了基因重组人凝血酶。通过基因工程技术有效制备人凝血酶，所述方法包括以下步骤：（1）培养用表达载体转染的转染细胞动物细胞，其中将编码人凝血酶原的基因并入启动子的下游，以产生并累积凝血酶原培养上清液并回收生产的人凝血酶原; （2）用ecarin处理步骤（1）中回收的含有人凝血酶原的溶液，以将人凝血酶原转化为人凝血酶; （3）纯化上述活化处理后得到的溶液，得到纯化人凝血酶。本发明允许以安全和经济的方式大规模提供人类凝血酶，因为排除了血液衍生的成分。

7. 发明授权

US08519751B2 Gate drive circuit 失效
标题翻译：门驱动电路
公开(公告)号：US08519751B2
公开(公告)日：2013-08-27
申请号：US13390721
申请日：2010-09-02
申请人： Tatsuya Kitamura , Hiroshi Nakatake , Yasushi Nakayama
发明人： Tatsuya Kitamura , Hiroshi Nakatake , Yasushi Nakayama
IPC分类号： H03K3/00
CPC分类号： H03K17/04106
摘要： A gate drive circuit capable of turning on a semiconductor switching element at high speed, which includes: a buffer circuit including a turn-on-drive switching element and a turn-off-drive switching element that are complementarily turned on and off, for driving the semiconductor switching element; a first DC voltage supply including a positive electrode connected to the source or emitter of the turn-on-drive switching element and a negative electrode connected to a reference potential; and a second DC voltage supply including a positive electrode connected to the source or emitter of the turn-off-drive switching element and a negative electrode connected to the reference potential.
摘要翻译：一种能够高速地接通半导体开关元件的栅极驱动电路，其特征在于包括：缓冲电路，其包括驱动开关元件和关断驱动开关元件，所述导通驱动开关元件和关断驱动开关元件互补地导通和截止，用于驱动半导体开关元件; 第一DC电压源，包括连接到驱动开关元件的源极或发射极的正极和连接到参考电位的负极; 以及包括连接到关断驱动开关元件的源极或发射极的正极和连接到参考电位的负极的第二直流电压源。

8. 发明授权

US08427225B2 Gate driving circuit 有权
标题翻译：门驱动电路
公开(公告)号：US08427225B2
公开(公告)日：2013-04-23
申请号：US12681515
申请日：2008-09-03
申请人： Hiroshi Nakatake , Masaru Fuku , Tatsuya Okuda , Yoshikazu Tsunoda
发明人： Hiroshi Nakatake , Masaru Fuku , Tatsuya Okuda , Yoshikazu Tsunoda
IPC分类号： H03K17/687
CPC分类号： H02M1/08 , H03K17/0406 , H03K17/0412 , H03K17/162 , H03K2217/0036
摘要： To obtain a gate driving circuit in which rising of a constant current of a constant current circuit is fast and power saving is achieved, the gate driving circuit includes: a constant current driving circuit (28) for supplying a constant current; a gate terminal of a power semiconductor element (1), which is connected to an output terminal of the constant current driving circuit; a comparator (22) for comparing a voltage at the gate terminal with a predetermined voltage value and outputting a signal indicating that the voltage is higher than the predetermined voltage value; and a driving control section (20) for increasing a current from the constant current driving circuit in response to a signal for turning on the power semiconductor element, and reducing the current from the constant current driving circuit in response to the signal from the comparator.
摘要翻译：为了获得恒定电流电路的恒定电流的上升快速并且实现功率节省的栅极驱动电路，栅极驱动电路包括：用于提供恒定电流的恒定电流驱动电路（28）; 功率半导体元件（1）的栅极端子，连接到恒流驱动电路的输出端子; 比较器（22），用于将栅极端子处的电压与预定电压值进行比较，并输出表示电压高于预定电压值的信号; 以及用于响应于用于接通功率半导体元件的信号而增加来自恒定电流驱动电路的电流并且响应于来自比较器的信号而减小来自恒定电流驱动电路的电流的驱动控制部分（20）。

9. 发明申请

US20100231269A1 DRIVE CIRCUIT FOR SEMICONDUCTOR ELEMENT 有权
标题翻译：半导体元件的驱动电路
公开(公告)号：US20100231269A1
公开(公告)日：2010-09-16
申请号：US12294437
申请日：2007-04-04
申请人： Hiroshi Nakatake , Satoshi Ishibashi , Shinsuke Idenoue , Takeshi Oi , Shinichi Kinouchi , Takeshi Horiguchi
发明人： Hiroshi Nakatake , Satoshi Ishibashi , Shinsuke Idenoue , Takeshi Oi , Shinichi Kinouchi , Takeshi Horiguchi
IPC分类号： H03K3/021
CPC分类号： H03K17/18 , H03K17/08128 , H03K17/168
摘要： A drive circuit wherein any abnormality of a semiconductor element is prevented from being erroneously sensed in a case where a gate “ON” command has entered in a state in which a gate voltage of the semiconductor element has not lowered fully. A detection process for a controlled variable of the semiconductor element is permitted only within a period which corresponds to a controlled variable of the semiconductor element at the time when an “ON” signal has been inputted to a control circuit, and a detected controlled variable which is detected within the period and a comparison controlled variable which is set in correspondence with the controlled variable are compared so as to output an abnormality signal, whereby the semiconductor element is turn-off at a speed lower than in normal turn-off.
摘要翻译：在半导体元件的栅极电压未完全降低的状态下，在栅极“ON”指令进入的情况下，防止半导体元件的任何异常被错误地检测到的驱动电路。只有在“ON”信号被输入到控制电路时的半导体元件的受控变量对应的期间内才允许半导体元件的受控变量的检测处理，以及检测到的控制变量，在与该控制变量对应的情况下设定的比较控制变量进行比较，从而输出异常信号，由此半导体元件以比正常关断低的速度关断。

10. 发明申请

US20140055190A1 GATE DRIVE CIRCUIT 有权
标题翻译：门控驱动电路
公开(公告)号：US20140055190A1
公开(公告)日：2014-02-27
申请号：US14114572
申请日：2011-06-09
申请人： Masashi Kaneko , Shizuri Tamura , Hiroshi Nakatake
发明人： Masashi Kaneko , Shizuri Tamura , Hiroshi Nakatake
IPC分类号： H03K17/042
CPC分类号： H03K17/04206 , H02M1/08 , H03K17/04213 , H03K17/164 , H03K17/168 , H03K17/74
摘要： A gate drive circuit for driving an IGBT serving as a power semiconductor device includes a constant-current gate drive circuit that charges a gate capacity of the IGBT at a constant current, and a constant-voltage gate drive circuit that is connected in parallel to the constant-current gate drive circuit between input and output terminals thereof via a series circuit constituted by a MOSFET and a resistor, and charges the gate capacity of the IGBT at a constant voltage, wherein the gate drive circuit charges the gate capacity of the IGBT using both the constant-current gate drive circuit and the constant-voltage gate drive circuit at the time of driving the IGBT.
摘要翻译：用于驱动用作功率半导体器件的IGBT的栅极驱动电路包括恒定电流栅极驱动电路，其以恒定电流对IGBT的栅极电容进行充电;以及恒压栅极驱动电路，其与通过由MOSFET和电阻构成的串联电路在其输入和输出端之间的恒流栅极驱动电路，并以恒定电压对IGBT的栅极电容充电，其中栅极驱动电路使IGBT的栅极电容充电在驱动IGBT时，恒流栅极驱动电路和恒压栅极驱动电路都是。

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