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    • 6. 发明申请
    • SECRETED FXYD PROTEINS EXPRESSED IN RESPONSE TO EPITHELIAL TISSUE DAMAGE, AND USES THEREFOR
    • 分泌的FXYD蛋白质对上皮组织损伤的反应及其用途
    • US20120183562A1
    • 2012-07-19
    • US13203193
    • 2010-02-24
    • Gerard BradyShaun AinsworthPatricia HurleyChristopher PottenJeffrey Moore
    • Gerard BradyShaun AinsworthPatricia HurleyChristopher PottenJeffrey Moore
    • A61K39/395C07K17/00C07K14/435G01N33/53A61K39/00C07H21/04A61P17/00C07K16/28A61K38/17
    • G01N33/6893
    • Secreted FXYD family proteins are expressed by intestinal mucosa and/or associated tissues to regulate cell production in intestinal crypts in response to tissue damage. Such tissue damage may arise from disease, exposure to injurious chemicals (e.g., due to poisoning, chemotherapy, chemical weapons), or exposure to injurious radiation (e.g., due to nuclear power accidents, radiological weapons, radiation therapy). Because these proteins are secreted in response to epithelial tissue damage, some of them are implicated in tissue repair response or an inflammatory response which prolongs or exacerbates the tissue damage. Examples of these proteins include FXYD 3, FXYD 4, and FXYD 5. Diagnostic methods based upon the role of the FXYD proteins in epithelial tissue damage are disclosed. Also provided are antibodies raised against the FXYD family proteins, a kit for detecting at least an epitope of a polypeptide, a method of producing an antibody raised against an epitope of a polypeptide, and a method of diagnosing damage to an epithelial tissue.
    • 分泌的FXYD家族蛋白质由肠粘膜和/或相关组织表达,以调节肠道隐窝中的细胞产生以响应组织损伤。 这种组织损伤可能由疾病,暴露于有害化学物质(例如由于中毒,化疗,化学武器)或暴露于有害辐射(例如由于核电事故,放射性武器,放射治疗)而产生。 因为这些蛋白质是响应于上皮组织损伤而分泌的,其中一些蛋白质涉及组织修复反应或延长或加剧组织损伤的炎症反应。 这些蛋白质的实例包括FXYD 3,FXYD 4和FXYD 5.基于FXYD蛋白在上皮组织损伤中的作用的诊断方法被公开。 还提供了针对FXYD家族蛋白产生的抗体,用于检测多肽的至少一个表位的试剂盒,产生针对多肽的表位产生的抗体的方法,以及诊断对上皮组织的损伤的方法。
    • 7. 发明申请
    • Flourescent organic nanofibrils as sensory materials for explosives detection
    • 荧光有机纳米纤维作为爆炸物检测的感觉材料
    • US20090233374A1
    • 2009-09-17
    • US12110869
    • 2008-04-28
    • Ling ZangJeffrey MooreTammene NaddoWei Zhang
    • Ling ZangJeffrey MooreTammene NaddoWei Zhang
    • G01N33/00B29C39/00G01N21/75
    • G01N33/0047G01N21/6428G01N27/4141G01N33/0057Y10T436/17
    • The present invention relates to a class of fluorescent, organic nanofibrils, and particularly the films comprising entangled piling of these nanofibrils exhibiting effective quenching of their fluorescence upon exposure the vapor of explosives. The invention also relates to a sensor and a method for sensing the explosives vapor and other volatile organic compounds, including the explosives taggants through the modulation of the fluorescence of the nanofibril film and the electrical conductivity of the nanofibrils. The invention also relates to a development of synthetic methods, protocols and techniques that leads to production of various arylene-ethynylene macrocycle (AEM) molecules, which consist of a shape-persistent, toroidal scaffold in planar conformation, with minimal ring strain and highly tunable ring sizes (from 0.5 nm to above 10 nm). The invention also relates to an approach to optimization of the one-dimensional molecular arrangement along the long axis of the nanofibril, which provides increased exciton (excited state) migration (via cofacial intermolecular electronic coupling) and charge transport (via pi-electronic delocalization). A combination of long-range exciton migration and efficient charge transport makes the nanofibrils ideal as sensory materials for detecting explosives and other volatile organic compounds through both optical and electrical sensing mechanisms.
    • 本发明涉及一类荧光,有机纳米原纤维,特别是涉及这些纳米纤维缠结的薄膜,这些纳米纤维在暴露爆炸物的蒸气时表现出有效的淬灭荧光。 本发明还涉及一种用于通过调节纳米纤维膜的荧光和纳米原纤维的电导率来感测爆炸物蒸汽和其它挥发性有机化合物(包括爆炸物标记物)的传感器和方法。 本发明还涉及导致生产各种亚芳基 - 亚乙炔大环(AEM)分子的合成方法,方案和技术的开发,所述亚芳基 - 亚乙炔大环(AEM)分子由平面构象中的形状持久的环形支架构成,具有最小的环应变和高度可调的 环尺寸(从0.5nm到10nm以上)。 本发明还涉及一种优化沿着纳米纤丝长轴的一维分子排列的方法,该方法提供增加的激子(激发态)迁移(通过共面分子间电子耦合)和电荷传输(通过π电子离域) 。 长距离激子迁移和高效电荷传输的组合使得纳米原纤维理想成为用于通过光学和电学感测机制检测爆炸物和其它挥发性有机化合物的感觉材料。