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1. 发明申请

US20120183562A1 SECRETED FXYD PROTEINS EXPRESSED IN RESPONSE TO EPITHELIAL TISSUE DAMAGE, AND USES THEREFOR 审中-公开
标题翻译：分泌的FXYD蛋白质对上皮组织损伤的反应及其用途
公开(公告)号：US20120183562A1
公开(公告)日：2012-07-19
申请号：US13203193
申请日：2010-02-24
申请人： Gerard Brady , Shaun Ainsworth , Patricia Hurley , Christopher Potten , Jeffrey Moore
发明人： Gerard Brady , Shaun Ainsworth , Patricia Hurley , Christopher Potten , Jeffrey Moore
IPC分类号： A61K39/395 , C07K17/00 , C07K14/435 , G01N33/53 , A61K39/00 , C07H21/04 , A61P17/00 , C07K16/28 , A61K38/17
CPC分类号： G01N33/6893
摘要： Secreted FXYD family proteins are expressed by intestinal mucosa and/or associated tissues to regulate cell production in intestinal crypts in response to tissue damage. Such tissue damage may arise from disease, exposure to injurious chemicals (e.g., due to poisoning, chemotherapy, chemical weapons), or exposure to injurious radiation (e.g., due to nuclear power accidents, radiological weapons, radiation therapy). Because these proteins are secreted in response to epithelial tissue damage, some of them are implicated in tissue repair response or an inflammatory response which prolongs or exacerbates the tissue damage. Examples of these proteins include FXYD 3, FXYD 4, and FXYD 5. Diagnostic methods based upon the role of the FXYD proteins in epithelial tissue damage are disclosed. Also provided are antibodies raised against the FXYD family proteins, a kit for detecting at least an epitope of a polypeptide, a method of producing an antibody raised against an epitope of a polypeptide, and a method of diagnosing damage to an epithelial tissue.
摘要翻译：分泌的FXYD家族蛋白质由肠粘膜和/或相关组织表达，以调节肠道隐窝中的细胞产生以响应组织损伤。这种组织损伤可能由疾病，暴露于有害化学物质（例如由于中毒，化疗，化学武器）或暴露于有害辐射（例如由于核电事故，放射性武器，放射治疗）而产生。因为这些蛋白质是响应于上皮组织损伤而分泌的，其中一些蛋白质涉及组织修复反应或延长或加剧组织损伤的炎症反应。这些蛋白质的实例包括FXYD 3，FXYD 4和FXYD 5.基于FXYD蛋白在上皮组织损伤中的作用的诊断方法被公开。还提供了针对FXYD家族蛋白产生的抗体，用于检测多肽的至少一个表位的试剂盒，产生针对多肽的表位产生的抗体的方法，以及诊断对上皮组织的损伤的方法。

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