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1. 发明授权

US06523356B2 Meted hyperpolarized noble gas dispensing methods and associated devices 失效
公开(公告)号：US06523356B2
公开(公告)日：2003-02-25
申请号：US09949394
申请日：2001-09-07
申请人： Kenton C. Hasson , Paul L. Bogorad , David L. Zollinger , Geri T. K. Zollinger , John Nouls
发明人： Kenton C. Hasson , Paul L. Bogorad , David L. Zollinger , Geri T. K. Zollinger , John Nouls
IPC分类号： F17C1302
CPC分类号： A61K49/1815
摘要： Methods of dispensing meted quantities of hyperpolarized gas to form a hyperpolarized gas mixture include pre-filling a gas syringe with a quantity of non-polarized gas, then introducing the hyperpolarized gas therein while the non-polarized gas is held therein, and expelling both the hyperpolarized gas and non-polarized gas from the syringe. Methods of inhibiting the presence of oxygen in gas flow paths and extraction systems are also described.

2. 发明授权

US06269648B1 Hyperpolarized gas containers, solenoids, transport and storage devices and associated transport and storage methods 失效
标题翻译：超极化气体容器，螺线管，运输和存储设备以及相关的运输和储存方法
公开(公告)号：US06269648B1
公开(公告)日：2001-08-07
申请号：US09333571
申请日：1999-06-16
申请人： Kenton C. Hasson , Geri T. K. Zollinger , David L. Zollinger , Paul L. Bogorad , Bradley A. Wheeler
发明人： Kenton C. Hasson , Geri T. K. Zollinger , David L. Zollinger , Paul L. Bogorad , Bradley A. Wheeler
IPC分类号： F25B2100
CPC分类号： G01R33/282 , A61K49/1815 , F17C1/00 , F17C3/00 , F17C13/002 , F17C13/005 , F17C2201/0128 , F17C2201/0176 , F17C2201/058 , F17C2203/0604 , F17C2203/0607 , F17C2203/0629 , F17C2203/0636 , F17C2203/0646 , F17C2203/066 , F17C2203/0685 , F17C2203/0697 , F17C2205/0134 , F17C2205/0323 , F17C2205/035 , F17C2205/0352 , F17C2205/0382 , F17C2221/07 , F17C2223/0123 , F17C2223/035 , F17C2225/0123 , F17C2225/035 , F17C2227/041 , F17C2227/044 , F17C2250/032 , F17C2250/0404 , F17C2250/0491 , F17C2260/012 , F17C2260/026 , F17C2260/03 , F17C2270/02 , F17C2270/0536 , Y10S62/914
摘要： A compact portable transport unit for shipping hyperpolarized noble gases and shielding same from electromagnetic interference and/or external magnetic fields includes a means for shifting the resonance frequency of the hyperpolarized gas outside the bandwidth of typical frequencies associated with prevalent time-dependent fields produced by electrical sources. Preferably the transport unit includes a magnetic holding field which is generated from a solenoid in the transport unit. The solenoid includes a plurality of coil segments and is sized and configured to receive the gas chamber of a container. The gas container is configured with a valve, a spherical body, and an extending capillary stem between the valve and the body. The gas container or hyperpolarized product container can also be formed as a resilient bag. The distribution method includes positioning a multi-bolus container within the transport unit to shield it and transporting same to a second site remote from the first site and subsequently dispensing into smaller patient sized formulations which can be transported (shielded) in another transport unit to yet another site.
摘要翻译：用于运输超极化惰性气体并将其与电磁干扰和/或外部磁场屏蔽的紧凑便携式运输单元包括用于将超极化气体的共振频率移动到与由电气产生的流行的时间依赖场相关的典型频率的带宽之外的装置来源。优选地，传送单元包括从传送单元中的螺线管产生的磁保持场。螺线管包括多个线圈段，其尺寸和构造用于容纳容器的气室。气体容器在阀和主体之间配置有阀，球体和延伸的毛细管杆。气体容器或超极化产品容器也可以形成为弹性袋。分配方法包括将多次推注容器定位在运输单元内以对其进行屏蔽并将其运送到远离第一部位的第二部位，并随后分配到可在另一运输单元中运输（屏蔽）的较小的患者尺寸的配方中另一个网站。

3. 发明授权

US06807810B2 Hyperpolarized gas containers, solenoids, transport and storage devices and associated transport and storage methods 失效
标题翻译：超极化气体容器，螺线管，运输和存储设备以及相关的运输和储存方法
公开(公告)号：US06807810B2
公开(公告)日：2004-10-26
申请号：US10192359
申请日：2002-07-10
申请人： Kenton C. Hasson , Geri T. K. Zollinger , David L. Zollinger , Paul L. Bogorad , Bradley A. Wheeler
发明人： Kenton C. Hasson , Geri T. K. Zollinger , David L. Zollinger , Paul L. Bogorad , Bradley A. Wheeler
IPC分类号： E25B2102
CPC分类号： G01R33/282 , A61K49/1815 , F17C1/00 , F17C3/00 , F17C13/002 , F17C13/005 , F17C2201/0128 , F17C2201/0176 , F17C2201/058 , F17C2203/0604 , F17C2203/0607 , F17C2203/0629 , F17C2203/0636 , F17C2203/0646 , F17C2203/066 , F17C2203/0685 , F17C2203/0697 , F17C2205/0134 , F17C2205/0323 , F17C2205/035 , F17C2205/0352 , F17C2205/0382 , F17C2221/07 , F17C2223/0123 , F17C2223/035 , F17C2225/0123 , F17C2225/035 , F17C2227/041 , F17C2227/044 , F17C2250/032 , F17C2250/0404 , F17C2250/0491 , F17C2260/012 , F17C2260/026 , F17C2260/03 , F17C2270/02 , F17C2270/0536 , Y10S62/914
摘要： A compact portable transport unit for shipping hyperpolarized noble gases and shielding same from electromagnetic interference and/or external magnetic fields includes a means for shifting the resonance frequency of the hyperpolarized gas outside the bandwidth of typical frequencies associated with prevalent time-dependent fields produced by electrical sources. Preferably the transport unit includes a magnetic holding field which is generated from a solenoid in the transport unit. The solenoid includes a plurality of coil segments and is sized and configured to receive the gas chamber of a container. The gas container is configured with a valve, a spherical body, and an extending capillary stem between the valve and the body. The gas container or hyperpolarized product container can also be formed as a resilient bag. The distribution method includes positioning a multi-bolus container within the transport unit to shield it and transporting same to a second site remote from the first site and subsequently dispensing into smaller patient sized formulations which can be transported (shielded) in another transport unit to yet another site.
摘要翻译：用于运输超极化惰性气体并将其与电磁干扰和/或外部磁场屏蔽的紧凑便携式运输单元包括用于将超极化气体的共振频率移动到与由电气产生的流行的时间依赖场相关的典型频率的带宽之外的装置来源。优选地，传送单元包括从传送单元中的螺线管产生的磁保持场。螺线管包括多个线圈段，其尺寸和构造用于容纳容器的气室。气体容器在阀和主体之间配置有阀，球体和延伸的毛细管杆。气体容器或超极化产品容器也可以形成为弹性袋。分配方法包括将多次推注容器定位在运输单元内以对其进行屏蔽并将其运送到远离第一部位的第二部位，并随后分配到可在另一运输单元中运输（屏蔽）的较小的患者尺寸的配方中另一个网站。

4. 发明授权

US06286319B1 Meted hyperpolarized noble gas dispensing methods and associated devices 失效
标题翻译： Meted超极化惰性气体分配方法及相关设备
公开(公告)号：US06286319B1
公开(公告)日：2001-09-11
申请号：US09528750
申请日：2000-03-20
申请人： Kenton C. Hasson , Paul L. Bogorad , David L. Zollinger , Geri T. K. Zollinger
发明人： Kenton C. Hasson , Paul L. Bogorad , David L. Zollinger , Geri T. K. Zollinger
IPC分类号： F17C1302
CPC分类号： G01R33/282 , A61K49/1815
摘要： Methods of extracting and removing hyperpolarized gas from a container include introducing an extraction fluid into the container to force the hyperpolarized gas out of an exit port. The hyperpolarized gas is forced out of the container separate and apart from the extraction fluid. Alternatively, if the fluid is a gas, a portion of the gas is mixed with the hyperpolarized gas to form a sterile mixed fluid product suitable for introduction to a patient. An additional method includes engaging a gas transfer source such as a syringe to a transport container and pulling a quantity of the hyperpolarized gas out of the container in a controlled manner. Alternatively, one or more gas syringes can be employed to mete out predictable quantities of hyperpolarized gas or gas mixtures including quantities of buffer gases. Another method includes introducing a quantity of liquid into a container and covering at least one predetermined internal surface or component with the liquid to mask the surfaces and keep the hyperpolarized gas away from the predetermined internal surface, thereby inhibiting any depolarizing affect from same. Examples of surfaces or components suitable for masking include valves, seals, and the like. Yet another extraction method includes expanding a resilient member inside the container to force the hyperpolarized gas to exit therefrom. Containers include a resilient member positioned in fluid communication with the hyperpolarized gas in the container. An additional container includes inlet and outlet ports in fluid communication with the chamber and positioned on opposing sides or end portions of the container. Another container includes a port configured to receive a portion of a syringe therein. An additional aspect of the disclosure relates to calibration methods and apparatus for identifying the hyperpolarization status of the gas.
摘要翻译：从容器中提取和去除超极化气体的方法包括将提取流体引入容器以迫使超极化气体离开出口。超极化气体被从容器中分离出并与提取液分开。或者，如果流体是气体，则将一部分气体与超极化气体混合以形成适于引入患者的无菌混合流体产品。附加方法包括将诸如注射器的气体输送源接合到运输容器，并以受控的方式将一定量的超极化气体从容器中拉出。或者，可以使用一个或多个气体注射器来消除可预测量的超极化气体或气体混合物，包括缓冲气体的量。另一种方法包括将一定量的液体引入容器并用液体覆盖至少一个预定的内表面或部件以掩蔽表面，并使超极化气体远离预定的内表面，由此抑制任何去极化的影响。适于掩蔽的表面或部件的实例包括阀，密封件等。另一种提取方法包括在容器内膨胀弹性构件以迫使超极化气体从其中排出。容器包括与容器中的超极化气体流体连通的弹性构件。另外的容器包括与腔室流体连通并定位在容器的相对侧或端部上的入口和出口。另一容器包括构造成在其中容纳一部分注射器的端口。本公开的另一方面涉及用于识别气体的超极化状态的校准方法和装置。

5. 发明授权

US06995641B2 Hyperpolarized gas containers, solenoids, transport and storage devices and associated transport and storage methods 失效
公开(公告)号：US06995641B2
公开(公告)日：2006-02-07
申请号：US10402491
申请日：2003-03-28
申请人： Kenton C. Hasson , Geri T. K. Zollinger , David L. Zollinger , Paul L. Bogorad , Bradley A. Wheeler
发明人： Kenton C. Hasson , Geri T. K. Zollinger , David L. Zollinger , Paul L. Bogorad , Bradley A. Wheeler
IPC分类号： H01F7/00
CPC分类号： G01R33/282 , A61K49/1815 , F17C1/00 , F17C3/00 , F17C13/002 , F17C13/005 , F17C2201/0128 , F17C2201/0176 , F17C2201/058 , F17C2203/0604 , F17C2203/0607 , F17C2203/0629 , F17C2203/0636 , F17C2203/0646 , F17C2203/066 , F17C2203/0685 , F17C2203/0697 , F17C2205/0134 , F17C2205/0323 , F17C2205/035 , F17C2205/0352 , F17C2205/0382 , F17C2221/07 , F17C2223/0123 , F17C2223/035 , F17C2225/0123 , F17C2225/035 , F17C2227/041 , F17C2227/044 , F17C2250/032 , F17C2250/0404 , F17C2250/0491 , F17C2260/012 , F17C2260/026 , F17C2260/03 , F17C2270/02 , F17C2270/0536 , Y10S62/914
摘要： A compact portable transport unit for shipping hyperpolarized noble gases and shielding same from electromagnetic interference and/or external magnetic fields includes a means for shifting the resonance frequency of the hyperpolarized gas outside the bandwidth of typical frequencies associated with prevalent time-dependent fields produced by electrical sources. Preferably the transport unit includes a magnetic holding field which is generated from a solenoid in the transport unit. The solenoid includes a plurality of coil segments and is sized and configured to receive the gas chamber of a container. The gas container is configured with a valve, a spherical body, and an extending capillary stem between the valve and the body. The gas container or hyperpolarized product container can also be formed as a resilient bag. The distribution method includes positioning a multi-bolus container within the transport unit to shield it and transporting same to a second site remote from the first site and subsequently dispensing into smaller patient sized formulations which can be transported (shielded) in another transport unit to yet another site.

6. 发明授权

US06430939B1 Hyperpolarized gas containers,solenoids, transport and storage devices and associated transport and storage methods 有权
公开(公告)号：US06430939B1
公开(公告)日：2002-08-13
申请号：US09846720
申请日：2001-05-01
申请人： Kenton C. Hasson , Geri T. K. Zollinger , David L. Zollinger , Paul L. Bogorad , Bradley A. Wheeler
发明人： Kenton C. Hasson , Geri T. K. Zollinger , David L. Zollinger , Paul L. Bogorad , Bradley A. Wheeler
IPC分类号： F17C1302
摘要： A compact portable transport unit for shipping hyperpolarized noble gases and shielding same from electromagnetic interference and/or external magnetic fields includes a means for shifting the resonance frequency of the hyperpolarized gas outside the bandwidth of typical frequencies associated with prevalent time-dependent fields produced by electrical sources. Preferably the transport unit includes a magnetic holding field which is generated from a solenoid in the transport unit. The solenoid includes a plurality of coil segments and is sized and configured to receive the gas chamber of a container. The gas container is configured with a valve, a spherical body, and an extending capillary stem between the valve and the body. The gas container or hyperpolarized product container can also be formed as a resilient bag. The distribution method includes positioning a multi-bolus container within the transport unit to shield it and transporting same to a second site remote from the first site and subsequently dispensing into smaller patient sized formulations which can be transported (shielded) in another transport unit to yet another site.

7. 发明授权

US06237363B1 Hyperpolarized noble gas extraction methods masking methods and associated transport containers 失效
标题翻译：超极化惰性气体提取方法掩蔽方法和相关运输容器
公开(公告)号：US06237363B1
公开(公告)日：2001-05-29
申请号：US09163721
申请日：1998-09-30
申请人： David L. Zollinger , Geri T. K. Zollinger , Kenton C. Hasson , Paul L. Bogorad , Bastiaan Driehuys
发明人： David L. Zollinger , Geri T. K. Zollinger , Kenton C. Hasson , Paul L. Bogorad , Bastiaan Driehuys
IPC分类号： F25J100
CPC分类号： G01R33/282 , A61K49/1815 , Y10T436/11 , Y10T436/24 , Y10T436/25
摘要： Methods of extracting and removing hyperpolarized gas from a container include introducing an extraction fluid into the container to force the hyperpolarized gas out of an exit port. The hyperpolarized gas is forced out of the container separate and apart from the extraction fluid. Alternatively, if the fluid is a gas, a portion of the gas is mixed with the hyperpolarized gas to form a sterile mixed fluid product suitable for introduction to a patient. An additional method includes engaging a gas transfer source such as a syringe to a transport container and pulling a quantity of the hyperpolarized gas out of the container in a controlled manner. Another method includes introducing a quantity of liquid into a container and covering at least one predetermined internal surface or component with the liquid to mask the surfaces and keep the hyperpolarized gas away from the predetermined internal surface, thereby inhibiting any depolarizing affect from same. Examples of surfaces or components suitable for masking include valves, seals, and the like. Yet another extraction method includes expanding a resilient member inside the container to force the hyperpolarized gas to exit therefrom. Containers include a resilient member positioned in fluid communication with the hyperpolarized gas in the container. An additional container includes inlet and outlet ports in fluid communication with the chamber and positioned on opposing sides or end portions of the container. Another container includes a port configured to receive a portion of a syringe therein. An additional aspect of the disclosure relates to calibration methods and apparatus for identifying the hyperpolarization status of the gas.
摘要翻译：从容器中提取和去除超极化气体的方法包括将提取流体引入容器以迫使超极化气体离开出口。超极化气体被从容器中分离出并与提取液分开。或者，如果流体是气体，则将一部分气体与超极化气体混合以形成适于引入患者的无菌混合流体产品。附加方法包括将诸如注射器的气体输送源接合到运输容器，并以受控的方式将一定量的超极化气体从容器中拉出。另一种方法包括将一定量的液体引入容器并用液体覆盖至少一个预定的内表面或部件以掩蔽表面，并使超极化气体远离预定的内表面，由此抑制任何去极化的影响。适于掩蔽的表面或部件的实例包括阀，密封件等。另一种提取方法包括在容器内膨胀弹性构件以迫使超极化气体从其中排出。容器包括与容器中的超极化气体流体连通的弹性构件。另外的容器包括与腔室流体连通并定位在容器的相对侧或端部上的入口和出口。另一容器包括构造成在其中容纳一部分注射器的端口。本公开的另一方面涉及用于识别气体的超极化状态的校准方法和装置。

8. 发明授权

US06427452B2 Hyperpolarized noble gas extraction methods, masking methods, and associated transport containers 失效
标题翻译：超极化惰性气体提取方法，掩蔽方法和相关运输容器
公开(公告)号：US06427452B2
公开(公告)日：2002-08-06
申请号：US09828636
申请日：2001-04-06
申请人： David L. Zollinger , Kenton C. Hasson , Paul L. Bogorad , Bastiaan Driehuys
发明人： David L. Zollinger , Kenton C. Hasson , Paul L. Bogorad , Bastiaan Driehuys
IPC分类号： F25B1900
CPC分类号： G01R33/282 , A61K49/1815 , Y10T436/11 , Y10T436/24 , Y10T436/25
摘要： Methods of extracting and removing hyperpolarized gas from a container include introducing an extraction fluid into the container to force the hyperpolarized gas out of an exit port. The hyperpolarized gas is forced out of the container separate and apart from the extraction fluid. Alternatively, if the fluid is a gas, a portion of the gas is mixed with the hyperpolarized gas to form a sterile mixed fluid product suitable for introduction to a patient. An additional method includes engaging a gas transfer source such as a syringe to a transport container and pulling a quantity of the hyperpolarized gas out of the container in a controlled manner. Another method includes introducing a quantity of liquid into a container and covering at least one predetermined internal surface or component with the liquid to mask the surfaces and keep the hyperpolarized gas away from the predetermined internal surface, thereby inhibiting any depolarizing affect from same. Examples of surfaces or components suitable for masking include valves, seals, and the like. Yet another extraction method includes expanding a resilient member inside the container to force the hyperpolarized gas to exit therefrom. Containers include a resilient member positioned in fluid communication with the hyperpolarized gas in the container. An additional container includes inlet and outlet ports in fluid communication with the chamber and positioned on opposing sides or end portions of the container. Another container includes a port configured to receive a portion of a syringe therein. An additional aspect of the disclosure relates to calibration methods and apparatus for identifying the hyperpolarization status of the gas.
摘要翻译：从容器中提取和去除超极化气体的方法包括将提取流体引入容器以迫使超极化气体离开出口。超极化气体被从容器中分离出并与提取液分开。或者，如果流体是气体，则将一部分气体与超极化气体混合以形成适于引入患者的无菌混合流体产品。附加方法包括将诸如注射器的气体输送源接合到运输容器，并以受控的方式将一定量的超极化气体从容器中拉出。另一种方法包括将一定量的液体引入容器并用液体覆盖至少一个预定的内表面或部件以掩蔽表面，并使超极化气体远离预定的内表面，由此抑制任何去极化的影响。适于掩蔽的表面或部件的实例包括阀，密封件等。另一种提取方法包括在容器内膨胀弹性构件以迫使超极化气体从其中排出。容器包括与容器中的超极化气体流体连通的弹性构件。另外的容器包括与腔室流体连通并定位在容器的相对侧或端部上的入口和出口。另一容器包括构造成在其中容纳一部分注射器的端口。本公开的另一方面涉及用于识别气体的超极化状态的校准方法和装置。

9. 发明授权

US06667008B2 Hyperpolarized noble gas extraction methods, masking methods, and associated transport containers 有权
公开(公告)号：US06667008B2
公开(公告)日：2003-12-23
申请号：US10348418
申请日：2003-01-21
申请人： David L. Zollinger , Kenton C. Hasson , Bastiaan Driehuys
发明人： David L. Zollinger , Kenton C. Hasson , Bastiaan Driehuys
IPC分类号： G01N700
CPC分类号： G01R33/282 , A61K49/1815 , Y10T436/11 , Y10T436/24 , Y10T436/25
摘要： Methods of extracting and removing hyperpolarized gas from a container include introducing an extraction fluid into the container to force the hyperpolarized gas out of an exit port. The hyperpolarized gas is forced out of the container separate and apart from the extraction fluid. Alternatively, if the fluid is a gas, a portion of the gas is mixed with the hyperpolarized gas to form a sterile mixed fluid product suitable for introduction to a patient. An additional method includes engaging a gas transfer source such as a syringe to a transport container and pulling a quantity of the hyperpolarized gas out of the container in a controlled manner. Another method includes introducing a quantity of liquid into a container and covering at least one predetermined internal surface or component with the liquid to mask the surfaces and keep the hyperpolarized gas away from the predetermined internal surface, thereby inhibiting any depolarizing affect from same. Examples of surfaces or components suitable for masking include valves, seals, and the like. Yet another extraction method includes expanding a resilient member inside the container to force the hyperpolarized gas to exit therefrom. Containers include a resilient member positioned in fluid communication with the hyperpolarized gas in the container. An additional container includes inlet and outlet ports in fluid communication with the chamber and positioned on opposing sides or end portions of the container. Another container includes a port configured to receive a portion of a syringe therein. An additional aspect of the disclosure relates to calibration methods and apparatus for identifying the hyperpolarization status of the gas.

10. 发明授权

US06537825B1 Hyperpolarized noble gas extraction methods, masking methods, and associated transport containers 有权
公开(公告)号：US06537825B1
公开(公告)日：2003-03-25
申请号：US09568859
申请日：2000-05-09
申请人： David L. Zollinger , Kenton C. Hasson , Bastiaan Driehuys
发明人： David L. Zollinger , Kenton C. Hasson , Bastiaan Driehuys
IPC分类号： G01N2400
CPC分类号： G01R33/282 , A61K49/1815 , Y10T436/11 , Y10T436/24 , Y10T436/25
摘要： Methods of extracting and removing hyperpolarized gas from a container include introducing an extraction fluid into the container to force the hyperpolarized gas out of an exit port. The hyperpolarized gas is forced out of the container separate and apart from the extraction fluid. Alternatively, if the fluid is a gas, a portion of the gas is mixed with the hyperpolarized gas to form a sterile mixed fluid product suitable for introduction to a patient. An additional method includes engaging a gas transfer source such as a syringe to a transport container and pulling a quantity of the hyperpolarized gas out of the container in a controlled manner. Another method includes introducing a quantity of liquid into a container and covering at least one predetermined internal surface or component with the liquid to mask the surfaces and keep the hyperpolarized gas away from the predetermined internal surface, thereby inhibiting any depolarizing affect from same. Examples of surfaces or components suitable for masking include valves, seals, and the like. Yet another extraction method includes expanding a resilient member inside the container to force the hyperpolarized gas to exit therefrom. Containers include a resilient member positioned in fluid communication with the hyperpolarized gas in the container. An additional container includes inlet and outlet ports in fluid communication with the chamber and positioned on opposing sides or end portions of the container. Another container includes a port configured to receive a portion of a syringe therein. An additional aspect of the disclosure relates to calibration methods and apparatus for identifying the hyperpolarization status of the gas.

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