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1. 发明申请

US20090022784A1 SYSTEMS, DEVICES, AND METHODS FOR IONTOPHORETIC DELIVERY OF COMPOSITIONS INCLUDING LIPOSOME-ENCAPSULATED INSULIN 审中-公开
标题翻译：用于组织输送的组织的装置，装置和方法，包括脂质体包被的胰岛素
公开(公告)号：US20090022784A1
公开(公告)日：2009-01-22
申请号：US12138230
申请日：2008-06-12
申请人： Kentaro Kogure , Misuzu Watanabe , Hideyoshi Harashima
发明人： Kentaro Kogure , Misuzu Watanabe , Hideyoshi Harashima
IPC分类号： A61K9/127 , A61K38/28 , A61P3/00
CPC分类号： A61N1/303 , A61K9/0009 , A61K9/0014 , A61K9/1272 , A61K38/28
摘要： Systems, devices, and methods for delivering one or more active ingredients to intradermal tissues, deep regions of pores, and intradermal tissues in the vicinity of pores. In some embodiments, a composition is provided including a plurality of liposomes including a cationic lipid, and an amphiphilic glycerophospholipid having a saturated fatty acid moiety and an unsaturated fatty acid moiety, and at least one insulin, insulin analog, or insulin derivative.
摘要翻译：将一种或多种活性成分递送到孔附近的真皮内组织，毛孔深部和皮内组织的系统，装置和方法。在一些实施方案中，提供了包含多个包含阳离子脂质的脂质体和具有饱和脂肪酸部分和不饱和脂肪酸部分的两亲性甘油磷脂以及至少一种胰岛素，胰岛素类似物或胰岛素衍生物的组合物。

2. 发明授权

US08097276B2 Method for coating particle with lipid film 失效
标题翻译：用脂质膜包覆颗粒的方法
公开(公告)号：US08097276B2
公开(公告)日：2012-01-17
申请号：US11795513
申请日：2006-01-18
申请人： Kentaro Kogure , Arisa Minoura , Hideyoshi Harashima
发明人： Kentaro Kogure , Arisa Minoura , Hideyoshi Harashima
IPC分类号： A61K9/127 , A01N25/26 , G01N33/00
CPC分类号： A61K9/127 , B01J13/02 , B01J13/04
摘要： A method for coating an object, i.e. a particle, with two sheets of lipid film having a space formed there between. In the method for coating a particle having a positive electrostatic-charging property with two sheets of lipid film, the particle having a positive electrostatic-charging property is brought into contact with a plurality of SUV type liposomes having a negative electrostatic-charging property to form a complex having a negative electrostatic-charging property containing the particle having a positive electrostatic-charging property and the SUV type liposomes having a negative electrostatic-charging property coupled electrostatically with the particle having a positive electrostatic-charging property, and then the complex having a negative electrostatic-charging property is treated with cation.
摘要翻译：一种用两层脂质膜涂覆物体即颗粒的方法，所述脂质膜在其间形成有空间。在利用两片脂质膜涂布具有正静电充电性的颗粒的方法中，具有正静电带电性的颗粒与多个具有负静电充电性质的SUV型脂质体接触以形成具有含有具有正静电充电性的颗粒的负静电充电性的复合物和具有负静电充电性能的SUV型脂质体与具有正静电充电性质的颗粒静电耦合，然后该络合物具有用阳离子处理负静电充电性能。

3. 发明申请

US20100136099A1 LIPOSOME FOR INDUCTION OF CELL-MEDIATED IMMUNITY 审中-公开
标题翻译：用于诱导细胞介导的免疫的脂质体
公开(公告)号：US20100136099A1
公开(公告)日：2010-06-03
申请号：US12449670
申请日：2008-02-26
申请人： Hideyoshi Harashima , Kentaro Kogure , Takashi Nakamura , Rumiko Moriguchi , Kohei Ono , Homhuan Atthachai
发明人： Hideyoshi Harashima , Kentaro Kogure , Takashi Nakamura , Rumiko Moriguchi , Kohei Ono , Homhuan Atthachai
IPC分类号： A61K9/127 , A61K39/00 , A61P35/04
CPC分类号： A61K9/1272 , A61K39/0011 , A61K39/385 , A61K39/39 , A61K2039/55516 , A61K2039/55555
摘要： Disclosed is a liposome which includes an antigenic substance therein and has, on its surface, a peptide containing several contiguous arginine residues. The liposome enables an antigen-presenting cell to achieve the selective antigen presentation through an MHC Class-I molecule, and can induce a cell-mediated immunity specifically. The liposome can also induce the antigen presentation by a matured dendritic cell.
摘要翻译：公开了一种在其中包含抗原物质的脂质体，其表面上含有几个连续的精氨酸残基的肽。脂质体使得抗原呈递细胞能够通过MHC I类分子实现选择性抗原呈递，并且可以特异性诱导细胞介导的免疫。脂质体也可以通过成熟的树突状细胞诱导抗原呈递。

4. 发明申请

US20080193514A1 COMPOSTIONS AND METHODS FOR IONTOPHORESIS DELIVERY OF ACTIVE INGREDIENTS THROUGH HAIR FOLLICLES 审中-公开
标题翻译：组合物和方法通过头发手段输送活性成分进行静脉输送
公开(公告)号：US20080193514A1
公开(公告)日：2008-08-14
申请号：US11929451
申请日：2007-10-30
申请人： Kentaro Kogure , Masahiko Yamamoto , Hideyoshi Harashima
发明人： Kentaro Kogure , Masahiko Yamamoto , Hideyoshi Harashima
IPC分类号： A61K9/127
CPC分类号： A61N1/0448 , A61K9/0009 , A61K9/1272 , A61N1/0444
摘要： Systems, devices, and methods for delivering one or more active ingredients to deep regions of hair follicles and intradermal tissues in the vicinity of hair follicles. In some embodiments, a composition is provided including an active ingredient carried in a liposome. The liposome includes a cationic lipid and an amphiphilic glycerophospholipid having a saturated fatty acid moiety and unsaturated fatty acid moiety.
摘要翻译：将一种或多种活性成分递送到毛囊附近的毛囊和皮内组织的深部区域的系统，装置和方法。在一些实施方案中，提供了包含在脂质体中携带的活性成分的组合物。脂质体包括阳离子脂质和具有饱和脂肪酸部分和不饱和脂肪酸部分的两亲性甘油磷脂。

5. 发明申请

US20070059353A1 Polyarginine-modified liposome having nuclear entry ability 失效
标题翻译：具有核进入能力的聚精氨酸改性脂质体
公开(公告)号：US20070059353A1
公开(公告)日：2007-03-15
申请号：US11396081
申请日：2006-03-31
申请人： Hideyoshi Harashima , Shiroh Futaki , Kentaro Kogure
发明人： Hideyoshi Harashima , Shiroh Futaki , Kentaro Kogure
IPC分类号： A61K48/00 , A61K9/127 , C12N15/88
CPC分类号： C12N15/88 , A61K9/1273 , A61K47/34 , A61K47/645 , A61K47/6911 , C07K1/1077
摘要： With the object of providing a liposome having cellular and nuclear entry ability, to achieve this object, a liposome is provided having on its surface a peptide comprising multiple consecutive arginine residues, and specifically a liposome is provided wherein the peptide is modified with a hydrophobic group or hydrophobic compound and the hydrophobic group or hydrophobic compound is inserted into a lipid bilayer so that the peptide is exposed on the surface of the bilayer.
摘要翻译：为了提供具有细胞和核进入能力的脂质体，为了达到这个目的，提供了一种脂质体，其表面上含有多个连续的精氨酸残基的肽，特别是提供一种脂质体，其中肽用疏水基团修饰或疏水性化合物，并且将疏水基团或疏水性化合物插入脂质双层中，使得该肽暴露在双层的表面上。

6. 发明授权

US08920845B2 Method of producing microcapsules 有权
标题翻译：生产微胶囊的方法
公开(公告)号：US08920845B2
公开(公告)日：2014-12-30
申请号：US12513237
申请日：2007-11-02
申请人： Yoshinobu Baba , Manabu Tokeshi , Noritada Kaji , Hideyoshi Harashima , Kentaro Kogure , Yasuo Shinohara , Hiroshi Kuramoto
发明人： Yoshinobu Baba , Manabu Tokeshi , Noritada Kaji , Hideyoshi Harashima , Kentaro Kogure , Yasuo Shinohara , Hiroshi Kuramoto
IPC分类号： A61K9/50 , A61K9/51 , A61K31/7088 , A61K48/00 , A61K9/127 , B01J13/04 , C12N15/87
CPC分类号： A61K48/0008 , A61K9/1271 , A61K9/1277 , A61K9/5169 , A61K9/5192 , A61K48/0041 , B01J13/04 , C12N15/87
摘要： It is intended to provide a method whereby various kinds of microcapsules, which are usable in, for example, a gene vector, can be produced in a small amount. This production method comprises: feeding a fluid containing a substance to be encapsulated into at lease one (13) of material-feeding microchannels in a substrate in which these material-feeding microchannels (12, 13, 14) and a reaction microchannel (18) connected to these material-feeding microchannels are formed; feeding an envelop-forming fluid containing a material for forming envelopes into at least one of the other material-feeding microchannels (12, 14); and allowing the envelope-forming fluid and the fluid containing the encapsulated substance that converge in the reaction microchannel from each material-feeding microchannel to flow through the reaction microchannel while continuously maintaining the interface between the fluids formed at the confluence thereof.
摘要翻译：旨在提供可以少量生产可用于例如基因载体的各种微胶囊的方法。该制造方法包括：将含有待包封物质的流体在至少一个材料供给微通道的基材中进料，其中这些材料供给微通道（12,13,14）和反应微通道（18）与这些送料微通道相连; 将含有用于形成信封的材料的包络成形流体进料到至少一个其它材料馈送微通道（12,14）中; 并且允许包络成形流体和含有从每个供料微通道收集到反应微通道中的包封物质的流体流过反应微通道，同时连续地保持在其汇合处形成的流体之间的界面。

7. 发明申请

US20100292454A1 NEURONAL REGENERATION PROMOTING AGENT 审中-公开
标题翻译：神经再生促进剂
公开(公告)号：US20100292454A1
公开(公告)日：2010-11-18
申请号：US11993575
申请日：2006-06-20
申请人： Yuji Mishina , Masahisa Yamada , Runa Araya , Haruo Kishida , Kentaro Kogure , Hideyoshi Harashima
发明人： Yuji Mishina , Masahisa Yamada , Runa Araya , Haruo Kishida , Kentaro Kogure , Hideyoshi Harashima
IPC分类号： C07H21/02
CPC分类号： A61K31/713
摘要： It is an object of the present invention to provide a novel neuronal regeneration promoting agent, particularly a neuronal regeneration promoting agent having an inhibitory effect on glial scar formation. The present invention provides a neuronal regeneration promoting agent which comprises an inhibitor of a bone morphogenetic protein type 1A receptor (BMPR1A) as an active ingredient.
摘要翻译：本发明的目的是提供一种新颖的神经元再生促进剂，特别是对胶质瘢痕形成具有抑制作用的神经元再生促进剂。本发明提供神经元再生促进剂，其包含作为活性成分的骨形态发生蛋白1A型受体（BMPR1A）的抑制剂。

8. 发明申请

US20100166840A1 LIPOSOME HAVING LIPID MEMBRANE CONTAINING BACTERIAL CELL COMPONENT 审中-公开
标题翻译：具有含有细胞细胞组分的脂质膜的脂质体
公开(公告)号：US20100166840A1
公开(公告)日：2010-07-01
申请号：US12300622
申请日：2007-05-11
申请人： Homhuan Atthachai , Kentaro Kogure , Hideyoshi Harashima , Ikuya Yano , Yoshio Hatakeyama , Hidehiro Yokomizo , Hideyuki Akaza
发明人： Homhuan Atthachai , Kentaro Kogure , Hideyoshi Harashima , Ikuya Yano , Yoshio Hatakeyama , Hidehiro Yokomizo , Hideyuki Akaza
IPC分类号： A61K9/127 , A61K39/04 , A61K39/05 , A61K39/02 , A61P35/00 , A61P37/04
CPC分类号： A61K9/127 , A61K9/1271 , A61K35/74 , A61K39/04 , A61K39/39 , A61K2039/55511 , A61K2039/55555 , A61K2039/57
摘要： The object is to provide a liposome by which a bacterial cell component insoluble in water and an organic solvent (e.g., BCG-CW) can be pharmaceutically prepared in a form applicable to a living body (i.e., a form in which the bacterial cell component can be dispersed in an aqueous solvent and has a controlled size) without using any surfactant. Disclosed is a liposome having a lipid membrane containing a bacterial cell component insoluble in water and an organic solvent (e.g., BCG-CW).
摘要翻译：本发明的目的是提供一种可溶于水和有机溶剂（例如BCG-CW）的细菌细胞组分可以以适用于生物体的形式（即细菌细胞成分可以分散在水性溶剂中并具有受控的尺寸），而不使用任何表面活性剂。公开了具有含有不溶于水的细菌细胞成分和有机溶剂（例如BCG-CW）的脂质膜的脂质体。

9. 发明申请

US20090136563A1 Method for Coating Particle with Lipid Film 失效
标题翻译：用脂质膜涂覆颗粒的方法
公开(公告)号：US20090136563A1
公开(公告)日：2009-05-28
申请号：US11795513
申请日：2006-01-18
申请人： Kentaro Kogure , Arisa Minoura , Hideyoshi Harashima
发明人： Kentaro Kogure , Arisa Minoura , Hideyoshi Harashima
IPC分类号： A61K9/127 , B01J13/04
CPC分类号： A61K9/127 , B01J13/02 , B01J13/04
摘要： A method for coating an object, i.e. a particle, with two sheets of lipid film having a space formed there between. In the method for coating a particle having a positive electrostatic-charging property with two sheets of lipid film, the particle having a positive electrostatic-charging property is brought into contact with a plurality of SUV type liposomes having a negative electrostatic-charging property to form a complex having a negative electrostatic-charging property containing the particle having a positive electrostatic-charging property and the SUV type liposomes having a negative electrostatic-charging property coupled electrostatically with the particle having a positive electrostatic-charging property, and then the complex having a negative electrostatic-charging property is treated with cation.
摘要翻译：一种用两层脂质膜涂覆物体即颗粒的方法，所述脂质膜在其间形成有空间。在利用两片脂质膜涂布具有正静电充电性的颗粒的方法中，具有正静电带电性的颗粒与多个具有负静电充电性质的SUV型脂质体接触以形成具有含有具有正静电充电性的颗粒的负静电充电性的复合物和具有负静电充电性能的SUV型脂质体与具有正静电充电性质的颗粒静电耦合，然后该络合物具有用阳离子处理负静电充电性能。

10. 发明授权

US08946380B2 Liposome allowing liposome-entrapped substance to escape from endosome 有权
标题翻译：脂质体允许脂质体包裹的物质从内体逃逸
公开(公告)号：US08946380B2
公开(公告)日：2015-02-03
申请号：US11652865
申请日：2007-01-12
申请人： Kentaro Kogure , Shiroh Futaki , Hideyoshi Harashima , Shigetada Chaki
发明人： Shinji Chaki , Kentaro Kogure , Shiroh Futaki , Hideyoshi Harashima
IPC分类号： A61K38/28 , C07K1/00 , A61K9/127 , C07K5/00 , C07K19/00 , C07K17/00 , C07K14/00 , C07K7/00 , C07K16/00
CPC分类号： A61K9/127 , A61K38/28 , C07K1/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , C07K19/00
摘要： With the aim of providing a liposome, having a hydrophilic polymer introduced into the outer surface of the liposome membrane, which is a liposome capable of allowing the liposome-entrapped substance to escape from the endosome and be released into the cytoplasm, a liposome membrane component bound to the peptide shown by (a) or (b) below and a liposome membrane component bound to one end of a hydrophilic polymer the other end of which is bound to the peptide shown by (a) or (b) below are included in the liposome: (a) a peptide comprising the amino acid sequence of SEQ ID NO:1; (b) a peptide comprising the amino acid sequence of SEQ ID NO:1 with 1 or more amino acids deleted, replaced or added therein, and capable of fusing lipid membranes with one another under acidic conditions.
摘要翻译：为了提供脂质体，其具有引入脂质体膜的外表面的亲水性聚合物，脂质体膜是能够使脂质体包裹的物质从内体中逸出并释放到细胞质中的脂质体，脂质体膜组分与下文（a）或（b）所示的肽结合，并且与另一端与下文（a）或（b）所示的肽结合的亲水性聚合物的一端结合的脂质体膜组分包括在脂质体：（a）包含SEQ ID NO：1的氨基酸序列的肽; （b）包含SEQ ID NO：1的氨基酸序列的肽，其中1个或多个缺失，替换或添加的氨基酸，并且能够在酸性条件下彼此融合脂质膜。

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