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1. 发明申请

US20100166840A1 LIPOSOME HAVING LIPID MEMBRANE CONTAINING BACTERIAL CELL COMPONENT 审中-公开
标题翻译：具有含有细胞细胞组分的脂质膜的脂质体
公开(公告)号：US20100166840A1
公开(公告)日：2010-07-01
申请号：US12300622
申请日：2007-05-11
申请人： Homhuan Atthachai , Kentaro Kogure , Hideyoshi Harashima , Ikuya Yano , Yoshio Hatakeyama , Hidehiro Yokomizo , Hideyuki Akaza
发明人： Homhuan Atthachai , Kentaro Kogure , Hideyoshi Harashima , Ikuya Yano , Yoshio Hatakeyama , Hidehiro Yokomizo , Hideyuki Akaza
IPC分类号： A61K9/127 , A61K39/04 , A61K39/05 , A61K39/02 , A61P35/00 , A61P37/04
CPC分类号： A61K9/127 , A61K9/1271 , A61K35/74 , A61K39/04 , A61K39/39 , A61K2039/55511 , A61K2039/55555 , A61K2039/57
摘要： The object is to provide a liposome by which a bacterial cell component insoluble in water and an organic solvent (e.g., BCG-CW) can be pharmaceutically prepared in a form applicable to a living body (i.e., a form in which the bacterial cell component can be dispersed in an aqueous solvent and has a controlled size) without using any surfactant. Disclosed is a liposome having a lipid membrane containing a bacterial cell component insoluble in water and an organic solvent (e.g., BCG-CW).
摘要翻译：本发明的目的是提供一种可溶于水和有机溶剂（例如BCG-CW）的细菌细胞组分可以以适用于生物体的形式（即细菌细胞成分可以分散在水性溶剂中并具有受控的尺寸），而不使用任何表面活性剂。公开了具有含有不溶于水的细菌细胞成分和有机溶剂（例如BCG-CW）的脂质膜的脂质体。

2. 发明申请

US20100136099A1 LIPOSOME FOR INDUCTION OF CELL-MEDIATED IMMUNITY 审中-公开
标题翻译：用于诱导细胞介导的免疫的脂质体
公开(公告)号：US20100136099A1
公开(公告)日：2010-06-03
申请号：US12449670
申请日：2008-02-26
申请人： Hideyoshi Harashima , Kentaro Kogure , Takashi Nakamura , Rumiko Moriguchi , Kohei Ono , Homhuan Atthachai
发明人： Hideyoshi Harashima , Kentaro Kogure , Takashi Nakamura , Rumiko Moriguchi , Kohei Ono , Homhuan Atthachai
IPC分类号： A61K9/127 , A61K39/00 , A61P35/04
CPC分类号： A61K9/1272 , A61K39/0011 , A61K39/385 , A61K39/39 , A61K2039/55516 , A61K2039/55555
摘要： Disclosed is a liposome which includes an antigenic substance therein and has, on its surface, a peptide containing several contiguous arginine residues. The liposome enables an antigen-presenting cell to achieve the selective antigen presentation through an MHC Class-I molecule, and can induce a cell-mediated immunity specifically. The liposome can also induce the antigen presentation by a matured dendritic cell.
摘要翻译：公开了一种在其中包含抗原物质的脂质体，其表面上含有几个连续的精氨酸残基的肽。脂质体使得抗原呈递细胞能够通过MHC I类分子实现选择性抗原呈递，并且可以特异性诱导细胞介导的免疫。脂质体也可以通过成熟的树突状细胞诱导抗原呈递。

3. 发明授权

US08946380B2 Liposome allowing liposome-entrapped substance to escape from endosome 有权
标题翻译：脂质体允许脂质体包裹的物质从内体逃逸
公开(公告)号：US08946380B2
公开(公告)日：2015-02-03
申请号：US11652865
申请日：2007-01-12
申请人： Kentaro Kogure , Shiroh Futaki , Hideyoshi Harashima , Shigetada Chaki
发明人： Shinji Chaki , Kentaro Kogure , Shiroh Futaki , Hideyoshi Harashima
IPC分类号： A61K38/28 , C07K1/00 , A61K9/127 , C07K5/00 , C07K19/00 , C07K17/00 , C07K14/00 , C07K7/00 , C07K16/00
CPC分类号： A61K9/127 , A61K38/28 , C07K1/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , C07K19/00
摘要： With the aim of providing a liposome, having a hydrophilic polymer introduced into the outer surface of the liposome membrane, which is a liposome capable of allowing the liposome-entrapped substance to escape from the endosome and be released into the cytoplasm, a liposome membrane component bound to the peptide shown by (a) or (b) below and a liposome membrane component bound to one end of a hydrophilic polymer the other end of which is bound to the peptide shown by (a) or (b) below are included in the liposome: (a) a peptide comprising the amino acid sequence of SEQ ID NO:1; (b) a peptide comprising the amino acid sequence of SEQ ID NO:1 with 1 or more amino acids deleted, replaced or added therein, and capable of fusing lipid membranes with one another under acidic conditions.
摘要翻译：为了提供脂质体，其具有引入脂质体膜的外表面的亲水性聚合物，脂质体膜是能够使脂质体包裹的物质从内体中逸出并释放到细胞质中的脂质体，脂质体膜组分与下文（a）或（b）所示的肽结合，并且与另一端与下文（a）或（b）所示的肽结合的亲水性聚合物的一端结合的脂质体膜组分包括在脂质体：（a）包含SEQ ID NO：1的氨基酸序列的肽; （b）包含SEQ ID NO：1的氨基酸序列的肽，其中1个或多个缺失，替换或添加的氨基酸，并且能够在酸性条件下彼此融合脂质膜。

4. 发明申请

US20100143482A1 METHOD OF PRODUCING MICROCAPSULES 有权
标题翻译：生产微生物的方法
公开(公告)号：US20100143482A1
公开(公告)日：2010-06-10
申请号：US12513237
申请日：2007-11-02
申请人： Yoshinobu Baba , Manabu Tokeshi , Noritada Kaji , Hideyoshi Harashima , Kentaro Kogure , Yasuo Shinohara , Hiroshi Kuramoto
发明人： Yoshinobu Baba , Manabu Tokeshi , Noritada Kaji , Hideyoshi Harashima , Kentaro Kogure , Yasuo Shinohara , Hiroshi Kuramoto
IPC分类号： A61K9/50 , A61K31/7088
CPC分类号： A61K48/0008 , A61K9/1271 , A61K9/1277 , A61K9/5169 , A61K9/5192 , A61K48/0041 , B01J13/04 , C12N15/87
摘要： It is intended to provide a method whereby various kinds of microcapsules, which are usable in, for example, a gene vector, can be produced in a small amount. This production method comprises: feeding a fluid containing a substance to be encapsulated into at lease one (13) of material-feeding microchannels in a substrate in which these material-feeding microchannels (12, 13, 14) and a reaction microchannel (18) connected to these material-feeding microchannels are formed; feeding an envelop-forming fluid containing a material for forming envelopes into at least one of the other material-feeding microchannels (12, 14); and allowing the envelope-forming fluid and the fluid containing the encapsulated substance that converge in the reaction microchannel from each material-feeding microchannel to flow through the reaction microchannel while continuously maintaining the interface between the fluids formed at the confluence thereof.
摘要翻译：旨在提供可以少量生产可用于例如基因载体的各种微胶囊的方法。该制造方法包括：将含有待包封物质的流体在至少一个材料供给微通道的基材中进料，其中这些材料供给微通道（12,13,14）和反应微通道（18）与这些送料微通道相连; 将含有用于形成信封的材料的包络成形流体进料到至少一个其它材料馈送微通道（12,14）中; 并且允许包络成形流体和含有从每个供料微通道收集到反应微通道中的包封物质的流体流过反应微通道，同时连续地保持在其汇合处形成的流体之间的界面。

5. 发明申请

US20090305409A1 Liposome Capable of Effective Delivery of Given Substance Into Nucleus 审中-公开
标题翻译：能够有效递送给予物质的脂质体
公开(公告)号：US20090305409A1
公开(公告)日：2009-12-10
申请号：US11887030
申请日：2006-03-24
申请人： Kentaro Kogure , Takashi Nakamura , Hidetaka Akita , Hideyoshi Harashima , Shiroh Futaki
发明人： Kentaro Kogure , Takashi Nakamura , Hidetaka Akita , Hideyoshi Harashima , Shiroh Futaki
IPC分类号： C12N5/00
CPC分类号： C12N15/88 , A61K48/00
摘要： Disclosed is a non-viral vector capable of delivering a given substance into the nucleus of a target cell effectively even when the target cells is a undividable cell such as a dendritic cell. A bilamellar liposome having a first lipid membrane and a second lipid membrane successively from the outside, the first lipid membrane having a membrane-fusing ability and the second lipid membrane having on its surface a nuclear transport peptide.
摘要翻译：公开了即使当靶细胞是不可分割的细胞例如树突状细胞时，能够有效地将给定物质有效地递送到靶细胞的细胞核中的非病毒载体。具有从外部连续地具有第一脂质膜和第二脂质膜的第二脂质膜，所述第一脂质膜具有膜融合能力，所述第二脂质膜在其表面上具有核转运肽。

6. 发明申请

US20070299244A1 Liposome allowing liposome-entrapped substance to escape from endosome 有权
标题翻译：脂质体允许脂质体包裹的物质从内体逃逸
公开(公告)号：US20070299244A1
公开(公告)日：2007-12-27
申请号：US11652865
申请日：2007-01-12
申请人： Shinji Chaki , Shigetada Chaki , Kentaro Kogure , Shiroh Futaki , Hideyoshi Harashima
发明人： Shinji Chaki , Shigetada Chaki , Kentaro Kogure , Shiroh Futaki , Hideyoshi Harashima
IPC分类号： C07K16/18 , C07H21/04 , C07K14/00
CPC分类号： A61K9/127 , A61K38/28 , C07K1/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , C07K19/00
摘要： With the aim of providing a liposome, having a hydrophilic polymer introduced into the outer surface of the liposome membrane, which is a liposome capable of allowing the liposome-entrapped substance to escape from the endosome and be released into the cytoplasm, a liposome membrane component bound to the peptide shown by (a) or (b) below and a liposome membrane component bound to one end of a hydrophilic polymer the other end of which is bound to the peptide shown by (a) or (b) below are included in the liposome: (a) a peptide comprising the amino acid sequence of SEQ ID NO:1; (b) a peptide comprising the amino acid sequence of SEQ ID NO:1 with 1 or more amino acids deleted, replaced or added therein, and capable of fusing lipid membranes with one another under acidic conditions.
摘要翻译：为了提供脂质体，其具有引入脂质体膜的外表面的亲水性聚合物，脂质体膜是能够使脂质体包裹的物质从内体中逸出并释放到细胞质中的脂质体，脂质体膜组分与下文（a）或（b）所示的肽结合，并且与另一端与下文（a）或（b）所示的肽结合的亲水性聚合物的一端结合的脂质体膜组分包括在脂质体：（a）包含SEQ ID NO：1的氨基酸序列的肽; （b）包含SEQ ID NO：1的氨基酸序列的肽，其中1个或多个缺失，替换或添加的氨基酸，并且能够在酸性条件下彼此融合脂质膜。

7. 发明授权

US08592210B2 Polyarginine-modified liposome having nuclear entry ability 失效
标题翻译：具有核进入能力的聚精氨酸改性脂质体
公开(公告)号：US08592210B2
公开(公告)日：2013-11-26
申请号：US11396081
申请日：2006-03-31
申请人： Hideyoshi Harashima , Shiroh Futaki , Kentaro Kogure
发明人： Hideyoshi Harashima , Shiroh Futaki , Kentaro Kogure
IPC分类号： A61K48/00 , A61K9/127 , C12N15/88
CPC分类号： C12N15/88 , A61K9/1273 , A61K47/34 , A61K47/645 , A61K47/6911 , C07K1/1077
摘要： With the object of providing a liposome having cellular and nuclear entry ability, to achieve this object, a liposome is provided having on its surface a peptide comprising multiple consecutive arginine residues, and specifically a liposome is provided wherein the peptide is modified with a hydrophobic group or hydrophobic compound and the hydrophobic group or hydrophobic compound is inserted into a lipid bilayer so that the peptide is exposed on the surface of the bilayer.
摘要翻译：为了提供具有细胞和核进入能力的脂质体，为了达到这个目的，提供了一种脂质体，其表面上含有多个连续的精氨酸残基的肽，特别是提供一种脂质体，其中肽用疏水基团修饰或疏水性化合物，并且将疏水基团或疏水性化合物插入脂质双层中，使得该肽暴露在双层的表面上。

8. 发明申请

US20100104623A1 AGENT FOR ENHANCING THE RESISTANCE OF LIPOSOME AGAINST BIOLOGICAL COMPONENT, AND LIPOSOME MODIFIED WITH THE AGENT 审中-公开
标题翻译：用于增强生物组分的脂质体抗性的试剂和用该试剂修饰的脂质体
公开(公告)号：US20100104623A1
公开(公告)日：2010-04-29
申请号：US12449817
申请日：2008-02-27
申请人： Hideyoshi Harashima , Kentaro Kogure , Hidetaka Akita , Akitada Iwasa , Yoshio Nakamura , Shiroh Futaki
发明人： Hideyoshi Harashima , Kentaro Kogure , Hidetaka Akita , Akitada Iwasa , Yoshio Nakamura , Shiroh Futaki
IPC分类号： A61K9/127
CPC分类号： A61K9/127 , A61K38/00 , A61K47/42 , C07K14/00
摘要： It is intended to provide a positively charged liposome, particularly having a polyarginine peptide on a surface thereof, which is capable of increasing the resistance to a negatively charged biological component such as a protein in the blood and maintaining a high ability to deliver a substance even in the blood. An agent for enhancing the resistance of liposome against biological component comprising a peptide having at least one of the following characteristics (a) and (b) as an active ingredient: (a) A peptide comprising an amino acid sequence represented by SEQ ID No: 1 or 2; and (b) A peptide comprising an amino acid sequence represented by SEQ ID No: 1 or 2, in which one or more amino acids are deleted, substituted or added, and having an activity for promoting lipid membrane fusion under acidic condition. An agent for enhancing the resistance of liposome against biological component in this invention, being included in a liposome, is capable of increasing the resistance to a negatively charged biological component such as a protein in the blood and maintaining a high ability to deliver a substance even in the blood.
摘要翻译：旨在提供带正电荷的脂质体，特别是在其表面具有聚精氨酸肽，其能够增加对带负电的生物成分如血液中的蛋白质的抗性，并且保持高的物质输送能力在血中用于增强脂质体对生物成分的抗性的试剂，其包含具有以下特征（a）和（b）中的至少一个作为活性成分的肽：（a）包含SEQ ID No： 1或2; 和（b）包含SEQ ID No：1或2所示的氨基酸序列的肽，其中一个或多个氨基酸缺失，取代或添加，并且具有在酸性条件下促进脂质膜融合的活性。包含在脂质体中的用于增强本发明中脂质体对抗生物成分的抗性的药剂能够增加对带负电的生物成分如血液中的蛋白质的抗性，并保持高的物质输送能力在血中

9. 发明申请

US20090221953A1 COMPOSITION COMPRISING PROTEIN-LIPOSOME COMPLEX FOR IONTOPHORESIS 审中-公开
标题翻译：包含蛋白质 - 脂质体复合物的组合物用于血液透析
公开(公告)号：US20090221953A1
公开(公告)日：2009-09-03
申请号：US12392885
申请日：2009-02-25
申请人： Kazuaki Kajimoto , Masahiko Yamamoto , Kentaro Kogure , Hideyoshi Harashima
发明人： Kazuaki Kajimoto , Masahiko Yamamoto , Kentaro Kogure , Hideyoshi Harashima
IPC分类号： A61N1/30 , A61K9/127 , A61K39/00
CPC分类号： A61K9/0009 , A61K9/127 , A61K39/39 , A61K2039/55555
摘要： Provided is a composition for iontophoresis comprising a negatively-charged protein-liposome complex, in which the protein-liposome complex is formed of a negatively-charged protein and a cationic liposome. Such may provide a composition capable of efficiently delivering a protein having a large molecular weight intradermally and inducing an immune response effectively by iontophoresis.
摘要翻译：提供了一种用于离子电渗的组合物，其包含带负电荷的蛋白质 - 脂质体复合物，其中蛋白质 - 脂质体复合物由带负电荷的蛋白质和阳离子脂质体形成。这样可提供能够有效地输送皮内具有大分子量的蛋白质并通过离子电渗法有效地诱导免疫应答的组合物。

10. 发明申请

US20080175895A1 SYSTEM, DEVICES, AND METHODS FOR IONTOPHORETIC DELIVERY OF COMPOSITIONS INCLUDING ANTIOXIDANTS ENCAPSULATED IN LIPOSOMES 审中-公开
标题翻译：系统，装置和方法，用于包含在脂质体中包埋的抗氧化剂的组合物的外部输送
公开(公告)号：US20080175895A1
公开(公告)日：2008-07-24
申请号：US11962011
申请日：2007-12-20
申请人： Kentaro Kogure , Moeko Miyashita , Hideyoshi Harashima
发明人： Kentaro Kogure , Moeko Miyashita , Hideyoshi Harashima
IPC分类号： A61K9/127 , A61K38/44 , A61P25/28 , A61P25/16 , A61P35/00 , A61P17/00
CPC分类号： A61K9/127 , A61K8/14 , A61K8/66 , A61K38/44 , A61K38/446 , A61K2800/522 , A61Q17/04 , A61Q19/004 , A61Q19/08 , C12Y111/01006 , C12Y111/01009 , C12Y115/01001
摘要： Systems, devices, and methods for delivering one or more active ingredients to intradermal tissues, deep regions of pores, and intradermal tissues in the vicinity of the pores. In some embodiments, a composition is provided including a plurality of liposomes including a cationic lipid, and an amphiphilic glycerophospholipid having a saturated fatty acid moiety and an unsaturated fatty acid moiety, and one or more antioxidants and/or antioxidant enzymes.
摘要翻译：用于将一种或多种活性成分递送至孔附近的真皮内组织，毛孔深部和皮内组织的系统，装置和方法。在一些实施方案中，提供了包含多个包含阳离子脂质的脂质体和具有饱和脂肪酸部分和不饱和脂肪酸部分的两亲性甘油磷脂以及一种或多种抗氧化剂和/或抗氧化酶的组合物。

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