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1. 发明授权

US5514577A Oligonucleotide therapies for modulating the effects of herpes viruses 失效
标题翻译：用于调节疱疹病毒效应的寡核苷酸疗法
公开(公告)号：US5514577A
公开(公告)日：1996-05-07
申请号：US31147
申请日：1993-03-12
申请人： Kenneth G. Draper , Stanley T. Crooke , Christopher K. Mirabelli , David J. Ecker , Ronnie C. Hanecak , Kevin P. Anderson , Vickie L. Brown-Driver , Jacqueline R. Wyatt
发明人： Kenneth G. Draper , Stanley T. Crooke , Christopher K. Mirabelli , David J. Ecker , Ronnie C. Hanecak , Kevin P. Anderson , Vickie L. Brown-Driver , Jacqueline R. Wyatt
IPC分类号： C12N15/09 , A61K31/70 , A61K31/7088 , A61K38/00 , A61P31/12 , A61P31/22 , C07H21/00 , C07H21/04 , C07K14/03 , C12N15/113 , C12N15/117 , C12Q1/70 , C12N7/06
CPC分类号： C12N15/1133 , A61K31/70 , C07H21/00 , C07K14/005 , C12N15/1137 , C12N15/117 , C12Q1/701 , C12Y207/07049 , C12Y301/01004 , A61K38/00 , C12N2310/151 , C12N2310/18 , C12N2310/3125 , C12N2310/315 , C12N2310/321 , C12N2310/33 , C12N2310/346 , C12N2310/3517 , C12N2310/3521 , C12N2710/16622
摘要： Compositions and methods are provided for the treatment and diagnosis of herpesvirus infections. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with RNA or DNA deriving from a herpesvirus gene corresponding to one of the open reading frames UL5, UL8, UL9, UL20, UL27, UL29, UL30, UL42, UL52 and IE175 of herpes simplex virus type 1. The oligonucleotide comprises nucleotide units sufficient in identity and number to effect said specific hybridization. In other preferred embodiments, the oligonucleotides are specifically hybridizable with a translation initiation site, a coding region or a 5'-untranslated region. Methods of treating animals suspected of being infected with herpesvirus comprising contacting the animal with an oligonucleotide of the invention are disclosed. Methods for treatment of infections caused by herpes simplex virus type 1, herpes simplex virus type 2, cytomegalovirus, human herpes virus 6, Epstein Barr virus or varicella zoster virus are disclosed.
摘要翻译：提供组合物和方法用于治疗和诊断疱疹病毒感染。根据优选实施方案，提供寡核苷酸，其与衍生自对应于开放阅读框UL5，UL8，UL9，UL20，UL27，UL29，UL20，UL27，UL29，UL30，UL42，UL52和IE175之一的疱疹病毒基因的RNA或DNA特异性杂交单纯疱疹病毒1型。寡核苷酸包含足以实现所述特异性杂交的同一性和数目的核苷酸单元。在其它优选实施方案中，寡核苷酸与翻译起始位点，编码区或5'-非翻译区具体杂交。公开了治疗疑似被疱疹病毒感染的动物的方法，包括使动物与本发明的寡核苷酸接触。公开了用于治疗由单纯疱疹病毒1型，2型单纯疱疹病毒，巨细胞病毒，人疱疹病毒6，爱泼斯坦巴尔病毒或水痘带状疱疹病毒引起的感染的方法。

2. 发明授权

US5248670A Antisense oligonucleotides for inhibiting herpesviruses 失效
标题翻译：用于抑制HERPESVIRUSES的抗体寡核苷酸
公开(公告)号：US5248670A
公开(公告)日：1993-09-28
申请号：US485297
申请日：1990-02-26
申请人： Kenneth G. Draper , David J. Ecker , Christopher K. Mirabelli , Stanley T. Crooke
发明人： Kenneth G. Draper , David J. Ecker , Christopher K. Mirabelli , Stanley T. Crooke
IPC分类号： A61K31/70 , A61K38/00 , A61K48/00 , A61P31/12 , A61P31/22 , C07H21/00 , C07K14/03 , C12N7/04 , C12N15/09 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/1133 , C07K14/005 , A61K38/00 , C12N2310/3125 , C12N2310/315 , C12N2710/16622
摘要： Antisense oligonucleotides are disclosed having a length of 15-30 nucleotides containing the CAT sequence and hybridizable to herpes simplex virus type I gene UL13, UL39, or UL40. These antisense oligomers inhibit the replication of the virus at least three-fold. Pharmaceutical compositions containing these oligonucleotides as the active ingredients are also disclosed.
摘要翻译：公开了具有长度为15-30个核苷酸的反义寡核苷酸，其含有CAT序列并可与单纯疱疹病毒I型基因UL13，UL39或UL40杂交。这些反义寡聚体抑制病毒复制至少三倍。还公开了含有这些寡核苷酸作为活性成分的药物组合物。

3. 发明授权

US5658891A Oligonucleotide therapies for modulating the effects of herpesviruses 失效
标题翻译：用于调节疱疹病毒的作用的寡核苷酸疗法
公开(公告)号：US5658891A
公开(公告)日：1997-08-19
申请号：US329212
申请日：1994-10-26
申请人： Kenneth G. Draper , David J. Ecker , Christopher K. Mirabelli , Stanley T. Crooke
发明人： Kenneth G. Draper , David J. Ecker , Christopher K. Mirabelli , Stanley T. Crooke
IPC分类号： A61K31/70 , A61K38/00 , A61K48/00 , A61P31/12 , A61P31/22 , C07H21/00 , C07K14/03 , C12N7/04 , C12N15/09 , C12N15/113 , C12Q1/68 , C12N5/10
CPC分类号： C12N15/1133 , C07K14/005 , A61K38/00 , C12N2310/3125 , C12N2310/315 , C12N2710/16622
摘要： Compositions and methods are provided for the treatment and diagnosis of herpesvirus infections. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with RNA or DNA deriving from a gene corresponding to one of the open reading frames UL5, UL8, UL9, UL13, UL29, UL30, UL39, UL40, UL42 AND UL52 of herpes simplex virus type 1. The oligonucleotide comprises nucleotide units sufficient in identity and number to effect said specific hybridization. In other preferred embodiments, the oligonucleotides are specifically hybridizable with a translation initiation site; it is also preferred that they comprise the sequence CAT. Methods of treating animals suspected of being infected with herpesvirus comprising contacting the animal with an oligonucleotide specifically hybridizable with RNA or DNA deriving from one of the foregoing genes of the herpesvirus; are disclosed. Methods for treatment of infections caused by herpes simplex virus type 1, herpes simplex virus type 2, cytomegalovirus, human herpes virus 6, Epstein Barr virus or varicella zoster virus are disclosed.
摘要翻译：提供组合物和方法用于治疗和诊断疱疹病毒感染。根据优选实施方案，提供寡核苷酸，其与衍生自相应于疱疹的开放阅读框UL5，UL8，UL9，UL13，UL29，UL30，UL39，UL29，UL30，UL39，UL40，UL42和UL52中的一个的基因的RNA或DNA特异性杂交单克隆病毒类型1.寡核苷酸包含足以实现所述特异性杂交的同一性和数目的核苷酸单元。在其它优选实施方案中，寡核苷酸与翻译起始位点特异性杂交; 还优选它们包含序列CAT。治疗疑似感染疱疹病毒的动物的方法，包括使动物与可衍生自疱疹病毒的前述基因之一的RNA或DNA特异性杂交的寡核苷酸接触; 被披露。公开了用于治疗由单纯疱疹病毒1型，2型单纯疱疹病毒，巨细胞病毒，人疱疹病毒6，爱泼斯坦巴尔病毒或水痘带状疱疹病毒引起的感染的方法。

4. 发明授权

US06310044B1 Oligonucleotide therapies for modulating the effects of herpesviruses 失效
标题翻译：用于调节疱疹病毒的作用的寡核苷酸疗法
公开(公告)号：US06310044B1
公开(公告)日：2001-10-30
申请号：US07852132
申请日：1992-04-28
申请人： Kenneth G. Draper , David J. Ecker , Christopher K. Mirabelli , Stanley T. Crooke
发明人： Kenneth G. Draper , David J. Ecker , Christopher K. Mirabelli , Stanley T. Crooke
IPC分类号： A61K4800
CPC分类号： C12N15/1133 , A61K38/00 , C07K14/005 , C12N2310/3125 , C12N2310/315 , C12N2710/16622
摘要： Compositions and methods are provided for the treatment and diagnosis of herpesvirus infections. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with RNA or DNA deriving from a gene corresponding to one of the open reading frames UL5, UL8, UL9, UL13, UL29, UL30, UL39, UL40, UL42 AND UL52 of herpes simplex virus type 1. The oligonucleotide comprises nucleotide units sufficient in identity and number to effect said specific hybridization. In other preferred embodiments, the oligonucleotides are specifically hybridizable with a translation initiation site; it is also preferred that they comprise the sequence CAT. Methods of treating animals suspected of being infected with herpesvirus comprising contacting the animal with an oligonucleotide specifically hybridizable with RNA or DNA deriving from one of the foregoing genes of the herpesvirus are disclosed. Methods for treatment of infections caused by herpes simplex virus type 1, herpes simplex virus type 2, cytomegalovirus, human herpes virus 6, Epstein Barr virus or varicella zoster virus are disclosed.
摘要翻译：提供组合物和方法用于治疗和诊断疱疹病毒感染。根据优选实施方案，提供寡核苷酸，其与衍生自相应于疱疹的开放阅读框UL5，UL8，UL9，UL13，UL29，UL30，UL39，UL29，UL30，UL39，UL40，UL42和UL52中的一个的基因的RNA或DNA特异性杂交单克隆病毒类型1.寡核苷酸包含足以实现所述特异性杂交的同一性和数目的核苷酸单元。在其它优选实施方案中，寡核苷酸与翻译起始位点特异性杂交; 还优选它们包含序列CAT。公开了治疗疑似被疱疹病毒感染的动物的方法，包括使动物与可衍生自疱疹病毒的前述基因之一的RNA或DNA特异性杂交的寡核苷酸接触。公开了用于治疗由单纯疱疹病毒1型，2型单纯疱疹病毒，巨细胞病毒，人疱疹病毒6，爱泼斯坦巴尔病毒或水痘带状疱疹病毒引起的感染的方法。

5. 发明授权

US5681944A Antisense oligonucleotides directed to papillomavirus 失效
标题翻译：针对乳头瘤病毒的反义寡核苷酸
公开(公告)号：US5681944A
公开(公告)日：1997-10-28
申请号：US334215
申请日：1994-11-04
申请人： Stanley T. Crooke , Christopher K. Mirabelli , David J. Ecker , Lex M. Cowsert
发明人： Stanley T. Crooke , Christopher K. Mirabelli , David J. Ecker , Lex M. Cowsert
IPC分类号： C12N15/00 , A61K31/70 , A61K31/7088 , A61K38/00 , A61K48/00 , A61P31/12 , A61P35/00 , C07H21/04 , C07K14/025 , C12N15/09 , C12N15/113 , C12Q1/68 , C12Q1/70
CPC分类号： C12N15/1131 , C07K14/005 , C12Q1/70 , C12Q1/708 , A61K38/00 , C12N2310/315 , C12N2710/20022 , C12Q1/6883
摘要： Oligonucleotides are provided which are capable of antisense interaction with messenger RNA of papillomavirus. Such oligonucleotides or oligonucleotide analogs can be used for diagnostics and therapeutics as well as for research purposes. In accordance with preferred embodiments of this invention, oligonucleotides are provided which are hybridizable with selected messenger RNA from a human papillomavirus. The oligonucleotide is able to inhibit the function of the RNA, and accordingly is useful for therapy for infections by such papillomavirus. In accordance with a preferred embodiment, portions of the papillomavirus are targeted for antisense attack. Thus oligonucleotides are preferably provided which hybridize with the E2, E6 and E7 messenger RNAs.
摘要翻译：提供能够与乳头瘤病毒的信使RNA反义相互作用的寡核苷酸。这样的寡核苷酸或寡核苷酸类似物可用于诊断和治疗以及用于研究目的。根据本发明的优选实施方案，提供可与来自人乳头瘤病毒的选定信使RNA杂交的寡核苷酸。寡核苷酸能够抑制RNA的功能，因此可用于由这种乳头瘤病毒感染的治疗。根据优选实施方案，乳头瘤病毒的一部分被靶向用于反义攻击。因此优选提供与E2，E6和E7信使RNA杂交的寡核苷酸。

6. 发明授权

US5811232A Oligonucleotides for Papillomavirus 失效
标题翻译：乳头瘤病毒的寡核苷酸
公开(公告)号：US5811232A
公开(公告)日：1998-09-22
申请号：US692257
申请日：1996-08-05
申请人： Stanley T. Crooke , Christopher K. Mirabelli , David J. Ecker , Lex M. Cowsert
发明人： Stanley T. Crooke , Christopher K. Mirabelli , David J. Ecker , Lex M. Cowsert
IPC分类号： C12Q1/68 , C12Q1/70 , C07H21/04
CPC分类号： C12Q1/70 , C12Q1/6883 , Y10S435/81
摘要： Oligonucleotides and oligonucleotide analogs are provided which are capable of antisense interaction with messenger RNA of papillomavirus. Such oligonucleotides or oligonucleotide analogs can be used for diagnostics and therapeutics as well as for research purposes. In accordance with preferred embodiments of this invention, oligonucleotide or oligonucleotide analog is provided which is hybridizable with a messenger RNA from a papillomavirus. The oligonucleotide or oligonucleotide analog is able to inhibit the function of the RNA, and accordingly is useful for therapy for infections by such papillomavirus. In accordance with a preferred embodiment, portions of the papillomavirus are targeted for antisense attack. Thus oligonucleotides are preferably provided which hybridize with the E2, E1, E7, or E6-7 messenger RNAs.
摘要翻译：提供寡核苷酸和寡核苷酸类似物，其能够与乳头瘤病毒的信使RNA反义相互作用。这样的寡核苷酸或寡核苷酸类似物可用于诊断和治疗以及用于研究目的。根据本发明的优选实施方案，提供可与来自乳头瘤病毒的信使RNA杂交的寡核苷酸或寡核苷酸类似物。寡核苷酸或寡核苷酸类似物能够抑制RNA的功能，因此可用于由这种乳头瘤病毒感染的治疗。根据优选实施方案，乳头瘤病毒的一部分被靶向用于反义攻击。因此优选提供与E2，E1，E7或E6-7信使RNA杂交的寡核苷酸。

7. 发明授权

US5457189A Antisense oligonucleotide inhibition of papillomavirus 失效
标题翻译：反义寡核苷酸抑制乳头瘤病毒
公开(公告)号：US5457189A
公开(公告)日：1995-10-10
申请号：US860925
申请日：1992-03-31
申请人： Stanley T. Crooke , Christopher K. Mirabelli , David J. Ecker , Lex M. Cowsert
发明人： Stanley T. Crooke , Christopher K. Mirabelli , David J. Ecker , Lex M. Cowsert
IPC分类号： C12N15/00 , A61K31/70 , A61K31/7088 , A61K38/00 , A61K48/00 , A61P31/12 , A61P35/00 , C07H21/04 , C07K14/025 , C12N15/09 , C12N15/113 , C12Q1/68 , C12Q1/70
CPC分类号： C12N15/1131 , C07K14/005 , C12Q1/70 , C12Q1/708 , A61K38/00 , C12N2310/315 , C12N2710/20022 , C12Q1/6883
摘要： Oligonucleotides are provided which are capable of antisense interaction with messenger RNA of papillomavirus. Such oligonucleotides or oligonucleotide analogs can be used for diagnostics and therapeutics as well as for research purposes. In accordance with preferred embodiments of this invention, oligonucleotide ISIS 2105 is provided which hybridizes with selected messenger RNA from a human papillomavirus. The oligonucleotide is able to inhibit the function of the RNA, and accordingly is useful for therapy for infections by such papillomavirus.In accordance with a preferred embodiment, portions of the papillomavirus are targeted for antisense attack. Thus oligonucleotides are preferably provided which hybridize with the E2, E6 and E7 messenger RNAs.
摘要翻译：提供能够与乳头瘤病毒的信使RNA反义相互作用的寡核苷酸。这样的寡核苷酸或寡核苷酸类似物可用于诊断和治疗以及用于研究目的。根据本发明的优选实施方案，提供了与来自人乳头瘤病毒的所选择的信使RNA杂交的寡核苷酸ISIS 2105。寡核苷酸能够抑制RNA的功能，因此可用于由这种乳头瘤病毒感染的治疗。根据优选实施方案，乳头瘤病毒的一部分被靶向用于反义攻击。因此优选提供与E2，E6和E7信使RNA杂交的寡核苷酸。

8. 发明授权

US06174870B1 Antisense oligonucleotide inhibition of papillomavirus 失效
标题翻译：反义寡核苷酸抑制乳头瘤病毒
公开(公告)号：US06174870B1
公开(公告)日：2001-01-16
申请号：US09130426
申请日：1998-08-06
申请人： Stanley T. Crooke , Christopher K. Mirabelli , David J. Ecker , Lex M. Cowsert
发明人： Stanley T. Crooke , Christopher K. Mirabelli , David J. Ecker , Lex M. Cowsert
IPC分类号： A61K3170
CPC分类号： C12Q1/708 , C12Q1/6883 , C12Q2525/101
摘要： Oligonucleotides and oligonucleotide analogs are provided which are capable of antisense interaction with messenger RNA of papillomavirus. Such oligonucleotides or oligonucleotide analogs can be used for diagnostics and therapeutics as well as for research purposes. In accordance with preferred embodiments of this invention, oligonucleotide or oligonucleotide analog is provided which is hybridizable with a messenger RNA from a papillomavirus. The oligonucleotide or oligonucleotide analog is able to inhibit the function of the RNA, and accordingly is useful for therapy for infections by such papillomavirus. In accordance with a preferred embodiment, portions of the papillomavirus are targeted for antisense attack. Thus oligonucleotides are preferably provided which hybridize with the E2, E1, E7, E6 or E6-7 messenger RNAs.
摘要翻译：提供寡核苷酸和寡核苷酸类似物，其能够与乳头瘤病毒的信使RNA反义相互作用。这样的寡核苷酸或寡核苷酸类似物可用于诊断和治疗以及用于研究目的。根据本发明的优选实施方案，提供可与来自乳头瘤病毒的信使RNA杂交的寡核苷酸或寡核苷酸类似物。寡核苷酸或寡核苷酸类似物能够抑制RNA的功能，因此可用于由这种乳头瘤病毒感染的治疗。根据优选实施方案，部分乳头瘤病毒是针对反义发作的。因此优选提供与E2，E1，E7，E6或E6-7信使RNA杂交的寡核苷酸。

9. 发明授权

US5756282A Oligonucleotides for the diagnosis of papillomavirus 失效
标题翻译：用于诊断乳头瘤病毒的寡核苷酸
公开(公告)号：US5756282A
公开(公告)日：1998-05-26
申请号：US370517
申请日：1995-01-09
申请人： Stanley T. Crooke , Christopher K. Mirabelli , David J. Ecker , Lex M. Cowsert
发明人： Stanley T. Crooke , Christopher K. Mirabelli , David J. Ecker , Lex M. Cowsert
IPC分类号： A61K38/00 , C07K14/025 , C12N15/113 , C12Q1/68 , C12Q1/70 , C07H21/04 , C12P19/34
CPC分类号： C12N15/1131 , C07K14/005 , C12Q1/70 , C12Q1/708 , A61K38/00 , C12N2310/315 , C12N2710/20022 , C12Q1/6883
摘要： Oligonucleotides are provided which are targeted to human papillomavirus E2 transactivator messenger RNA. Such oligonucleotides can be used for diagnostics and therapeutics as well as for research purposes.
摘要翻译：提供靶向人乳头状瘤病毒E2反式激活因子信使RNA的寡核苷酸。此类寡核苷酸可用于诊断和治疗以及研究目的。

10. 发明授权

US5665580A Antisense oligonucleotide inhibition of papillomavirus transformed cells 失效
标题翻译：反义寡核苷酸抑制乳头瘤病毒转化细胞
公开(公告)号：US5665580A
公开(公告)日：1997-09-09
申请号：US307682
申请日：1994-10-14
申请人： Stanley T. Crooke , Christopher K. Mirabelli , David J. Ecker , Lex M. Cowsert
发明人： Stanley T. Crooke , Christopher K. Mirabelli , David J. Ecker , Lex M. Cowsert
IPC分类号： C12N15/00 , A61K31/70 , A61K31/7088 , A61K38/00 , A61K48/00 , A61P31/12 , A61P35/00 , C07H21/04 , C07K14/025 , C12N15/09 , C12N15/113 , C12Q1/68 , C12Q1/70
CPC分类号： C12N15/1131 , C07K14/005 , C12Q1/70 , C12Q1/708 , A61K38/00 , C12N2310/315 , C12N2710/20022 , C12Q1/6883
摘要： Antisense oligonucleotides are taught which hybridize to human papilloma virus transcripts. These oligonucleotides when added to tissue culture cells transformed with human papilloma virus inhibit growth of the transformed cell.
摘要翻译： PCT No.PCT / US93 / 03075 Sec。 371日期：1994年10月14日 102（e）1994年10月14日PCT PCT 1993年3月31日PCT公布。公开号WO93 / 20095 日期1993年10月14日教导了与人乳头状瘤病毒转录物杂交的反义寡核苷酸。当加入到用人乳头状瘤病毒转化的组织培养细胞中时，这些寡核苷酸抑制转化细胞的生长。

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