专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5470997A Amphetamine derivatives and protein and polypeptide amphetamine derivative conjugates and labels 失效
标题翻译：安非他明衍生物和蛋白质和多肽苯丙胺衍生物缀合物和标签
公开(公告)号：US5470997A
公开(公告)日：1995-11-28
申请号：US864108
申请日：1992-04-06
申请人： Kenneth F. Buechler , Joseph B. Noar , Si S. Moi
发明人： Kenneth F. Buechler , Joseph B. Noar , Si S. Moi
IPC分类号： A61K39/385 , C07C271/14 , C07C323/10 , C07C323/23 , C07C323/25 , C07C323/50 , C07C323/60 , C07C327/20 , C07C327/30 , C07C327/32 , C07K1/113 , C07K14/00 , C07K14/705 , C07K16/00 , C07C327/22 , C07C323/41 , C07C323/52
CPC分类号： C07C323/25 , C07C271/14 , C07C323/60 , C07C327/30 , C07C327/32
摘要： The present invention is directed to novel amphetamine derivatives which are synthesized for the covalent attachment to antigens (proteins or polypeptides) for the preparation of antibodies or receptors to amphetamine and amphetamine metabolites. The resulting novel antigens may be used for the production of antibodies or receptors using standard methods. Once generated, the antibodies or receptors and the novel derivatives which are covalently attached to proteins, polypeptides or labels may be used in the immunoassay process.
摘要翻译：本发明涉及新颖的苯丙胺衍生物，其被合成用于与抗原（蛋白质或多肽）的共价连接，用于制备苯丙胺和苯丙胺代谢物的抗体或受体。所得的新抗原可以用于使用标准方法生产抗体或受体。一旦产生，共价连接到蛋白质，多肽或标记的抗体或受体和新型衍生物可用于免疫测定过程。

2. 发明授权

US5302703A Tetrahydrocannabinol derivatives and protein and polypeptide tetrahydrocannabinol derivative conjugates and labels 失效
标题翻译：四氢大麻酚衍生物和蛋白质和多肽四氢大麻酚衍生物缀合物和标签
公开(公告)号：US5302703A
公开(公告)日：1994-04-12
申请号：US32598
申请日：1993-03-17
申请人： Kenneth F. Buechler , Si S. Moi
发明人： Kenneth F. Buechler , Si S. Moi
IPC分类号： G01N33/53 , A61K39/385 , C07D311/80 , C07D409/12 , C07K1/113 , C07K14/00 , C07K16/44 , G01N33/566 , C07K17/06 , C07D49/16 , C07H13/02 , G01N33/532
CPC分类号： C07D409/12 , Y10S435/964
摘要： The present invention is directed to novel THC derivatives which are synthesized for the covalent attachment to antigens (proteins or polypeptides) for the preparation of antibodies or receptors to the THC metabolites. The resulting novel antigens may be used for the production of antibodies or receptors using standard methods. Once generated, the antibodies or receptors and the novel derivatives which are covalently attached to proteins, polypeptides or labels may be used in the immunoassay process.
摘要翻译：本发明涉及合成用于共价连接到抗原（蛋白质或多肽）以用于制备THC代谢物的抗体或受体的新型THC衍生物。所得的新抗原可以用于使用标准方法生产抗体或受体。一旦产生，共价连接到蛋白质，多肽或标记的抗体或受体和新型衍生物可用于免疫测定过程。

3. 发明授权

US5237057A Tetrahydrocannabinol derivatives and protein and polypeptide tetrahydrocannabinol derivative conjugates and labels 失效
标题翻译：四氢大麻酚衍生物和蛋白质和多肽四氢大麻酚衍生物缀合物和标签
公开(公告)号：US5237057A
公开(公告)日：1993-08-17
申请号：US864106
申请日：1992-04-06
申请人： Kenneth F. Buechler , Si S. Moi
发明人： Kenneth F. Buechler , Si S. Moi
IPC分类号： G01N33/53 , A61K39/385 , C07D311/80 , C07D409/12 , C07K1/113 , C07K14/00 , C07K16/44 , G01N33/566
CPC分类号： C07D409/12 , Y10S435/964
摘要： The present invention is directed to novel THC derivatives which are synthesized for the covalent attachment to antigens (proteins or polypeptides) for the preparation of antibodies or receptors to the THC metabolites. The resulting novel antigens may be used for the production of antibodies or receptors using standard methods. Once generated, the antibodies or receptors and the novel derivatives which are covalently attached to proteins, polypeptides or labels may be used in the immunoassay process.
摘要翻译：本发明涉及合成用于共价连接到抗原（蛋白质或多肽）以用于制备THC代谢物的抗体或受体的新型THC衍生物。所得的新抗原可以用于使用标准方法生产抗体或受体。一旦产生，共价连接到蛋白质，多肽或标记的抗体或受体和新型衍生物可用于免疫测定过程。

4. 发明授权

US07322927B2 Hybrid phthalocyanine derivatives and their uses 失效
标题翻译：杂化酞菁衍生物及其用途
公开(公告)号：US07322927B2
公开(公告)日：2008-01-29
申请号：US11448613
申请日：2006-06-06
申请人： Kenneth F. Buechler , Joseph B. Noar , Lema Tadesse
发明人： Kenneth F. Buechler , Joseph B. Noar , Lema Tadesse
IPC分类号： C40B30/04
CPC分类号： G01N33/54346 , C07F7/025 , G01N33/533 , Y10S436/80
摘要： Water soluble hybrid phthalocyanine derivatives useful in competitive and noncompetitive assays immunoassays, nucleic acid and assays are disclosed and claimed having (1) at least one donor subunit with a desired excitation peak, and (2) at least one acceptor subunit with a desired emission peak, wherein said derivative(s) is/are capable of intramolecular energy transfer from said donor subunit to said acceptor subunit. Such derivatives also may contain an electron transfer subunit. Axial ligands may be covalently bound to the metals contained in the water soluble hybrid phthalocyanine derivatives. Ligands, ligand analogues, polypeptides, proteins and nucleic acids can be linked to the axial ligands of the dyes to form dye conjugates useful in immunoassays and nucleic acid assays.
摘要翻译：在竞争性和非竞争性测定中有用的水溶性杂合酞菁衍生物公开和要求保护具有（1）具有所需激发峰的至少一个供体亚基，和（2）至少一个具有期望发射峰的受体亚单位，其中所述衍生物能够从所述供体亚单位转移到所述受体亚单位的分子内能量。这样的衍生物也可以含有电子转移子单元。轴向配体可以与水溶性杂合酞菁衍生物中所含的金属共价结合。配体，配体类似物，多肽，蛋白质和核酸可以连接到染料的轴向配体上，以形成可用于免疫测定和核酸测定的染料缀合物。

5. 发明授权

US07083984B2 Hybrid phthalocyanine derivatives and their uses 失效
公开(公告)号：US07083984B2
公开(公告)日：2006-08-01
申请号：US09776599
申请日：2001-02-01
申请人： Kenneth F. Buechler , Joseph B. Noar , Lema Tadesse
发明人： Kenneth F. Buechler , Joseph B. Noar , Lema Tadesse
IPC分类号： G01N33/543
CPC分类号： G01N33/587 , C07D487/22 , C07F7/0838 , C09B47/045 , C09B47/08 , C09B67/0097 , G01N33/533 , G01N33/582 , G01N33/76 , Y10S436/80
摘要： Water soluble hybrid phthalocyanine derivatives useful in competitive and noncompetitive assays immunoassays, nucleic acid and assays are disclosed and claimed having (1) at least one donor subunit with a desired excitation peak; and (2) at least one acceptor subunit with a desired emission peak, wherein said derivative(s) is/are capable of intramolecular energy transfer from said donor subunit to said acceptor subunit. Such derivatives also may contain an electron transfer subunit. Axial ligands may be covalently bound to the metals contained in the water soluble hybrid phthalocyanine derivatives. Ligands, ligand analogues, polypeptides, proteins and nucleic acids can be linked to the axial ligands of the dyes to form dye conjugates useful in immunoassays and nucleic acid assays.

6. 发明授权

US5824799A Hybrid phthalocyanine derivatives and their uses 失效
标题翻译：杂化酞菁衍生物及其用途
公开(公告)号：US5824799A
公开(公告)日：1998-10-20
申请号：US620597
申请日：1996-03-22
申请人： Kenneth F. Buechler , Joseph B. Noar , Lema Tadesse
发明人： Kenneth F. Buechler , Joseph B. Noar , Lema Tadesse
IPC分类号： C07D487/22 , C07F7/08 , C09B47/04 , C09B47/08 , C09B67/02 , G01N33/533 , G01N33/58 , G01N33/76 , C09B47/00 , C09B47/30
CPC分类号： C07D487/22 , C07F7/0863 , C09B47/045 , C09B47/08 , C09B67/0097 , G01N33/533 , G01N33/582 , G01N33/585 , G01N33/76
摘要： Water soluble hybrid phthalocyanine derivatives useful in competitive and noncompetitive assays immunoassays, nucleic acid and assays are disclosed and claimed having (1) at least one donor subunit with a desired excitation peak; and (2) at least one acceptor subunit with a desired emission peak, wherein said derivative(s) is/are capable of intramolecular energy transfer from said donor subunit to said acceptor subunit. Such derivatives also may contain an electron transfer subunit. Axial ligands may be covalently bound to the metals contained in the water soluble hybrid phthalocyanine derivatives. Ligands, ligand analogs, polypeptides, proteins and nucleic acids can be linked to the axial ligands of the dyes to form dye conjugates useful in immunoassays and nucleic acid assays.
摘要翻译：在竞争性和非竞争性测定中有用的水溶性杂合酞菁衍生物公开和要求具有（1）具有所需激发峰的至少一个供体亚基; 和（2）具有所需发射峰的至少一个受体亚基，其中所述衍生物能够从所述供体亚基到所述受体亚基的分子内能量转移。这样的衍生物也可以含有电子转移子单元。轴向配体可以与水溶性杂合酞菁衍生物中所含的金属共价结合。配体，配体类似物，多肽，蛋白质和核酸可以连接到染料的轴向配体上，以形成可用于免疫测定和核酸测定的染料缀合物。

7. 发明授权

US5302715A Benzodiazepine derivatives 失效
标题翻译：苯并二氮杂衍生物
公开(公告)号：US5302715A
公开(公告)日：1994-04-12
申请号：US864093
申请日：1992-04-06
申请人： Kenneth F. Buechler , Joseph B. Noar
发明人： Kenneth F. Buechler , Joseph B. Noar
IPC分类号： A61K38/00 , A61K39/385 , A61K39/42 , A61K47/48 , C07D243/24 , C07D403/12 , C07D409/12 , C07K5/078 , C07K5/097 , C07K14/00 , C07K14/705 , C07K16/00 , C07K16/44 , G01N33/94 , A61K31/55
CPC分类号： C07D403/12 , A61K47/4833 , C07D243/24 , C07D409/12 , C07K14/705 , C07K16/00 , C07K16/44 , C07K5/06139 , C07K5/0821 , G01N33/948 , A61K38/00
摘要： The present invention is directed to novel benzodiazepine derivatives which are synthesized for the covalent attachment to antigens (proteins or polypeptides) for the preparation of antibodies or receptors to the benzodiazepine metabolites. The resulting novel antigens may be used for the production of antibodies or receptors using standard methods. Once generated, the antibodies or receptors and the novel derivatives which are covalently attached to proteins, polypeptides or labels may be used in the immunoassay process.
摘要翻译：本发明涉及用于共价连接到抗原（蛋白质或多肽）上用于制备苯二氮卓代谢物的抗体或受体的新型苯并二氮杂衍生物。所得的新抗原可以用于使用标准方法生产抗体或受体。一旦产生，共价连接到蛋白质，多肽或标记的抗体或受体和新型衍生物可用于免疫测定过程。

8. 发明授权

US06964844B1 Hybrid phthalocyanine derivatives and their uses 失效
标题翻译：杂化酞菁衍生物及其用途
公开(公告)号：US06964844B1
公开(公告)日：2005-11-15
申请号：US09066255
申请日：1998-04-24
申请人： Kenneth F. Buechler , Joseph B. Noar , Lema Tadesse
发明人： Kenneth F. Buechler , Joseph B. Noar , Lema Tadesse
IPC分类号： C07D487/22 , C12Q1/68 , C12Q1/70 , G01N33/53 , G01N33/533 , G01N33/542
CPC分类号： G01N33/533 , C07D487/22 , G01N33/542 , Y10T436/145555
摘要： Water soluble hybrid phthalocyanine derivatives useful in competitive and noncompetitive assays immunoassays, nucleic acid and assays are disclosed and claimed having (1) at least one donor subunit with a desired excitation peak; and (2) at least one acceptor subunit with a desired emission peak, wherein said derivative(s) is/are capable of intramolecular energy transfer from said donor subunit to said acceptor subunit. Such derivatives also may contain an electron transfer subunit. Axial ligands may be covalently bound to the metals contained in the water soluble hybrid phthalocyanine derivatives. Ligands, ligand analogues, polypeptides, proteins and nucleic acids can be linked to the axial ligands of the dyes to form dye conjugates useful in immunoassays and nucleic acid assays.
摘要翻译：在竞争性和非竞争性测定中有用的水溶性杂合酞菁衍生物公开和要求具有（1）具有所需激发峰的至少一个供体亚基; 和（2）具有所需发射峰的至少一个受体亚基，其中所述衍生物能够从所述供体亚基到所述受体亚基的分子内能量转移。这样的衍生物也可以含有电子转移子单元。轴向配体可以与水溶性杂合酞菁衍生物中所含的金属共价结合。配体，配体类似物，多肽，蛋白质和核酸可以连接到染料的轴向配体上，以形成可用于免疫测定和核酸测定的染料缀合物。

9. 发明申请

US20110065210A1 Use of B-Type Natriuretic Peptide as a Prognostic Indicator in Acute Coronary Syndromes 审中-公开
标题翻译：使用B型钠尿肽作为急性冠状动脉综合征的预后指标
公开(公告)号：US20110065210A1
公开(公告)日：2011-03-17
申请号：US12874859
申请日：2010-09-02
申请人： Jeffrey R. Dahlen , Kenneth F. Buechler , Gunars E. Valkirs
发明人： Jeffrey R. Dahlen , Kenneth F. Buechler , Gunars E. Valkirs
IPC分类号： G01N33/566
CPC分类号： G01N33/6887 , G01N33/6893 , G01N2333/58 , G01N2800/324
摘要： The present invention relates to materials and procedures for evaluating the prognosis of patients suffering from acute coronary syndromes. In particular, the level of BNP, or a marker related to BNP, in a patient sample, alone or in combination with one or more other prognostic markers, provides prognostic information useful for predicting near-term morbidity and/or mortality across the entire spectrum of acute coronary syndromes, including unstable angina, non-ST-elevation non-Q wave myocardial infarction, ST-elevation non-Q wave MI, and transmural (Q-wave) MI.
摘要翻译：本发明涉及用于评估患有急性冠状动脉综合征的患者的预后的材料和程序。特别地，在患者样品中单独或与一种或多种其他预后标志物组合的BNP或与BNP相关的标志物的水平提供了可用于预测整个频谱中的近期发病率和/或死亡率的预后信息急性冠状动脉综合征，包括不稳定型心绞痛，非ST段抬高型非Q波心肌梗死，ST段抬高型非Q波心肌梗死和透壁（Q波）MI。

10. 发明授权

US07604946B2 Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays 失效
标题翻译：测定肌钙蛋白I和T的方法以及肌钙蛋白I和T的复合物以及免疫测定中使用的抗体选择
公开(公告)号：US07604946B2
公开(公告)日：2009-10-20
申请号：US10850954
申请日：2004-05-21
申请人： Kenneth F. Buechler , Paul H. McPherson
发明人： Kenneth F. Buechler , Paul H. McPherson
IPC分类号： G01N33/53
CPC分类号： G01N33/6887 , Y10S435/961 , Y10S435/962 , Y10S435/971 , Y10S435/973 , Y10S436/811 , Y10S436/819
摘要： Assay systems and specialized antibodies for the detection and quantitation of troponin I and troponin T in body fluids as an indicator of myocardial infarction. Since troponin I and T exist in various conformations in the blood, the ratios of the monomeric troponin I an T and the binary and ternary complexes, as well as which form of troponin present in the blood, may be related to the metabolic state of the heart. Disclosed is a system to determine the presence of a troponin form or a group of troponin forms in a sample of whole blood, serum or plasma.Disclosed is a stabilized composition of troponin; the stabilized composition can comprise a stabilized composition of troponin I, wherein the troponin I is oxidized, the troponin I can be unbound or the troponin I can be in a complex.Disclosed is a method for improving the recovery of troponin I or T from a surface used in immunoassaysAlso disclosed are antibodies which recognize, unbound troponin forms, the forms of troponin in binary complexes, the ternary complex of troponin I, T and C, and the conformations of troponin I having intramolecularly oxidized and reduced cysteines.
摘要翻译：用于检测和定量体液中肌钙蛋白I和肌钙蛋白T的测定系统和专用抗体作为心肌梗死的指标。由于肌钙蛋白I和T存在于血液中的各种构象中，单体肌钙蛋白I与T和二元和三元复合物的比例以及存在于血液中的肌钙蛋白形式可能与代谢状态有关心。公开了一种确定全血，血清或血浆样品中肌钙蛋白形式或一组肌钙蛋白形式存在的系统。公开了稳定的肌钙蛋白的组合物; 稳定的组合物可以包含肌钙蛋白I的稳定化组合物，其中肌钙蛋白I被氧化，肌钙蛋白I可以是未结合的，或者肌钙蛋白I可以在复合物中。公开了一种从免疫测定中使用的表面改善肌钙蛋白I或T的回收方法。还公开了识别未结合的肌钙蛋白形式的抗体，二元复合物中肌钙蛋白的形式，肌钙蛋白I，T和C的三元复合物，以及具有分子内氧化和还原半胱氨酸的肌钙蛋白I的构象。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式