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    • 7. 发明申请
    • Polyalkylene glycol derivative and modified bio-related substance
    • 聚亚烷基二醇衍生物和改性生物相关物质
    • US20060115450A1
    • 2006-06-01
    • US11142683
    • 2005-06-02
    • Ken-ichiro NakamotoSyunsuke OhashiYuji YamamotoKenji SakanoueChika ItohTohru Yasukohchi
    • Ken-ichiro NakamotoSyunsuke OhashiYuji YamamotoKenji SakanoueChika ItohTohru Yasukohchi
    • A61K31/765C08F283/00
    • C08G65/2609A61K47/48215A61K47/60C08G65/329C08G65/333
    • A polyalkylene glycol derivative containing a compound of the formula (1): wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, the groups represented by OA2 are the same or different from each other in one molecule, m is an average number of moles of the above oxyalkylene group added, m represents 10 to 1000, X represents a functional group capable of chemically reacting with a bio-related substance, and Y is a linker and represents an ether bond, an amide bond, a urethane bond, an ester bond, a secondary amino group, a carbonate bond, or an alkylene group containing these bonds, polydispersity Mw/Mn of the above polyalkylene glycol derivative in gel permeation chromatography satisfying the following relationship: Mw/Mn≦1.08 wherein Mw represents a weight average molecular weight and Mn represents a number average molecular weight.
    • 含有式(1)化合物的聚亚烷基二醇衍生物:其中R为碳原子数为1〜24的烃基,OA 1和O 2各自为氧化烯 具有2至4个碳原子的基团,由R表示的基团在一个分子中彼此相同或不同,在一个分子中由OA 2表示的基团彼此相同或不同, m是上述氧化烯基的平均加成摩尔数,m表示10〜1000,X表示与生物相关物质发生化学反应的官能团,Y为连接基,表示醚键,酰胺键 氨基甲酸酯键,酯键,仲氨基,碳酸酯键或含有这些键的亚烷基,上述聚亚烷基二醇衍生物在凝胶渗透色谱中的多分散性Mw / Mn满足以下关系: -formulae description =“In-line Formulas”end =“lead”?> Mw / Mn <= 1.08 < in-line-formula description =“In-line Formulas”end =“tail”?>其中Mw表示重均分子量,Mn表示数均分子量。