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1. 发明授权

US08828373B2 Polyalkylene glycol derivative and modified bio-related substance 有权
标题翻译：聚亚烷基二醇衍生物和改性生物相关物质
公开(公告)号：US08828373B2
公开(公告)日：2014-09-09
申请号：US11142683
申请日：2005-06-02
申请人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
发明人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
IPC分类号： A61K31/765 , C08F283/00 , C08G65/329 , C08G65/333 , C08G65/26 , A61K47/48
CPC分类号： C08G65/2609 , A61K47/48215 , A61K47/60 , C08G65/329 , C08G65/333
摘要： A polyalkylene glycol derivative containing a compound of the formula (1): wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, the groups represented by OA2 are the same or different from each other in one molecule, m is an average number of moles of the above oxyalkylene group added, m represents 10 to 1000, X represents a functional group capable of chemically reacting with a bio-related substance, and Y is a linker and represents an ether bond, an amide bond, a urethane bond, an ester bond, a secondary amino group, a carbonate bond, or an alkylene group containing these bonds, polydispersity Mw/Mn of the above polyalkylene glycol derivative in gel permeation chromatography satisfying the following relationship: Mw/Mn≦1.08 wherein Mw represents a weight average molecular weight and Mn represents a number average molecular weight.
摘要翻译：含有式（1）化合物的聚亚烷基二醇衍生物：其中R为碳原子数为1〜24的烃基，OA1和OA2分别为碳原子数2〜4的氧化烯基，由R表示的基团相同或在一个分子中彼此不同，在一个分子中由OA2表示的基团相同或不同，m为上述加成的氧化烯基的平均摩尔数，m表示10〜1000，X表示官能团能够与生物相关物质进行化学反应的基团，Y为连接基，表示醚键，酰胺键，氨基甲酸酯键，酯键，仲氨基，碳酸酯键或含有这些基团的亚烷基键，多分散性上述聚亚烷基二醇衍生物的Mw / Mn满足以下关系式：Mw / Mn＆nlE 1.08其中Mw表示重均分子量，Mn表示数均mol 精神重量

2. 发明申请

US20090192320A1 MODIFIED BIO-RELATED SUBSTANCE, PROCESS FOR PRODUCING THE SAME, AND INTERMEDIATE 有权
标题翻译：改良的生物相关物质，其生产方法和中间体
公开(公告)号：US20090192320A1
公开(公告)日：2009-07-30
申请号：US12399249
申请日：2009-03-06
申请人： Ken-ichiro NAKAMOTO , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
发明人： Ken-ichiro NAKAMOTO , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
IPC分类号： C07D207/404 , C07C43/13 , C07C309/68
CPC分类号： C08G65/329 , A61K47/60 , C08G65/2609
摘要： A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.
摘要翻译：一种改性的生物相关物质，其中至少一种由下式（1）表示的聚（亚烷基二醇）氧基在分子中组合：其中R是具有1至24个碳原子的烃基，OA1和OA2各自具有2至4个碳原子的氧化烯基，由一个分子中由R表示的基团彼此相同或不同，并且由OA2表示的基团在一个分子中彼此相同或不同，n和m各自为氧化烯基的平均加成摩尔数，n表示0〜1000，m表示10〜1000。

3. 发明授权

US08034981B2 Modified bio-related substance, process for producing the same, and intermediate 有权
标题翻译：改性生物相关物质，其生产方法和中间体
公开(公告)号：US08034981B2
公开(公告)日：2011-10-11
申请号：US12942554
申请日：2010-11-09
申请人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
发明人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
IPC分类号： C07D249/18
CPC分类号： C08G65/329 , A61K47/60 , C08G65/2609
摘要： A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.
摘要翻译：一种改性的生物相关物质，其中至少一种由下式（1）表示的聚（亚烷基二醇）氧基在分子中组合：其中R是具有1至24个碳原子的烃基，OA1和OA2各自具有2至4个碳原子的氧化烯基，由一个分子中由R表示的基团彼此相同或不同，并且由OA2表示的基团在一个分子中彼此相同或不同，n和m各自为氧化烯基的平均加成摩尔数，n表示0〜1000，m表示10〜1000。

4. 发明授权

US07524875B2 Modified bio-related substance, process for producing the same, and intermediate 有权
标题翻译：改性生物相关物质，其生产方法和中间体
公开(公告)号：US07524875B2
公开(公告)日：2009-04-28
申请号：US11142255
申请日：2005-06-02
申请人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
发明人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
IPC分类号： A61K31/075 , A61K31/4015 , A61K31/4164 , A61K31/4192 , C07C43/11 , C07D207/444 , C07D233/64 , C07D249/04 , C07D487/06
CPC分类号： C08G65/329 , A61K47/60 , C08G65/2609
摘要： A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.
摘要翻译：一种改性的生物相关物质，其中至少一种由下式（1）表示的聚（亚烷基二醇）氧基在分子中组合：其中R是具有1至24个碳原子的烃基，OA1和OA2各自具有2至4个碳原子的氧化烯基，由一个分子中由R表示的基团彼此相同或不同，并且由OA2表示的基团在一个分子中彼此相同或不同，n和m各自为氧化烯基的平均加成摩尔数，n表示0〜1000，m表示10〜1000。

5. 发明申请

US20060115450A1 Polyalkylene glycol derivative and modified bio-related substance 有权
标题翻译：聚亚烷基二醇衍生物和改性生物相关物质
公开(公告)号：US20060115450A1
公开(公告)日：2006-06-01
申请号：US11142683
申请日：2005-06-02
申请人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
发明人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
IPC分类号： A61K31/765 , C08F283/00
CPC分类号： C08G65/2609 , A61K47/48215 , A61K47/60 , C08G65/329 , C08G65/333
摘要： A polyalkylene glycol derivative containing a compound of the formula (1): wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, the groups represented by OA2 are the same or different from each other in one molecule, m is an average number of moles of the above oxyalkylene group added, m represents 10 to 1000, X represents a functional group capable of chemically reacting with a bio-related substance, and Y is a linker and represents an ether bond, an amide bond, a urethane bond, an ester bond, a secondary amino group, a carbonate bond, or an alkylene group containing these bonds, polydispersity Mw/Mn of the above polyalkylene glycol derivative in gel permeation chromatography satisfying the following relationship: Mw/Mn≦1.08 wherein Mw represents a weight average molecular weight and Mn represents a number average molecular weight.
摘要翻译：含有式（1）化合物的聚亚烷基二醇衍生物：其中R为碳原子数为1〜24的烃基，OA 1和O 2各自为氧化烯具有2至4个碳原子的基团，由R表示的基团在一个分子中彼此相同或不同，在一个分子中由OA 2表示的基团彼此相同或不同， m是上述氧化烯基的平均加成摩尔数，m表示10〜1000，X表示与生物相关物质发生化学反应的官能团，Y为连接基，表示醚键，酰胺键氨基甲酸酯键，酯键，仲氨基，碳酸酯键或含有这些键的亚烷基，上述聚亚烷基二醇衍生物在凝胶渗透色谱中的多分散性Mw / Mn满足以下关系： -formulae description =“In-line Formulas”end =“lead”？> Mw / Mn <= 1.08 < in-line-formula description =“In-line Formulas”end =“tail”？>其中Mw表示重均分子量，Mn表示数均分子量。

6. 发明授权

US08003117B2 Polyalkylene glycol derivative and modified bio-related substance 有权
标题翻译：聚亚烷基二醇衍生物和改性生物相关物质
公开(公告)号：US08003117B2
公开(公告)日：2011-08-23
申请号：US11142678
申请日：2005-06-02
申请人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
发明人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
IPC分类号： C07C41/00 , C07C43/00
CPC分类号： C08G65/333 , C08G65/2609 , C08G65/329
摘要： A polyalkylene glycol derivative containing a compound of the formula (1): wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA2 is an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, the groups represented by OA2 are the same or different from each other in one molecule, m is an average number of moles of the oxyalkylene group added, m represents 10 to 1000, and X represents a functional group capable of chemically reactive with a bio-related substance, polydispersity Mw/Mn of the above polyalkylene glycol derivative in gel permeation chromatography satisfying the following relationship: Mw/Mn≦1.07 wherein Mw represents a weight average molecular weight and Mn represents a number average molecular weight.
摘要翻译：含有式（1）化合物的聚亚烷基二醇衍生物：其中R为碳原子数1〜24的烃基，OA2为碳原子数2〜4的氧化烯基，由R表示的基团相同或不同，在一个分子中，由一个分子表示的基团彼此相同或不同，m是加成的氧化烯基的平均摩尔数，m表示10〜1000，X表示能够与生物相关物质化学反应，上述聚亚烷基二醇衍生物的多分散性Mw / Mn在凝胶渗透色谱中满足以下关系式：Mw / Mn＆nlE 1.07其中Mw表示重均分子量，Mn表示数均分子量。

7. 发明授权

US07851491B2 Modified bio-related substance, process for producing the same, and intermediate 有权
标题翻译：改性生物相关物质，其生产方法和中间体
公开(公告)号：US07851491B2
公开(公告)日：2010-12-14
申请号：US12399249
申请日：2009-03-06
申请人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
发明人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
IPC分类号： A61K31/4192 , C07D249/18
CPC分类号： C08G65/329 , A61K47/60 , C08G65/2609
摘要： A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.
摘要翻译：一种改性的生物相关物质，其中至少一种由下式（1）表示的聚（亚烷基二醇）氧基在分子中组合：其中R是具有1至24个碳原子的烃基，OA1和OA2各自具有2至4个碳原子的氧化烯基，由一个分子中由R表示的基团彼此相同或不同，并且由OA2表示的基团在一个分子中彼此相同或不同，n和m各自为氧化烯基的平均加成摩尔数，n表示0〜1000，m表示10〜1000。

8. 发明申请

US20060073113A1 Polyalkylene glycol derivative and modified bio-related substance 有权
标题翻译：聚亚烷基二醇衍生物和改性生物相关物质
公开(公告)号：US20060073113A1
公开(公告)日：2006-04-06
申请号：US11142678
申请日：2005-06-02
申请人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
发明人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
IPC分类号： A61K31/765 , C08G59/14
CPC分类号： C08G65/333 , C08G65/2609 , C08G65/329
摘要： A polyalkylene glycol derivative containing a compound of the formula (1): wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA2 is an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, the groups represented by OA2 are the same or different from each other in one molecule, m is an average number of moles of the oxyalkylene group added, m represents 10 to 1000, and X represents a functional group capable of chemically reactive with a bio-related substance, polydispersity Mw/Mu of the above polyalkylene glycol derivative in gel permeation chromatography satisfying the following relationship: Mw/Mn≦1.07 wherein Mw represents a weight average molecular weight and Mn represents a number average molecular weight.
摘要翻译：含有式（1）化合物的聚亚烷基二醇衍生物：其中R是具有1至24个碳原子的烃基，OA 2是具有2至4个碳原子的氧化烯基，所表示的基团在一个分子中，R彼此相同或不同，在一个分子中由OA 2表示的基团彼此相同或不同，m是氧化烯基的平均摩尔数 m表示10〜1000，X表示能够与生物相关物质发生化学反应的官能团，上述聚亚烷基二醇衍生物的多分散性Mw / Mu在凝胶渗透色谱中满足以下关系：＆lt; 公式描述=“在线公式”end =“lead”？> Mw / Mn <= 1.07 <？in-line-formula description =“In-line Formulas”end =“tail”？>其中Mw表示重量平均分子量，Mn表示数均分子量。

9. 发明申请

US20050288490A1 Modified bio-related substance, process for producing the same, and intermediate 有权
标题翻译：改性生物相关物质，其生产方法和中间体
公开(公告)号：US20050288490A1
公开(公告)日：2005-12-29
申请号：US11142255
申请日：2005-06-02
申请人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
发明人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
IPC分类号： A61K47/48 , A61P43/00 , C07C43/13 , C07C43/164 , C07K14/47 , C08G65/26 , C08G65/28 , C08G65/329 , C08G85/00 , A61K35/14
CPC分类号： C08G65/329 , A61K47/60 , C08G65/2609
摘要： A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.
摘要翻译：一种改性的生物相关物质，其中至少一种由下式（1）表示的聚（亚烷基二醇）氧基在分子中组合：其中R是具有1至24个碳原子的烃基，OA 1 和/或O 2各自为具有2〜4个碳原子的氧化烯基，由R表示的基团在一个分子中彼此相同或不同， SUP> 2个在一个分子中彼此相同或不同，n和m各自是加成的氧化烯基的平均摩尔数，n表示0〜1000，m表示10〜1000。

10. 发明申请

US20050058620A1 Modified bio-related substance, process for producing the same, and intermediate 审中-公开
标题翻译：改性生物相关物质，其生产方法和中间体
公开(公告)号：US20050058620A1
公开(公告)日：2005-03-17
申请号：US10716432
申请日：2003-11-20
申请人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
发明人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
IPC分类号： A61K47/48 , A61P43/00 , C07C43/13 , C07C43/164 , C07K14/47 , C08G65/26 , C08G65/28 , C08G65/329 , C08G85/00 , A61K31/765 , C08G59/14
CPC分类号： C08G65/329 , A61K47/60 , C08G65/2609
摘要： A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, R and OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.
摘要翻译：一种改性的生物相关物质，其中至少一种由下式（1）表示的聚（亚烷基二醇）氧基在分子中组合：其中R是具有1至24个碳原子的烃基，OA 1和 OA 2各自为具有2〜4个碳原子的氧化烯基，R 1和OA 2在一个分子中相同或不同，n和m各自是加入的氧化烯基的平均摩尔数，n 表示0〜1000，m表示10〜1000。

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